LOCUS       NM_002772               4076 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane serine protease 15 (TMPRSS15),
            transcript variant 2, mRNA.
ACCESSION   NM_002772
VERSION     NM_002772.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4076)
  AUTHORS   Hayashi,H., Kubo,Y., Izumida,M., Takahashi,E., Kido,H., Sato,K.,
            Yamaya,M., Nishimura,H., Nakayama,K. and Matsuyama,T.
  TITLE     Enterokinase Enhances Influenza A Virus Infection by Activating
            Trypsinogen in Human Cell Lines
  JOURNAL   Front Cell Infect Microbiol 8, 91 (2018)
   PUBMED   29629340
  REMARK    GeneRIF: Enterokinases was able to enhance the proliferation of
            H1N1 virus in 293T human kidney cells, but the proliferation was
            reduced by knocking down the endogenous enterokinase in A549 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4076)
  AUTHORS   Dowling,J.K., Becker,C.E., Bourke,N.M., Corr,S.C., Connolly,D.J.,
            Quinn,S.R., Pandolfi,P.P., Mansell,A. and O'Neill,L.A.J.
  TITLE     Promyelocytic leukemia protein interacts with the
            apoptosis-associated speck-like protein to limit inflammasome
            activation
  JOURNAL   J Biol Chem 289 (10), 6429-6437 (2014)
   PUBMED   24407287
REFERENCE   3  (bases 1 to 4076)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   4  (bases 1 to 4076)
  AUTHORS   Smith,E.T. and Johnson,D.A.
  TITLE     Human enteropeptidase light chain: bioengineering of recombinants
            and kinetic investigations of structure and function
  JOURNAL   Protein Sci 22 (5), 577-585 (2013)
   PUBMED   23436726
  REMARK    GeneRIF: The Y174R variant showed improved specificities for
            substrates containing the sequences DDDDK (kcat/KM = 6.83 x 106 M-1
            sec-1) and DDDDR (kcat/KM = 1.89 x 107 M-1 sec-1) relative to all
            other enteropeptidase variants reported to date.
REFERENCE   5  (bases 1 to 4076)
  AUTHORS   Braud,S., Ciufolini,M.A. and Harosh,I.
  TITLE     Enteropeptidase: a gene associated with a starvation human
            phenotype and a novel target for obesity treatment
  JOURNAL   PLoS One 7 (11), e49612 (2012)
   PUBMED   23185382
  REMARK    GeneRIF: Enteropeptidase is a gene associated with a starvation
            human phenotype and a novel target for obesity treatment
REFERENCE   6  (bases 1 to 4076)
  AUTHORS   Kitamoto,Y., Veile,R.A., Donis-Keller,H. and Sadler,J.E.
  TITLE     cDNA sequence and chromosomal localization of human enterokinase,
            the proteolytic activator of trypsinogen
  JOURNAL   Biochemistry 34 (14), 4562-4568 (1995)
   PUBMED   7718557
REFERENCE   7  (bases 1 to 4076)
  AUTHORS   Kitamoto,Y., Yuan,X., Wu,Q., McCourt,D.W. and Sadler,J.E.
  TITLE     Enterokinase, the initiator of intestinal digestion, is a mosaic
            protease composed of a distinctive assortment of domains
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7588-7592 (1994)
   PUBMED   8052624
REFERENCE   8  (bases 1 to 4076)
  AUTHORS   Freeman,T.C., Davies,R. and Calam,J.
  TITLE     Interactions of pancreatic secretory trypsin inhibitor in small
            intestinal juice: its hydrolysis and protection by intraluminal
            factors
  JOURNAL   Clin Chim Acta 195 (1-2), 27-39 (1990)
   PUBMED   2093478
REFERENCE   9  (bases 1 to 4076)
  AUTHORS   Hadorn,B., Haworth,J.C., Gourley,B., Prasad,A. and Troesch,V.
  TITLE     Intestinal enterokinase deficiency. Occurrence in two sibs and age
            dependency of clinical expression
  JOURNAL   Arch Dis Child 50 (4), 277-282 (1975)
   PUBMED   1147667
REFERENCE   10 (bases 1 to 4076)
  AUTHORS   Haworth,J.C., Gourley,B., Hadorn,B. and Sumida,C.
  TITLE     Malabsorption and growth failure due to intestinal enterokinase
            deficiency
  JOURNAL   J Pediatr 78 (3), 481-490 (1971)
   PUBMED   4322674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000455.5, AP000456.4 and
            AL078474.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002772.2.
            
            Summary: This gene encodes an enzyme that converts the pancreatic
            proenzyme trypsinogen to trypsin, which activates other proenzymes
            including chymotrypsinogen and procarboxypeptidases. The precursor
            protein is cleaved into two chains that form a heterodimer linked
            by a disulfide bond. This protein is a member of the trypsin family
            of peptidases. Mutations in this gene cause enterokinase
            deficiency, a malabsorption disorder characterized by diarrhea and
            failure to thrive. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09860.1, BC111749.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284885.8/ ENSP00000284885.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               AP000455.5         18626-18933         c
            309-439             AP000455.5         13347-13477         c
            440-507             AP000455.5         13027-13094         c
            508-659             AP000456.4         49288-49439         c
            660-695             AP000456.4         44944-44979         c
            696-827             AP000456.4         37854-37985         c
            828-936             AP000456.4         30801-30909         c
            937-1043            AP000456.4         25418-25524         c
            1044-1184           AP000456.4         19384-19524         c
            1185-1334           AP000456.4         18564-18713         c
            1335-1440           AP000456.4         9616-9721           c
            1441-1591           AP000456.4         9167-9317           c
            1592-1727           AP000456.4         7074-7209           c
            1728-1817           AL078474.2         4357-4446
            1818-1943           AL078474.2         7236-7361
            1944-2084           AL078474.2         9958-10098
            2085-2195           AL078474.2         21274-21384
            2196-2328           AL078474.2         23453-23585
            2329-2424           AL078474.2         38701-38796
            2425-2474           AL078474.2         41878-41927
            2475-2649           AL078474.2         42086-42260
            2650-2831           AL078474.2         55309-55490
            2832-2927           AL078474.2         57471-57566
            2928-3067           AL078474.2         61194-61333
            3068-4076           AL078474.2         66406-67414
FEATURES             Location/Qualifiers
     source          1..4076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     gene            1..4076
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /note="transmembrane serine protease 15"
                     /db_xref="GeneID:5651"
                     /db_xref="HGNC:HGNC:9490"
                     /db_xref="MIM:606635"
     exon            1..308
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..3223
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /EC_number="3.4.21.9"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; enteropeptidase; protease, serine, 7
                     (enterokinase); enterokinase catalytic subunit;
                     transmembrane protease, serine 15; serine protease 7"
                     /codon_start=1
                     /product="enteropeptidase isoform 2 precursor"
                     /protein_id="NP_002763.3"
                     /db_xref="CCDS:CCDS13571.1"
                     /db_xref="GeneID:5651"
                     /db_xref="HGNC:HGNC:9490"
                     /db_xref="MIM:606635"
                     /translation="MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIK
                     ESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNL
                     KNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLN
                     SVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDN
                     KMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYY
                     TDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAF
                     NSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGF
                     YISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKT
                     VFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYP
                     EPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQL
                     HFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLAR
                     GGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFN
                     GTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVK
                     LNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPW
                     VVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVP
                     RLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAG
                     WGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSG
                     GPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH"
     exon            309..439
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            440..507
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            508..659
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            660..695
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            696..827
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            828..936
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1043
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1184
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1334
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1440
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1591
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1727
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1817
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1943
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2084
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2195
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2328
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2424
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2474
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2649
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2831
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2927
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3067
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..4076
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /note="hexamer: AATAAA"
     polyA_site      3854
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /note="major polyA site"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
                     /note="hexamer: AATAAA"
     polyA_site      4076
                     /gene="TMPRSS15"
                     /gene_synonym="ENTK; PRSS7"
ORIGIN      
        1 gccaaagaga catacacaac tcacttacac tgactggtat gcatgtagac aggtggttgt
       61 tgctttacac atctttaaaa atttgagaga tttttctctt cagttggtag aattatttat
      121 attctctttc agttcttaaa ttagcaagcc ttcaaaacca aaaatggggt cgaaaagagg
      181 catatcttct aggcatcatt ctctcagctc ctatgaaatc atgtttgcag ctctctttgc
      241 catattggta gtgctctgtg ctggattaat tgcagtatcc tgcctgacaa tcaaggaatc
      301 ccaacgaggt gcagcacttg gacagagtca tgaagccaga gcgacattta aaataacatc
      361 cggagttaca tataatccta atttgcaaga caaactctca gtggatttca aagttcttgc
      421 ttttgacctt cagcaaatga tagatgagat ctttctatca agcaatctga agaatgaata
      481 taagaactca agagttttac aatttgaaaa tggcagcatt atagtcgtat ttgacctttt
      541 ctttgcccag tgggtgtcag atgaaaatgt aaaagaagaa ctgattcaag gccttgaagc
      601 aaataaatcc agccaactgg tcactttcca tattgatttg aacagcgttg atatcctaga
      661 caagctaaca accaccagtc atctggcaac tccaggaaat gtctcaatag agtgcctgcc
      721 tggttcaagt ccttgtactg atgctctaac gtgtataaaa gctgatttat tttgtgatgg
      781 agaagtaaac tgtccagatg gttctgacga agacaataaa atgtgtgcca cagtttgtga
      841 tggaagattt ttgttaactg gatcatctgg gtctttccag gctactcatt atccaaaacc
      901 ttctgaaaca agtgttgtct gccagtggat catacgtgta aaccaaggac tttccattaa
      961 actgagcttc gatgatttta atacatatta tacagatata ttagatattt atgaaggtgt
     1021 aggatcaagc aagattttaa gagcttctat ttgggaaact aatcctggca caataagaat
     1081 tttttccaac caagttactg ccacctttct tatagaatct gatgaaagtg attatgttgg
     1141 ctttaatgca acatatactg catttaacag cagtgagctt aataattatg agaaaattaa
     1201 ttgtaacttt gaggatggct tttgtttctg ggtccaggat ctaaatgatg ataatgaatg
     1261 ggaaaggatt cagggaagca ccttttctcc ttttactgga cccaattttg accacacttt
     1321 tggcaatgct tcaggatttt acatttctac cccaactgga ccaggaggga gacaagaacg
     1381 agtggggctt ttaagcctcc ctttggaccc cactttggag ccagcttgcc ttagtttctg
     1441 gtatcatatg tatggtgaaa atgtccataa attaagcatt aatatcagca atgaccaaaa
     1501 tatggagaag acagttttcc aaaaggaagg aaattatgga gacaattgga attatggaca
     1561 agtaacccta aatgaaacag ttaaatttaa ggttgctttt aatgctttta aaaacaagat
     1621 cctgagtgat attgcgttgg atgacattag cctaacatat gggatttgca atgggagtct
     1681 ttatccagaa ccaactttgg tgccaactcc tccaccagaa cttcctacgg actgtggagg
     1741 accttttgag ctgtgggagc caaatacaac attcagttct acgaactttc caaacagcta
     1801 ccctaatctg gctttctgtg tttggatttt aaatgcacaa aaaggaaaga atatacaact
     1861 tcattttcaa gaatttgact tagaaaatat taacgatgta gttgaaataa gagatggtga
     1921 agaagctgat tccttgctct tagctgtgta cacagggcct ggcccagtaa aggatgtgtt
     1981 ctctaccacc aacagaatga ctgtgcttct catcactaac gatgtgttgg caagaggagg
     2041 gtttaaagca aactttacta ctggctatca cttggggatt ccagagccat gcaaggcaga
     2101 ccattttcaa tgtaaaaatg gagagtgtgt tccactggtg aatctctgtg acggtcatct
     2161 gcactgtgag gatggctcag atgaagcaga ttgtgtgcgt tttttcaatg gcacaacgaa
     2221 caacaatggt ttagtgcggt tcagaatcca gagcatatgg catacagctt gtgctgagaa
     2281 ctggaccacc cagatttcaa atgatgtttg tcaactgctg ggactaggga gtggaaactc
     2341 atcaaagcca atcttcccta ccgatggtgg accatttgtc aaattaaaca cagcacctga
     2401 tggccactta atactaacac ccagtcaaca gtgtttacag gattccttga ttcggttaca
     2461 gtgtaaccat aaatcttgtg gaaaaaaact ggcagctcaa gacatcaccc caaagattgt
     2521 tggaggaagt aatgccaaag aaggggcctg gccctgggtt gtgggtctgt attatggcgg
     2581 ccgactgctc tgcggcgcat ctctcgtcag cagtgactgg ctggtgtccg ccgcacactg
     2641 cgtgtatggg agaaacttag agccatccaa gtggacagca atcctaggcc tgcatatgaa
     2701 atcaaatctg acctctcctc aaacagtccc tcgattaata gatgaaattg tcataaaccc
     2761 tcattacaat aggcgaagaa aggacaacga cattgccatg atgcatctgg aatttaaagt
     2821 gaattacaca gattacatac aacctatttg tttaccggaa gaaaatcaag tttttcctcc
     2881 aggaagaaat tgttctattg ctggttgggg gacggttgta tatcaaggta ctactgcaaa
     2941 catattgcaa gaagctgatg ttcctcttct atcaaatgag agatgccaac agcagatgcc
     3001 agaatataac attactgaaa atatgatatg tgcaggctat gaagaaggag gaatagattc
     3061 ttgtcagggg gattcaggag gaccattaat gtgccaagaa aacaacaggt ggttccttgc
     3121 tggtgtgacc tcatttggat acaagtgtgc cctgcctaat cgccccggag tgtatgccag
     3181 ggtctcaagg tttaccgaat ggatacaaag ttttctacat tagcgcattt cttaaactaa
     3241 acaggaaagt cgcattattt tcccattcta ctctagaaag catggaaatt aagtgtttcg
     3301 tacaaaaatt ttaaaaagtt accaaaggtt tttattctta cctatgtcaa tgaaatgcta
     3361 gggggccagg gaaacaaaat tttaaaaata ataaaattca ccatagcaat acagaataac
     3421 tttaaaatac cattaaatac atttgtattt cattgtgaac aggtatttct tcacagatct
     3481 catttttaaa attcttaatg attattttta ttacttactg ttgtttaaag ggatgttatt
     3541 ttaaagcata taccatacac ttaagaaatt tgagcagaat ttaaaaaaga aagaaaataa
     3601 attgtttttc ccaaagtatg tcactgttgg aaataaactg ccataaattt tctagttcca
     3661 gtttagtttg ctgctattag cagaaactca attgtttctc tgtcttttct atcaaaattt
     3721 tcaacatatg cataacctta gtattttccc aaccaataga aactatttat tgtaagctta
     3781 tgtcacaggc ctggactaaa ttgattttac gttcctctta aataagttaa ttaaataaaa
     3841 gataaattaa ctgatatagt cattgtatat tagataaatt ttacctattt atttcaagca
     3901 agtattttta agtctcaaga aaataatcag acataccaaa gaaatgcacc tattgcaaat
     3961 cctggtcttg gtttatgtgt gttacagtgg atatttctaa tatatgaaaa cttatttaga
     4021 cacagctgaa tcacccatga gaaggtcaaa tatgtgtaat aaatgaattt gcttca
//
