LOCUS       NM_013353               1232 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tropomodulin 4 (TMOD4), mRNA.
ACCESSION   NM_013353
VERSION     NM_013353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. doi:
            10.1172/JCI80057.. PMID: 25654555]
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Cox,P.R., Siddique,T. and Zoghbi,H.Y.
  TITLE     Genomic organization of Tropomodulins 2 and 4 and unusual
            intergenic and intraexonic splicing of YL-1 and Tropomodulin 4
  JOURNAL   BMC Genomics 2, 7 (2001)
   PUBMED   11716785
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Cox,P.R. and Zoghbi,H.Y.
  TITLE     Sequencing, expression analysis, and mapping of three unique human
            tropomodulin genes and their mouse orthologs
  JOURNAL   Genomics 63 (1), 97-107 (2000)
   PUBMED   10662549
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Almenar-Queralt,A., Lee,A., Conley,C.A., Ribas de Pouplana,L. and
            Fowler,V.M.
  TITLE     Identification of a novel tropomodulin isoform, skeletal
            tropomodulin, that caps actin filament pointed ends in fast
            skeletal muscle
  JOURNAL   J Biol Chem 274 (40), 28466-28475 (1999)
   PUBMED   10497209
  REMARK    Erratum:[J Biol Chem 2000 Apr 28;275(17):13164]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF177173.2.
            
            On Nov 22, 2018 this sequence version replaced NM_013353.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017810.1, AF177173.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295314.9/ ENSP00000295314.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1232              AF177173.2         36-1267
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1232
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /note="tropomodulin 4"
                     /db_xref="GeneID:29765"
                     /db_xref="HGNC:HGNC:11874"
                     /db_xref="MIM:605834"
     exon            1..58
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            59..223
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1138
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /note="actin-capping protein; skeletal muscle
                     tropomodulin; tropomodulin 4 (muscle); skeletal
                     tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-4"
                     /protein_id="NP_037485.2"
                     /db_xref="CCDS:CCDS988.1"
                     /db_xref="GeneID:29765"
                     /db_xref="HGNC:HGNC:11874"
                     /db_xref="MIM:605834"
                     /translation="MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENML
                     LPAGLRQRDQTKKSPTGPLDREALLQYLEQQALEVKERDDLVPFTGEKKGKPYIQPKR
                     EIPAEEQITLEPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGEICNTEG
                     ISSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCE
                     AMKANTYVRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAV
                     RENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTR
                     NNELRRQQKKR"
     exon            224..380
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            381..497
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            498..587
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            588..718
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            719..826
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            827..970
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1115
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1232
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1213..1218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /note="hexamer: AATAAA"
     polyA_site      1232
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /note="major polyA site"
ORIGIN      
        1 agaacagaca gacctactga cacaggggag gtgagaaggg aggtgaccac caggactggc
       61 tctgtgagta ccacacagtg gggagggggt gggggccacc atgtcatcat atcagaagga
      121 actggagaaa tacagagaca tagatgaaga tgagatccta aggaccttga gccccgagga
      181 gctagagcag ctggactgcg aactacagga gatggatcct gagaacatgc tcctgccagc
      241 tggactaaga caacgtgacc agacaaagaa gagcccaacg gggccactgg accgagaggc
      301 ccttttgcag tacttggagc aacaggcact agaagtcaaa gagcgtgatg acttggtgcc
      361 cttcacaggc gagaagaagg ggaaacccta tattcagccc aagagggaaa tcccagcaga
      421 ggagcagatc accctggagc ctgagctgga ggaggcactg gcacatgcca cagatgctga
      481 aatgtgtgac attgcagcaa ttctggacat gtacacactg atgagtaaca agcaatacta
      541 tgatgccctc tgcagtggag aaatctgcaa cactgaaggc attagcagtg tggtacagcc
      601 tgacaagtat aagccagtgc cggatgaacc cccaaatccc acaaacattg aggagatact
      661 aaagagggtc cgaagcaatg acaaggagct ggaggaggtg aacttgaata atatacagga
      721 catcccaata cccatgctaa gtgagctgtg tgaggcaatg aaggcaaata cctatgtgcg
      781 gagcttcagt ctggtagcca cgaggagtgg tgaccccatt gccaatgcag tggctgacat
      841 gttgcgtgag aatcgtagcc tccagagcct aaacatcgaa tccaacttca ttagcagcac
      901 aggactcatg gctgtgctga aggcagttcg ggaaaatgcc acactcactg agctccgtgt
      961 agacaatcag cgccagtggc ctggtgatgc agtggagatg gagatggcca ccgtgctaga
     1021 gcagtgtccc tctattgtcc gctttggcta ccactttaca cagcaggggc cacgagctcg
     1081 ggcagcccag gccatgaccc gaaacaatga actacgtcgc cagcaaaaga agagataaca
     1141 ctgcatttcc ctttaccaac tagcgctggg agcactggac acttaaatcc tcatctgtcc
     1201 tcctttcctg taaataaaag cccttctatc ca
//
