LOCUS       NM_194324                652 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens thymosin beta 15B (TMSB15B), transcript variant 1,
            mRNA.
ACCESSION   NM_194324 XM_936687
VERSION     NM_194324.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 652)
  AUTHORS   Banyard,J., Barrows,C. and Zetter,B.R.
  TITLE     Differential regulation of human thymosin beta 15 isoforms by
            transforming growth factor beta 1
  JOURNAL   Genes Chromosomes Cancer 48 (6), 502-509 (2009)
   PUBMED   19296525
  REMARK    GeneRIF: Our data show that the TMSB15A and TMSB15B isoforms have
            distinct expression patterns in different tumor cell lines and
            tissues.
REFERENCE   2  (bases 1 to 652)
  AUTHORS   Banyard,J., Hutchinson,L.M. and Zetter,B.R.
  TITLE     Thymosin beta-NB is the human isoform of rat thymosin beta15
  JOURNAL   Ann N Y Acad Sci 1112, 286-296 (2007)
   PUBMED   17567946
  REMARK    GeneRIF: TMSL8 is well conserved in many mammalian species. Two
            isoforms, thymosin beta15a and b, exist at different locations,
            1.4Mb apart, on human chromosome X, with 98% identity across the
            coding sequences.
            Review article
REFERENCE   3  (bases 1 to 652)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 652)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC093093.1 and BQ011701.1.
            
            On Nov 23, 2018 this sequence version replaced NM_194324.3.
            
            Transcript Variant: This variant (1) encodes the canonical isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093093.1, BC054476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000540220.6/ ENSP00000455371.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-649               BC093093.1         1-649
            650-652             BQ011701.1         32-34               c
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.2"
     gene            1..652
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /note="thymosin beta 15B"
                     /db_xref="GeneID:286527"
                     /db_xref="HGNC:HGNC:28612"
                     /db_xref="MIM:301011"
     exon            1..97
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /inference="alignment:Splign:2.1.0"
     exon            98..214
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..252
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Thymosin beta-15A; NB thymosin beta; Thymosin-like protein
                     8"
                     /codon_start=1
                     /product="thymosin beta-15B isoform 1"
                     /protein_id="NP_919305.2"
                     /db_xref="CCDS:CCDS59172.1"
                     /db_xref="GeneID:286527"
                     /db_xref="HGNC:HGNC:28612"
                     /db_xref="MIM:301011"
                     /translation="MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQT
                     S"
     exon            215..652
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      634..639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /note="hexamer: AATAAA"
     polyA_site      652
                     /gene="TMSB15B"
                     /gene_synonym="Tbeta15b; TMSB15A; TMSL8; TMSNB"
                     /note="major polyA site"
ORIGIN      
        1 agcactgcag ggctctgggc gggaaggcta acctggtgcg gagccagcct gggtctcagc
       61 cccgcgtacg gcctttcacg agtcttcaag ccttcaggct ttcttctagt caagatgagt
      121 gataaaccag acttgtcgga agtggagaag tttgacaggt caaaactgaa gaaaactaat
      181 actgaagaaa aaaatactct tccctcaaag gaaactatcc agcaggagaa agagtgtgtt
      241 caaacatcat aaaatgggga tctcctccaa agagcagatt tcagcattgc ctgacagtct
      301 tggttttagg cttgtttttt tgtaaacctg tgtgtttgta gagatttcag acatcttctg
      361 atttcttctc acctatattc cctggttaag aggtcagggg tagtgaatgt ttccttaagt
      421 tcctttttaa acttcccatt ggtatgtaaa ttccaaatgg cagatgctgt caataacctt
      481 gccatggatg acctttgtgt aggtagtcct tgcacctcat gcaggataag ccaattttaa
      541 ctttctacaa tgggtgcctc aatagtttca taatcttcat gaagttgcat cctttggcag
      601 cttcttacag tttattttca cttccaatgt agcaataaaa taataaatat aa
//
