LOCUS       NM_182502               2645 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens transmembrane serine protease 11B (TMPRSS11B), mRNA.
ACCESSION   NM_182502
VERSION     NM_182502.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Updegraff,B.L., Zhou,X., Guo,Y., Padanad,M.S., Chen,P.H., Yang,C.,
            Sudderth,J., Rodriguez-Tirado,C., Girard,L., Minna,J.D., Mishra,P.,
            DeBerardinis,R.J. and O'Donnell,K.A.
  TITLE     Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by
            Enhancing Lactate Export and Glycolytic Metabolism
  JOURNAL   Cell Rep 25 (8), 2223-2233 (2018)
   PUBMED   30463017
  REMARK    GeneRIF: These findings establish an oncogenic role for TMPRSS11B
            and provide support for the development of therapies that target
            this enzyme at the surface of cancer cells.
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Miller,G.S., Zoratti,G.L., Murray,A.S., Bergum,C., Tanabe,L.M. and
            List,K.
  TITLE     HATL5: a cell surface serine protease differentially expressed in
            epithelial cancers
  JOURNAL   PLoS One 9 (2), e87675 (2014)
   PUBMED   24498351
  REMARK    GeneRIF: Data indicate that TMPRSS11b (BC126195), encoding human
            airway trypsin-like protease 5 (HATL5), is localized on the cell
            surface of differentiated epithelial cells in the stratified
            squamous epithelia of cervix, esophagus, and oral cavity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290904.1 and AC098799.2.
            
            On May 8, 2008 this sequence version replaced NM_182502.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537945.1, AL833167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332644.6/ ENSP00000330475.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-822               AK290904.1         1-822
            823-1082            AC098799.2         83611-83870         c
            1083-1225           AC098799.2         83096-83238         c
            1226-2645           AC098799.2         81007-82426         c
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2645
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /note="transmembrane serine protease 11B"
                     /db_xref="GeneID:132724"
                     /db_xref="HGNC:HGNC:25398"
     exon            1..144
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1387
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /note="airway trypsin-like protease 5; transmembrane
                     protease, serine 11B"
                     /codon_start=1
                     /product="transmembrane protease serine 11B"
                     /protein_id="NP_872308.2"
                     /db_xref="CCDS:CCDS3521.1"
                     /db_xref="GeneID:132724"
                     /db_xref="HGNC:HGNC:25398"
                     /translation="MYRHGISSQRSWPLWTTIFIFLGVAAILGVTIGLLVHFLAVEKT
                     YYYQGDFHISGVTYNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKL
                     LPNANGSNVQLQLKFKFPPAEGVSMRTKIKAKLHQMLKNNMASWNAVPASIKLMEISK
                     AASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSR
                     WLLSAAHCFAKKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQL
                     AEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKI
                     CNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCG
                     KKNKPGVYTRVTSYRNWITSKTGL"
     exon            145..260
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            261..376
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            377..444
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            445..605
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            606..644
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            645..822
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1082
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1225
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..2645
                     /gene="TMPRSS11B"
                     /gene_synonym="HATL5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacataag tcaaaagctg cgtcagaagg ttctaacttt tgtcatcact attaccagca
       61 ttgtcatcgt tatcgttatc ttcgtcatca tcattaccac cgttatacct gatactgcca
      121 taacaatcag aacattatgt acaggcacgg catatcttcc caaagatctt ggccactatg
      181 gactacgatc tttatttttc ttggagtggc ggcaatcttg ggagtaacca ttggtcttct
      241 tgttcatttt ctggcagttg agaagactta ctattatcaa ggtgattttc atatttctgg
      301 agtcacatac aatgataatt gtgaaaacgc agcttcacaa gccagcacaa atctaagcaa
      361 agatattgag actaagatgt taaatgcatt tcaaaattcc agtatatata aggaatatgt
      421 caaatctgag gtcatcaaac ttctgcctaa tgccaatggt tcaaatgtgc agttacagct
      481 gaaattcaag tttcctccag cagaaggagt tagcatgagg actaaaatca aggctaaatt
      541 acatcagatg ttgaaaaaca acatggcatc ctggaatgca gttcctgctt ccattaaact
      601 catggaaatc agcaaggctg cttctgaaat gcttaccaac aactgttgtg ggagacaagt
      661 agccaacagt atcataactg gcaacaaaat tgtgaatgga aaaagctccc tggagggggc
      721 atggccatgg caggccagca tgcaatggaa aggccgtcac tactgtggag cctctctgat
      781 cagcagcagg tggctattat ctgcagctca ctgctttgct aagaaaaata attcaaaaga
      841 ttggactgtc aactttggaa ttgtagtaaa taaaccatat atgacacgga aagtccaaaa
      901 cattattttt catgaaaatt atagcagtcc tgggcttcat gatgatattg cccttgtgca
      961 gcttgctgaa gaagtttctt ttacagagta cattcgtaag atttgtcttc ctgaagccaa
     1021 aatgaagctc tcagaaaatg acaatgttgt agttacaggt tggggaacac tttatatgaa
     1081 tggttcattt ccagtgatac ttcaagaaga ctttttgaag attattgaca acaaaatttg
     1141 caatgcctca tatgcatact ctggctttgt gactgataca atgttatgtg ctggatttat
     1201 gtcaggagaa gctgatgcat gtcagaatga ttctggtgga ccactagctt accctgattc
     1261 cagaaatatc tggcatcttg ttggaatagt aagctggggt gatggatgtg gtaaaaagaa
     1321 taagccaggt gtctatactc gagtgacttc ttatcgcaat tggattacat ccaagactgg
     1381 actctgaaaa aaaaggaatt atacaaagga acataaagac cactgtaggc tatccttatc
     1441 tgtggctttg ggatcttttt attttgattg ttggtaaact aatcatttta ttatatataa
     1501 aaatataaat gtctttatta atattttatt atatctaaaa cactgtccat gcatttatta
     1561 atcttttaaa ttaatgtaag agataggaag aggccaggtg tagtggctca tgcctgtaat
     1621 cctagcactt tgagaggccg agataggcgg attgcttgag cccaggagtt tgagggcagc
     1681 ctgggaaaca tggctaaatc cgtgttcaaa aaatacaaaa attagctagg catggtggcg
     1741 tgcacctata gtcccagcta ttcaggaggc tgaggtggga ggattgcttg agcccagcag
     1801 gttgaggctg tggtgatttg tgattgcgcc accactgcac tccagcctgg gcaacagagt
     1861 gagaccctgt ctcaaaaaaa aaaaaaaaaa aaggagagaa gaaaataaag aaggctaata
     1921 tataattttt cttaatagct gagttgtgat tcattttacc attatattca gaattgacct
     1981 taatttgttt tccagaatca aaagaaaata aaatataaat tttgaaacta tgagaacata
     2041 tataggggat ttatcaaatg agttactttt tattatatca attataattt cattttatta
     2101 actggaataa gtgcgaaagt gtacattact ttttaactta tatgtgaaat gattcatgta
     2161 cctcacaaaa tcatgcaatc ttgcagtgaa gaaggagtat cagagctcca gctacactga
     2221 gtctttcaat ttacagatca agaaactgaa gaccagagaa gagaaatgat ttggttaaag
     2281 tcactctcca tcatctgtga taagttgaca aatttatcct tacacaaatt tgtcctcatt
     2341 gagttgacat ccaaaatttg tcaggaatta aagaatgact tttgagtggc aattatttat
     2401 ataacatttt ccattgtctt catattcacc ttttgtcatt tgtttgcttt ctcttgcagc
     2461 aaaaataata tgaggtcatc aagggcagag aactgtgtgg catctcctta tagtaaaagt
     2521 gcaatcatat ggatggctaa ctttgtaatc tctacaaata atttacctta tgtaattttc
     2581 caaatgtaaa agtcaccaaa aacttaaagg cattaaaata aactaaaaaa gtactcattt
     2641 cttca
//
