LOCUS       NM_004202               1337 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens thymosin beta 4 Y-linked (TMSB4Y), mRNA.
ACCESSION   NM_004202
VERSION     NM_004202.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1337)
  AUTHORS   Lu,B., Yu,Y., Xing,X.L. and Liu,R.Y.
  TITLE     miR-183/TMSB4Y, a new potential signaling axis, involving in the
            progression of laryngeal cancer via modulating cell adhesion
  JOURNAL   J Recept Signal Transduct Res 42 (2), 133-140 (2022)
   PUBMED   33356743
  REMARK    GeneRIF: miR-183/TMSB4Y, a new potential signaling axis, involving
            in the progression of laryngeal cancer via modulating cell
            adhesion.
REFERENCE   2  (bases 1 to 1337)
  AUTHORS   Wong,H.Y., Wang,G.M., Croessmann,S., Zabransky,D.J., Chu,D.,
            Garay,J.P., Cidado,J., Cochran,R.L., Beaver,J.A., Aggarwal,A.,
            Liu,M.L., Argani,P., Meeker,A., Hurley,P.J., Lauring,J. and
            Park,B.H.
  TITLE     TMSB4Y is a candidate tumor suppressor on the Y chromosome and is
            deleted in male breast cancer
  JOURNAL   Oncotarget 6 (42), 44927-44940 (2015)
   PUBMED   26702755
  REMARK    GeneRIF: Suggest Y chromosome gene TMSB4Y may function as a tumor
            suppressor gene in male breast cancer.
REFERENCE   3  (bases 1 to 1337)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   4  (bases 1 to 1337)
  AUTHORS   Lee,H.R., Yoon,S.Y., Kang,H.B., Park,S., Kim,K.E., Cho,Y.H.,
            Kim,S., Kim,C.W., Cho,B.J., Lee,W.J., Bang,S.I., Park,H. and Cho,D.
  TITLE     Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
  JOURNAL   Immunol Lett 123 (1), 72-76 (2009)
   PUBMED   19369144
  REMARK    GeneRIF: T beta 4 is a key activator of NK cell cytotoxicity.
REFERENCE   5  (bases 1 to 1337)
  AUTHORS   Torikai,H., Akatsuka,Y., Miyazaki,M., Warren,E.H. 3rd, Oba,T.,
            Tsujimura,K., Motoyoshi,K., Morishima,Y., Kodera,Y., Kuzushima,K.
            and Takahashi,T.
  TITLE     A novel HLA-A*3303-restricted minor histocompatibility antigen
            encoded by an unconventional open reading frame of human TMSB4Y
            gene
  JOURNAL   J Immunol 173 (11), 7046-7054 (2004)
   PUBMED   15557202
  REMARK    GeneRIF: TMSB4Y has been found to encode a novel
            HLA-A*3303-restricted minor histocompatibility H-Y antigen,
            revealed during cytotoxicity assays of T cell lines from a
            female-to-male hemopoietic stem cell transplantation patient.
REFERENCE   6  (bases 1 to 1337)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   7  (bases 1 to 1337)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
REFERENCE   8  (bases 1 to 1337)
  AUTHORS   Yu,F.X., Lin,S.C., Morrison-Bogorad,M., Atkinson,M.A. and Yin,H.L.
  TITLE     Thymosin beta 10 and thymosin beta 4 are both actin monomer
            sequestering proteins
  JOURNAL   J Biol Chem 268 (1), 502-509 (1993)
   PUBMED   8416954
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC119763.1 and BC022482.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004202.2.
            
            Summary: This gene lies within the male specific region of
            chromosome Y. Its homolog on chromosome X escapes X inactivation
            and encodes an actin sequestering protein. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1073402.1,
                                           SRR3476690.971176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284856.4/ ENSP00000284856.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-755               BC119763.1         91-845
            756-1337            BC022482.1         351-932
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.221"
     gene            1..1337
                     /gene="TMSB4Y"
                     /gene_synonym="TB4Y"
                     /note="thymosin beta 4 Y-linked"
                     /db_xref="GeneID:9087"
                     /db_xref="HGNC:HGNC:11882"
                     /db_xref="MIM:400017"
     exon            1..537
                     /gene="TMSB4Y"
                     /gene_synonym="TB4Y"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..572
                     /gene="TMSB4Y"
                     /gene_synonym="TB4Y"
                     /note="thymosin, beta 4, Y chromosome"
                     /codon_start=1
                     /product="thymosin beta-4, Y-chromosomal"
                     /protein_id="NP_004193.1"
                     /db_xref="CCDS:CCDS14786.1"
                     /db_xref="GeneID:9087"
                     /db_xref="HGNC:HGNC:11882"
                     /db_xref="MIM:400017"
                     /translation="MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES
                     "
     exon            538..1337
                     /gene="TMSB4Y"
                     /gene_synonym="TB4Y"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMSB4Y"
                     /gene_synonym="TB4Y"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="TMSB4Y"
                     /gene_synonym="TB4Y"
                     /note="major polyA site"
ORIGIN      
        1 gttgtttgca gagaggccgt ggctacaaaa tggaagtgct tttgcgacct gggctccatt
       61 ttaggaattc ttgcccgatt ttaaccactt gaacgcggaa gtggctttcc tattctcttc
      121 caagccagcc tttaatttta aacgctgtaa ttaacagttc acaggggtca aattccttta
      181 ttccggaaca ttccactttg agagggatct gtcctctttg gtcccctgcg ttttcaaata
      241 tttgaggaaa ggtgtcgcct ctttttctgt ggaaagagga agctcatgag cgcgaaacag
      301 caggggacgg agggcgagaa gggctttctc aggttgcggg tcggagggca gaagcacagt
      361 tcccagtaca gagacccgga caggtggctg tttctcacgc tcactttgga ttgctcccta
      421 cggcttcctc cgcagccatg tctgacaaac ctggtatggc tgagatcgag aaattcgata
      481 agtcgaaact gaagaagaca gaaacgcaag agaagaatcc attgtcttcc aaagaaacta
      541 tcgaacagga gaggcaagca ggcgaatctt aaacaggcat gtgccaccaa tatctactgt
      601 acattctaca agcattgctt tcttatttta cttcttttac ttgtttaact tggttagatg
      661 caaacacgtt ggatgagttt gaaaggacta tgctgccctt ttgacatcaa agacctgctg
      721 acaatggagg ccacgcctgc ttctcccatc gcctgtctgg ctggcaggga aggaaaatag
      781 cttgaatgtt ggtgaaagac ttagcggagt gggagggcag tgaaatctag agtaaaacca
      841 agttgggcca agtgtcctgc agaatctaaa atgaagttta atcagcgtgc catttttgtt
      901 gttgtttgaa agattttaat ttttggaatg cacagttttt atttaaaaaa gacattttta
      961 aaccactgct tgtgagattg cttgttgatt ggaaagagtg ttttattcac catttaaacg
     1021 tttgcaaagt ggcgtgcccc ttggcctcac aggcaaagaa taacttaaaa gctgacgatt
     1081 tgaataaatt atgttacagt atgaaatatg ttttacctgg atatgtaaaa taccttcttt
     1141 attctagcta attgggagat gatttttttt ggctaattga gattaccttt agattatgtt
     1201 ttcaaaactg gcttatactg taatctacaa ctaataagca ctaatttaga gttcagctat
     1261 attgttgcat gtagtgagaa gggacttaat tacaaactta agacgtaagt gtgcaataaa
     1321 gtaagctaag aagaaaa
//
