LOCUS       NM_001076674            2202 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane and ubiquitin like domain containing 2
            (TMUB2), transcript variant 3, mRNA.
ACCESSION   NM_001076674
VERSION     NM_001076674.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2202)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2202)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2202)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   4  (bases 1 to 2202)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004596.2, BI906577.1, AL533563.3, AL538440.3 and BM999307.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001076674.2.
            
            Transcript Variant: This variant (3) includes an alternate exon
            with an upstream start codon, compared to variant 1. The resulting
            protein (isoform b) has a longer N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.224290.1,
                                           SRR1660803.130558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538716.7/ ENSP00000444565.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC004596.2         34841-34854         c
            15-26               BI906577.1         1-12
            27-504              AL533563.3         8-485
            505-872             AL538440.3         486-853
            873-1674            AC004596.2         30425-31226         c
            1675-2202           BM999307.1         18-545              c
FEATURES             Location/Qualifiers
     source          1..2202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2202
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /note="transmembrane and ubiquitin like domain containing
                     2"
                     /db_xref="GeneID:79089"
                     /db_xref="HGNC:HGNC:28459"
     exon            1..138
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /inference="alignment:Splign:2.1.0"
     exon            139..206
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1137
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /note="isoform b is encoded by transcript variant 3;
                     transmembrane and ubiquitin-like domain-containing protein
                     2"
                     /codon_start=1
                     /product="transmembrane and ubiquitin-like
                     domain-containing protein 2 isoform b"
                     /protein_id="NP_001070142.1"
                     /db_xref="CCDS:CCDS54134.1"
                     /db_xref="GeneID:79089"
                     /db_xref="HGNC:HGNC:28459"
                     /translation="MISRHLQNNLMSVDPASSQAMELSDVTLIEGVGNEVMVVAGVVV
                     LILALVLAWLSTYVADSGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHP
                     SEGNDEKAEEAGEGRGDSTGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLR
                     SEDSTCLPPSPGLITVRLKFLNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGR
                     LLQDPARTLRSLNITDNCVIHCHRSPPGSAVPGPSASLAPSATEPPSLGVNVGSLMVP
                     VFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR"
     exon            207..773
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /inference="alignment:Splign:2.1.0"
     exon            774..2202
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1978..1983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /note="hexamer: AATAAA"
     polyA_site      2004
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /note="major polyA site"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
                     /note="hexamer: AATAAA"
     polyA_site      2202
                     /gene="TMUB2"
                     /gene_synonym="FP2653"
ORIGIN      
        1 aacagcttcc gggagaagcc ggaagagacc ggaccctgaa cagaatcgca gattgccagc
       61 ccttttcccg acccctacgg aaagacgagt ccaggggccg tcctggcgag gtcaaaacat
      121 ttagtctggt cttttcagtg tgccaggcac tgtgccaagt attttgcttc gatgatttca
      181 cgtcatcttc aaaacaacct catgagcgtg gaccctgcca gcagccaggc catggagctc
      241 tctgatgtca ccctcattga gggtgtgggt aatgaggtga tggtggtggc aggtgtggtg
      301 gtgctgattc tagccttggt cctagcttgg ctctctacct acgtagcaga cagcggtagc
      361 aaccagctcc tgggcgctat tgtgtcagca ggcgacacat ccgtcctcca cctggggcat
      421 gtggaccacc tggtggcagg ccaaggcaac cccgagccaa ctgaactccc ccatccatca
      481 gagggtaatg atgagaaggc tgaagaggcg ggtgaaggtc ggggagactc cactggggag
      541 gctggagctg ggggtggtgt tgagcccagc cttgagcatc tccttgacat ccaaggcctg
      601 cccaaaagac aagcaggtgc aggcagcagc agtccagagg cccccctgag atctgaggat
      661 agcacctgcc tccctcccag ccctggcctc atcactgtgc ggctcaaatt cctcaatgat
      721 accgaggagc tggctgtggc taggccagag gataccgtgg gtgccctgaa gagcaaatac
      781 ttccctggac aagaaagcca gatgaaactg atctaccagg gccgcctgct acaagaccca
      841 gcccgcacac tgcgttctct gaacattacc gacaactgtg tgattcactg ccaccgctca
      901 cccccagggt cagctgttcc aggcccctca gcctccttgg ccccctcggc cactgagcca
      961 cccagccttg gtgtcaatgt gggcagcctc atggtgcctg tctttgtggt gctgttgggt
     1021 gtggtctggt acttccgaat caattaccgc caattcttca cagcacctgc cactgtctcc
     1081 ctggtgggag tcaccgtctt cttcagcttc ctagtatttg ggatgtatgg acgataagga
     1141 cataggaaga aaatgaaagg catggtcttt ctcctttacg gcctccccac ttttcctggc
     1201 cagagctggg cccaagggcc ggggagggag gggtggaaag gatgtgatgg aaatctcctc
     1261 cataggacac aggaggcaag tatgcggcct ccccttctca tccacaggag tacagatgtc
     1321 cctcccgtgc gagcacaact caggtagaaa tgaggatgtc atcttccttc acttttaggg
     1381 tcctctgaag gagttcaaag ctgctggcca agctcagtgg ggagcctggg ctctgagatt
     1441 ccctcccacc tgtggttctg actcttccca gtgtcctgca tgtctgcccc cagcacccag
     1501 ggctgcctgc aagggcagct cagcatggcc ccagcacaac tccgtaggga gcctggagta
     1561 tccttccatt tctcagccaa atactcatct tttgagactg aaatcacact ggcgggaatg
     1621 aagattgtgc cagccttctc ttatgggcac ctagccgcct tcaccttctt cctctacccc
     1681 ttagcaggaa tagggtgtcc tcccttcttt caaagcactt tgcttgcatt ttattttatt
     1741 tttttaagag tccttcatag agctcagtca ggaaggggat ggggcaccaa gccaagcccc
     1801 cagcattggg agcggccagg ccacagctgc tgctcccgta gtcctcaggc tgtaagcaag
     1861 agacagcact ggcccttggc cagcgtccta ccctgcccaa ctccaaggac tgggtatgga
     1921 ttgctgggcc ctaggctctt gcttctgggg ctattggagg gtcagtgtct gtgactgaat
     1981 aaagttccat tttgtggtcc tgcagcctct ttctgtgaca gagaatggct ttgcgctgcc
     2041 cccaggaaaa tggtaatgag agtaggtagg ccggggctac caacgggaga tgcagtttat
     2101 ttacaccagc agccatgggg gcagagggaa tacacagcgt ttacaaagtt agctacctgt
     2161 acagaatgga ttacatatgc aaaaataaaa atctcaagac ca
//
