LOCUS       NM_014547               8232 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tropomodulin 3 (TMOD3), mRNA.
ACCESSION   NM_014547
VERSION     NM_014547.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8232)
  AUTHORS   Zhong,B., Ma,D.D., Zhang,T., Gong,Q., Dong,Y., Zhang,J.X., Li,Z.H.
            and Jin,W.D.
  TITLE     Clinicopathological Characteristics, Prognosis, and Correlated
            Tumor Cell Function of Tropomodulin-3 in Pancreatic Adenocarcinoma
  JOURNAL   Comb Chem High Throughput Screen 27 (7), 1011-1021 (2024)
   PUBMED   37563820
  REMARK    GeneRIF: Clinicopathological Characteristics, Prognosis, and
            Correlated Tumor Cell Function of Tropomodulin-3 in Pancreatic
            Adenocarcinoma.
REFERENCE   2  (bases 1 to 8232)
  AUTHORS   Kuwabara,Y., York,A.J., Lin,S.C., Sargent,M.A., Grimes,K.M.,
            Pirruccello,J.P. and Molkentin,J.D.
  TITLE     A human FLII gene variant alters sarcomeric actin thin filament
            length and predisposes to cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 120 (19), e2213696120 (2023)
   PUBMED   37126682
REFERENCE   3  (bases 1 to 8232)
  AUTHORS   Kumari,R., Jiu,Y., Carman,P.J., Tojkander,S., Kogan,K.,
            Varjosalo,M., Gunning,P.W., Dominguez,R. and Lappalainen,P.
  TITLE     Tropomodulins Control the Balance between Protrusive and
            Contractile Structures by Stabilizing Actin-Tropomyosin Filaments
  JOURNAL   Curr Biol 30 (5), 767-778 (2020)
   PUBMED   32037094
  REMARK    GeneRIF: Tropomodulins Control the Balance between Protrusive and
            Contractile Structures by Stabilizing Actin-Tropomyosin Filaments.
REFERENCE   4  (bases 1 to 8232)
  AUTHORS   Zheng,H., Yang,Y., Hong,Y.G., Wang,M.C., Yuan,S.X., Wang,Z.G.,
            Bi,F.R., Hao,L.Q., Yan,H.L. and Zhou,W.P.
  TITLE     Tropomodulin 3 modulates EGFR-PI3K-AKT signaling to drive
            hepatocellular carcinoma metastasis
  JOURNAL   Mol Carcinog 58 (10), 1897-1907 (2019)
   PUBMED   31313392
  REMARK    GeneRIF: These findings reveal that Tmod3 enhances aggressive
            behavior of hepatocellular carcinoma (HCC) both in vitro and in
            vivo by interacting with EFGR and by activating the PI3K-AKT
            signaling pathway.
            Erratum:[Mol Carcinog. 2022 Sep;61(9):892-893. doi:
            10.1002/mc.23444.. PMID: 35801417]
REFERENCE   5  (bases 1 to 8232)
  AUTHORS   Jin,C., Chen,Z., Shi,W. and Lian,Q.
  TITLE     Tropomodulin 3 promotes liver cancer progression by activating the
            MAPK/ERK signaling pathway
  JOURNAL   Oncol Rep 41 (5), 3060-3068 (2019)
   PUBMED   30864730
  REMARK    GeneRIF: TMOD3 expression was found to be elevated in liver cancer
            cells and tissues. In the in vitro experiments, liver cancer cell
            proliferation, invasion and migration were inhibited by TMOD3
            knockdown and promoted by ectopic expression of TMOD3. TMOD3
            overexpression activated MAPK/ERK signaling and increased the
            levels of other targets of this pathway.
REFERENCE   6  (bases 1 to 8232)
  AUTHORS   Weber,K.L., Fischer,R.S. and Fowler,V.M.
  TITLE     Tmod3 regulates polarized epithelial cell morphology
  JOURNAL   J Cell Sci 120 (Pt 20), 3625-3632 (2007)
   PUBMED   17928307
  REMARK    GeneRIF: findings show that the pointed-end capping protein Tmod3
            contributes to epithelial cell shape within confluent monolayers of
            polarized epithelial cells
REFERENCE   7  (bases 1 to 8232)
  AUTHORS   Fischer,R.S., Yarmola,E.G., Weber,K.L., Speicher,K.D.,
            Speicher,D.W., Bubb,M.R. and Fowler,V.M.
  TITLE     Tropomodulin 3 binds to actin monomers
  JOURNAL   J Biol Chem 281 (47), 36454-36465 (2006)
   PUBMED   17012745
  REMARK    GeneRIF: the Tmod3 isoform may regulate actin dynamics differently
            in cells than the previously described tropomodulin isoforms
REFERENCE   8  (bases 1 to 8232)
  AUTHORS   Pawlak,G., McGarvey,T.W., Nguyen,T.B., Tomaszewski,J.E.,
            Puthiyaveettil,R., Malkowicz,S.B. and Helfman,D.M.
  TITLE     Alterations in tropomyosin isoform expression in human transitional
            cell carcinoma of the urinary bladder
  JOURNAL   Int J Cancer 110 (3), 368-373 (2004)
   PUBMED   15095301
  REMARK    GeneRIF: levels of TM1, TM2 and TM3 are reduced in human
            transitional cell carcinoma cells, but significantly upregulated by
            inhibition of the mitogen-activated protein kinase-signaling
            pathway
REFERENCE   9  (bases 1 to 8232)
  AUTHORS   Fischer,R.S., Fritz-Six,K.L. and Fowler,V.M.
  TITLE     Pointed-end capping by tropomodulin3 negatively regulates
            endothelial cell motility
  JOURNAL   J Cell Biol 161 (2), 371-380 (2003)
   PUBMED   12707310
  REMARK    GeneRIF: capping of actin filament pointed ends by Tmod3 inhibits
            cell migration and reveal a novel control mechanism for regulation
            of actin filaments in lamellipodia.
REFERENCE   10 (bases 1 to 8232)
  AUTHORS   Cox,P.R. and Zoghbi,H.Y.
  TITLE     Sequencing, expression analysis, and mapping of three unique human
            tropomodulin genes and their mouse orthologs
  JOURNAL   Genomics 63 (1), 97-107 (2000)
   PUBMED   10662549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090971.3, BC020542.2, AL137543.1 and BM975185.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014547.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.280976.1,
                                           SRR1660803.4893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308580.12/ ENSP00000308753.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC090971.3         35421-35459
            40-2160             BC020542.2         1-2121
            2161-3261           AC090971.3         115422-116522
            3262-4578           AL137543.1         2215-3531
            4579-4645           BM975185.1         13-79               c
            4646-8232           AC090971.3         117907-121493
FEATURES             Location/Qualifiers
     source          1..8232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..8232
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="tropomodulin 3"
                     /db_xref="GeneID:29766"
                     /db_xref="HGNC:HGNC:11873"
                     /db_xref="MIM:605112"
     exon            1..184
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            185..384
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1317
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="ubiquitous tropomodulin; tropomodulin 3
                     (ubiquitous)"
                     /codon_start=1
                     /product="tropomodulin-3"
                     /protein_id="NP_055362.1"
                     /db_xref="CCDS:CCDS10145.1"
                     /db_xref="GeneID:29766"
                     /db_xref="HGNC:HGNC:11873"
                     /db_xref="MIM:605112"
                     /translation="MALPFRKDLEKYKDLDEDELLGNLSETELKQLETVLDDLDPENA
                     LLPAGFRQKNQTSKSTTGPFDREHLLSYLEKEALEHKDREDYVPYTGEKKGKIFIPKQ
                     KPVQTFTEEKVSLDPELEEALTSASDTELCDLAAILGMHNLITNTKFCNIMGSSNGVD
                     QEHFSNVVKGEKILPVFDEPPNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKD
                     FAKALETNTHVKCFSLAATRSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALI
                     DALRDNETLAELKIDNQRQQLGTAVELEMAKMLEENTNILKFGYQFTQQGPRTRAANA
                     ITKNNDLVRKRRVEGDHQ"
     exon            385..541
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            542..664
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            665..754
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            755..885
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            886..993
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1137
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1282
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..8232
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4415..4420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="hexamer: AATAAA"
     polyA_site      4444
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="major polyA site"
     regulatory      4558..4563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="hexamer: TATAAA"
     polyA_site      4578
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="major polyA site"
     regulatory      8206..8211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
                     /note="hexamer: AATAAA"
     polyA_site      8232
                     /gene="TMOD3"
                     /gene_synonym="UTMOD"
ORIGIN      
        1 gaaggaggaa cccaccgcac ctacagggcg gtcgagtgag ggagctgctg gcgggtgggt
       61 ctggcaactc tttgggaggc cgacgcgggc ggaccggcgg gtgctgggaa ccgagcctcg
      121 gcttgcggcc ggcagtttcc gtgggtctgt gaagaggtcg gcggcccctg cgggcgccag
      181 tcagctttaa gaaaaagtag agatcacttc tgactgtact gaacagcaaa aattaagtga
      241 cttgctgccc tgcacatcat ggcactgcca ttccgtaagg acttagaaaa gtacaaagac
      301 cttgatgaag atgagctcct tgggaatctg tcagaaacag aactgaaaca actggaaact
      361 gttttggatg atcttgaccc cgagaatgcc cttctgcctg cagggttccg gcagaagaac
      421 cagacatcaa agtccaccac agggccattt gatagagagc atctcctttc atatctggag
      481 aaagaagcat tggagcataa agacagggaa gactatgtgc cctacactgg agaaaaaaaa
      541 gggaaaatat ttatccccaa acagaaacct gtacagactt ttacagaaga aaaagtgtct
      601 cttgatccag aattagaaga agctttgaca agtgcttctg atacagaatt gtgtgacctc
      661 gcagcaattc ttgggatgca caatttgata acgaatacaa agttctgtaa tataatggga
      721 agtagtaatg gtgttgacca agaacatttt tcaaatgtgg tcaaaggtga aaagattctt
      781 ccggtatttg atgagccacc aaatccaacc aatgtagaag agagtttgaa gagaactaaa
      841 gaaaacgatg ctcatcttgt tgaagttaat ttgaataata taaagaatat cccaattcca
      901 accctaaaag attttgcaaa ggctttggaa accaacacac atgtgaaatg tttcagtctt
      961 gcagccaccc ggagcaatga ccctgttgct actgcttttg cagaaatgct gaaagtgaac
     1021 aaaactttga agagcttaaa tgtggagtcc aactttatca cgggagttgg gattctggca
     1081 ctgattgatg cgttaagaga taatgaaacc ctggcagagc tcaagattga caatcagagg
     1141 cagcagttgg ggacagctgt agaattggaa atggccaaga tgcttgagga aaatacaaat
     1201 atccttaaat ttggatatca gtttacacag cagggaccac gaaccagagc agctaatgct
     1261 ataacaaaaa acaatgactt agtgcgtaag agacgagttg aaggagatca ccagtaagtc
     1321 tgcaaaggtg taatctttgg aagacttcag aagatcacca agggctcatg ttggtgacat
     1381 catgtaaaat tttcctgggt agaagggaaa agactggaaa aattttttta gtgacatgca
     1441 tttttttttt agttgttatc aaattgtaaa atcagtaatg tgatatttta tattctgaaa
     1501 catttctact ttctgctaaa atcaatttta atttagttta attgaatgat ttatgatgaa
     1561 tcttgggcaa aaaaatacaa ctgtaaaaaa tttcacaggt catttgtgta gaataatttg
     1621 aacattgtga ggaccaatct tttttaaatc aaaagggatg ttgctggtat cagaattgtt
     1681 attgcttcat ttagacataa aacacttaag tgttttcttc actccgtgac ctggagagtt
     1741 ttccattttt taaaatacat gaacttggca agggtgtgat ttttctttat caagagaaca
     1801 aaatgccaga atgttaaaac agttaactca aaatctagtc atctgtgtag gagctaaagc
     1861 aggtctccag ggagagaggg tggtcgtctg tgcattccag gttactgcac ttgtctgatg
     1921 tgacgtagca acacccaggt cttcttaaaa caaagtcatc agctttgcca ggttacatac
     1981 tttatttaaa agtatagtga ggtcgaagtt cattccagtg tttcatttta ataatgtggg
     2041 cattattaaa tttttgtgga agctaatagt aaaaaataaa agctgttttc accacctccc
     2101 tccccacccc ccaaaaaagg cgtacagcca actcttagtt atttagggta agagaaaaaa
     2161 gaaaactgtt aaacaatgaa atcaaagata ataaatatga tagatttcca gtatgaggca
     2221 cttgcaaaac agtcatttaa actgatggtt actgtaagtc agttggaagc tggcatgtat
     2281 gtaaattact tggtgttaca ccatatccga agaagttcct atgtgcagtg cagaattgca
     2341 taaacagtat ttaatcactg ctacaaatct tccaaccaag aaggaaaact gctattcttc
     2401 ataaatctaa tttttagtat atgcttcctt tcatcttata cttttatcaa tatttataaa
     2461 agtcatttct ataataaaag cagtctttct tgctcaaagt attaaggtga acaattgaat
     2521 agagtactgt ggtcgggaga ctgatttgag actgcagagc tgatgctggg tagagggtct
     2581 ggacttgtat tcatgttctg tctcagggca gcccctggag caggagatgg cagaggcatt
     2641 tacagctgca gaaaacaggg aggaatggaa tctgaggtag ccctggcctc aaaattcagg
     2701 cctggctgta tcatttacag agatttttct ggagggaaaa gtctcatttc tgaggaaggc
     2761 aaggtggcta atcattatta atttttttta aactttttgg gccgggcgca gtggctcacg
     2821 cctgtaatcc cagcactttt gggaagccaa agtgggtgga tcacttaagg tcaggagttc
     2881 aagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaatcaaa aaagtagccg
     2941 ggtgtggtgg tgcacacctg taatcccagc tactcaggag gctgaggcag gagaattgct
     3001 tgaacctggg agatggagat tgcagtgagc tgagatcgta ccactgcact gcagtctggg
     3061 tgacaaagca agactctgtc tcaaaaaaca aacaaacaaa caaacttttt gaaattgaat
     3121 tgcaatatgt ctgctacttt ggcttgggct ggacagttta tctaataagc aaggcagctt
     3181 cttgtgtgct atggtaataa gccttcttaa caggctaagc ttccctcata agaactgtgg
     3241 tgtttctctt tttttttttt tgttttggtt tgttttggtt ttttggtttt gttttgtttt
     3301 gttttttaaa tcagtatcca atgttttata ggggccaaag gttaactttg cactattccc
     3361 tgtcagttaa aggccactga tatttttcta agttagcaag gctcacttgc ttgctttctt
     3421 gcctcccttg cctccatccc tctcccttcc taccttctct atttacctat ttctctccct
     3481 ccctctcttc tcctctcttt ttttttcccc gcatatgcag ctttttgatt gtacttgatt
     3541 ttatagagac tgcacagttc cagcaagatt gggagtcagg catggagcag gcatctcagg
     3601 ctaccagaaa gaattggtca cctagacttt cagtcaggca tcctcgtttg cattgtcctg
     3661 taagtcaatt agttgataaa tagttccccc ttcatccctt aagttttgtt tttgtttttg
     3721 tttttaatat aggtaagtgg gactctacct aaaattttgc atcatactta tgggtaatat
     3781 ctttttcata tattatttat caaagtatga agttgagtat tttgcttgta ccatttcaat
     3841 tctgcattat agtagttcat tgtataactg aaagaaatga tttcttcata agtgacatta
     3901 aatatgaaca ttcatccaat tgaatttaca aaatctttcc aaaattataa gggagaaaaa
     3961 tcgggtttac ttcaatcttt aaaaatctgg cacctcttag taactttcag tatttctaaa
     4021 ttgctctaaa attttataat aaatagatta gggttttgca atagtcttaa tttttaagcc
     4081 aaaggttttc tgagacctta ggttttgtag tctaaccagc ttatgtggtt atttaaaaga
     4141 atattctttg tgtttttaaa ttgctatttt taaaaaagct ttttattacc cattttataa
     4201 aatgttatac tcatatttgt ctgaattttt ccagtattcc tacatgaaat tgtatgtatt
     4261 aaaaactcaa tattagtggc aaatattaat actattaaaa tggattttgg tgctatattc
     4321 ttgtagctaa agcctagtag aattctcaag aataggtgaa atacactttc aaagttgcct
     4381 gtcatttaaa agaccaaata agcattttgt attaaataaa ttagcagatg gttagagact
     4441 tcaaggagag ttagcttggt catttaattg cgacttcatg ttatttgatt gaaataaccc
     4501 acatccttgc tttgtataag atattcgctc tggagaagtt acatgtaaat agaattctat
     4561 aaattgtttt ccagttgacc gagtatctgt tgtgtttttg tttaaaaaga ggattccatg
     4621 acataataaa aattatttta aaaaatgttt tgggccgggt gcggtggctc acgcctgtaa
     4681 tcctagcact ttgggaggcc gaggtgggcg gatcacctga ggtcaggagt tcgagaccag
     4741 cctgaccaac atggagaaac cctgtctcta ctaaaaatac aaaattagcc aggcgtggtg
     4801 gcacacacct gtgatctcag ctactcggga ggctgaggca ggagaatcac tagaactcgg
     4861 gaggcggagg ttgcagttag ctgaggtcgc gccattgcac tccagcatgg gcaacaagag
     4921 tgaaactccg tctcaaaaaa aaaaaaattt tttttttttt ataaaatgtt actcatatca
     4981 tattgtacgt tatatttaac tcttgctgtc attaaaataa gatgacaaca tttatgaagt
     5041 tttataaaat cttacatttt agggtctgtg ttcccagggc tgcctcactt tttccctaaa
     5101 aaactaggaa ccactgttaa cctcccagca gatgcaagga tcatgctttc tctggagtcc
     5161 ttagtcactt ccattctttg caagtttagt actgcccaaa tttactcatt ctacagtgtt
     5221 actgcacttt gaacgtattg acccatgtca cccaagagaa gcaaacatat ggatgcacta
     5281 gagacaactc gggttgctgc tctcagttaa gggctatgag ttcttggggt ctaagtatct
     5341 gtaaaattat cctctccatc agctctcact gatcattaat gtttctggat atttcttacc
     5401 ctaagatttg cttaccaaca aatcaaagaa acgcttcact aattattttt aaattgagaa
     5461 aatagtattc agaggcaaag atttttatat tcttttttga gaccaagtct cactctgtca
     5521 tccaggctgg agtgcagtgg tgcgatctca gctcactgca gcttccacct cccagattca
     5581 agtgattctc ctgcctcagc ctcccaagta gctgggatta caggcgtccg ccaccacgcc
     5641 cggataactt tttgtatttt taatagagac ggggtttcac catgttggcc gggctgttct
     5701 caaagtgacc tcaggtgatc cactcgcctc ggcctcccaa agtgctggga ttacaggctt
     5761 gagccaccac actcagcctt attcttatat tttaatttgg tcattcttag atctacagat
     5821 tgaacatccc taattgaaaa ctttttgagt actaacatag tgttcaaagg aaatgcttat
     5881 tggagcattt agaatttcag attttcagat tagggatgct gaactggtgt aatgcccagt
     5941 attccaaaat ccaaaataat ttgaaatctg aaacacttaa tggtcccagc atgttggata
     6001 agggatactc aacctgtatt gatttttctc cactataatt cagttctata agttcttccc
     6061 tataaaaaat gaatgaatta gaaatttgat aataaaacat attttattaa ttttaaactc
     6121 tatcttgcag tctgatcatt cagaaaggtc aacctagaaa aaagacatgg ctaagtaaac
     6181 tattttaagc cataactaag tattttggaa agccttcatt aacacataaa gaattttggc
     6241 caagtactgt ggcttatgcc tgtaatccta gcactttgga aagccgaggc cgacggatca
     6301 cttgagctca ggagtttgag accaacctgc gtaacatggt gaaaccccat atctacaaaa
     6361 agtacaaaaa ttagctgggt gcggtggcgc atgcctgtag tcccatctac tcggaagact
     6421 gaggcagcag aaccgcttga gcctaggagg tggaggttgc agtaagatga gatcatgctg
     6481 ctgtactcta gcctgggcaa tgagagtgaa actcttatct caaaaaaaaa aaaaaaaaaa
     6541 gagctatact catagtactt tgggagacca agcagggagg attacttgag accaggagtt
     6601 tgagactacc atggacaaca tagcaagacc ccatctttac aaaaaattta aaaattagcc
     6661 agacacctat agtaccagct acttaggagt ctaaagtggg agaattgctt gagcctggga
     6721 ggttgaagca gcagtgagct ttgatcatgc cactgcattc cagcctgggt aacaagagtg
     6781 agactgtctc aaaaaacaaa acaaaacaaa aaaatgggtt tttttgttgt tgtttttgtc
     6841 ttttacttag gacacctgct ctagaggcta gataaaaata gattgtaatg gccgggtgca
     6901 gtggctcaca cttgtaatcc cagcactgtg gaggctgagg tgggcggatc acttgaggtc
     6961 aggagtacga gaccagtctg gccaacatgg tgaaacccca tctctactaa aaatacaaaa
     7021 aattagttgg gcgtggtgat gcgcacctgt aattctagct acttgggagc ctaaggcagg
     7081 agaatcactt gaacctggga ggcagaagtt gcagtgagcc gagattgtgc cattgcactc
     7141 cagcctgggt gacagagtga gactccatct caaaaaaata tatgtattaa gaaataccac
     7201 cagcagtgtt ttgctaacat agctgtaaca aattattaag ttcttttttt tttttaagat
     7261 ggaggttcac tcttgtcgcc caggctggag cgcaatggtg cgatctcagc tcactgcaac
     7321 ctccgcctcc tgggttcaga tgattttcct gcctcagcct cctgggtagc tgggactaca
     7381 ggtgcccgcc accacgcctg actaattttt gtattttcag tagagacgga gtttcaccat
     7441 cttggccagg ctggtctcga actcctgacc tcgtaatcca cccgcctcgg cctcccaaag
     7501 tgctgggatt acaggtgttt gccaccgcgc ccagcccaaa ttattacatt cgtaagacag
     7561 acacctctta gaatctatat atatgaggtt ttactccctt ttctacactc agtatgtttt
     7621 aattgatgca aagcaattaa ttggcctaaa atgtttcaaa tattatagtc tatacattca
     7681 gaaagtaagg tttaagaatg aattattggt gcttcttggt gggtgtatat agcagttttt
     7741 agaagtttaa atttcacctc tactcagaaa gataagcttt tgattcagtg gtttcaaatt
     7801 ttcagatcaa tccatttaag aattgttttt tcaaatgtat atacacgtat aacataaaaa
     7861 tttttgtaat ttcaaatgtc tttttttcag ttttttggat gaattattat atttggtttt
     7921 agttacattt aaaagcttga aaattacctt tctaacaatc atttgaatgt cattcattgt
     7981 cacatgaaat caggtattta cgtttttttc taatgctaaa atatccaaca ttgtaattgc
     8041 cctatttttc catttttata agtataaaag caatgaattt taacactggt atttaaataa
     8101 tacaaaatat tatccaaatt cataacagca cagtgaagtt tcttttgaag actatgtact
     8161 ggaagcattt agaacttacc aatatatact gggataaatc gtttcaataa agtttatcaa
     8221 atattctgta aa
//
