LOCUS       NM_001077263            3397 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane serine protease 13 (TMPRSS13),
            transcript variant 1, mRNA.
ACCESSION   NM_001077263
VERSION     NM_001077263.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Gatineau,J., Nidercorne,C., Dupont,A., Puiffe,M.L., Cohen,J.L.,
            Molinier-Frenkel,V., Niedergang,F. and Castellano,F.
  TITLE     IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike
  JOURNAL   Front Immunol 13, 982839 (2022)
   PUBMED   36131918
  REMARK    GeneRIF: IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2
            spike.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Martin,C.E., Murray,A.S., Sala-Hamrick,K.E., Mackinder,J.R.,
            Harrison,E.C., Lundgren,J.G., Varela,F.A. and List,K.
  TITLE     Posttranslational modifications of serine protease TMPRSS13
            regulate zymogen activation, proteolytic activity, and cell surface
            localization
  JOURNAL   J Biol Chem 297 (4), 101227 (2021)
   PUBMED   34562451
  REMARK    GeneRIF: Posttranslational modifications of serine protease
            TMPRSS13 regulate zymogen activation, proteolytic activity, and
            cell surface localization.
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Ohno,A., Maita,N., Tabata,T., Nagano,H., Arita,K., Ariyoshi,M.,
            Uchida,T., Nakao,R., Ulla,A., Sugiura,K., Kishimoto,K.,
            Teshima-Kondo,S., Okumura,Y. and Nikawa,T.
  TITLE     Crystal structure of inhibitor-bound human MSPL that can activate
            high pathogenic avian influenza
  JOURNAL   Life Sci Alliance 4 (6), e202000849 (2021)
   PUBMED   33820827
  REMARK    GeneRIF: Crystal structure of inhibitor-bound human MSPL that can
            activate high pathogenic avian influenza.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Kishimoto,M., Uemura,K., Sanaki,T., Sato,A., Hall,W.W., Kariwa,H.,
            Orba,Y., Sawa,H. and Sasaki,M.
  TITLE     TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
  JOURNAL   Viruses 13 (3), 384 (2021)
   PUBMED   33671076
  REMARK    GeneRIF: TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike
            Protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3397)
  AUTHORS   Murray,A.S., Hyland,T.E., Sala-Hamrick,K.E., Mackinder,J.R.,
            Martin,C.E., Tanabe,L.M., Varela,F.A. and List,K.
  TITLE     The cell-surface anchored serine protease TMPRSS13 promotes breast
            cancer progression and resistance to chemotherapy
  JOURNAL   Oncogene 39 (41), 6421-6436 (2020)
   PUBMED   32868877
  REMARK    GeneRIF: The cell-surface anchored serine protease TMPRSS13
            promotes breast cancer progression and resistance to chemotherapy.
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Hashimoto,T., Kato,M., Shimomura,T. and Kitamura,N.
  TITLE     TMPRSS13, a type II transmembrane serine protease, is inhibited by
            hepatocyte growth factor activator inhibitor type 1 and activates
            pro-hepatocyte growth factor
  JOURNAL   FEBS J 277 (23), 4888-4900 (2010)
   PUBMED   20977675
  REMARK    GeneRIF: results suggest that TMPRSS13 functions as an
            HGF-converting protease, the activity of which may be regulated by
            HAI-1
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Okumura,Y., Takahashi,E., Yano,M., Ohuchi,M., Daidoji,T.,
            Nakaya,T., Bottcher,E., Garten,W., Klenk,H.D. and Kido,H.
  TITLE     Novel type II transmembrane serine proteases, MSPL and TMPRSS13,
            Proteolytically activate membrane fusion activity of the
            hemagglutinin of highly pathogenic avian influenza viruses and
            induce their multicycle replication
  JOURNAL   J Virol 84 (10), 5089-5096 (2010)
   PUBMED   20219906
  REMARK    GeneRIF: The authors report that serine proteases, MSPL and its
            splice variant TMPRSS13, are novel candidates for proteases
            processing HA proteins of highly pathogenic avian influenza (HPAI)
            viruses.
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Kido,H. and Okumura,Y.
  TITLE     MSPL/TMPRSS13
  JOURNAL   Front Biosci 13, 754-758 (2008)
   PUBMED   17981585
  REMARK    GeneRIF: cloning of MSPL/TMPRSS13, which may play roles in the
            proteolytic processing of prohormones, precursors of growth
            factors, and also play roles in the pathogenicity of many viruses
            and bacteria in vivo
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3397)
  AUTHORS   Kim,D.R., Sharmin,S., Inoue,M. and Kido,H.
  TITLE     Cloning and expression of novel mosaic serine proteases with and
            without a transmembrane domain from human lung
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 204-209 (2001)
   PUBMED   11267681
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002962.2, BC114928.1 and
            AW014913.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001077263.2.
            
            Summary: This gene encodes a member of the type II transmembrane
            serine protease family. The encoded protein contains a type II
            transmembrane domain, a receptor class A domain, a scavenger
            receptor cysteine-rich domain and a protease domain. Transmembrane
            serine proteases are regulated by protease inhibitors and known to
            function in development, homeostasis, infection, and tumorigenesis.
            This protein facilitates entry of viruses into host cells by
            proteolytically cleaving and activating viral envelope
            glycoproteins. [provided by RefSeq, Aug 2021].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114928.1, AK300283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000524993.6/ ENSP00000434279.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AP002962.2         44284-44399         c
            117-546             AP002962.2         33406-33835         c
            547-997             BC114928.1         517-967
            998-1041            AP002962.2         25704-25747         c
            1042-1772           BC114928.1         1012-1742
            1773-3393           AP002962.2         15642-17262         c
            3394-3397           AW014913.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3397
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /note="transmembrane serine protease 13"
                     /db_xref="GeneID:84000"
                     /db_xref="HGNC:HGNC:29808"
                     /db_xref="MIM:610050"
     exon            1..116
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1799
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protease, serine 11; membrane-type mosaic
                     serine protease; transmembrane protease, serine 13"
                     /codon_start=1
                     /product="transmembrane protease serine 13 isoform 1"
                     /protein_id="NP_001070731.1"
                     /db_xref="CCDS:CCDS41721.1"
                     /db_xref="GeneID:84000"
                     /db_xref="HGNC:HGNC:29808"
                     /db_xref="MIM:610050"
                     /translation="MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQA
                     SPAGTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSG
                     RSSSARSASVTTSPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWR
                     EGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCK
                     LKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTE
                     VAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASD
                     SKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLP
                     EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWI
                     TGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQ
                     GDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRK
                     S"
     exon            117..546
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            547..651
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            652..774
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            775..904
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            905..997
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1041
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1204
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1377
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1476
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1619
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1772
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..3397
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3375..3380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="TMPRSS13"
                     /gene_synonym="MSP; MSPL; MSPS; TMPRSS11"
                     /note="major polyA site"
ORIGIN      
        1 aactccttta ccctacatgc ctgagaagcc agggaccaag atggatcttc tcctcgacat
       61 cagctaagcc tggaggactc ttcccctcag agaccatgga gagggacagc cacgggaatg
      121 catctccagc aagaacacct tcagctggag catctccagc ccaggcatct ccagctggga
      181 cacctccagg ccgggcatct ccagcccagg catctccagc ccaggcatct ccagctggga
      241 cacctccggg ccgggcatct ccagcccagg catctccagc tggtacacct ccaggccggg
      301 catctccagg ccgggcatct ccagcccagg catctccagc ccaggcatct ccagcccggg
      361 catctccggc tctggcatca ctttccaggt cctcatccgg caggtcatca tccgccaggt
      421 cagcctcggt gacaacctcc ccaaccagag tgtaccttgt tagagcaaca ccagtggggg
      481 ctgtacccat ccgatcatct cctgccaggt cagcaccagc aaccagggcc accagggaga
      541 gcccaggtac gagcctgccc aagttcacct ggcgggaggg ccagaagcag ctaccgctca
      601 tcgggtgcgt gctcctcctc attgccctgg tggtttcgct catcatcctc ttccagttct
      661 ggcagggcca cacagggatc aggtacaagg agcagaggga gagctgtccc aagcacgctg
      721 ttcgctgtga cggggtggtg gactgcaagc tgaagagtga cgagctgggc tgcgtgaggt
      781 ttgactggga caagtctctg cttaaaatct actctgggtc ctcccatcag tggcttccca
      841 tctgtagcag caactggaat gactcctact cagagaagac ctgccagcag ctgggtttcg
      901 agagtgctca ccggacaacc gaggttgccc acagggattt tgccaacagc ttctcaatct
      961 tgagatacaa ctccaccatc caggaaagcc tccacaggtc tgaatgccct tcccagcggt
     1021 atatctctct ccagtgttcc cactgcggac tgagggccat gaccgggcgg atcgtgggag
     1081 gggcgctggc ctcggatagc aagtggcctt ggcaagtgag tctgcacttc ggcaccaccc
     1141 acatctgtgg aggcacgctc attgacgccc agtgggtgct cactgccgcc cactgcttct
     1201 tcgtgacccg ggagaaggtc ctggagggct ggaaggtgta cgcgggcacc agcaacctgc
     1261 accagttgcc tgaggcagcc tccattgccg agatcatcat caacagcaat tacaccgatg
     1321 aggaggacga ctatgacatc gccctcatgc ggctgtccaa gcccctgacc ctgtccgctc
     1381 acatccaccc tgcttgcctc cccatgcatg gacagacctt tagcctcaat gagacctgct
     1441 ggatcacagg ctttggcaag accagggaga cagatgacaa gacatccccc ttcctccggg
     1501 aggtgcaggt caatctcatc gacttcaaga aatgcaatga ctacttggtc tatgacagtt
     1561 accttacccc aaggatgatg tgtgctgggg accttcgtgg gggcagagac tcctgccagg
     1621 gagacagcgg ggggcctctt gtctgtgagc agaacaaccg ctggtacctg gcaggtgtca
     1681 ccagctgggg cacaggctgt ggccagagaa acaaacctgg tgtgtacacc aaagtgacag
     1741 aagttcttcc ctggatttac agcaagatgg agagcgaggt gcgattcaga aaatcctaac
     1801 cagctggcct gctgctctgc acagcaccgg ctgctgtgaa gactctggcc atggtgactg
     1861 gccatgtgtg gcatcatctg ggctaatggc caccgggcac catcggactc ccacctccac
     1921 tgtctgctgc ctctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgcatat gtgtgcattg
     1981 ccactctccc aagtttttca gaaaccagca gagctgtcaa ctcttctcaa aatcccaggc
     2041 tggaaattac ctggagacaa gagttgagta ccgtggatgt tcctacagga gtgtccatag
     2101 atggatggag gaggtggagc ccagagccca aggaagagct gggaattctt gcttctctga
     2161 ccctcactta cagactagcc cagtgtgggc agatgccagc ggcccaggtg gcgccattgc
     2221 tgtcctggga tggatcgtgg gttttggtgg atgcagcttc ccagggcctg gaccgtcttc
     2281 ggtgaaaagc tgctcccgtt ggctttatga gcatcaagtc ctcacccaga ccccctgctg
     2341 gtgccgtgga tgtcaccagt cggactgtgc tgtggctaac caggctgaca actgagatga
     2401 ggattcactg tactcatttg gtcacaagct gctggggcgg gttttatttt attttatttt
     2461 tatatttaag aaatgaaaat acgggtattt ttaaagattc tccaaaaagt ccagaagcct
     2521 tgacagctgg catcaatcag cccaagaccc ccaggggatt catgggaaat gtcgtatttt
     2581 agagtcctac agaatatttc tggcctcaag gaactggatg aagagactgg acaaagtccc
     2641 caggatgggc atcccccaag tcactacagc atctggagcc cctaggagat actcagggaa
     2701 gcaaatcctt gtttgggctg gcaagcaaat ccgacacgac gaggtccaca aactgtttct
     2761 gcatcccagg gctctgacga aggcgttaag aaacagatgc tgttcccgcg taggctccca
     2821 ggggccccag ggaggtccag gtggactgcc tctctcattc ccagtagctg tcctgggact
     2881 ttgggatttc ttctcagctt tctccacctt tcagtttctc agttgtttca gaaacatagc
     2941 aatgacataa aaactgctat ggagagaaag ctaacatggt cccatgcctt ccaggcagcc
     3001 ctgctgaagg atctaagttg gccctgttcc tgcaaatcat caacgtgcct ggactcgcca
     3061 gctaaaagcc tgggccttcc ccagcctttt ttctggggca cctattcctc tgccagtcct
     3121 gctcccctca ccttccttgg gcccgtcaga gtcttttgtg gtgctgtgct tctcagaggc
     3181 aggatccaag cagatcagcc cagcctagcc cagctcaggc aggccatggc cgctcaaggg
     3241 aaagactgcc ccagaagagc aagctggaga ggctgggcag gggctgatgg ggctgggtac
     3301 actggggaat gttagcaaga ctgggaagga ggccacattc ctgtctgcag cagccgccag
     3361 cgatggtctt cagcaataaa agttgtgtga cctgaga
//
