LOCUS       NM_207407               2077 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane serine protease 11F (TMPRSS11F), mRNA.
ACCESSION   NM_207407
VERSION     NM_207407.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   Yan,R., Liu,M., Hu,Y., Wang,L., Wang,C., Jiang,Y., Zhou,Q., Qi,X.,
            Dong,N. and Wu,Q.
  TITLE     Ectopic expression of human airway trypsin-like protease 4 in acute
            myeloid leukemia promotes cancer cell invasion and tumor growth
  JOURNAL   Cancer Med 8 (5), 2348-2359 (2019)
   PUBMED   30843660
  REMARK    GeneRIF: Results indicate that ectopic HAT-L4 expression is a
            pathological mechanism in neutrophils and monocytes from acute
            myeloid leukemia (AML) and that HAT-L4 may be used as a cell
            surface marker for AML blast detection.
REFERENCE   2  (bases 1 to 2077)
  AUTHORS   Zhang,Z., Hu,Y., Yan,R., Dong,L., Jiang,Y., Zhou,Z., Liu,M.,
            Zhou,T., Dong,N. and Wu,Q.
  TITLE     The Transmembrane Serine Protease HAT-like 4 Is Important for
            Epidermal Barrier Function to Prevent Body Fluid Loss
  JOURNAL   Sci Rep 7, 45262 (2017)
   PUBMED   28338078
  REMARK    GeneRIF: Study reveals a role of HAT-L4 in the epidermal barrier
            function to prevent body fluid loss, providing another example of
            cell membrane-bound serine proteases in epidermal development and
            function.
            Erratum:[Sci Rep. 2020 Apr 10;10(1):6467. doi:
            10.1038/s41598-020-62767-5.. PMID: 32277073]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122625.1, DA441628.1 and AC096727.3.
            
            On Jul 10, 2008 this sequence version replaced NM_207407.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356291.3/ ENSP00000348639.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AK122625.1         1-46
            47-568              DA441628.1         37-558
            569-1260            AK122625.1         569-1260
            1261-1897           AC096727.3         111440-112076       c
            1898-2077           AK122625.1         1898-2077
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2077
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /note="transmembrane serine protease 11F"
                     /db_xref="GeneID:389208"
                     /db_xref="HGNC:HGNC:29994"
     exon            1..60
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1366
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /note="airway trypsin-like protease 4; transmembrane
                     protease, serine 11F"
                     /codon_start=1
                     /product="transmembrane protease serine 11F"
                     /protein_id="NP_997290.2"
                     /db_xref="CCDS:CCDS3520.1"
                     /db_xref="GeneID:389208"
                     /db_xref="HGNC:HGNC:29994"
                     /translation="MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIA
                     IGIVTHFVVEDDKSFYYLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHS
                     SVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLS
                     LTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEW
                     PWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNV
                     RKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGS
                     IVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGP
                     LVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTGM"
     exon            61..212
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            213..331
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            332..399
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            400..563
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            564..602
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            603..804
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1064
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1207
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2077
                     /gene="TMPRSS11F"
                     /gene_synonym="HATL4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatacagatc agatggtgac tgaatagaag ctgccccagt cctgggttca tgatgtacgc
       61 acctgttgaa ttttcagaag ctgaattctc acgagctgaa tatcaaagaa agcagcaatt
      121 ttgggactca gtacggctag ctcttttcac attagcaatt gtagcaatca taggaattgc
      181 aattggtatt gttactcatt ttgttgttga ggatgataag tctttctatt accttgcctc
      241 ttttaaagtc acaaatatca aatataaaga aaattatggc ataagatctt caagagagtt
      301 tatagaaagg agtcatcaga ttgaaagaat gatgtctagg atatttcgac attcttctgt
      361 aggcggtcga tttatcaaat ctcatgttat caaattaagt ccagatgaac aaggtgtgga
      421 tattcttata gtgctcatat ttcgataccc atctactgat agtgctgaac aaatcaagaa
      481 aaaaattgaa aaggctttat atcaaagttt gaagaccaaa caattgtctt tgaccataaa
      541 caaaccatca tttagactca cacctattga cagcaaaaag atgaggaatc ttctcaacag
      601 tcgctgtgga ataaggatga catcttcaaa catgccatta ccagcatcct cttctactca
      661 aagaattgtc caaggaaggg aaacagctat ggaaggggaa tggccatggc aggccagcct
      721 ccagctcata gggtcaggcc atcagtgtgg agccagcctc atcagtaaca catggctgct
      781 cacagcagct cactgctttt ggaaaaataa agacccaact caatggattg ctacttttgg
      841 tgcaactata acaccacccg cagtgaaacg aaatgtgagg aaaattattc ttcatgagaa
      901 ttaccataga gaaacaaatg aaaatgacat tgctttggtt cagctctcta ctggagttga
      961 gttttcaaat atagtccaga gagtttgcct cccagactca tctataaagt tgccacctaa
     1021 aacaagtgtg ttcgtcacag gatttggatc cattgtagat gatggaccta tacaaaatac
     1081 acttcggcaa gccagagtgg aaaccataag cactgatgtg tgtaacagaa aggatgtgta
     1141 tgatggcctg ataactccag gaatgttatg tgctggattc atggaaggaa aaatagatgc
     1201 atgtaaggga gattctggtg gacctctggt ttatgataat catgacatct ggtacattgt
     1261 aggtatagta agttggggac aatcatgtgc acttcccaaa aaacctggag tctacaccag
     1321 agtaactaag tatcgagatt ggattgcctc aaagactggt atgtagtgtg gattgcccat
     1381 gagttataca catggcacac agagctgata ctcctgcgta ttttgtattg tttaaattca
     1441 tttactttgg attagtgctt ttgctagatg tcaagaagcc cttcagaccc agacaaatct
     1501 aatatcctga ggtggccttt acatacgtag gaccaaaccc tctctaccat gagggaagaa
     1561 gacacagcaa atgacagaca gcacctattc cttactcaca agggaaactg cttgtgatac
     1621 ttcctaataa gataaataag tggtttccct caattgaaga caggaacatc attttccaca
     1681 ggatatgaag agctgccagt aatgccaaaa tcttacctca tataatacct ggagcatgtg
     1741 agattcttct agtgaaaaag aacagtcttc cctgaagact cagggcttca acattctaga
     1801 actgataagt ggaccttcag tgtgcaagaa tggagaagca tgggatttgc attatgactt
     1861 gaactgggct tatatctaat aatacagagc actatctcta acctcaacag ttgacatttt
     1921 aaaagttttt aaatgtatct gaacttgctg ttaacacagt gttataactc aagcactagc
     1981 ttcaggaagc atgttgtgtt gttaagaagc ttttctgatt tattctttaa cagcatcttg
     2041 ccatctatat gttagtagca gttggcccag aaaggac
//
