LOCUS       NP_037485                345 aa            linear   PRI 09-FEB-2025
DEFINITION  tropomodulin-4 [Homo sapiens].
ACCESSION   NP_037485
VERSION     NP_037485.2
DBSOURCE    REFSEQ: accession NM_013353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 345)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 345)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. doi:
            10.1172/JCI80057.. PMID: 25654555]
REFERENCE   3  (residues 1 to 345)
  AUTHORS   Cox,P.R., Siddique,T. and Zoghbi,H.Y.
  TITLE     Genomic organization of Tropomodulins 2 and 4 and unusual
            intergenic and intraexonic splicing of YL-1 and Tropomodulin 4
  JOURNAL   BMC Genomics 2, 7 (2001)
   PUBMED   11716785
REFERENCE   4  (residues 1 to 345)
  AUTHORS   Cox,P.R. and Zoghbi,H.Y.
  TITLE     Sequencing, expression analysis, and mapping of three unique human
            tropomodulin genes and their mouse orthologs
  JOURNAL   Genomics 63 (1), 97-107 (2000)
   PUBMED   10662549
REFERENCE   5  (residues 1 to 345)
  AUTHORS   Almenar-Queralt,A., Lee,A., Conley,C.A., Ribas de Pouplana,L. and
            Fowler,V.M.
  TITLE     Identification of a novel tropomodulin isoform, skeletal
            tropomodulin, that caps actin filament pointed ends in fast
            skeletal muscle
  JOURNAL   J Biol Chem 274 (40), 28466-28475 (1999)
   PUBMED   10497209
  REMARK    Erratum:[J Biol Chem 2000 Apr 28;275(17):13164]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF177173.2.
            
            On Aug 24, 2007 this sequence version replaced NP_037485.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017810.1, AF177173.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295314.9/ ENSP00000295314.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     Protein         1..345
                     /product="tropomodulin-4"
                     /note="actin-capping protein; skeletal muscle
                     tropomodulin; tropomodulin 4 (muscle); skeletal
                     tropomodulin"
                     /calculated_mol_wt=39204
     Region          4..143
                     /region_name="Tropomodulin"
                     /note="pfam03250"
                     /db_xref="CDD:460862"
     Region          42..63
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZQ9.1)"
     Region          <194..>285
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     CDS             1..345
                     /gene="TMOD4"
                     /gene_synonym="SK-TMOD"
                     /coded_by="NM_013353.3:101..1138"
                     /db_xref="CCDS:CCDS988.1"
                     /db_xref="GeneID:29765"
                     /db_xref="HGNC:HGNC:11874"
                     /db_xref="MIM:605834"
ORIGIN      
        1 mssyqkelek yrdidedeil rtlspeeleq ldcelqemdp enmllpaglr qrdqtkkspt
       61 gpldreallq yleqqalevk erddlvpftg ekkgkpyiqp kreipaeeqi tlepeleeal
      121 ahatdaemcd iaaildmytl msnkqyydal csgeicnteg issvvqpdky kpvpdeppnp
      181 tnieeilkrv rsndkeleev nlnniqdipi pmlselceam kantyvrsfs lvatrsgdpi
      241 anavadmlre nrslqslnie snfisstglm avlkavrena tltelrvdnq rqwpgdavem
      301 ematvleqcp sivrfgyhft qqgpraraaq amtrnnelrr qqkkr
//
