LOCUS       NM_152637               1316 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens thiol methyltransferase 1B (TMT1B), mRNA.
ACCESSION   NM_152637
VERSION     NM_152637.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Robey,R.W., Fitzsimmons,C.M., Guiblet,W.M., Frye,W.J.E., Gonzalez
            Dalmasy,J.M., Wang,L., Russell,D.A., Huff,L.M., Perciaccante,A.J.,
            Ali-Rahmani,F., Lipsey,C.C., Wade,H.M., Mitchell,A.V.,
            Maligireddy,S.S., Terrero,D., Butcher,D., Edmondson,E.F.,
            Jenkins,L.M., Nikitina,T., Zhurkin,V.B., Tiwari,A.K.,
            Piscopio,A.D., Totah,R.A., Bates,S.E., Arda,H.E., Gottesman,M.M.
            and Batista,P.J.
  TITLE     The Methyltransferases METTL7A and METTL7B Confer Resistance to
            Thiol-Based Histone Deacetylase Inhibitors
  JOURNAL   Mol Cancer Ther 23 (4), 464-477 (2024)
   PUBMED   38151817
  REMARK    GeneRIF: The Methyltransferases METTL7A and METTL7B Confer
            Resistance to Thiol-Based Histone Deacetylase Inhibitors.
REFERENCE   2  (bases 1 to 1316)
  AUTHORS   Russell,D.A., Chau,M.K., Shi,Y., Levasseur,I.N., Maldonato,B.J. and
            Totah,R.A.
  TITLE     METTL7A (TMT1A) and METTL7B (TMT1B) Are Responsible for Alkyl
            S-Thiol Methyl Transferase Activity in Liver
  JOURNAL   Drug Metab Dispos 51 (8), 1024-1034 (2023)
   PUBMED   37137720
REFERENCE   3  (bases 1 to 1316)
  AUTHORS   Li,Z., Song,Y. and Zhang,J.
  TITLE     lncRNA PDCD4-AS1 Promotes the Progression of Glioma by Regulating
            miR-30b-3p/METTL7B Signaling
  JOURNAL   Oxid Med Cell Longev 2023, 3492480 (2023)
   PUBMED   37151605
  REMARK    GeneRIF: lncRNA PDCD4-AS1 Promotes the Progression of Glioma by
            Regulating miR-30b-3p/METTL7B Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1316)
  AUTHORS   Lei,J., Li,G., Yu,H. and An,T.
  TITLE     Potent necrosis effect of methanethiol mediated by METTL7B enzyme
            bioactivation mechanism in 16HBE cell
  JOURNAL   Ecotoxicol Environ Saf 236, 113486 (2022)
   PUBMED   35397445
  REMARK    GeneRIF: Potent necrosis effect of methanethiol mediated by METTL7B
            enzyme bioactivation mechanism in 16HBE cell.
REFERENCE   5  (bases 1 to 1316)
  AUTHORS   Huang,D. and Yan,H.
  TITLE     Methyltransferase like 7B is upregulated in sepsis and modulates
            lipopolysaccharide-induced inflammatory response and macrophage
            polarization
  JOURNAL   Bioengineered 13 (5), 11753-11766 (2022)
   PUBMED   35603523
  REMARK    GeneRIF: Methyltransferase like 7B is upregulated in sepsis and
            modulates lipopolysaccharide-induced inflammatory response and
            macrophage polarization.
REFERENCE   6  (bases 1 to 1316)
  AUTHORS   Yang,X., Yuan,Y. and Xie,D.
  TITLE     Low Molecular Pectin Inhibited the Lipid Accumulation by
            Upregulation of METTL7B
  JOURNAL   Appl Biochem Biotechnol 193 (5), 1469-1481 (2021)
   PUBMED   33484445
  REMARK    GeneRIF: Low Molecular Pectin Inhibited the Lipid Accumulation by
            Upregulation of METTL7B.
REFERENCE   7  (bases 1 to 1316)
  AUTHORS   Maldonato,B.J., Russell,D.A. and Totah,R.A.
  TITLE     Human METTL7B is an alkyl thiol methyltransferase that metabolizes
            hydrogen sulfide and captopril
  JOURNAL   Sci Rep 11 (1), 4857 (2021)
   PUBMED   33649426
  REMARK    GeneRIF: Human METTL7B is an alkyl thiol methyltransferase that
            metabolizes hydrogen sulfide and captopril.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1316)
  AUTHORS   Ye,D., Jiang,Y., Sun,Y., Li,Y., Cai,Y., Wang,Q., Wang,O., Chen,E.
            and Zhang,X.
  TITLE     METTL7B promotes migration and invasion in thyroid cancer through
            epithelial-mesenchymal transition
  JOURNAL   J Mol Endocrinol 63 (1), 51-61 (2019)
   PUBMED   31121562
  REMARK    GeneRIF: Results indicate that METTL7B may promote metastasis of
            thyroid cancer through EMT and may therefore be considered as a
            potential biomarker for the diagnosis and prognosis of thyroid
            carcinoma.
REFERENCE   9  (bases 1 to 1316)
  AUTHORS   Turro,S., Ingelmo-Torres,M., Estanyol,J.M., Tebar,F.,
            Fernandez,M.A., Albor,C.V., Gaus,K., Grewal,T., Enrich,C. and
            Pol,A.
  TITLE     Identification and characterization of associated with lipid
            droplet protein 1: A novel membrane-associated protein that resides
            on hepatic lipid droplets
  JOURNAL   Traffic 7 (9), 1254-1269 (2006)
   PUBMED   17004324
REFERENCE   10 (bases 1 to 1316)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290112.1 and BC020509.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152637.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.62325.1,
                                           SRR1660809.1656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394252.4/ ENSP00000377796.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-762               AK290112.1         191-952
            763-1316            BC020509.1         862-1415
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..1316
                     /gene="TMT1B"
                     /gene_synonym="ALDI; METTL7B"
                     /note="thiol methyltransferase 1B"
                     /db_xref="GeneID:196410"
                     /db_xref="HGNC:HGNC:28276"
     exon            1..517
                     /gene="TMT1B"
                     /gene_synonym="ALDI; METTL7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..754
                     /gene="TMT1B"
                     /gene_synonym="ALDI; METTL7B"
                     /EC_number="2.1.1.9"
                     /note="methyltransferase-like protein 7B; associated with
                     lipid droplets 1; thiol S-methyltransferase METTL7B;
                     methyltransferase like 7B; thiol S-methyltransferase
                     TMT1B"
                     /codon_start=1
                     /product="thiol S-methyltransferase TMT1B precursor"
                     /protein_id="NP_689850.2"
                     /db_xref="CCDS:CCDS8887.2"
                     /db_xref="GeneID:196410"
                     /db_xref="HGNC:HGNC:28276"
                     /translation="MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLT
                     PKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPH
                     FEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEV
                     RRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFS
                     EIQMERQPPPLKWLPVGPHIMGKAVK"
     exon            518..1316
                     /gene="TMT1B"
                     /gene_synonym="ALDI; METTL7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMT1B"
                     /gene_synonym="ALDI; METTL7B"
                     /note="hexamer: AATAGA"
     polyA_site      1316
                     /gene="TMT1B"
                     /gene_synonym="ALDI; METTL7B"
                     /note="major polyA site"
ORIGIN      
        1 agctcagagc tggtctgcca tggacatcct ggtcccactc ctgcagctgc tggtgctgct
       61 tcttaccctg cccctgcacc tcatggctct gctgggctgc tggcagcccc tgtgcaaaag
      121 ctacttcccc tacctgatgg ccgtgctgac tcccaagagc aaccgcaaga tggagagcaa
      181 gaaacgggag ctcttcagcc agataaaggg gcttacagga gcctccggga aagtggccct
      241 actggagctg ggctgcggaa ccggagccaa ctttcagttc tacccaccgg gctgcagggt
      301 cacctgccta gacccaaatc cccactttga gaagttcctg acaaagagca tggctgagaa
      361 caggcacctc caatatgagc ggtttgtggt ggctcctgga gaggacatga gacagctggc
      421 tgatggctcc atggatgtgg tggtctgcac tctggtgctg tgctctgtgc agagcccaag
      481 gaaggtcctg caggaggtcc ggagagtact gagaccggga ggtgtgctct ttttctggga
      541 gcatgtggca gaaccatatg gaagctgggc cttcatgtgg cagcaagttt tcgagcccac
      601 ctggaaacac attggggatg gctgctgcct caccagagag acctggaagg atcttgagaa
      661 cgcccagttc tccgaaatcc aaatggaacg acagccccct cccttgaagt ggctacctgt
      721 tgggccccac atcatgggaa aggctgtcaa ataatctttc ccaagctcca aggcactcat
      781 ttgctccttc cccagcctcc aattagaaca agccacccac cagcctatct atcttccact
      841 gagagggacc tagcagaatg agagaagaca ttcatgtacc acctactagt ccctctctcc
      901 ccaacctctg ccagggcaat ctctaacttc aatcccgcct tcgacagtga aaaagctcta
      961 cttctacgct gacccaggga ggaaacacta ggaccctgtt gtatcctcaa ctgcaagttt
     1021 ctggactagt ctcccaacgt ttgcctccca atgttgtccc tttccttcgt tcccatggta
     1081 aagctcctct cgctttcctc ctgaggctac acccatgcgt ctctaggaac tggtcacaaa
     1141 agtcatggtg cctgcatccc tgccaagccc ccctgaccct ctctccccac taccaccttc
     1201 ttcctgagct gggggcacca gggagaatca gagatgctgg ggatgccaga gcaagactca
     1261 aagaggcaga ggttttgttc tcaaatattt tttaataaat agacgaaacc acgaaa
//
