LOCUS       NM_021109                622 bp    mRNA    linear   PRI 04-MAR-2025
DEFINITION  Homo sapiens thymosin beta 4 X-linked (TMSB4X), mRNA.
ACCESSION   NM_021109
VERSION     NM_021109.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 622)
  AUTHORS   Li,W., Yang,Y., Lin,Y. and Mu,D.
  TITLE     In Vitro Study of Thymosin Beta 4 Promoting Transplanted Fat
            Survival by Regulating Adipose-Derived Stem Cells
  JOURNAL   Aesthetic Plast Surg 48 (11), 2179-2189 (2024)
   PUBMED   38409346
  REMARK    GeneRIF: In Vitro Study of Thymosin Beta 4 Promoting Transplanted
            Fat Survival by Regulating Adipose-Derived Stem Cells.
REFERENCE   2  (bases 1 to 622)
  AUTHORS   Hao,M., Zhong,K., Bai,X., Wu,S., Li,L., He,Y., Wang,Z., Sun,X.,
            Wang,Q., Guo,Y., Sun,Y. and Wu,L.
  TITLE     Upregulated Tbeta4 expression in inflammatory bowel disease impairs
            the intestinal mucus barrier by inhibiting autophagy in mice
  JOURNAL   Exp Cell Res 434 (1), 113871 (2024)
   PUBMED   38049080
  REMARK    GeneRIF: Upregulated Tbeta4 expression in inflammatory bowel
            disease impairs the intestinal mucus barrier by inhibiting
            autophagy in mice.
REFERENCE   3  (bases 1 to 622)
  AUTHORS   Mason,W.J. and Vasilopoulou,E.
  TITLE     The Pathophysiological Role of Thymosin beta4 in the Kidney
            Glomerulus
  JOURNAL   Int J Mol Sci 24 (9), 7684 (2023)
   PUBMED   37175390
  REMARK    GeneRIF: The Pathophysiological Role of Thymosin beta4 in the
            Kidney Glomerulus.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 622)
  AUTHORS   Lee,J.W., Thuy,P.X., Koo,J.H. and Moon,E.Y.
  TITLE     Nuclear factor (erythroid-derived 2)-like 2 counter-regulates
            thymosin beta-4 expression and primary cilium formation for HeLa
            cervical cancer cell survival
  JOURNAL   Sci Rep 12 (1), 20170 (2022)
   PUBMED   36424462
  REMARK    GeneRIF: Nuclear factor (erythroid-derived 2)-like 2
            counter-regulates thymosin beta-4 expression and primary cilium
            formation for HeLa cervical cancer cell survival.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 622)
  AUTHORS   Kuo,C.Y., Jhuang,J.Y., Huang,W.C. and Cheng,S.P.
  TITLE     Aberrant Expression of Thymosin Beta-4 Correlates With Advanced
            Disease and BRAF V600E Mutation in Thyroid Cancer
  JOURNAL   J Histochem Cytochem 70 (10), 707-716 (2022)
   PUBMED   36321670
  REMARK    GeneRIF: Aberrant Expression of Thymosin Beta-4 Correlates With
            Advanced Disease and BRAF V600E Mutation in Thyroid Cancer.
REFERENCE   6  (bases 1 to 622)
  AUTHORS   Cassimeris,L., Safer,D., Nachmias,V.T. and Zigmond,S.H.
  TITLE     Thymosin beta 4 sequesters the majority of G-actin in resting human
            polymorphonuclear leukocytes
  JOURNAL   J Cell Biol 119 (5), 1261-1270 (1992)
   PUBMED   1447300
REFERENCE   7  (bases 1 to 622)
  AUTHORS   Goldschmidt-Clermont,P.J., Furman,M.I., Wachsstock,D., Safer,D.,
            Nachmias,V.T. and Pollard,T.D.
  TITLE     The control of actin nucleotide exchange by thymosin beta 4 and
            profilin. A potential regulatory mechanism for actin polymerization
            in cells
  JOURNAL   Mol Biol Cell 3 (9), 1015-1024 (1992)
   PUBMED   1330091
REFERENCE   8  (bases 1 to 622)
  AUTHORS   Sanders,M.C., Goldstein,A.L. and Wang,Y.L.
  TITLE     Thymosin beta 4 (Fx peptide) is a potent regulator of actin
            polymerization in living cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4678-4682 (1992)
   PUBMED   1584803
REFERENCE   9  (bases 1 to 622)
  AUTHORS   Safer,D., Elzinga,M. and Nachmias,V.T.
  TITLE     Thymosin beta 4 and Fx, an actin-sequestering peptide, are
            indistinguishable
  JOURNAL   J Biol Chem 266 (7), 4029-4032 (1991)
   PUBMED   1999398
REFERENCE   10 (bases 1 to 622)
  AUTHORS   Clauss,I.M., Wathelet,M.G., Szpirer,J., Islam,M.Q., Levan,G.,
            Szpirer,C. and Huez,G.A.
  TITLE     Human thymosin-beta 4/6-26 gene is part of a multigene family
            composed of seven members located on seven different chromosomes
  JOURNAL   Genomics 9 (1), 174-180 (1991)
   PUBMED   2004759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV715954.1 and BC001631.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021109.3.
            
            Summary: This gene encodes an actin sequestering protein which
            plays a role in regulation of actin polymerization. The protein is
            also involved in cell proliferation, migration, and
            differentiation. This gene escapes X inactivation and has a homolog
            on chromosome Y. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083509.1, AW162675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451311.7/ ENSP00000414376.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AV715954.1         4-19
            17-622              BC001631.1         1-606
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..622
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /note="thymosin beta 4 X-linked"
                     /db_xref="GeneID:7114"
                     /db_xref="HGNC:HGNC:11881"
                     /db_xref="MIM:300159"
     exon            1..59
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /inference="alignment:Splign:2.1.0"
     exon            60..175
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..210
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /note="thymosin, beta 4, X chromosome; prothymosin beta-4;
                     t beta-4"
                     /codon_start=1
                     /product="thymosin beta-4"
                     /protein_id="NP_066932.1"
                     /db_xref="CCDS:CCDS35202.1"
                     /db_xref="GeneID:7114"
                     /db_xref="HGNC:HGNC:11881"
                     /db_xref="MIM:300159"
                     /translation="MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
                     "
     exon            176..622
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      558
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /note="major polyA site"
     regulatory      606..611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /note="hexamer: AATAAA"
     polyA_site      622
                     /gene="TMSB4X"
                     /gene_synonym="FX; PTMB4; TB4X; TMSB4"
                     /note="major polyA site"
ORIGIN      
        1 aactcggtgg tggccactgc gcagaccaga cttcgctcgt actcgtgcgc ctcgcttcgc
       61 ttttcctccg caaccatgtc tgacaaaccc gatatggctg agatcgagaa attcgataag
      121 tcgaaactga agaagacaga gacgcaagag aaaaatccac tgccttccaa agaaacgatt
      181 gaacaggaga agcaagcagg cgaatcgtaa tgaggcgtgc gccgccaata tgcactgtac
      241 attccacaag cattgccttc ttattttact tcttttagct gtttaacttt gtaagatgca
      301 aagaggttgg atcaagttta aatgactgtg ctgccccttt cacatcaaag aactactgac
      361 aacgaaggcc gcgcctgcct ttcccatctg tctatctatc tggctggcag ggaaggaaag
      421 aacttgcatg ttggtgaagg aagaagtggg gtggaagaag tggggtggga cgacagtgaa
      481 atctagagta aaaccaagct ggcccaaggt gtcctgcagg ctgtaatgca gtttaatcag
      541 agtgccattt ttttttttgt tcaaatgatt ttaattattg gaatgcacaa tttttttaat
      601 atgcaaataa aaagtttaaa aa
//
