LOCUS       NM_001039770            4310 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein with metallophosphoesterase
            domain (TMPPE), transcript variant 1, mRNA.
ACCESSION   NM_001039770 XM_929395 XM_933642
VERSION     NM_001039770.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4310)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112211.2, AK126979.1, BC136872.1 and AK128242.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039770.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126979.1, SRR5189667.227919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342462.5/ ENSP00000343398.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AC112211.2         132690-133034       c
            346-1160            AK126979.1         1-815
            1161-3350           BC136872.1         742-2931
            3351-3352           AC112211.2         127268-127269       c
            3353-4079           AK126979.1         3008-3734
            4080-4310           AK128242.1         3220-3450
FEATURES             Location/Qualifiers
     source          1..4310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..4310
                     /gene="TMPPE"
                     /note="transmembrane protein with metallophosphoesterase
                     domain"
                     /db_xref="GeneID:643853"
                     /db_xref="HGNC:HGNC:33865"
     exon            1..428
                     /gene="TMPPE"
                     /inference="alignment:Splign:2.1.0"
     exon            429..4310
                     /gene="TMPPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1898
                     /gene="TMPPE"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein with
                     metallophosphoesterase domain isoform 1"
                     /protein_id="NP_001034859.2"
                     /db_xref="CCDS:CCDS33732.1"
                     /db_xref="GeneID:643853"
                     /db_xref="HGNC:HGNC:33865"
                     /translation="MAIFRQLSLGAKATLAAVTVFVSMIASRSYLAESLELRAWRWLL
                     RLQLALFVNSLLLIGSLYIWRSTVSNLCHSPAAESTCFQLWKVVVLAFLALAHSSFFT
                     MFFLVAEEPYLFSLAAYSCLGAYIIMLFFLFILSGMEQAYQLLAWRSGRVVGSLEKTR
                     KLVLRPALAVGVTAVLSVAGILNAAQPPAVKTVEVPIHQLPASMNNLKIVLLSDIHLG
                     PTVGRTKMEMFVRMVNVLEPDITVIVGDLSDSEASVLRTAVAPLGQLHSHLGAYFVTG
                     NHEYYTSDVSNWFALLESLHVQPLHNENVKISATRAQRGGGGSGSGSEDEDWICLAGV
                     DDIEADILHYSGHGMDLDKALEGCSPDHTIILLAHQPLAAKRALQARPDINLILSGHT
                     HAGQIFPLNVAAYLLNPFFAGLYQVAQATFVYVSPGTAYYGIPMRLGSRAEITELILQ
                     RSP"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMPPE"
                     /note="hexamer: AATAAA"
     polyA_site      4310
                     /gene="TMPPE"
                     /note="major polyA site"
ORIGIN      
        1 agtcaagtga cgcgaagcgg ccggcctggg cgccgactgc agagccggga ggctggtggt
       61 catgccgggg ttcctggttc gcatcctccc tctgttgctg gttctgctgc ttctgggccc
      121 tacgcgcggc ttgcgcgtaa gtctgcggga cccgggtacg gggaggcatt gctaggggac
      181 aggctggcgg ggaaccgggc tggggtcgca gccacccgcg gtcccgcagg gcggggagcc
      241 tgagccccga agtgcccccc agcaggctcg cggccggcgg aacgcaggca gtggaccggc
      301 cttcccgtcg ggggcgggcc gggcggggcg cgcgtccttc caggcagctc ggtcgcttgt
      361 gcgttccgct ccggccgccc tttgcgcttg gatccacttc cccatctgta acgaggtgtt
      421 gagacgaggc ggagttgacc tggaaacctc tccttggcca ctgtcctttc taaggaactc
      481 atttccagag tccaccagca cagaactggt gggggagcct actaggagca gagaaaatgg
      541 ccatcttcag gcagctgtcc ctaggcgcga aggccaccct ggctgctgtc actgtcttcg
      601 tgtccatgat cgcctcccgc tcgtatctgg cagagagcct tgagctcagg gcctggcgtt
      661 ggctgcttcg cttgcagctt gccctgtttg tcaactcgct cttgctcatt ggctccctct
      721 acatttggcg cagcacagtg agcaacctct gccactcccc agctgcagag tcaacctgtt
      781 ttcagctttg gaaggtggtg gttctggcat ttctggccct ggcccattcc agtttcttta
      841 ccatgttctt tttagtggcc gaagagccct atctcttttc cttggcggcc tactcctgcc
      901 tgggtgctta catcatcatg ctcttcttcc tcttcatcct cagcggcatg gagcaggcct
      961 accagctctt ggcctggcgc agtggtaggg tcgtgggcag ccttgagaag acaaggaagc
     1021 tcgtgctcag gcctgccctg gcagtgggag tgactgctgt gctcagcgtg gccgggattc
     1081 tgaatgccgc gcagcccccg gctgtgaaaa ctgtggaggt gcccatccat cagctgcctg
     1141 cctcaatgaa caacctcaag atcgtgctcc tctcagacat tcacttgggc cccacagtgg
     1201 gcaggaccaa gatggaaatg tttgtgagga tggtgaatgt gctggaacca gacatcacgg
     1261 tgattgtggg tgacctctcc gactcagaag cctcggtcct gcggacggct gtcgctcctc
     1321 tgggccagct tcattcacat ctcggtgcct acttcgtcac aggcaatcat gagtactaca
     1381 cgtcagatgt cagcaactgg tttgcacttc tggaatccct gcatgtccag cctcttcata
     1441 atgagaacgt gaagatttcc gccacacggg cccaacgtgg tggtggtggc agtggcagtg
     1501 ggagtgagga tgaggactgg atctgcttgg ctggggtgga cgatattgaa gcagacatcc
     1561 tgcactactc tggccatggc atggatcttg acaaggccct ggagggctgc agcccagacc
     1621 acacaatcat cttgctagct caccagcccc tggctgccaa gagagctctc caggctcggc
     1681 cagatattaa cctgatcctt tctgggcaca cacatgctgg gcagatcttc cccttgaacg
     1741 tagcagccta tctcctgaat cccttctttg ctggtctcta ccaggtggcc caggctacat
     1801 tcgtgtatgt cagcccaggc acagcctact acgggatacc catgaggctg ggtagcaggg
     1861 ccgagatcac agagctcatc ctgcagcggt ctccctgaac tggccctgcc ctgtgcacct
     1921 ctgccctgcc cttgtcctcg accctccatc ctgcttcaga gtggtttgcc tgcttttccc
     1981 ctccagcctt gcccactcat ccttgcctac acacccttgg tcacaagcct gactcaaaca
     2041 gtgacttatg gtgggcctgc ctggcatgtt caggctggtt taactatttc cttggccagt
     2101 tgcttttttt gatgcacttg tgagatcact aaggtcacat atattagcac tcccctctat
     2161 tttccagatg atgtggaatg gggaccttct cctgcagagc tcccagggat gaacctcccc
     2221 tcggggttgc tagaaaggca tacctctaga aggtggggcg gggaggagca ggagcatttt
     2281 tctcctggtg ttttaaaatt gtctttagga cttaagtggt ttccagaatc attgatccag
     2341 agcctttctg gggaaggggt agtgttgcca ggtaatttgg gagaacaggc aagatggaag
     2401 ggccctctgg ctgctagaga agaatatttt cttttcctct gattctatca ggatcacctc
     2461 tattgagggc atcagcaaaa tctactggaa tgcaaagctc ctcctgttcc aggccttgag
     2521 ggatgctatt taactgtctg tgctcctggg cctttggggg caaggtcagg ggagaagaac
     2581 ggtgggcgcc atggtcggtg atggtgagaa catggctgct taggaattca gagggctttg
     2641 cctcccttgt ctcattttat acaacccttc ggggagctca ctggggacag gctgcttttc
     2701 cctatttgga gataaggaaa ccaaggcaaa gagagatagg gcacaggcag tatgacaaga
     2761 tatgtaggag atttggggct agaaaccagg tcttgtacct cccagtaaaa gcggtgcttt
     2821 tgcccttttg ccagaagcaa tagatccttt gatcctgaga tggagataag cacccgtgtt
     2881 agaaaaggcc tcactgagaa gacagggctg ggctggtttc ctgctgggtg atttaggctt
     2941 gtgatggaaa gtcttcctcc aatggggagt gaagacactc gctctgactg gagaggctaa
     3001 ccctgctgct cactcatagg gcagcgttgg gtgggtgact ttccctcact cagccttggt
     3061 ttccatcaac cctaaaatgg ggataattat cgtatctacc tcaagattgt tttgtcagga
     3121 gggatccatc aagccttgtg catgagttcc acatggcaca gcgtgcacag taaacactca
     3181 atgttaattt ttcaacgttc cagtggagct tgctaaggaa ctctgttggg cacaggtgcc
     3241 cagaggattc atggagcagc cagtcctggg gaatgtgagt gggtagcgag ctgcctgctg
     3301 ctggggcagg tgatgtgtca aagcagcaac tgctaggggt ttgccttcct tccctcatgt
     3361 gcattctggc aggcaaaggg ggtttcttcc tttcctcctt gtcctcctgg tgtatagtgg
     3421 ggttctgggg gatctggaga ccaccctttt tgttcccagg cagccacggt attgacagtg
     3481 ggccatacca tgcagtttaa aatgtatctt tgagttgaaa ttttggtggt ttccttattc
     3541 ttttttctct cttcactgtc cttccaaact cacttttctt gtgtcccgac cgcattttgt
     3601 gaatcatcct tactcccttt aagttctcgc tttggatttc accaggtggg ctagatggtg
     3661 ccatttcact tccactgttt gatgcggctg gtaatgtttg actcacctgt tacgtgttat
     3721 ttcactggtt tcttgatttt acatctttct catcagtgac ctgggcttga tgaaattagc
     3781 tttcattaag tcctattttt tttttaattt tgcatcctta cctcttttct ttctcttgaa
     3841 tgccatcatt gtgtggtctt atgtaccctt catccactct gaagtccttg cttgactgat
     3901 tgctttctat tagcagaaag aaaacaggtc catcctatgt atctgagaaa caacatcaac
     3961 accctctcgt atgtggtttg tattccctga cgcggcggac atttttgcag cagaaatttc
     4021 tccatcactg tccagattct ggccctggtg ggcaggtctc catgacacct ttagtccctt
     4081 tgttcaacat tcttaaacca tggacctttt tgtttgtttg tggccggggg aggtggtgag
     4141 aaacgttact tgaagcttga tcattctttc aatttcattt gtttctttat ttttaatctg
     4201 ttagatgcaa attgaaatgc aatgcttttt gaaaatcagc aatagtgtct gtagtatatg
     4261 atgctgtcac aaaatctcaa taaattgatc ctgctgccat tccttccaaa
//
