LOCUS       NM_014033               3117 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens thiol methyltransferase 1A (TMT1A), mRNA.
ACCESSION   NM_014033
VERSION     NM_014033.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Robey,R.W., Fitzsimmons,C.M., Guiblet,W.M., Frye,W.J.E., Gonzalez
            Dalmasy,J.M., Wang,L., Russell,D.A., Huff,L.M., Perciaccante,A.J.,
            Ali-Rahmani,F., Lipsey,C.C., Wade,H.M., Mitchell,A.V.,
            Maligireddy,S.S., Terrero,D., Butcher,D., Edmondson,E.F.,
            Jenkins,L.M., Nikitina,T., Zhurkin,V.B., Tiwari,A.K.,
            Piscopio,A.D., Totah,R.A., Bates,S.E., Arda,H.E., Gottesman,M.M.
            and Batista,P.J.
  TITLE     The Methyltransferases METTL7A and METTL7B Confer Resistance to
            Thiol-Based Histone Deacetylase Inhibitors
  JOURNAL   Mol Cancer Ther 23 (4), 464-477 (2024)
   PUBMED   38151817
  REMARK    GeneRIF: The Methyltransferases METTL7A and METTL7B Confer
            Resistance to Thiol-Based Histone Deacetylase Inhibitors.
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Zhang,D., Zou,T., Liu,Q., Chen,J., Xiao,M., Zheng,A., Zhang,Z.,
            Du,F., Dai,Y., Xiang,S., Wu,X., Li,M., Chen,Y., Zhao,Y., Shen,J.,
            Chen,G. and Xiao,Z.
  TITLE     Transcriptomic characterization revealed that METTL7A inhibits
            melanoma progression via the p53 signaling pathway and
            immunomodulatory pathway
  JOURNAL   PeerJ 11, e15799 (2023)
   PUBMED   37547717
  REMARK    GeneRIF: Transcriptomic characterization revealed that METTL7A
            inhibits melanoma progression via the p53 signaling pathway and
            immunomodulatory pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Russell,D.A., Chau,M.K., Shi,Y., Levasseur,I.N., Maldonato,B.J. and
            Totah,R.A.
  TITLE     METTL7A (TMT1A) and METTL7B (TMT1B) Are Responsible for Alkyl
            S-Thiol Methyl Transferase Activity in Liver
  JOURNAL   Drug Metab Dispos 51 (8), 1024-1034 (2023)
   PUBMED   37137720
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Vera-Montecinos,A., Galiano-Landeira,J., Roldan,M.,
            Vidal-Domenech,F., Claro,E. and Ramos,B.
  TITLE     A Novel Localization of METTL7A in Bergmann Glial Cells in Human
            Cerebellum
  JOURNAL   Int J Mol Sci 24 (9), 8405 (2023)
   PUBMED   37176112
  REMARK    GeneRIF: A Novel Localization of METTL7A in Bergmann Glial Cells in
            Human Cerebellum.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Wang,Z., He,J., Bach,D.H., Huang,Y.H., Li,Z., Liu,H., Lin,P. and
            Yang,J.
  TITLE     Induction of m6A methylation in adipocyte exosomal LncRNAs mediates
            myeloma drug resistance
  JOURNAL   J Exp Clin Cancer Res 41 (1), 4 (2022)
   PUBMED   34980213
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Zhou,S., Shen,Y., Zheng,M., Wang,L., Che,R., Hu,W. and Li,P.
  TITLE     DNA methylation of METTL7A gene body regulates its transcriptional
            level in thyroid cancer
  JOURNAL   Oncotarget 8 (21), 34652-34660 (2017)
   PUBMED   28416772
  REMARK    GeneRIF: Results revealed that the methylation level of METTL7A was
            downregulated in thyroid cancer, and determined the methylation
            level of one CpG site at the exon of the METTL7A gene body impacted
            the transcriptional activity.
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Park,E.M., Lim,Y.S., Ahn,B.Y. and Hwang,S.B.
  TITLE     AAM-B Interacts with Nonstructural 4B and Regulates Hepatitis C
            Virus Propagation
  JOURNAL   PLoS One 10 (7), e0132839 (2015)
   PUBMED   26185986
  REMARK    GeneRIF: AAM-B is predominantly localized in lipid droplets and may
            be involved in recruitment of NS4B protein in the proximity of
            lipid droplets.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Zehmer,J.K., Bartz,R., Bisel,B., Liu,P., Seemann,J. and
            Anderson,R.G.
  TITLE     Targeting sequences of UBXD8 and AAM-B reveal that the ER has a
            direct role in the emergence and regression of lipid droplets
  JOURNAL   J Cell Sci 122 (Pt 20), 3694-3702 (2009)
   PUBMED   19773358
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Zehmer,J.K., Bartz,R., Liu,P. and Anderson,R.G.
  TITLE     Identification of a novel N-terminal hydrophobic sequence that
            targets proteins to lipid droplets
  JOURNAL   J Cell Sci 121 (11), 1852-1860 (2008)
   PUBMED   18477614
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM805242.1, AY358797.1 and AC008121.43.
            
            On Nov 22, 2018 this sequence version replaced NM_014033.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225689.1, SRR1803617.98158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332160.5/ ENSP00000331787.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               BM805242.1         287-762
            477-900             AY358797.1         509-932
            901-3117            AC008121.43        42223-44439         c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..3117
                     /gene="TMT1A"
                     /gene_synonym="AAM-B; AAMB; METTL7A"
                     /note="thiol methyltransferase 1A"
                     /db_xref="GeneID:25840"
                     /db_xref="HGNC:HGNC:24550"
                     /db_xref="MIM:618338"
     exon            1..522
                     /gene="TMT1A"
                     /gene_synonym="AAM-B; AAMB; METTL7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..759
                     /gene="TMT1A"
                     /gene_synonym="AAM-B; AAMB; METTL7A"
                     /EC_number="2.1.1.348"
                     /EC_number="2.1.1.9"
                     /note="methyltransferase-like protein 7A; protein AAM-B;
                     putative methyltransferase-like protein 7A;
                     methyltransferase like 7A; methyltransferase TMT1A;
                     N6-adenosine-methyltransferase TMT1A; thiol
                     S-methyltransferase TMT1A"
                     /codon_start=1
                     /product="thiol S-methyltransferase TMT1A precursor"
                     /protein_id="NP_054752.3"
                     /db_xref="CCDS:CCDS8804.1"
                     /db_xref="GeneID:25840"
                     /db_xref="HGNC:HGNC:24550"
                     /db_xref="MIM:618338"
                     /translation="MELTIFILRLAIYILTFPLYLLNFLGLWSWICKKWFPYFLVRFT
                     VIYNEQMASKKRELFSNLQEFAGPSGKLSLLEVGCGTGANFKFYPPGCRVTCIDPNPN
                     FEKFLIKSIAENRHLQFERFVVAAGENMHQVADGSVDVVVCTLVLCSVKNQERILREV
                     CRVLRPGGAFYFMEHVAAECSTWNYFWQQVLDPAWHLLFDGCNLTRESWKALERASFS
                     KLKLQHIQAPLSWELVRPHIYGYAVK"
     exon            523..3117
                     /gene="TMT1A"
                     /gene_synonym="AAM-B; AAMB; METTL7A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMT1A"
                     /gene_synonym="AAM-B; AAMB; METTL7A"
                     /note="hexamer: AATAAA"
     polyA_site      3117
                     /gene="TMT1A"
                     /gene_synonym="AAM-B; AAMB; METTL7A"
                     /note="major polyA site"
ORIGIN      
        1 atctgttttt ttcccttctg agcaatggag cttaccatct ttatcctgag actggccatt
       61 tacatcctga catttccctt gtacctgctg aactttctgg gcttgtggag ctggatatgc
      121 aaaaaatggt tcccctactt cttggtgagg ttcactgtga tatacaacga acagatggca
      181 agcaagaagc gggagctctt cagtaacctg caggagtttg cgggcccctc cgggaaactc
      241 tccctgctgg aagtgggctg tggcacgggg gccaacttca agttctaccc acctgggtgc
      301 agggtgacct gtattgaccc caaccccaac tttgagaagt ttttgatcaa gagcattgca
      361 gagaaccgac acctgcagtt tgagcgcttt gtggtagctg ccggggagaa catgcaccag
      421 gtggctgatg gctctgtgga tgtggtggtc tgcaccctgg tgctgtgctc tgtgaagaac
      481 caggagcgga ttctccgcga ggtgtgcaga gtgctgagac cgggaggggc tttctatttc
      541 atggagcatg tggcagctga gtgttcgact tggaattact tctggcaaca agtcctggat
      601 cctgcctggc accttctgtt tgatgggtgc aacctgacca gagagagctg gaaggccctg
      661 gagcgggcca gcttctctaa gctgaagctg cagcacatcc aggccccact gtcctgggag
      721 ttggtgcgcc ctcatatcta tggatatgct gtgaaatagt gtgagctggc agttaagagc
      781 tgaatggctc aaagaattta aagcttcagt tttacattta aaatgctaag tgggagaaga
      841 gaaacctttt ttttgggggg cggttttttt ggtttgttgt tggttttttt tttttttttg
      901 gcgggaagaa agagttttgc tcttgttgcc caggctggag tgcaatgacg tgatctccgc
      961 tcactgcaac ctccacctcg cgggtttaag cgattcttct gcctcagcct ccctagtagc
     1021 tgggattaca ggtgcccacc accatgccca gctaatttgt atttttagtt gagacagggt
     1081 ttcactacgt tggccaggct ggtcttgaac tcctgatctc aggcaatcca cccacctcag
     1141 cctcccaaag tgctgggatg acaggcgtga gcaaccgcac ccagcttaag gtttttttgt
     1201 tttgttttga gacggagttt tcgctcttgt tgcccaggct ggagtgcaat gctgtgatct
     1261 cagcttacca caacctccac ctcccgggtt caagtgattc acctgcctca gcctcctgag
     1321 tagctggtat tacaggcatg cgtcaccacg ccggctaatt ttgtactttt agtagagatg
     1381 gtgtttcccc acgttggtca gtctggtctc aaattcctga cctcaggtga tctgcctgcc
     1441 tcggcctccc aaagtgctgt gattacagac gtcagccacc atgcctggcc tgaaaccttt
     1501 tttaggtaaa gttgaattcc atccttaaaa gtttctgtta tatcctattt agccattttc
     1561 tattgtctcc caaagaattc acatcaaaaa aacagctttg aactccccct tcaaaggaaa
     1621 cagtcgactt tcataattag catctaccat tatccccaaa tcttatttta ttcattgact
     1681 tgaaattttt tccaattgct tttttttttt tttttttaag gttaagagca gaggtttact
     1741 aggccaaaga aagagaatag ctctctgttg cagagagggg tcctggagaa atgggttacc
     1801 ccagttgtct tatttaaatg gttacccatc agattttaat tttatcttct ctttgagagc
     1861 ttggtaataa gaagcactta aatcactcca aagaagactt taaaaaggga gcagtgaaaa
     1921 ggtcttaata atttattgat tgaattaaga aatactagct aattaagaat ctgagtctaa
     1981 acagcacaga ttttttcttt ctgcttttaa attgtgtttt aaaaaaagag acagggggct
     2041 gggcgtggtg gctcacgcct gtaatcctag cactttggga ggccgaggcg ggtggatcac
     2101 gaggtaggag ttaaagacca gcctggccaa catggcaaaa ccctactaaa gatacaaaaa
     2161 aaaaaaaaaa ttagccaggc gtggtggtgg gtgcctgtaa tcccaggtac ttggaaggct
     2221 gaggcaggag aatctcttga acccagaagg cgaaggttgc agtgaaccga gatcatgcca
     2281 ttgtactcta gcctgggtga caagagcaag actccgtctc aaaaaaaaaa aaaaaaaaaa
     2341 aaagaagtag agacagggag acagggtctc actgtgttgc ctaggccggt cttgaactcc
     2401 tgggctcaag tgattctccc accttgacct cctaaattgt tgggattaca ggtgtgagac
     2461 agtgcacctg gccgaaatag ctcaagtttc tgaaaaacaa atctgaatct atttgttatt
     2521 cttagcgtca ctggtctggc tttcagaatt aacatacaag gttgccacac ctagttctgc
     2581 ccagctttat gtcttttatt ccagtattcc accaaagttt gttttcctgc attccagttc
     2641 tcaagtctta agataaagat tgtacttgac agtttagtat atccataaaa ctatttgagg
     2701 tggttaaggt tcttgggttc attttcctta atactttgct gaatattgta gattgtaggc
     2761 aatgaaaaag tctactaaat taggaaaacc ttgaataatt aggtatccta ggtaagagcc
     2821 cctaaacatc aagcaatctg tgagtctgta aagaaataaa tattttttgg attattctta
     2881 tctaattcca cccctgttgg aagatgattt ctttgttctt tgcaactatg gaagctgtga
     2941 aaatcatcac aagtgcctct gaaagcgagt gttaggttgg ttagagggtt taatattttc
     3001 tgcaatggtt tgtaggaatt ttaataaatg tagtatattt tctgagatga ttttgtaaaa
     3061 gtactatttt aaatatcaaa tcaaccaata aattcacatt tgtgttagga acagaaa
//
