LOCUS       NM_021992                634 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens thymosin beta 15A (TMSB15A), mRNA.
ACCESSION   NM_021992
VERSION     NM_021992.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 634)
  AUTHORS   Darb-Esfahani,S., Kronenwett,R., von Minckwitz,G., Denkert,C.,
            Gehrmann,M., Rody,A., Budczies,J., Brase,J.C., Mehta,M.K.,
            Bojar,H., Ataseven,B., Karn,T., Weiss,E., Zahm,D.M., Khandan,F.,
            Dietel,M. and Loibl,S.
  TITLE     Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response
            in triple-negative breast cancer
  JOURNAL   Br J Cancer 107 (11), 1892-1900 (2012)
   PUBMED   23079573
  REMARK    GeneRIF: Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy
            response in triple-negative breast cancer.
REFERENCE   2  (bases 1 to 634)
  AUTHORS   Banyard,J., Barrows,C. and Zetter,B.R.
  TITLE     Differential regulation of human thymosin beta 15 isoforms by
            transforming growth factor beta 1
  JOURNAL   Genes Chromosomes Cancer 48 (6), 502-509 (2009)
   PUBMED   19296525
  REMARK    GeneRIF: Our data show that the TMSB15A and TMSB15B isoforms have
            distinct expression patterns in different tumor cell lines and
            tissues.
REFERENCE   3  (bases 1 to 634)
  AUTHORS   Kim,Y.W., Kim,Y., Kim,E.H., Koh,D., Sun,W. and Kim,H.
  TITLE     Expression and subcellular localization of thymosin beta15
            following kainic acid treatment in rat brain
  JOURNAL   Biochem Biophys Res Commun 371 (4), 664-669 (2008)
   PUBMED   18452710
  REMARK    GeneRIF: Thymosin beta15 (Tbeta15) was translocated into nuclei
            following kainic acid (KA) treatments in a subset of entorhinal
            cortex neurons which are the population that undergo delayed
            apoptosis after KA treatment.
REFERENCE   4  (bases 1 to 634)
  AUTHORS   Gu,Y.M., Li,S.Y., Qiu,X.S. and Wang,E.H.
  TITLE     Elevated thymosin beta15 expression is associated with progression
            and metastasis of non-small cell lung cancer
  JOURNAL   APMIS 116 (6), 484-490 (2008)
   PUBMED   18754322
  REMARK    GeneRIF: findings suggest that increased thymosin beta15 expression
            correlates with the progression and metastasis of non-small cell
            lung cancer
REFERENCE   5  (bases 1 to 634)
  AUTHORS   Dhaese,S., Jonckheere,V., Goethals,M., Waltregny,D.,
            Vandekerckhove,J., Ampe,C. and Van Troys,M.
  TITLE     Functional and profiling studies prove that prostate cancer
            upregulated neuroblastoma thymosin beta is the true human homologue
            of rat thymosin beta15
  JOURNAL   FEBS Lett 581 (25), 4809-4815 (2007)
   PUBMED   17888914
  REMARK    GeneRIF: Human thymosin beta neuroblastoma has a higher affinity
            for actin in comparison to thymosin beta4 and promotes cell
            migration.
REFERENCE   6  (bases 1 to 634)
  AUTHORS   Bertheau,P., Turpin,E., Rickman,D.S., Espie,M., de Reynies,A.,
            Feugeas,J.P., Plassa,L.F., Soliman,H., Varna,M., de Roquancourt,A.,
            Lehmann-Che,J., Beuzard,Y., Marty,M., Misset,J.L., Janin,A. and de
            The,H.
  TITLE     Exquisite sensitivity of TP53 mutant and basal breast cancers to a
            dose-dense epirubicin-cyclophosphamide regimen
  JOURNAL   PLoS Med 4 (3), e90 (2007)
   PUBMED   17388661
REFERENCE   7  (bases 1 to 634)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 634)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   9  (bases 1 to 634)
  AUTHORS   Bao,L., Loda,M., Janmey,P.A., Stewart,R., Anand-Apte,B. and
            Zetter,B.R.
  TITLE     Thymosin beta 15: a novel regulator of tumor cell motility
            upregulated in metastatic prostate cancer
  JOURNAL   Nat Med 2 (12), 1322-1328 (1996)
   PUBMED   8946830
  REMARK    GeneRIF: Identification of thymosin beta15, the rat homolog of
            human thymosin beta 15/thymosin beta NB/thymosin-like 8. Thymosin
            beta15 levels increase in human prostate cancer, correlating
            positively with Gleason tumor grade.
REFERENCE   10 (bases 1 to 634)
  AUTHORS   Yokoyama,M., Nishi,Y., Yoshii,J., Okubo,K. and Matsubara,K.
  TITLE     Identification and cloning of neuroblastoma-specific and nerve
            tissue-specific genes through compiled expression profiles
  JOURNAL   DNA Res 3 (5), 311-320 (1996)
   PUBMED   9039501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D82345.1 and BG829126.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021992.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG829126.1, D82345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267752, SAMN03267760
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289373.5/ ENSP00000289373.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-633               D82345.1           7-639
            634-634             BG829126.1         616-616
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..634
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /note="thymosin beta 15A"
                     /db_xref="GeneID:11013"
                     /db_xref="HGNC:HGNC:30744"
                     /db_xref="MIM:300939"
     exon            1..74
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /inference="alignment:Splign:2.1.0"
     exon            75..191
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..229
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /note="thymosin-like 8; thymosin, beta, identified in
                     neuroblastoma cells; Thymosin beta-15B; NB thymosin beta;
                     thymosin-like protein 8"
                     /codon_start=1
                     /product="thymosin beta-15A"
                     /protein_id="NP_068832.1"
                     /db_xref="CCDS:CCDS14498.1"
                     /db_xref="GeneID:11013"
                     /db_xref="HGNC:HGNC:30744"
                     /db_xref="MIM:300939"
                     /translation="MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQT
                     S"
     exon            192..634
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      610..615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /note="hexamer: AATAAA"
     polyA_site      634
                     /gene="TMSB15A"
                     /gene_synonym="Tb15; TbNB; TMSB15; TMSB15B; TMSL8; TMSNB"
                     /note="major polyA site"
ORIGIN      
        1 aacgctaacc tggtccggag cgagtctggg tctcagcccc gcgaacagcc tttcacgagt
       61 cttcaagctt tcaggctatc ttctagtcaa gatgagtgat aagccagact tgtcggaagt
      121 ggagaagttt gacaggtcaa aactgaagaa aactaatact gaagaaaaaa atactcttcc
      181 ctcaaaggaa actatccagc aagagaaaga gtgtgttcaa acatcataaa atggggatcg
      241 cctcccaaca gcagatttcg acattacctg agagtcttga ttttaggctt gttttttgta
      301 aacccatgtg tttgtagaga ttttaggcgt cttcggatat cttctcacct atgttccctg
      361 gctaagaagt cagaggtagc caatgtttcc ttaaattcat ttttaaactt accattggtg
      421 catatgttcc agatggcaga tgctgtcaat aatctcacca ttgatgacct ttgtgtatgt
      481 agttcttgca tcctatactg gataagcctg ttttaacctg ctatgatggg tgcttccatt
      541 gcttcataat cttcatgaag ttgcatgctt ttgcagcttt tcacagttta tttgcatttc
      601 taatgtagta ataaagtaac caatataatc atta
//
