LOCUS       NM_181783               7192 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane O-mannosyltransferase targeting
            cadherins 3 (TMTC3), transcript variant 1, mRNA.
ACCESSION   NM_181783
VERSION     NM_181783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7192)
  AUTHORS   Yuan,H., Zhao,Z., Guo,Z., Ma,L., Han,J. and Song,Y.
  TITLE     A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma
            Progression by Activating GRP78/PERK Signaling Pathway
  JOURNAL   Int J Biol Sci 18 (13), 4853-4868 (2022)
   PUBMED   35982901
  REMARK    GeneRIF: A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell
            Carcinoma Progression by Activating GRP78/PERK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7192)
  AUTHORS   Biyik,I., Kalkan,U. and Simsek,S.
  TITLE     The deep infiltrating endometriosis tissue has lower T-cadherin,
            E-cadherin, progesterone receptor and oestrogen receptor than
            endometrioma tissue
  JOURNAL   Taiwan J Obstet Gynecol 60 (6), 1059-1065 (2021)
   PUBMED   34794738
  REMARK    GeneRIF: The deep infiltrating endometriosis tissue has lower
            T-cadherin, E-cadherin, progesterone receptor and oestrogen
            receptor than endometrioma tissue.
REFERENCE   3  (bases 1 to 7192)
  AUTHORS   Eisenhaber,B., Sinha,S., Jadalanki,C.K., Shitov,V.A., Tan,Q.W.,
            Sirota,F.L. and Eisenhaber,F.
  TITLE     Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4,
            new O-mannosyltransferases from the GT-C/PMT clan, are rationalized
            as ligand binding sites
  JOURNAL   Biol Direct 16 (1), 4 (2021)
   PUBMED   33436046
  REMARK    GeneRIF: Conserved sequence motifs in human TMTC1, TMTC2, TMTC3,
            and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are
            rationalized as ligand binding sites.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7192)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Siukstaite,L.,
            Harrison,O.J., Brasch,J., Goodman,K.M., Hansen,L., Shapiro,L.,
            Honig,B., Vakhrushev,S.Y., Clausen,H. and Halim,A.
  TITLE     Discovery of an O-mannosylation pathway selectively serving
            cadherins and protocadherins
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11163-11168 (2017)
   PUBMED   28973932
  REMARK    GeneRIF: O-mannosylation pathway dedicated to cadherins/
            protocadherins orchestrated by the four TMTC1-4 genes
REFERENCE   5  (bases 1 to 7192)
  AUTHORS   Jerber,J., Zaki,M.S., Al-Aama,J.Y., Rosti,R.O., Ben-Omran,T.,
            Dikoglu,E., Silhavy,J.L., Caglar,C., Musaev,D., Albrecht,B.,
            Campbell,K.P., Willer,T., Almuriekhi,M., Caglayan,A.O., Vajsar,J.,
            Bilguvar,K., Ogur,G., Abou Jamra,R., Gunel,M. and Gleeson,J.G.
  TITLE     Biallelic Mutations in TMTC3, Encoding a Transmembrane and
            TPR-Containing Protein, Lead to Cobblestone Lissencephaly
  JOURNAL   Am J Hum Genet 99 (5), 1181-1189 (2016)
   PUBMED   27773428
REFERENCE   6  (bases 1 to 7192)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7192)
  AUTHORS   Yun,E.J. and Vu,T.H.
  TITLE     mSmile is necessary for bronchial smooth muscle and alveolar
            myofibroblast development
  JOURNAL   Anat Rec (Hoboken) 295 (1), 167-176 (2012)
   PUBMED   21956870
  REMARK    GeneRIF: SMILE is a novel transgene specifying both bronchial
            smooth muscle and lung alveolar myofibroblast lineages,
            contributing to the understanding of the biological control of the
            development of these cells.
REFERENCE   8  (bases 1 to 7192)
  AUTHORS   Racape,M., Duong Van Huyen,J.P., Danger,R., Giral,M., Bleicher,F.,
            Foucher,Y., Pallier,A., Pilet,P., Tafelmeyer,P., Ashton-Chess,J.,
            Dugast,E., Pettre,S., Charreau,B., Soulillou,J.P. and Brouard,S.
  TITLE     The involvement of SMILE/TMTC3 in endoplasmic reticulum stress
            response
  JOURNAL   PLoS One 6 (5), e19321 (2011)
   PUBMED   21603654
  REMARK    GeneRIF: that SMILE is involved in the endoplasmic reticulum stress
            response, by modulating proteasome activity and XBP-1 transcript
            expression. This function of SMILE may influence immune cell
            behavior in the context of transplantation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290436.1, BX538169.1,
            BC117175.1, CR749309.1, CR933632.1, BG287027.1 and CR737828.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_181783.3.
            
            Summary: This gene encodes a protein that belongs to the
            transmembrane and tetratricopeptide repeat-containing protein
            family. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.255540.1,
                                           SRR1660807.161222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266712.11/ ENSP00000266712.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK290436.1         12-28
            18-1251             BX538169.1         2-1235
            1252-3028           BC117175.1         1084-2860
            3029-3346           BX538169.1         3013-3330
            3347-5520           CR749309.1         3345-5518
            5521-6337           CR933632.1         5482-6298
            6338-6758           BG287027.1         185-605
            6759-7192           CR737828.1         249-682
FEATURES             Location/Qualifiers
     source          1..7192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.32"
     gene            1..7192
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /note="transmembrane O-mannosyltransferase targeting
                     cadherins 3"
                     /db_xref="GeneID:160418"
                     /db_xref="HGNC:HGNC:26899"
                     /db_xref="MIM:617218"
     exon            1..181
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            182..398
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2954
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /EC_number="2.4.1.109"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and TPR repeat-containing protein 3; protein
                     O-mannosyl-transferase TMTC3; transmembrane and
                     tetratricopeptide repeat containing 3"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase TMTC3 isoform 1"
                     /protein_id="NP_861448.2"
                     /db_xref="CCDS:CCDS9032.1"
                     /db_xref="GeneID:160418"
                     /db_xref="HGNC:HGNC:26899"
                     /db_xref="MIM:617218"
                     /translation="MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHP
                     STPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAV
                     VSVIFLKVCKLFLDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYT
                     RSKGPDNSIIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTA
                     GQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPT
                     PTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLG
                     VFSIRYSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHG
                     WQKISTKSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWN
                     NVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKS
                     LMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAY
                     ISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRAL
                     ELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDK
                     KDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLI
                     LKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETL
                     ALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSVEGKKIPTESVKEIRGESRQT
                     QIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAALKRLEEIERILNGE
                     "
     exon            399..617
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            618..717
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            718..833
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1006
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1259
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1408
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1529
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1641
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1745
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1915
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2142
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..7192
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6310..6315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /note="hexamer: ATTAAA"
     polyA_site      6337
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /note="major polyA site"
     regulatory      7169..7174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /note="hexamer: AATAAA"
     polyA_site      7192
                     /gene="TMTC3"
                     /gene_synonym="LIS8; SMILE"
                     /note="major polyA site"
ORIGIN      
        1 aagactgcga cggtaccggg gcggcgggga aggaccgaga ggcgggagga gcagcggctc
       61 aggcgcctgc aaactggtgg cctgaacgag gtagaccatg actgtggttt cagtggcgtc
      121 actcgctggg ctgctcttcc tgaggttttc ctaagccatc ccctggcgga accgccccca
      181 gtttttgtcc agaagtgctt atagaaaaga tggctaatat taacctaaaa gaaataacct
      241 taatagtagg tgtggttact gcctgctatt ggaacagcct cttttgtggt tttgtttttg
      301 atgatgtttc agcaatactg gataacaaag acttgcatcc atctacacct ttaaaaactt
      361 tatttcaaaa tgacttctgg ggaaccccta tgtctgagga gagaagccac aagtcttacc
      421 gtcccttaac agtattgaca tttcgcttaa attatttgtt aagtgaacta aaaccaatgt
      481 catatcatct cctgaatatg atttttcatg ctgtggttag tgtgatattt ctcaaagtat
      541 gcaaactttt tctggacaac aagagtagtg tgattgcttc tttacttttt gcagtgcacc
      601 caatacacac agaagcagta acaggagttg ttggaagagc agaacttttg tcatctatct
      661 tttttctagc agcttttttg tcatatacca gatcaaaagg accagacaat tccataatat
      721 ggactccaat tgccttgaca gtgtttttag tggctgttgc aacattatgt aaagaacaag
      781 gaataacagt tgtaggaatt tgctgtgtgt atgaagtgtt tattgcccag gggtatactt
      841 tgccattact atgtactact gctggacagt ttctccgtgg aaagggtagc attccatttt
      901 ctatgctgca gacactagta aaactcattg tcttgatgtt cagtacatta ttacttgttg
      961 tgattagagt ccaggttatt caatcccaac ttccagtatt caccaggttt gataacccag
     1021 ctgctgtaag cccaactcct acaaggcaac taacttttaa ctacctcctt cctgtgaatg
     1081 cttggttgtt attaaatcct tcagagctct gctgtgattg gaccatggga acaataccac
     1141 ttatagagtc attactagat attcgaaatc tggccacatt tactttcttt tgttttctgg
     1201 ggatgttggg agtattcagt atcagatact ctggtgattc ctccaagact gttttaatgg
     1261 cgctttgttt aatggcatta ccatttattc ctgcatcgaa cctttttttt ccagttggat
     1321 ttgttgttgc cgagcgagta ttatatgttc ccagcatggg gttctgtatt ttggtagccc
     1381 atggatggca gaaaatatca acaaaaagtg tatttaaaaa gctatcctgg atttgtctgt
     1441 ctatggtgat actcactcat tccttaaaaa cattccacag aaattgggat tgggagtctg
     1501 aatatacatt gtttatgtca gccttgaagg taaataaaaa taatgccaaa ctttggaata
     1561 atgtgggtca tgctctggaa aatgaaaaga actttgagag agctttgaaa tacttcttac
     1621 aggctaccca tgttcagcca gatgatattg gtgcccatat gaatgtagga agaacttata
     1681 aaaatttaaa tagaaccaaa gaagctgaag aatcttacat gatggctaaa tcactgatgc
     1741 ctcaaattat tcctggtaaa aaatatgcag ccagaattgc ccctaaccac ctaaatgttt
     1801 atatcaatct ggctaacctg atccgagcaa atgagtcccg actggaagaa gcagatcagc
     1861 tgtaccgtca agcaataagc atgaggcccg acttcaagca ggcttacatt agcagaggag
     1921 aattgctttt aaaaatgaat aaacctctta aagcaaagga agcatatctt aaagcactag
     1981 agctggacag aaataatgca gatctttggt acaacttggc aattgtacat attgaactta
     2041 aagaaccaaa tgaagcccta aaaaacttta atcgtgctct ggaactaaat ccaaagcata
     2101 aactagcatt attcaactct gctatagtaa tgcaagaatc aggtgaggtt aaactcagac
     2161 ctgaagctag aaaacgactt ctaagttata taaatgaaga gccactagat gctaatgggt
     2221 atttcaattt gggaatgctt gccatggatg acaaaaagga caatgaagca gagatttgga
     2281 tgaagaaagc cataaagtta caagccgact tccgaagtgc tttgtttaat ctggctctcc
     2341 tgtattccca gactgcaaag gaattaaagg ctttgccaat tttggaggag ttactcagat
     2401 actaccctga tcatatcaag ggcctcattt taaaaggaga cattctgatg aatcaaaaga
     2461 aagatatact aggagcaaaa aaatgttttg aaaggatttt ggagatggat ccaagcaatg
     2521 tgcaaggaaa acacaatctt tgtgttgttt attttgaaga aaaagactta ttaaaagctg
     2581 aaagatgcct tcttgaaaca ctggcattag caccacatga agaatatatt cagcgccatt
     2641 tgaatatagt cagggataag atttcctcat ctagttttat agagccaata ttcccaacca
     2701 gtaagatttc aagtgtggaa ggaaagaaaa ttccaactga aagtgtaaaa gaaattagag
     2761 gtgaatccag acaaacacaa atagtaaaaa caagtgataa taaaagtcag tctaaatcca
     2821 acaaacaatt aggaaaaaat ggagacgaag agacacccca caaaacaaca aaagacatca
     2881 aagaaattga gaagaaaaga gttgctgctt taaaaagact agaagagatt gaacgtattt
     2941 taaatggtga ataacattaa tatttatcgt gacaatggta tcaaagaaca tcaatccgta
     3001 tcatgtgatt gcttttactg ggagctttga aaaaaagttc aagggttcct aatggtcaat
     3061 catgagctgc cttgaagtag gatcaaaata agattttcat taaagacctg tattatccca
     3121 ggatgtatat tatgtatcgc tgttttcaga gtgtgggtga atatagcaga aatattacag
     3181 cggaagtgac aaatttacaa cttttattat agaaagaagg tgtttctggc aatgtaatct
     3241 ttactgctct caattaaaaa taattttgag gcctgaatga taatcccttg aggacaaatc
     3301 caacatgtgc tggtttattc tgttaattcc catttatttg cctacttcat ttttcttgca
     3361 cctcttagaa tctaactatg aattgaaaac acttaagtaa ttctgtttaa tcaagggatt
     3421 tacactacaa aagaatgctg gcttttttta tgttgtattc cttagttgag ttttagaagg
     3481 aatgcttgat gaaacatttt aaaataagtc atgacatgtt agcttgagaa tgtattttca
     3541 taattgtata cttgttttta actttaaatg taatttttaa tcaggtaaag tttgacacat
     3601 gtatagctac atacacacat ttttaatggt gctcatatat actgtatttt ttgttgttta
     3661 gttttactta ttgagagtgt cacaacatga atcacataat catgattttt tttttttact
     3721 tttactcccc aaattattca tgtttcttag atcgtagtca ttgagaagtc ccaataactc
     3781 taaacttttg agttataacg tagtaaactt ctctttcatc tttgtgttag ctctgtagtc
     3841 ttaacctgga ttttaatttt tttgtttcca aagtcacaat tgaattattc ttagatacct
     3901 taagccactg aattcagttc tgtttgactg aaagcaaaac aacgtgacag tttattttca
     3961 aacactaact tcttgatatt ttgttatggt atatcttttt attaaatatt tattttgact
     4021 aagctttcat aaaatatttg aagctatttt aatcatcaag tatggaaaac aaattactat
     4081 tgcattttcc tatatatgca tatattatgg attaaccaga attgtatcat ttttggccta
     4141 atgtctggat ataaaagata attagcctac tatagtatta ataaattttt cagttggttt
     4201 gggcaaattt aaacctgaaa aataggttaa aaagtagtta caaattaaac ttactaattt
     4261 atacctgatt ttttttcttg aattaaagta cattttaaat gagctttata ataccttaaa
     4321 aagttggttc taatttaaaa tatgaaagct ctggctatca tcctgggata gtaatttcta
     4381 attatatagt atttcaaaac tatatatttt ttagttcctt tgagataact aatttctaat
     4441 tatatatgtt tcaaaaacca tatcctgtat tttttttaag aattgtttta taaataggtc
     4501 ataagataca aggtctgcat tagaagaccc actcttacta ggttccctaa ggatctgcca
     4561 tagatttttt tttttttttt ttttttttta ggtagtttaa agcaagcact gataccagtg
     4621 ggagttggtc ttgatctagg agattctgtt aagcatccaa aaacaatgcc taatttcagt
     4681 tcttaggtta tggcttgtga ctccagataa aagatggaga atacctcatg tactgtgact
     4741 tgaaaatgaa ttcttaaaat tcttaggctc tctccatgta tctttcttaa ggaaaagttt
     4801 ctgagtgtga tctctctttt gccatagtat caagtggagg gtagttcaga aaagttaata
     4861 ggaaatcttt tgtgacagca gactataata gaagtttgag taatatttta ataaatttat
     4921 ataattcaaa tgataaaaat gtatcaatgt tatccaatga tttttattaa aaaattacct
     4981 tattattaga actgtgccta ttacataaaa agtgctcatg tatttgaatt ttaaataatt
     5041 tatttaaatc aagaccacca taagtcatta ataatttaat aattgtttta aatcagtggt
     5101 tttcaaccct cacttcatat tagaatcatc tgaggacttt taatatggaa tccacctcat
     5161 aacaattaag tctaaatttc tggaagatgg agccatgctt gtttttccaa aagctctttg
     5221 agtgattcta atttgtagtc agagttgaag accactgctc taaattagtg caggaaaatg
     5281 cttttatttc tcccatgtta acttttaaaa ctagtaatgt acccagttaa gttttgatgg
     5341 tttaaattcc actaaagaac atattcttct aataactagc atttattaca tgaaatttaa
     5401 gagtttaagt tccatcaaac tagcccttgt gtaagattat tatttcttct ctataacttc
     5461 aaaatagata tttcattcaa actgttcagg tgagaaaaca taatggattt tttttttttt
     5521 cctctggagc tgcctgttca gtgagatgga ggaggtgggc acatttaagg tcagttcact
     5581 aacctatggt tcagagttct gatcatatgg aagtttggaa aagagagctt atcacaggtt
     5641 tgtatgctgg tgaatggata gttttaattc tcactgtctc aaaagagaat cagctctcca
     5701 gcagttctag aaaagctttg acaatcccca aggggcagtg ttaccttact ccttcactgc
     5761 ttcttagaag gtagaattaa gtttctggaa ttgcacctac atgttttctt attaacattc
     5821 agaattggga atattaattt ttccagtgag tagttttctg aaattggtaa cttggagagt
     5881 aaaataacgt attttgcttt tcaattttgt gtttgtttac ttttatgtaa aaatttgata
     5941 tgtgaattac acagttctaa taaaacctca tgccttttca ttacatctaa tttgaactct
     6001 caacttcatg ttacagaatg ctttaaagat gctttaatga aaagtattaa gaaaatatat
     6061 agatttgtat gtcagtttat acttcagaaa tccatatatt tgtcatattt atttttttag
     6121 aaacctccta attggataac tagatggtat ttaaaatgaa tgcccaaaaa tatcttgtac
     6181 ctttgtccaa aagtttatct gttggaagcc gccagccatt catgtagaga gtttataaga
     6241 aaataattta aaattgtatg cattttatat tactatggta tctgtgtacc atatttctaa
     6301 gtattcatta ttaaattggt acttcttaaa accataacct ggcttgcctt ttagtgttaa
     6361 aaaaatacaa cattgtatat agagatttct tttatgaaga agagctgacg taatttatta
     6421 gcagtgatct gagaaagaca ttaaataagt ttctgagagt gatacatttt caaacatgag
     6481 gagtgacaac caccaaatta agaaaaggaa acaactcaga cttggaattt tatacgaatt
     6541 tcatttctat atgtgcctgg tattgcctct ggcataactt agaggaaatt gttctaccta
     6601 tatgtcctca gtttcttcat ctacaagttg ggaaaaacat tttcctctta aaattgtgaa
     6661 gaggatttat atatttatat gatatattgt atatattaat atatttaaat tgcttagagt
     6721 ttctagcaca tagcaaataa taaatattag ttattagtat aaacataagg cttaaagtct
     6781 tggatttgat gcatatgact taatttgtat ttgtgctagt agctgtaatg tcagtgacag
     6841 gataacaagc aaatgattag aaatctaata gtaatgcttg ttcctttgct atctatgcta
     6901 acaagtacat agatagccta agataaatta tacttaggat gaagctaaaa tgcataactg
     6961 agacacctta aaattgtact accttgtgct gttcactgcc atcagggagg tagcataaaa
     7021 tgaaagataa agtctgaaga ctggatccag gcaaattcat gttctttctt tgtaactcac
     7081 tttcttcgtc aacatttctg tgactcaatg gatagcatat ttccatcaag tagcacgtat
     7141 aacgtgatgc tttcatgttt ctgccttaaa taaaataacc ctcaaaaaac ca
//
