LOCUS       NM_001395507            2827 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens transmembrane serine protease 7 (TMPRSS7), transcript
            variant 4, mRNA.
ACCESSION   NM_001395507
VERSION     NM_001395507.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Luostari,K., Hartikainen,J.M., Tengstrom,M., Palvimo,J.J.,
            Kataja,V., Mannermaa,A. and Kosma,V.M.
  TITLE     Type II transmembrane serine protease gene variants associate with
            breast cancer
  JOURNAL   PLoS One 9 (7), e102519 (2014)
   PUBMED   25029565
  REMARK    GeneRIF: Single nucleotide polymorphism in TMPRSS7(rs2399403) is
            significantly associated with breast cancer risk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Lee,J.H., Cheng,R., Honig,L.S., Feitosa,M., Kammerer,C.M.,
            Kang,M.S., Schupf,N., Lin,S.J., Sanders,J.L., Bae,H., Druley,T.,
            Perls,T., Christensen,K., Province,M. and Mayeux,R.
  TITLE     Genome wide association and linkage analyses identified three
            loci-4q25, 17q23.2, and 10q11.21-associated with variation in
            leukocyte telomere length: the Long Life Family Study
  JOURNAL   Front Genet 4, 310 (2014)
   PUBMED   24478790
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024887.22.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN03568912 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000452346.7/ ENSP00000398236.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC024887.22        81818-81975         c
            159-408             AC024887.22        78390-78639         c
            409-539             AC024887.22        74661-74791         c
            540-607             AC024887.22        72389-72456         c
            608-801             AC024887.22        70768-70961         c
            802-840             AC024887.22        69699-69737         c
            841-1069            AC024887.22        68744-68972         c
            1070-1200           AC024887.22        66737-66867         c
            1201-1313           AC024887.22        65928-66040         c
            1314-1420           AC024887.22        59580-59686         c
            1421-1557           AC024887.22        54788-54924         c
            1558-1665           AC024887.22        53079-53186         c
            1666-1776           AC024887.22        50209-50319         c
            1777-1893           AC024887.22        42299-42415         c
            1894-2065           AC024887.22        41219-41390         c
            2066-2334           AC024887.22        39567-39835         c
            2335-2471           AC024887.22        37833-37969         c
            2472-2827           AC024887.22        35442-35797         c
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..2827
                     /gene="TMPRSS7"
                     /note="transmembrane serine protease 7"
                     /db_xref="GeneID:344805"
                     /db_xref="HGNC:HGNC:30846"
     exon            1..158
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2642
                     /gene="TMPRSS7"
                     /note="isoform 3 is encoded by transcript variant 4; type
                     II transmembrane serine protease 7; matriptase-3;
                     transmembrane protease, serine 7"
                     /codon_start=1
                     /product="transmembrane protease serine 7 isoform 3"
                     /protein_id="NP_001382436.1"
                     /db_xref="CCDS:CCDS93340.1"
                     /db_xref="GeneID:344805"
                     /db_xref="HGNC:HGNC:30846"
                     /translation="MDKENSDVSAAPADLKISNISVQVVSAQKKLPVRRPPLPGRRLP
                     LPGRRPPQRPIGKAKPKKQSKKKVPFWNVQNKIILFTVFLFILAVIAWTLLWLYISKT
                     ESKDAFYFAGMFRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQS
                     VVADVSSNNKGGLLVHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQ
                     GLAVDMDSVVLNAGLRSDYSSTIGSDKGCSQYFYAEHLSLHYPLEISAASGRLMCHFK
                     LVAIVGYLIRLSIKSIQIEADNCVTDSLTIYDSLLPIRSSILYRICEPTRTLMSFVST
                     NNLMLVTFKSPHIRRLSGIRAYFEVIPEQKCENTVLVKDITGFEGKISSPYYPSYYPP
                     KCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGCEHGWWEINEHMYCGSYMDHQTIFR
                     VPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPVGSFRCSSGLCVPQAQRCDGVND
                     CFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKC
                     GNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLH
                     FVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVV
                     HEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHE
                     ADNKGSLVLQQAEVELIDQTLCVSTYGIITSRMLCAGIMSGKRDACKGDSGGPLSCRR
                     KSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSLL"
     exon            159..408
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            409..539
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            540..607
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            608..801
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            802..840
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1069
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1200
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1313
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1420
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1557
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1665
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1776
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1893
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2065
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2334
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2471
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2827
                     /gene="TMPRSS7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctagcttg aatgcggtga cggttctctc aattcttctc aagagagcat ataaggggca
       61 aaaactggct ttgagacacc cctggatgat cacacacaaa acgcctaata atggacaaag
      121 aaaacagcga tgtttcagcc gcacctgctg acctgaaaat atccaatatc tcagtccaag
      181 tggtcagtgc ccaaaagaag ctgccagtga gacgaccacc gttgccaggg agacgactac
      241 cattgccagg aagacgacca ccacaaagac ccattggcaa agccaaaccc aagaagcaat
      301 ccaagaaaaa agttcccttt tggaatgtac aaaataaaat cattctcttc acagtatttt
      361 tattcatcct agcagtcata gcctggacac ttctgtggct gtatatcagt aaaacagaaa
      421 gcaaagatgc tttttacttt gctgggatgt ttcgcatcac caacattgag tttcttcccg
      481 aataccgaca aaaggagtcc agggaatttc tttcagtgtc acggactgtg cagcaagtga
      541 taaacctggt ttatacaaca tctgccttct ccaaatttta tgagcagtct gttgttgcag
      601 atgtcagcag caacaacaaa ggcggcctcc ttgtccactt ttggattgtt tttgtcatgc
      661 cacgtgccaa aggccacatc ttctgtgaag actgtgttgc cgccatcttg aaggactcca
      721 tccagacaag catcataaac cggacctctg tggggagctt gcagggactg gctgtggaca
      781 tggactctgt ggtactaaat gctgggcttc ggtcggatta ctcgtcaacc ataggatctg
      841 acaaaggctg ctctcagtac ttctatgcag agcatctgtc tctccactac ccgctggaga
      901 tttctgcagc ctcagggagg ctgatgtgtc acttcaagct ggtggccata gtgggctacc
      961 tgattcgtct ctcaatcaag tccatccaaa tcgaagccga caactgtgtc actgactccc
     1021 tgaccattta cgactccctt ttgcccatcc ggagcagcat cttgtacaga atttgtgaac
     1081 ccacaagaac attaatgtca tttgtttcta caaataatct catgttggtg acatttaagt
     1141 ctcctcatat acggaggctc tcaggaatcc gggcatattt tgaggtcatt ccagaacaaa
     1201 agtgtgaaaa cacagtgttg gtcaaagaca tcactggctt tgaagggaaa atttcaagcc
     1261 catattaccc gagctactat cctccaaaat gcaagtgtac ctggaaattt cagacttctc
     1321 tatcaactct tggcatagca ctgaaattct ataactattc aataaccaag aagagtatga
     1381 aaggctgtga gcatggatgg tgggaaatta atgagcacat gtactgtggc tcctacatgg
     1441 atcatcagac aatttttcga gtgcccagcc ctctggttca cattcagctc cagtgcagtt
     1501 caaggctttc agacaagcca cttttggcag aatatggcag ttacaacatc agtcaaccct
     1561 gccctgttgg atcttttaga tgctcctccg gtttatgtgt ccctcaggcc cagcgttgtg
     1621 atggagtaaa tgactgcttt gatgaaagtg atgaactgtt ttgcgtgagc cctcaacctg
     1681 cctgcaatac cagctccttc aggcagcatg gccctctcat ctgtgatggc ttcagggact
     1741 gtgagaatgg ccgggatgag caaaactgca ctcaaagtat tccatgcaac aacagaactt
     1801 ttaagtgtgg caatgatatt tgctttagga aacaaaatgc aaaatgtgat gggacagtgg
     1861 attgtccaga tggaagtgat gaagaaggct gcacctgcag caggagttcc tccgcccttc
     1921 accgcatcat cggaggcaca gacaccctgg aggggggttg gccgtggcag gtcagcctcc
     1981 actttgttgg atctgcctac tgtggtgcct cagtcatctc cagggagtgg cttctttctg
     2041 cagcccactg ttttcatgga aacaggctgt cagatcccac accatggact gcacacctcg
     2101 ggatgtatgt tcaggggaat gccaagtttg tctccccggt gagaagaatt gtggtccacg
     2161 agtactataa cagtcagact tttgattatg atattgcttt gctacagctc agtattgcct
     2221 ggcctgagac cctgaaacag ctcattcagc caatatgcat tcctcccact ggtcagagag
     2281 ttcgcagtgg ggagaagtgc tgggtaactg gctgggggcg aagacacgaa gcagataata
     2341 aaggctccct cgttctgcag caagcggagg tagagctcat tgatcaaacg ctctgtgttt
     2401 ccacctacgg gatcatcact tctcggatgc tctgtgcagg cataatgtca ggcaagagag
     2461 atgcctgcaa aggagattcg ggtggacctt tatcttgtcg aagaaaaagt gatggaaaat
     2521 ggattttgac tggcattgtt agctggggac atggaagtgg acgaccaaac tttcctggtg
     2581 tttacacaag ggtgtcaaac tttgttccct ggattcataa atatgtccct tctcttttgt
     2641 aattgtacca gttgtatttt tactgtgatt tatgttaaaa atagatactt taaaatgatg
     2701 cagtaattgg ctgggtgcgc tggctcacac ctgtaatccc agcacgttgg gaggccgagg
     2761 cgggcagatc acgaggtcag gaggtcaaga ccatcctggc taacatggtg aaaccctgtc
     2821 tctactg
//
