LOCUS       NM_182559               1457 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane serine protease 12 (TMPRSS12), mRNA.
ACCESSION   NM_182559
VERSION     NM_182559.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Larasati,T., Noda,T., Fujihara,Y., Shimada,K., Tobita,T., Yu,Z.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     Tmprss12 is required for sperm motility and uterotubal junction
            migration in micedagger
  JOURNAL   Biol Reprod 103 (2), 254-263 (2020)
   PUBMED   32529245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013244.39 and AC008121.43.
            
            On Nov 23, 2018 this sequence version replaced NM_182559.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005521.1, SRR5189664.125619.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398458.4/ ENSP00000381476.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC013244.39        27595-27820         c
            227-422             AC013244.39        26709-26904         c
            423-691             AC013244.39        11693-11961         c
            692-834             AC008121.43        89343-89485         c
            835-1457            AC008121.43        86847-87469         c
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..1457
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /note="transmembrane serine protease 12"
                     /db_xref="GeneID:283471"
                     /db_xref="HGNC:HGNC:28779"
     exon            1..226
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1086
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /note="transmembrane (C-terminal) protease, serine 12;
                     testicular tissue protein Li 208; transmembrane protease,
                     serine 12"
                     /codon_start=1
                     /product="transmembrane protease serine 12 precursor"
                     /protein_id="NP_872365.2"
                     /db_xref="CCDS:CCDS44881.1"
                     /db_xref="GeneID:283471"
                     /db_xref="HGNC:HGNC:28779"
                     /translation="MRLGLLSVALLFVGSSHLYSDHYSPSGRHRLGPSPEPAASSQQA
                     EAVRKRLRRRREGGAHAEDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRV
                     LVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIH
                     PNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEG
                     NATNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYL
                     PEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEHFFHASTQGILTINILRGQ
                     ILIALCFVILLATT"
     exon            227..422
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /inference="alignment:Splign:2.1.0"
     exon            423..691
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /inference="alignment:Splign:2.1.0"
     exon            692..834
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1457
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1423..1428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /note="hexamer: AATAAA"
     polyA_site      1457
                     /gene="TMPRSS12"
                     /gene_synonym="CT151"
                     /note="major polyA site"
ORIGIN      
        1 gggaagtacc tgccgccatc ttgctcacca gcctccaaaa tgcggctggg gctcctgagc
       61 gtggcgctgt tgtttgtggg gagctctcac ttatactcag accactactc gccctctgga
      121 aggcacaggc tcggcccctc gccggaaccg gcggctagtt cccagcaggc tgaggccgtc
      181 cgcaagaggc tccggcggcg gagggaggga ggggcgcatg cagaggattg tggaacagca
      241 ccgcttaagg atgtgttgca agggtctcgg attatagggg gcaccgaagc acaagctggc
      301 gcatggccgt gggtggtgag cctgcagatt aaatatggcc gtgttcttgt tcatgtatgt
      361 gggggaaccc tagtgagaga gaggtgggtc ctcacagctg cccactgcac taaagacgct
      421 agcgatcctt taatgtggac agctgtgatt ggaactaata atatacatgg acgctatcct
      481 cataccaaga agataaaaat taaagcaatc attattcatc caaacttcat tttggaatct
      541 tatgtaaatg atattgcact ttttcactta aaaaaagcag tgaggtataa tgactatatt
      601 cagcctattt gcctaccttt tgatgttttc caaatcctgg acggaaacac aaagtgtttt
      661 ataagtggct ggggaagaac aaaagaagaa ggtaacgcta caaatatttt acaagatgca
      721 gaagtgcatt atatttctcg agagatgtgt aattctgaga ggagttatgg gggaataatt
      781 cctaacactt cattttgtgc aggtgatgaa gatggagctt ttgatacttg caggggtgac
      841 agtgggggac cattaatgtg ctacttacca gaatataaaa gattttttgt aatgggaatt
      901 accagttacg gacatggctg tggtcgaaga ggttttcctg gtgtctatat tgggccatcc
      961 ttctaccaaa agtggctgac agagcatttc ttccatgcaa gcactcaagg catacttact
     1021 ataaatattt tacgtggcca gatcctcata gctttatgtt ttgtcatctt actagcaaca
     1081 acataaagaa attctgaagg ctttcatatc tttattttgc attgtgtccc tttctatgtt
     1141 ctatataatg aacatcattt attcttctag caattaattg cctacattag agatttcatg
     1201 tgaacatttt atgggctata agtattgtga cagatataca attgtaattt tggcactgaa
     1261 tcacatgtct ccttgaaata tcttgattat tttataatca taattctgta tctggaatac
     1321 tcatagagtt tgtacaaaat attcagttaa acatatattt tatgtgtata aatgccaaat
     1381 aatagtttat aattaaaatg aaagctgtca tttggttaaa ttaataaaaa ttctttctta
     1441 gattttattc taaaaaa
//
