LOCUS       NM_021103                461 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens thymosin beta 10 (TMSB10), mRNA.
ACCESSION   NM_021103
VERSION     NM_021103.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Li,W., Chen,J., Xiang,C., Long,Y., Wu,K. and Li,J.
  TITLE     The Clinical Relevance and Functional Implications of Thymosin
            Beta-10 in Glioma
  JOURNAL   Genet Res (Camb) 2023, 5517445 (2023)
   PUBMED   38026448
  REMARK    GeneRIF: The Clinical Relevance and Functional Implications of
            Thymosin Beta-10 in Glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Wang,C., He,Y., You,Z. and Chen,X.
  TITLE     TMSB10 Promotes Progression of Clear Cell Renal Cell Carcinoma via
            JUN Transcription Regulation
  JOURNAL   Ann Clin Lab Sci 52 (2), 230-239 (2022)
   PUBMED   35414502
  REMARK    GeneRIF: TMSB10 Promotes Progression of Clear Cell Renal Cell
            Carcinoma via JUN Transcription Regulation.
REFERENCE   3  (bases 1 to 461)
  AUTHORS   Li,J., Zhou,S., Li,H., Xu,Y., Zhou,N. and Liu,R.
  TITLE     PTEN/AKT upregulation of TMSB10 contributes to lung cancer cell
            growth and predicts poor survival of the patients
  JOURNAL   Biosci Biotechnol Biochem 85 (4), 805-813 (2021)
   PUBMED   33686397
  REMARK    GeneRIF: PTEN/AKT upregulation of TMSB10 contributes to lung cancer
            cell growth and predicts poor survival of the patients.
REFERENCE   4  (bases 1 to 461)
  AUTHORS   Zeng,J., Yang,X., Yang,L., Li,W. and Zheng,Y.
  TITLE     Thymosin beta10 promotes tumor-associated macrophages M2 conversion
            and proliferation via the PI3K/Akt pathway in lung adenocarcinoma
  JOURNAL   Respir Res 21 (1), 328 (2020)
   PUBMED   33349268
  REMARK    GeneRIF: Thymosin beta10 promotes tumor-associated macrophages M2
            conversion and proliferation via the PI3K/Akt pathway in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 461)
  AUTHORS   Pan,Q., Cheng,G., Liu,Y., Xu,T., Zhang,H. and Li,B.
  TITLE     TMSB10 acts as a biomarker and promotes progression of clear cell
            renal cell carcinoma
  JOURNAL   Int J Oncol 56 (5), 1101-1114 (2020)
   PUBMED   32319572
  REMARK    GeneRIF: TMSB10 acts as a biomarker and promotes progression of
            clear cell renal cell carcinoma.
REFERENCE   6  (bases 1 to 461)
  AUTHORS   Tsitsiloni,O.E., Yialouris,P.P., Echner,H., Voelter,W. and
            Haritos,A.A.
  TITLE     Evidence for the extranuclear localization of thymosins in thymus
  JOURNAL   Experientia 48 (4), 398-402 (1992)
   PUBMED   1582498
REFERENCE   7  (bases 1 to 461)
  AUTHORS   Condon,M.R. and Hall,A.K.
  TITLE     Expression of thymosin beta-4 and related genes in developing human
            brain
  JOURNAL   J Mol Neurosci 3 (3), 165-170 (1992)
   PUBMED   1627460
REFERENCE   8  (bases 1 to 461)
  AUTHORS   Lin,S.C. and Morrison-Bogorad,M.
  TITLE     Cloning and characterization of a testis-specific thymosin beta 10
            cDNA. Expression in post-meiotic male germ cells
  JOURNAL   J Biol Chem 266 (34), 23347-23353 (1991)
   PUBMED   1744129
REFERENCE   9  (bases 1 to 461)
  AUTHORS   Hall,A.K.
  TITLE     Differential expression of thymosin genes in human tumors and in
            the developing human kidney
  JOURNAL   Int J Cancer 48 (5), 672-677 (1991)
   PUBMED   2071228
REFERENCE   10 (bases 1 to 461)
  AUTHORS   Hall,A.K., Hempstead,J. and Morgan,J.I.
  TITLE     Thymosin beta 10 levels in developing human brain and its
            regulation by retinoic acid in the HTB-10 neuroblastoma
  JOURNAL   Brain Res Mol Brain Res 8 (2), 129-135 (1990)
   PUBMED   2169566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC016731.1 and AC022210.8.
            
            On Nov 22, 2018 this sequence version replaced NM_021103.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AU122997.2, BP206070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233143.6/ ENSP00000233143.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               BC016731.1         5-464
            461-461             AC022210.8         21888-21888
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..461
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /note="thymosin beta 10"
                     /db_xref="GeneID:9168"
                     /db_xref="HGNC:HGNC:11879"
                     /db_xref="MIM:188399"
     exon            1..63
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /inference="alignment:Splign:2.1.0"
     exon            64..178
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..213
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /note="migration-inducing gene 12; migration-inducing
                     protein 12"
                     /codon_start=1
                     /product="thymosin beta-10"
                     /protein_id="NP_066926.1"
                     /db_xref="CCDS:CCDS1970.1"
                     /db_xref="GeneID:9168"
                     /db_xref="HGNC:HGNC:11879"
                     /db_xref="MIM:188399"
                     /translation="MADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS
                     "
     exon            179..461
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      441..446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /note="hexamer: AATAAA"
     polyA_site      461
                     /gene="TMSB10"
                     /gene_synonym="MIG12; TB10"
                     /note="major polyA site"
ORIGIN      
        1 gtttcttgct gcagcaacgc gagtgggagc accaggatct cgggctcgga acgagactgc
       61 acggattgtt ttaagaaaat ggcagacaaa ccagacatgg gggaaatcgc cagcttcgat
      121 aaggccaagc tgaagaaaac ggagacgcag gagaagaaca ccctgccgac caaagagacc
      181 attgagcagg agaagcggag tgaaatttcc taagatcctg gaggatttcc tacccccgtc
      241 ctcttcgaga ccccagtcgt gatgtggagg aagagccacc tgcaagatgg acacgagcca
      301 caagctgcac tgtgaacctg ggcactccgc gccgatgcca ccggcctgtg ggtctctgaa
      361 gggacccccc cccaatcgga ctgccaaatt ctccggtttg ccccgggata ttatagaaaa
      421 ttatttgtat gaataatgaa aataaaacac acctcgtggc a
//
