LOCUS       NM_014058               2122 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane serine protease 11E (TMPRSS11E), mRNA.
ACCESSION   NM_014058 NM_001099662
VERSION     NM_014058.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Li,S., Chen,Z., Zhang,W., Wang,T., Wang,X., Wang,C., Chao,J. and
            Liu,L.
  TITLE     Elevated expression of the membrane-anchored serine protease
            TMPRSS11E in NSCLC progression
  JOURNAL   Carcinogenesis 43 (11), 1092-1102 (2022)
   PUBMED   35951670
  REMARK    GeneRIF: Elevated expression of the membrane-anchored serine
            protease TMPRSS11E in NSCLC progression.
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Ng,H.Y., Ko,J.M., Yu,V.Z., Ip,J.C., Dai,W., Cal,S. and Lung,M.L.
  TITLE     DESC1, a novel tumor suppressor, sensitizes cells to apoptosis by
            downregulating the EGFR/AKT pathway in esophageal squamous cell
            carcinoma
  JOURNAL   Int J Cancer 138 (12), 2940-2951 (2016)
   PUBMED   26856390
  REMARK    GeneRIF: DESC1 may suppress esophageal squamous cell carcinoma
            development by sensitizing cells to apoptosis under an apoptotic
            stimulus through downregulating the EGFR/AKT signaling pathway.
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Zmora,P., Blazejewska,P., Moldenhauer,A.S., Welsch,K.,
            Nehlmeier,I., Wu,Q., Schneider,H., Pohlmann,S. and Bertram,S.
  TITLE     DESC1 and MSPL activate influenza A viruses and emerging
            coronaviruses for host cell entry
  JOURNAL   J Virol 88 (20), 12087-12097 (2014)
   PUBMED   25122802
  REMARK    GeneRIF: study demonstrates that two cellular serine proteases,
            DESC1 and MSPL, activate influenza viruses and emerging
            coronaviruses in cell culture and, because of their expression in
            human lung tissue, might promote viral spread in the infected host
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Swaminathan,S., Huentelman,M.J., Corneveaux,J.J., Myers,A.J.,
            Faber,K.M., Foroud,T., Mayeux,R., Shen,L., Kim,S., Turk,M.,
            Hardy,J., Reiman,E.M. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative  and  NIA-LOAD/NCRAD
            Family Study Group
  TITLE     Analysis of copy number variation in Alzheimer's disease in a
            cohort of clinically characterized and neuropathologically verified
            individuals
  JOURNAL   PLoS One 7 (12), e50640 (2012)
   PUBMED   23227193
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Kyrieleis,O.J., Huber,R., Ong,E., Oehler,R., Hunter,M.,
            Madison,E.L. and Jacob,U.
  TITLE     Crystal structure of the catalytic domain of DESC1, a new member of
            the type II transmembrane serine proteinase family
  JOURNAL   FEBS J 274 (8), 2148-2160 (2007)
   PUBMED   17388811
  REMARK    GeneRIF: The domain of DESC1 exhibits a trypsin-like serine
            proteinase fold with a thrombin-like S1 pocket, a urokinase-type
            plasminogen activator-type S2 pocket, to accept small residues, and
            an open hydrophobic S3/S4 cavity to accept large hydrophobic
            residues.
REFERENCE   7  (bases 1 to 2122)
  AUTHORS   Hobson,J.P., Netzel-Arnett,S., Szabo,R., Rehault,S.M., Church,F.C.,
            Strickland,D.K., Lawrence,D.A., Antalis,T.M. and Bugge,T.H.
  TITLE     Mouse DESC1 is located within a cluster of seven DESC1-like genes
            and encodes a type II transmembrane serine protease that forms
            serpin inhibitory complexes
  JOURNAL   J Biol Chem 279 (45), 46981-46994 (2004)
   PUBMED   15328353
REFERENCE   8  (bases 1 to 2122)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2122)
  AUTHORS   Lang,J.C. and Schuller,D.E.
  TITLE     Differential expression of a novel serine protease homologue in
            squamous cell carcinoma of the head and neck
  JOURNAL   Br J Cancer 84 (2), 237-243 (2001)
   PUBMED   11161383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB013544.1, AY359017.1 and AC079749.5.
            
            On Nov 23, 2018 this sequence version replaced NM_014058.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292787.1, AF064819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305363.9/ ENSP00000307519.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DB013544.1         15-33
            20-1326             AY359017.1         1-1307
            1327-2122           AC079749.5         40337-41132
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2122
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /note="transmembrane serine protease 11E"
                     /db_xref="GeneID:28983"
                     /db_xref="HGNC:HGNC:24465"
                     /db_xref="MIM:610399"
     exon            1..61
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1322
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /EC_number="3.4.21.-"
                     /note="transmembrane protease serine 11E2; serine protease
                     DESC1; transmembrane protease, serine 11E"
                     /codon_start=1
                     /product="transmembrane protease serine 11E precursor"
                     /protein_id="NP_054777.2"
                     /db_xref="CCDS:CCDS33993.1"
                     /db_xref="GeneID:28983"
                     /db_xref="HGNC:HGNC:24465"
                     /db_xref="MIM:610399"
                     /translation="MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVR
                     YNQKKTYNYYSTLSFTTDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVK
                     SQVIKFSQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSV
                     KIKKINKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCG
                     ATLINATWLVSAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDY
                     DISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQV
                     TLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIV
                     SWGDECAKPNKPGVYTRVTALRDWITSKTGI"
     exon            62..186
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            187..308
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..376
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..540
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            541..579
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..757
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1017
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1160
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..2122
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1439..1444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /note="hexamer: AATAAA"
     polyA_site      1464
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /note="major polyA site"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /note="hexamer: AATAAA"
     polyA_site      2122
                     /gene="TMPRSS11E"
                     /gene_synonym="DESC1; TMPRSS11E2"
                     /note="major polyA site"
ORIGIN      
        1 acttggatgt agacctcgac cttcacagga ctcttcattg ctggttggca atgatgtatc
       61 ggccagatgt ggtgagggct aggaaaagag tttgttggga accctgggtt atcggcctcg
      121 tcatcttcat atccctgatt gtcctggcag tgtgcattgg actcactgtt cattatgtga
      181 gatataatca aaagaagacc tacaattact atagcacatt gtcatttaca actgacaaac
      241 tatatgctga gtttggcaga gaggcttcta acaattttac agaaatgagc cagagacttg
      301 aatcaatggt gaaaaatgca ttttataaat ctccattaag ggaagaattt gtcaagtctc
      361 aggttatcaa gttcagtcaa cagaagcatg gagtgttggc tcatatgctg ttgatttgta
      421 gatttcactc tactgaggat cctgaaactg tagataaaat tgttcaactt gttttacatg
      481 aaaagctgca agatgctgta ggacccccta aagtagatcc tcactcagtt aaaattaaaa
      541 aaatcaacaa gacagaaaca gacagctatc taaaccattg ctgcggaaca cgaagaagta
      601 aaactctagg tcagagtctc aggatcgttg gtgggacaga agtagaagag ggtgaatggc
      661 cctggcaggc tagcctgcag tgggatggga gtcatcgctg tggagcaacc ttaattaatg
      721 ccacatggct tgtgagtgct gctcactgtt ttacaacata taagaaccct gccagatgga
      781 ctgcttcctt tggagtaaca ataaaacctt cgaaaatgaa acggggtctc cggagaataa
      841 ttgtccatga aaaatacaaa cacccatcac atgactatga tatttctctt gcagagcttt
      901 ctagccctgt tccctacaca aatgcagtac atagagtttg tctccctgat gcatcctatg
      961 agtttcaacc aggtgatgtg atgtttgtga caggatttgg agcactgaaa aatgatggtt
     1021 acagtcaaaa tcatcttcga caagcacagg tgactctcat agacgctaca acttgcaatg
     1081 aacctcaagc ttacaatgac gccataactc ctagaatgtt atgtgctggc tccttagaag
     1141 gaaaaacaga tgcatgccag ggtgactctg gaggaccact ggttagttca gatgctagag
     1201 atatctggta ccttgctgga atagtgagct ggggagatga atgtgcgaaa cccaacaagc
     1261 ctggtgttta tactagagtt acggccttgc gggactggat tacttcaaaa actggtatct
     1321 aagagagaaa agcctcatgg aacagataac attttttttt gttttttggg tgtggaggcc
     1381 atttttagag atacagaatt ggagaagact tgcaaaacag ctagatttga ctgatctcaa
     1441 taaactgttt gcttgatgca tgtattttct tcccagctct gttccgcaca taagcatcct
     1501 gcttctgcca gatcaactct gtcatctgtg agcaatagtt gaaactttat gtacatagag
     1561 aaatagataa tacaatatta cattacagcc tgtattcatt tgttctctag aagttttgtc
     1621 agaattttga cttgttgaca taaatttgta atgcatatat acaatttgaa gcactccttt
     1681 tcttcagttc ctcagctcct ctcatttcag caaatatcca ttttcaaggt gcagaacaag
     1741 gagtgaaaga aaatataaga agaaaaaaat cccctacatt ttattggcac agaaaagtat
     1801 taggtgtttt tcttagtgga atattagaaa tgatcatatt cattatgaaa ggtcaagcaa
     1861 agacagcaga ataccaatca cttcatcatt taggaagtat gggaactaag ttaaggaaat
     1921 ccagaaagaa gccaagatat atccttattt tcatttccaa acaactacta tgataaatgt
     1981 gaagaagatt ctgttttttt gtgacctata ataattatac aaacttcatg caatgtactt
     2041 gttctaagca aattaaagca aatatttatt taacattgtt actgaggatg tcaacatata
     2101 acaataaaat ataaatcacc ca
//
