LOCUS       NM_004262               2787 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.
ACCESSION   NM_004262
VERSION     NM_004262.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Feng,S., Zhao,J., Yang,T. and Li,L.
  TITLE     TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110869 (2023)
   PUBMED   37666068
  REMARK    GeneRIF: TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Selb,J., Rijavec,M., Kopac,P., Lyons,J.J. and Korosec,P.
  TITLE     HalphaT is associated with increased risk for severe Hymenoptera
            venom-triggered anaphylaxis
  JOURNAL   J Allergy Clin Immunol 151 (3), 804-805 (2023)
   PUBMED   36529562
  REMARK    GeneRIF: HalphaT is associated with increased risk for severe
            Hymenoptera venom-triggered anaphylaxis.
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Kishimoto,M., Uemura,K., Sanaki,T., Sato,A., Hall,W.W., Kariwa,H.,
            Orba,Y., Sawa,H. and Sasaki,M.
  TITLE     TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
  JOURNAL   Viruses 13 (3), 384 (2021)
   PUBMED   33671076
  REMARK    GeneRIF: TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike
            Protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Kucher,A.N., Babushkina,N.P., Sleptcov,A.A. and Nazarenko,M.S.
  TITLE     Genetic Control of Human Infection with SARS-CoV-2
  JOURNAL   Russ J Genet 57 (6), 627-641 (2021)
   PUBMED   34248311
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Iwakiri,K., Ghazizadeh,M., Jin,E., Fujiwara,M., Takemura,T.,
            Takezaki,S., Kawana,S., Yasuoka,S. and Kawanami,O.
  TITLE     Human airway trypsin-like protease induces PAR-2-mediated IL-8
            release in psoriasis vulgaris
  JOURNAL   J Invest Dermatol 122 (4), 937-944 (2004)
   PUBMED   15102084
  REMARK    GeneRIF: HAT might promote PAR-2-mediated IL-8 production to
            accumulate inflammatory cells in the epidermal layer of psoriasis.
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Miki,M., Nakamura,Y., Takahashi,A., Nakaya,Y., Eguchi,H.,
            Masegi,T., Yoneda,K., Yasuoka,S. and Sone,S.
  TITLE     Effect of human airway trypsin-like protease on intracellular free
            Ca2+ concentration in human bronchial epithelial cells
  JOURNAL   J Med Invest 50 (1-2), 95-107 (2003)
   PUBMED   12630574
  REMARK    GeneRIF: HAT regulates cellular functions of human bronchial
            epithelial cells via activation of protease-activated receptor-2.
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Takahashi,M., Sano,T., Yamaoka,K., Kamimura,T., Umemoto,N.,
            Nishitani,H. and Yasuoka,S.
  TITLE     Localization of human airway trypsin-like protease in the airway:
            an immunohistochemical study
  JOURNAL   Histochem Cell Biol 115 (3), 181-187 (2001)
   PUBMED   11326745
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Yamaoka,K., Masuda,K., Ogawa,H., Takagi,K., Umemoto,N. and
            Yasuoka,S.
  TITLE     Cloning and characterization of the cDNA for human airway
            trypsin-like protease
  JOURNAL   J Biol Chem 273 (19), 11895-11901 (1998)
   PUBMED   9565616
REFERENCE   10 (bases 1 to 2787)
  AUTHORS   Yasuoka,S., Ohnishi,T., Kawano,S., Tsuchihashi,S., Ogawara,M.,
            Masuda,K., Yamaoka,K., Takahashi,M. and Sano,T.
  TITLE     Purification, characterization, and localization of a novel
            trypsin-like protease found in the human airway
  JOURNAL   Am J Respir Cell Mol Biol 16 (3), 300-308 (1997)
   PUBMED   9070615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096653.1, AL603214.1,
            AB002134.1, AK094054.1 and BC033295.1.
            
            On May 17, 2019 this sequence version replaced NM_004262.2.
            
            Summary: This gene encodes a trypsin-like serine protease released
            from the submucosal serous glands onto mucous membrane. It is a
            type II integral membrane protein and has 29-38% identity in the
            sequence of the catalytic region with human hepsin,
            enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic
            region has little similarity to other known proteins. This protein
            may play some biological role in the host defense system on the
            mucous membrane independently of or in cooperation with other
            substances in airway mucous or bronchial secretions. This protein
            facilitates entry of viruses into host cells by proteolytically
            cleaving and activating viral envelope glycoproteins. [provided by
            RefSeq, Aug 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125196.1, AB002134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000283916.11/ ENSP00000283916.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC096653.1         53465-53468         c
            5-8                 AL603214.1         1-4
            9-1508              AB002134.1         1-1500
            1509-2782           AK094054.1         1172-2445
            2783-2787           BC033295.1         1259-1263
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2787
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /note="transmembrane serine protease 11D"
                     /db_xref="GeneID:9407"
                     /db_xref="HGNC:HGNC:24059"
                     /db_xref="MIM:605369"
     exon            1..77
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1326
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /note="airway trypsin-like protease; transmembrane
                     protease, serine 11D; adrenal secretory serine protease"
                     /codon_start=1
                     /product="transmembrane protease serine 11D"
                     /protein_id="NP_004253.1"
                     /db_xref="CCDS:CCDS3518.1"
                     /db_xref="GeneID:9407"
                     /db_xref="HGNC:HGNC:24059"
                     /db_xref="MIM:605369"
                     /translation="MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFD
                     QKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHV
                     AKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSL
                     TDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLIN
                     NMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALV
                     RLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISN
                     DVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQ
                     CGLPDKPGVYTRVTAYLDWIRQQTGI"
     exon            78..199
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            200..318
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            319..386
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            387..544
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            545..583
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            584..761
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1021
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1164
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..2787
                     /gene="TMPRSS11D"
                     /gene_synonym="ASP; HAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcatttga gtgggaatct caaagcagtt gagtaggcag aaaaaagaac ctcttcatta
       61 aggattaaaa tgtataggcc agcacgtgta acttcgactt caagatttct gaatccatat
      121 gtagtatgtt tcattgtcgt cgcaggggta gtgatcctgg cagtcaccat agctctactt
      181 gtttactttt tagcttttga tcaaaaatct tacttttata ggagcagttt tcaactccta
      241 aatgttgaat ataatagtca gttaaattca ccagctacac aggaatacag gactttgagt
      301 ggaagaattg aatctctgat tactaaaaca ttcaaagaat caaatttaag aaatcagttc
      361 atcagagctc atgttgccaa actgaggcaa gatggtagtg gtgtgagagc ggatgttgtc
      421 atgaaatttc aattcactag aaataacaat ggagcatcaa tgaaaagcag aattgagtct
      481 gttttacgac aaatgctgaa taactctgga aacctggaaa taaacccttc aactgagata
      541 acatcactta ctgaccaggc tgcagcaaat tggcttatta atgaatgtgg ggccggtcca
      601 gacctaataa cattgtctga gcagagaatc cttggaggca ctgaggctga ggagggaagc
      661 tggccgtggc aagtcagtct gcggctcaat aatgcccacc actgtggagg cagcctgatc
      721 aataacatgt ggatcctgac agcagctcac tgcttcagaa gcaactctaa tcctcgtgac
      781 tggattgcca cgtctggtat ttccacaaca tttcctaaac taagaatgag agtaagaaat
      841 attttaattc ataacaatta taaatctgca actcatgaaa atgacattgc acttgtgaga
      901 cttgagaaca gtgtcacctt taccaaagat atccatagtg tgtgtctccc agctgctacc
      961 cagaatattc cacctggctc tactgcttat gtaacaggat ggggcgctca agaatatgct
     1021 ggccacacag ttccagagct aaggcaagga caggtcagaa taataagtaa tgatgtatgt
     1081 aatgcaccac atagttataa tggagccatc ttgtctggaa tgctgtgtgc tggagtacct
     1141 caaggtggag tggacgcatg tcagggtgac tctggtggcc cactagtaca agaagactca
     1201 cggcggcttt ggtttattgt ggggatagta agctggggag atcagtgtgg cctgccggat
     1261 aagccaggag tgtatactcg agtgacagcc taccttgact ggattaggca acaaactggg
     1321 atctagtgca acaagtgcat ccctgttgca aagtctgtat gcaggtgtgc ctgtcttaaa
     1381 ttccaaagct ttacatttca actgaaaaag aaactagaaa tgtcctaatt taacatcttg
     1441 ttacataaat atggtttaac aaacactgtt taacctttct ttattattaa aggttttcta
     1501 ttttctccag agaactatat gaatgttgca tagtactgtg gctgtgtaac agaagaaaca
     1561 cactaaacta attacaaagt taacaatttc attacagttg tgctaaatgc ccgtagtgag
     1621 aagaacagga accttgagca tgtatagtag aggaacctgc acaggtctga tgggtcagag
     1681 gggtcttctc tgggtttcac tgaggatgag aagtaagcaa actgtggaaa catgcaaagg
     1741 aaaaagtgat agaataatat tcaagacaaa aagaacagta tgaggcaaga gaaataatat
     1801 gtatttaaaa tttttggtta ctcaatatct tatacttagt atgagtccta aaattaaaaa
     1861 tgtgaaactg ttgtactata cgtataacct aaccttaatt attctgtaag aacatgcttc
     1921 cataggaaat agtggataat tttcagctat ttaaggcaaa agctaaaata gttcactcct
     1981 caactgagac ccaaagaatt atagatattt ttcatgatga cccatgaaaa atatcactca
     2041 tctacataaa ggagagacta tatctatttt atagagaagc taagaaatat acctacacaa
     2101 acttgtcagg tgctttacaa ctacatagta ctttttaaca acaaaataat aattttaaga
     2161 atgaaaaatt taatcatcgg gaagaacgtc ccactacaga cttcctatca ctggcagtta
     2221 tatttttgag cgtaaaaggg tcgtcaaacg ctaaatctaa gtaacgaatt gaaagtttaa
     2281 agagggggaa gagttggttt gcaaaggaaa agtttaaata gcttaatatc aatagaatga
     2341 tcctgaagac agaaaaaact ttgtcactct tcctctctca ttttctttct ctctctctcc
     2401 ccttctcata cacatgcctc ccccaccaaa gaatataatg taaattaaat ccactaaaat
     2461 gtaatggcat gaaaatctct gtagtctgaa tcactaatat tcctgagttt ttatgagctc
     2521 ctagtacagc taaagtttgc ctatgcatga tcatctatgc gtcagagctt cctccttcta
     2581 caagctaact ccctgcatct gggcatcagg actgctccat acatttgctg aaaacttctt
     2641 gtatttcctg atgtaaaatt gtgcaaacac ctacaataaa gccatctact tttagggaaa
     2701 gggagttgaa aatgcaacca actcttggcg aactgtacaa acaaatcttt gctatacttt
     2761 atttcaaata aattcttttt aaaataa
//
