LOCUS       NM_001136044            1295 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane and ubiquitin like domain containing 1
            (TMUB1), transcript variant 2, mRNA.
ACCESSION   NM_001136044
VERSION     NM_001136044.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1295)
  AUTHORS   Lu,Y., Wang,K., Peng,Y., Zhang,J., Ju,Q., Xu,Q., Ouyang,M. and
            He,Z.
  TITLE     TMUB1 expression is associated with the prognosis of colon cancer
            and immune cell infiltration
  JOURNAL   PeerJ 11, e16334 (2023)
   PUBMED   38025742
  REMARK    GeneRIF: TMUB1 expression is associated with the prognosis of colon
            cancer and immune cell infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1295)
  AUTHORS   Zhang,X., Hu,Y., Zhang,Z., Zhang,X., Liang,L., Cui,X., Wu,Y., Hu,F.
            and Wu,X.
  TITLE     Inhibition of TMUB1 blocks apoptosis and NF-kappaB pathway-mediated
            inflammation in recurrent spontaneous abortion
  JOURNAL   Immun Inflamm Dis 11 (5), e879 (2023)
   PUBMED   37249279
  REMARK    GeneRIF: Inhibition of TMUB1 blocks apoptosis and NF-kappaB
            pathway-mediated inflammation in recurrent spontaneous abortion.
REFERENCE   3  (bases 1 to 1295)
  AUTHORS   Shi,C., Wang,Y., Wu,M., Chen,Y., Liu,F., Shen,Z., Wang,Y., Xie,S.,
            Shen,Y., Sang,L., Zhang,Z., Gao,Z., Yang,L., Qu,L., Yang,Z., He,X.,
            Guo,Y., Pan,C., Che,J., Ju,H., Liu,J., Cai,Z., Yan,Q., Yu,L.,
            Wang,L., Dong,X., Xu,P., Shao,J., Liu,Y., Li,X., Wang,W., Zhou,R.,
            Zhou,T. and Lin,A.
  TITLE     Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1
            polyubiquitination and glycosylation
  JOURNAL   Nat Commun 13 (1), 6951 (2022)
   PUBMED   36376293
  REMARK    GeneRIF: Promoting anti-tumor immunity by targeting TMUB1 to
            modulate PD-L1 polyubiquitination and glycosylation.
            Erratum:[Nat Commun. 2024 Dec 10;15(1):10663. doi:
            10.1038/s41467-024-55049-5.. PMID: 39658552]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1295)
  AUTHORS   Hao,T., Yu,H., Huang,D. and Liu,Q.
  TITLE     TMUB1 Correlated with Immune Infiltration Is a Prognostic Marker
            for Colorectal Cancer
  JOURNAL   Dis Markers 2022, 5884531 (2022)
   PUBMED   35928927
  REMARK    GeneRIF: TMUB1 Correlated with Immune Infiltration Is a Prognostic
            Marker for Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1295)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1295)
  AUTHORS   Christianson,J.C., Olzmann,J.A., Shaler,T.A., Sowa,M.E.,
            Bennett,E.J., Richter,C.M., Tyler,R.E., Greenblatt,E.J.,
            Harper,J.W. and Kopito,R.R.
  TITLE     Defining human ERAD networks through an integrative mapping
            strategy
  JOURNAL   Nat Cell Biol 14 (1), 93-105 (2011)
   PUBMED   22119785
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1295)
  AUTHORS   Jo,Y., Sguigna,P.V. and DeBose-Boyd,R.A.
  TITLE     Membrane-associated ubiquitin ligase complex containing gp78
            mediates sterol-accelerated degradation of
            3-hydroxy-3-methylglutaryl-coenzyme A reductase
  JOURNAL   J Biol Chem 286 (17), 15022-15031 (2011)
   PUBMED   21343306
REFERENCE   8  (bases 1 to 1295)
  AUTHORS   Liu,G.Y., Liu,S.X., Li,P., Tang,L., Han,Y.M., An,H.Z., Li,J.Y.,
            Dai,X.K., Li,N., Cao,X.T. and Yu,Y.Z.
  TITLE     Cloning and characterization of DULP, a novel ubiquitin-like
            molecule from human dendritic cells
  JOURNAL   Cell Mol Immunol 6 (1), 27-33 (2009)
   PUBMED   19254477
  REMARK    GeneRIF: a novel ubiquitin-like molecule DULP from human dendritic
            cells was identified.
REFERENCE   9  (bases 1 to 1295)
  AUTHORS   Della Fazia,M.A., Castelli,M., Bartoli,D., Pieroni,S.,
            Pettirossi,V., Piobbico,D., Viola-Magni,M. and Servillo,G.
  TITLE     HOPS: a novel cAMP-dependent shuttling protein involved in protein
            synthesis regulation
  JOURNAL   J Cell Sci 118 (Pt 14), 3185-3194 (2005)
   PUBMED   16014383
REFERENCE   10 (bases 1 to 1295)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000936.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001136044.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            as compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000936.1, AY037155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297533.9/ ENSP00000297533.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1295              BC000936.1         41-1335
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1295
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /note="transmembrane and ubiquitin like domain containing
                     1"
                     /db_xref="GeneID:83590"
                     /db_xref="HGNC:HGNC:21709"
                     /db_xref="MIM:614792"
     exon            1..60
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /inference="alignment:Splign:2.1.0"
     exon            61..479
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..831
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /note="ubiquitin-like protein DULP; ubiquitin-like protein
                     SB144; hepatocyte odd protein shuttling protein; dendritic
                     cell-derived ubiquitin-like protein"
                     /codon_start=1
                     /product="transmembrane and ubiquitin-like
                     domain-containing protein 1"
                     /protein_id="NP_001129516.1"
                     /db_xref="CCDS:CCDS5920.1"
                     /db_xref="GeneID:83590"
                     /db_xref="HGNC:HGNC:21709"
                     /db_xref="MIM:614792"
                     /translation="MTLIEGVGDEVTVLFSVLACLLVLALAWVSTHTAEGGDPLPQPS
                     GTPTPSQPSAAMAATDSMRGEAPGAETPSLRHRGQAAQPEPSTGFTATPPAPDSPQEP
                     LVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLH
                     LPPNCVLHCHVSTRVGPPNPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYR
                     PFFPLTATLGLAGFTLLLSLLAFAMYRP"
     exon            480..1295
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1272..1277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /note="hexamer: ATTAAA"
     polyA_site      1295
                     /gene="TMUB1"
                     /gene_synonym="C7orf21; DULP; HOPS; SB144"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcgcct cccgcccgga agtgcccgag gggccgcgat ggagctgggg gagccgggcg
       61 ctcggtagcg cggcgggcaa ggcaggcgcc atgaccctga ttgaaggggt gggtgatgag
      121 gtgaccgtcc ttttctcggt gcttgcctgc cttctggtgc tggcccttgc ctgggtctca
      181 acgcacaccg ctgagggcgg ggacccactg ccccagccgt cagggacccc aacgccatcc
      241 cagcccagcg cagccatggc agctaccgac agcatgagag gggaggcccc aggggcagag
      301 acccccagcc tgagacacag aggtcaagct gcacagccag agcccagcac ggggttcaca
      361 gcaacaccgc cagccccgga ctccccgcag gagcccctcg tgctacggct gaaattcctc
      421 aatgattcag agcaggtggc cagggcctgg ccccacgaca ccattggctc cttgaaaagg
      481 acccagtttc ccggccggga acagcaggtg cgactcatct accaagggca gctgctaggc
      541 gacgacaccc agaccctggg cagccttcac ctccctccca actgcgttct ccactgccac
      601 gtgtccacga gagtcggtcc cccaaatccc ccctgcccgc cggggtccga gcccggcccc
      661 tccgggctgg aaatcggcag cctgctgctg cccctgctgc tcctgctgtt gctgctgctc
      721 tggtactgcc agatccagta ccggcccttc tttcccctga ccgccactct gggcctggcc
      781 ggcttcaccc tgctcctcag tctcctggcc tttgccatgt accgcccgta gtgcctccgc
      841 gggcgcttgg cagcgtcgcc ggcccctccg gaccttgctc cccgcgccgc ggcgggagct
      901 gctgcctgcc caggcccgcc tctccggcct gcctcttccc gccgccctgg agcccagccc
      961 tgcgccgcag aggactcccg ggactggcgg aggccccgcc ctgcgaccgc cggggctcgg
     1021 ggccacctcc cggggctgct gaccctcagc ccgcactggg agtgggctcc tcggggtcgg
     1081 gcatctgctg tcgctgcctc ggccccgggc agagccgggc cgccccgggg gcccgtctta
     1141 gtgttctgcc ggaggaccca gccgcctcca atccctgaca gctccttggg ctgagttggg
     1201 gacgccaggt cggtgggagg ctggtgaagg ggagcgggga ggggcagagg agttccccgg
     1261 aacccgtgca gattaaagta actgtgaagt tttca
//
