LOCUS       NM_001193451            8846 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane O-mannosyltransferase targeting
            cadherins 1 (TMTC1), transcript variant 1, mRNA.
ACCESSION   NM_001193451
VERSION     NM_001193451.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8846)
  AUTHORS   Lu,Y., Qing,L., Hu,L., Yin,W., Chen,X., Wang,Z., Cheng,T., Wang,J.,
            Liu,L. and Nie,S.
  TITLE     Hypomethylation and high expression of the TMTC1 gene in patients
            with schizophrenia
  JOURNAL   Asian J Psychiatr 93, 103922 (2024)
   PUBMED   38232443
  REMARK    GeneRIF: Hypomethylation and high expression of the TMTC1 gene in
            patients with schizophrenia.
REFERENCE   2  (bases 1 to 8846)
  AUTHORS   Yeh,T.C., Lin,N.Y., Chiu,C.Y., Hsu,T.W., Wu,H.Y., Lin,H.Y.,
            Chen,C.H. and Huang,M.C.
  TITLE     TMTC1 promotes invasiveness of ovarian cancer cells through
            integrins beta1 and beta4
  JOURNAL   Cancer Gene Ther 30 (8), 1134-1143 (2023)
   PUBMED   37221403
  REMARK    GeneRIF: TMTC1 promotes invasiveness of ovarian cancer cells
            through integrins beta1 and beta4.
REFERENCE   3  (bases 1 to 8846)
  AUTHORS   Eisenhaber,B., Sinha,S., Jadalanki,C.K., Shitov,V.A., Tan,Q.W.,
            Sirota,F.L. and Eisenhaber,F.
  TITLE     Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4,
            new O-mannosyltransferases from the GT-C/PMT clan, are rationalized
            as ligand binding sites
  JOURNAL   Biol Direct 16 (1), 4 (2021)
   PUBMED   33436046
  REMARK    GeneRIF: Conserved sequence motifs in human TMTC1, TMTC2, TMTC3,
            and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are
            rationalized as ligand binding sites.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8846)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 8846)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Siukstaite,L.,
            Harrison,O.J., Brasch,J., Goodman,K.M., Hansen,L., Shapiro,L.,
            Honig,B., Vakhrushev,S.Y., Clausen,H. and Halim,A.
  TITLE     Discovery of an O-mannosylation pathway selectively serving
            cadherins and protocadherins
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11163-11168 (2017)
   PUBMED   28973932
  REMARK    GeneRIF: O-mannosylation pathway dedicated to cadherins/
            protocadherins orchestrated by the four TMTC1-4 genes
REFERENCE   6  (bases 1 to 8846)
  AUTHORS   Sunryd,J.C., Cheon,B., Graham,J.B., Giorda,K.M., Fissore,R.A. and
            Hebert,D.N.
  TITLE     TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide
            repeat-containing adapter proteins involved in calcium homeostasis
  JOURNAL   J Biol Chem 289 (23), 16085-16099 (2014)
   PUBMED   24764305
  REMARK    GeneRIF: findings provide an important link between aneuploidy and
            the stress pathways activated by Aurora B inhibition and also
            support the use of Aurora B inhibitors in combination therapy for
            treatment of cancer.
REFERENCE   7  (bases 1 to 8846)
  AUTHORS   Levinson,D.F., Shi,J., Wang,K., Oh,S., Riley,B., Pulver,A.E.,
            Wildenauer,D.B., Laurent,C., Mowry,B.J., Gejman,P.V., Owen,M.J.,
            Kendler,K.S., Nestadt,G., Schwab,S.G., Mallet,J., Nertney,D.,
            Sanders,A.R., Williams,N.M., Wormley,B., Lasseter,V.K., Albus,M.,
            Godard-Bauche,S., Alexander,M., Duan,J., O'Donovan,M.C., Walsh,D.,
            O'Neill,A., Papadimitriou,G.N., Dikeos,D., Maier,W., Lerer,B.,
            Campion,D., Cohen,D., Jay,M., Fanous,A., Eichhammer,P.,
            Silverman,J.M., Norton,N., Zhang,N., Hakonarson,H., Gao,C.,
            Citri,A., Hansen,M., Ripke,S., Dudbridge,F. and Holmans,P.A.
  CONSRTM   Schizophrenia Psychiatric GWAS Consortium
  TITLE     Genome-wide association study of multiplex schizophrenia pedigrees
  JOURNAL   Am J Psychiatry 169 (9), 963-973 (2012)
   PUBMED   22885689
REFERENCE   8  (bases 1 to 8846)
  AUTHORS   Smith,N.L., Felix,J.F., Morrison,A.C., Demissie,S., Glazer,N.L.,
            Loehr,L.R., Cupples,L.A., Dehghan,A., Lumley,T., Rosamond,W.D.,
            Lieb,W., Rivadeneira,F., Bis,J.C., Folsom,A.R., Benjamin,E.,
            Aulchenko,Y.S., Haritunians,T., Couper,D., Murabito,J., Wang,Y.A.,
            Stricker,B.H., Gottdiener,J.S., Chang,P.P., Wang,T.J., Rice,K.M.,
            Hofman,A., Heckbert,S.R., Fox,E.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Rotter,J.I., Willerson,J.T., Levy,D., van
            Duijn,C.M., Psaty,B.M., Witteman,J.C., Boerwinkle,E. and Vasan,R.S.
  TITLE     Association of genome-wide variation with the risk of incident
            heart failure in adults of European and African ancestry: a
            prospective meta-analysis from the cohorts for heart and aging
            research in genomic epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 3 (3), 256-266 (2010)
   PUBMED   20445134
REFERENCE   9  (bases 1 to 8846)
  AUTHORS   Lunetta,K.L., D'Agostino,R.B. Sr., Karasik,D., Benjamin,E.J.,
            Guo,C.Y., Govindaraju,R., Kiel,D.P., Kelly-Hayes,M., Massaro,J.M.,
            Pencina,M.J., Seshadri,S. and Murabito,J.M.
  TITLE     Genetic correlates of longevity and selected age-related
            phenotypes: a genome-wide association study in the Framingham Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S13 (2007)
   PUBMED   17903295
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022078.12, GQ865601.1, BC042083.1, AC012151.14 and BG413338.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001193451.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ865601.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539277.6/ ENSP00000442046.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC022078.12        74421-74552
            133-249             GQ865601.1         1-117
            250-263             AC022078.12        74670-74683
            264-2890            GQ865601.1         132-2758
            2891-3705           BC042083.1         2850-3664
            3706-8776           AC012151.14        77080-82150         c
            8777-8846           BG413338.1         37-106              c
FEATURES             Location/Qualifiers
     source          1..8846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..8846
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /note="transmembrane O-mannosyltransferase targeting
                     cadherins 1"
                     /db_xref="GeneID:83857"
                     /db_xref="HGNC:HGNC:24099"
                     /db_xref="MIM:615855"
     exon            1..493
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2840
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /EC_number="2.4.1.109"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein O-mannosyl-transferase TMTC1; transmembrane and
                     tetratricopeptide repeat containing 1A"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase TMTC1 isoform 1"
                     /protein_id="NP_001180380.1"
                     /db_xref="CCDS:CCDS53772.1"
                     /db_xref="GeneID:83857"
                     /db_xref="HGNC:HGNC:24099"
                     /db_xref="MIM:615855"
                     /translation="MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRS
                     LQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKL
                     NIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEA
                     VAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLV
                     KETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQ
                     QRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTL
                     CYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVF
                     PFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
                     LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRT
                     ALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEE
                     AITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGV
                     FLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHK
                     AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMT
                     NHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
                     LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDS
                     KLLKENLAKLDRLEKRLQEVREKDQT"
     exon            494..671
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            672..745
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            746..922
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1129
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1319
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1441
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1609
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1723
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1867
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1976
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2079
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2215
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2360
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2498
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2621
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2699
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..8846
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /note="hexamer: ATTAAA"
     polyA_site      3705
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /note="major polyA site"
     regulatory      8837..8842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /note="hexamer: ATTAAA"
     polyA_site      8846
                     /gene="TMTC1"
                     /gene_synonym="ARG99; OLF; TMTC1A"
                     /note="major polyA site"
ORIGIN      
        1 gtttatttgc agctgggcca actccgcggc gcaggcggcg gcggagcgcg gggagctcgc
       61 ggcgggtcca gctgccgcag caccatgccc gagcccccct ccgggcagac gccgcgcgcc
      121 gccggggccc cggtagggga ggatgccaga cgcccgggag aggccagggc agcagcggcg
      181 gcggcggcgc gatggtggtg accacctctg cccgaggcgg cggcggggac cgcacaccct
      241 cccggcggcg gggctgcggg ctagcgccgg ccggggccgc ggcgctgctg gccggggcaa
      301 gctgcctgtg ctacggccgc tccctgcagg gcgagttcgt gcacgacgac gtgtgggcga
      361 tcgtgaacaa ccccgacgtg cggcccggcg ccccgctccg ctggggcatc ttcaccaacg
      421 acttctgggg caagggcatg gccgagaaca ccagccacaa gtcctaccgg ccgctctgcg
      481 tcctcacctt caagctaaac atatttttga ctggtatgaa cccattctac tttcatgcag
      541 taaatataat tttacactgc ttagtgactc ttgtgctgat gtacacctgt gataaaactg
      601 tcttcaagaa tcgtggactt gcttttgtaa cggcattgct ttttgctgta catcctattc
      661 atactgaggc ggtggctggg atcgttggca gagcggacgt gttagcgtgt ctgctgtttc
      721 tattggcctt tctctcgtac aacaggagtc tggatcaggg ctgtgttggg ggaagtttcc
      781 cttccacggt gtctcccttc ttcttgctgc tcagtttgtt tctggggacc tgtgcgatgc
      841 tggtgaaaga gacaggcatc acggtgtttg gagtgtgctt ggtttatgac ctcttttccc
      901 tttccaacaa gcaagacaag tcgagcaatg gggccctctg tccacgcagc ccacagcagc
      961 ccgggagccc ccagccctcc tcactgccag gccatcctca ccgggagaat gggaagcagc
     1021 agcggttccc tcacaaagga gcttggggtg gctgccactc tccactgcca ccagaaccca
     1081 agagcagtgg attcccagtg tccccacgag ctgtgtggtc catgatgaga ttcctcacct
     1141 attcctacct cttggccttc aatgtgtggc ttctgcttgc acccgtgacc ctgtgctatg
     1201 actggcaggt cggcagtatt cctctggtag agaccatatg ggacatgcgg aacttagcca
     1261 ccatctttct ggcggttgtg atggccttat tgagcctgca ctgcttagca gcctttaaga
     1321 gactggagca caaggaggtt ttagtcggct tgttgttcct ggtgttcccg ttcattccag
     1381 ccagcaacct cttcttcagg gtgggttttg tggtggcgga gagagtcctt tacatgccta
     1441 gcatgggcta ctgcatcctt tttgtgcatg gactgagcaa gctctgcact tggctgaatc
     1501 gatgtggggc caccaccctg attgtgtcca ctgtgttgct gctgttgctt ttctcttgga
     1561 aaactgtgaa acagaatgaa atttggctgt caagagagtc cctattcagg tctggagttc
     1621 aaactctgcc ccacaatgcc aaggttcact acaactatgc caatttcctg aaggaccaag
     1681 gtcggaacaa ggaagcgatc taccactaca gaacagctct caagttgtat ccacgccatg
     1741 caagtgcgct caacaacctt ggaacactga cgagagacac agcagaggca aagatgtact
     1801 atcagagggc tctccagctc catccacagc ataaccgggc tcttttcaat ctggggaatc
     1861 tcctcaagtc ccaggagaaa aaggaagaag ctatcacctt actgaaggat tccatcaaat
     1921 atggtccaga gtttgcagat gcatattcaa gcttagcttc gttattggct gagcaggagc
     1981 ggtttaaaga agctgaagaa atataccaaa ctggaataaa gaactgtcca gacagctcag
     2041 atttacacaa caactatggg gttttcttag ttgatactgg cttaccagaa aaggcagtgg
     2101 cccattacca gcaggccatc aaacttagcc ccagtcatca cgtggccatg gtgaacttgg
     2161 gaagactcta caggtcactg ggagagaaca gcatggctga agaatggtac aagcgcgccc
     2221 tgcaggtggc acacaaagct gagatattgt cacctttggg agcactgtat tacaacactg
     2281 gccgatacga agaggctttg cagatttacc aggaagctgc agcacttcag ccttctcaga
     2341 gggagctccg cttggcactg gctcaggttt tggccgtgat gggtcagaca aaagaagctg
     2401 aaaagatgac caatcacatt gtgtcagagg agaccggatg ccttgaatgc tatcgcctct
     2461 tgtcagccat ctatagcaag caggagaacc acgacaaggc acttgatgct atagacaagg
     2521 ctctccagct gaaaccaaag gacccaaaag tcatttctga actttttttc acaaaaggaa
     2581 accaattaag agagcagaac cttctcgaca aagcttttga gagctataga gtggctgtgc
     2641 aactaaaccc agaccaagca caggcctgga tgaacatggg tggcatccaa cacatcaagg
     2701 gaaaatatgt gtctgcaaga gcttattatg agagagcctt acagctggtt ccagacagca
     2761 aactgctgaa ggaaaatctt gccaaattgg atcgcctaga aaaacgatta caagaagttc
     2821 gagaaaagga tcaaacatag caccaccgtc tgacccaacc tcataggata atgtggtgcc
     2881 tctgaaaggg gagtgatgga agccttgctt tcacatcagc aggggcacaa ctaatgagat
     2941 tttctctcat tccgagttca gggtgacaca ttttgggaca tctgctggta gcccagtgct
     3001 gaaggacttg cttttccatg aagaagacga aaacagcaaa caagggcaag aaggtctgag
     3061 agggaaggag aatgacattt acacatttta cagatttttg tttggtttaa ctccagattt
     3121 ctcttgatat atctctgtgc ttttgagacc tggagatcta attctgttta gacatttttt
     3181 gtcccagaaa tacagaagct tgaaatgcta tgaaggcaga gcttctattc tttatgggat
     3241 gaaatatttc aaaagaggat aaatcctctg tggtaagcca tttggaaaat cctaccaaga
     3301 attggcttat ttaattttcc agaaccagga atgagtatct aatagctttt gtagaacctt
     3361 ccagaatatg tggggaaaaa gggctattgc taagtgagct ttatctaata tcctcctaag
     3421 agttttacta gtgctttttt gaggaattac agggaagctc ctggaattgt acatggatat
     3481 ctttatccct agggggaaat caaggagctg ggcaccccta attctttatg gaagtgttta
     3541 aaactatttt aattttatta caagtattac tagagtggtg gttctactct aagatttcaa
     3601 aagtgcattt aaaatcatac atgttcccgc ctgcaaatat attgttattt tggtggagaa
     3661 aaaaatagta tattctacat aaaaaattaa agatattaac taagagaaat gtcctacttt
     3721 attatcttaa tgttcagaca tcatgagatt tattattttt ttgaaaaata tattgaacca
     3781 ttgaggaacc tttatgatgt atcacagaaa tcttcataga ttctaactag atggaaaaag
     3841 agctctattt atttgtgttc ctaggcttaa tgagaattct gggcttagaa catcaacgat
     3901 taatacccag aattctttgt tttgagaata ttatggagaa tgctctaaaa atctagggta
     3961 aagatctaaa ttcaaatttt aaatatatat ttatatttaa gaaataggaa aggcaaagtt
     4021 gaactcacaa tttgacattt atttttagtg ttatttattt cataacttat aaaatattta
     4081 atatatacat acacactctt cttttttctc tgtacaaagt ggttttaata tcagctttca
     4141 aaactgatct tataaaatgt aaatctaaat tgtaaaatag ttaagtttta acagtccctc
     4201 ccaaactttg tgttgattat tcacttgcta aagagatgtg aggaatcagc cttcagtttt
     4261 ttggcagtag tatattttgg aagtgaagaa attggaacac ctgtttctaa tttggtcttc
     4321 atcattagag acaaaaccaa aacactccag gcagtactgt ttatagtgct gagccaggta
     4381 gcacacagac atagtagcct aaaggctcac ataattcgca tgctcaggcc agggcagggt
     4441 aaaaatagcc ttctgcttct ttcaacccag tatcaggaag cactacccca gtgttattat
     4501 ttgttttgtc aaggtaagtc taaataaaca agaaaaactt cttcggaagg catggcgaag
     4561 ggagtatttt aaatgaaaat gattacagaa tttgaattag catgcatctc tttgtgtgca
     4621 acagtaatcc aagaatgtat atgttaccac tacaaccatt tgtttctaat agttttttca
     4681 tgttatataa cataaatgta tccacaacct taattaagaa ctattcttcc cccaaaatca
     4741 tagtcctagt gtcaagaaac atactccagt gtttattgta aaataacaac cacaccctca
     4801 aattgaaaaa agtgaatgtc taggacttta ttacaacttt tcagaataat ctgtaatgaa
     4861 aactcatgct taaaaattta atggaaaaga ctgagcccca aattttgaat agtgattacg
     4921 ccttacttga agtgctaata aaggtaggag agtacatttg ttggaataac agaaatggtg
     4981 atttcagcct aaaagtttct gagggtaaag gatcacatga ccttcaggaa actctctgcc
     5041 tcctgtaggt gctttcctat ctcccccatc cttccctacc ccttttccct tttccttcct
     5101 ctctttttct ctcactgtca ctctgtctac acacactggc atcttttgaa cactaaaagt
     5161 aagcactgtt ttttaaaaaa gtaattattt gttggatcag atacttttat cccaagtgaa
     5221 taccttcact gagatgtggc caatgcaata gtttcacagt aaaaacagtg cctataagaa
     5281 aatagatcac atactatttt tcaatgatat taagtgtatt ttgtaactat tttcatttgg
     5341 tccttgtaac atgaaataat acatggaact tacctttata ataaaaatgg agtgccctgg
     5401 ttcatcatag aggtgcatct agtttgccct taatggaagt atacttgctg tgtggattga
     5461 tagcaccttc ttgaaatgga ggagctcagc tggcctcatg gatgtgcaat ttttgcagtc
     5521 ccacagggcc ttgcatacag aagcaccccg agctcagttg aatgtctgtt tgattttttc
     5581 ttatttattt ttttgagaca cagttccact ttgtcttttt gtcacccagg atggagttca
     5641 gtggcacaaa catggctcac tgtagcctcg acctccctgg ctgaagggat cctcccacct
     5701 cagcctccca agtaaccgag actacaggca tatgccagca tgtccagcta atttttgtat
     5761 tttttgtaga gacagggttt caccatgttg cccaggctgg tctcaaactc ctgggctcaa
     5821 gcgatctgcc cacctctgcc tcccaaagtg ctgggattaa aggcataagc caccatgtcc
     5881 aactgaaatt cttaataatt aataattttt gagcaagagg tccacacttt cattttgcac
     5941 tgggttccca aacaggtcct gggtaggaag gatggctgag gataaaacag gagttgcttt
     6001 ggcctggctg aacatttgaa ccaatgatca gagtttcatt ttatgattgt gttactctga
     6061 acagatttgc tatttttttc cagctacatt tagagttcct catgtatata tcacccctct
     6121 ttttccagtc catctaacct ctcctttttt ttgtgcctag aatcagttct ccttgccttc
     6181 aaaatccctg ataagtgtcc atttcttttt gtatcctttg atgtagaagc cacaagaatg
     6241 gctttagcag cttattttaa tcttatgaat tattcattca ggatttttta aatgattcag
     6301 atgctttcaa tctgttaaca gtatttataa aacatgtttc agtgatacaa cataggtgaa
     6361 ctaaaccaaa gatgcaaatg ccttggagga aaagaaattg tattatagag aatcctgaga
     6421 tatatccttt tgggttgttt aatttaaagc ctatcacaaa acaaagagaa ttgtcgcact
     6481 ttaattccaa cctcctgcag tacttcacaa cccttagcat aagattctga aatttgtaat
     6541 aggtggtacc tagtttgatg cagggttttg cagcagttgt gcgaatgcct ctgcgcaacg
     6601 gcctttcagt cagactaaat gagaaaatcc aaactgtcct atcaaaactg acccacaata
     6661 actgtactct gaggcgaaac agagcaaatg tgggtttcct gttttcattg taaaacattc
     6721 caggttctca gattgaagag ctacattcag ctgatagttg acatctgttc cctcacacgt
     6781 agtggctctc aacacgggct gcactttgga atcacctgag gacctttcgg aatcttcggt
     6841 tgaatcatcc tggctgtcct ggtgatgctt cttatgtgca gctaggctgg agaaccacta
     6901 cagggctgac acctggaatg ggagcttgta acttttacaa aataatagat gtttatcatc
     6961 ttttgcaatt tttactttta agtctatact aaaatgagcc aaagaagtct taacaatgat
     7021 gtatggcaca attggttggt tgaggctatc attccatgat tacaaatagg tggttatgtg
     7081 gggtggtttt gcacttgtgg caattggact gcaatttggc cttaaaatga cacaattcct
     7141 cgttctcaga tggagaggaa ttgccttgaa atttgcatgt accagactaa gtgccagtat
     7201 atatatgact gatattttcg tgactcatag aaggtgtcca tggtatagag tttatgccta
     7261 catctctatc tttattttgg gcacacatga gcttttgtta attatttctt tgtacttgtt
     7321 agaatctgtt tttgaaaaaa aaaaaaactt ttgctttgat ttgtggtgga ttcaccttct
     7381 taaaataata aatttagagg atattaggaa tgacattcaa aacaaatata gtgagaggtg
     7441 attttttaaa aatttttgtt cctggtttcc aaattatgtt tactttgatt tgattatatg
     7501 ttggtatctc ccaaatatag gttaacttag ctatttaaat ggtatctttt gacatttaaa
     7561 aagaattaag tacctgtcaa atctagcatt gaggttgcag ttgaataaga taaaagctta
     7621 ggatgtcaaa aaataatata gagaaatatt ataagatttt atgattattc ttgacgtttt
     7681 tgatgcaaaa ggaaaatatg ctgaatagtt cttccaaaaa atattatttc cctcaatatt
     7741 ttatttgtag ccatgtaatt taaagagaac agaaaataac tgcaatcaaa agtatggttt
     7801 aatatcaatc aaagtggcac aacagaattg ataagatctt tataacaatc aattggctga
     7861 tattaaaata ttgattttaa ttgatctttt caattaaaat ctttagggcc tgtaactcat
     7921 aaaatcagca tccaccacaa tatatggtca ttattggttt gtaagcatag atcaccattg
     7981 actcctacct ggagagacat gtctatttct aaaaatccag tagtttcttt gcattctcag
     8041 tagtacacgt tgtatatata tatatgtaac aaatttggta gttttcagta tgtgtgatgt
     8101 cctttggggg ttatttatct tgctggtcca taggaggggt acactacccc aagaatcaag
     8161 acatctgagt tctagttcta gttctagctc tgccactgaa gagccacctt acctggggca
     8221 agttagccat tgtctcccag tcatgtttac cacccatgaa aggactcgtc ggtttgatgt
     8281 ttccattaag ctcaatgagt aactctaata gttactcttg aatctggatt gaaaaacacc
     8341 atgcatctga tgagataatt cataaatgtt gccccttttt taaatgatac aaccctaaaa
     8401 gtgactgaat tgcccaagtg cttgaacatg gcagaggtag ttactcctat tttgcagttt
     8461 gtgcacttaa aaattcctac agtgattgtt actttactgg ggaaaaaaga tgaggtgaaa
     8521 cttcctccca aggaattaaa atatctgtag aagccatggc ttgcttttat aatgtggaaa
     8581 tcatttgatt tgctgtaatt cacgcagatc cctccttttg tcagggggaa atgatttgca
     8641 tcatgttctt ttttcataat gcttttactt cctgtttgga tcagttgtat gtaaatgtac
     8701 atttttgtta ctttggctgt gcccgttaga atttatcttc cataaagtat ttctcccatt
     8761 gagtctaatg atgtatactt tgcctaggtc tttccaaaat taaatttatg taaatgtcta
     8821 ttttatataa aatatgatta aaataa
//
