LOCUS       NM_003275               3311 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens tropomodulin 1 (TMOD1), transcript variant 1, mRNA.
ACCESSION   NM_003275
VERSION     NM_003275.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Geng,X., Xia,X., Liang,Z., Li,S., Yue,Z., Zhang,H., Guo,L., Ma,S.,
            Jiang,S., Lian,X., Zhou,J., Sung,L.A., Wang,X. and Yao,W.
  TITLE     Tropomodulin1 exacerbates inflammatory response in macrophages by
            negatively regulating LPS-induced TLR4 endocytosis
  JOURNAL   Cell Mol Life Sci 81 (1), 402 (2024)
   PUBMED   39276234
  REMARK    GeneRIF: Tropomodulin1 exacerbates inflammatory response in
            macrophages by negatively regulating LPS-induced TLR4 endocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Vasilescu,C., Colpan,M., Ojala,T.H., Manninen,T., Mutka,A.,
            Ylanen,K., Rahkonen,O., Poutanen,T., Martelius,L., Kumari,R.,
            Hinterding,H., Brilhante,V., Ojanen,S., Lappalainen,P.,
            Koskenvuo,J., Carroll,C.J., Fowler,V.M., Gregorio,C.C. and
            Suomalainen,A.
  TITLE     Recessive TMOD1 mutation causes childhood cardiomyopathy
  JOURNAL   Commun Biol 7 (1), 7 (2024)
   PUBMED   38168645
  REMARK    GeneRIF: Recessive TMOD1 mutation causes childhood cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   Tong,K., Zhang,C., Yang,T., Guo,R., Wang,X., Guan,R. and Jin,T.
  TITLE     Suggestive evidence of the genetic association of TMOD1 and PTCSC2
            polymorphisms with thyroid carcinoma in the Chinese Han population
  JOURNAL   BMC Endocr Disord 22 (1), 263 (2022)
   PUBMED   36316666
  REMARK    GeneRIF: Suggestive evidence of the genetic association of TMOD1
            and PTCSC2 polymorphisms with thyroid carcinoma in the Chinese Han
            population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Feng,L., Zhang,Y., Yang,Q., Guo,L. and Yang,F.
  TITLE     MicroRNA-885 regulates the growth and epithelial mesenchymal
            transition of human liver cancer cells by suppressing tropomodulin
            1 expression
  JOURNAL   Arch Biochem Biophys 693, 108588 (2020)
   PUBMED   32937160
  REMARK    GeneRIF: MicroRNA-885 regulates the growth and epithelial
            mesenchymal transition of human liver cancer cells by suppressing
            tropomodulin 1 expression.
REFERENCE   5  (bases 1 to 3311)
  AUTHORS   Kumari,R., Jiu,Y., Carman,P.J., Tojkander,S., Kogan,K.,
            Varjosalo,M., Gunning,P.W., Dominguez,R. and Lappalainen,P.
  TITLE     Tropomodulins Control the Balance between Protrusive and
            Contractile Structures by Stabilizing Actin-Tropomyosin Filaments
  JOURNAL   Curr Biol 30 (5), 767-778 (2020)
   PUBMED   32037094
  REMARK    GeneRIF: Tropomodulins Control the Balance between Protrusive and
            Contractile Structures by Stabilizing Actin-Tropomyosin Filaments.
REFERENCE   6  (bases 1 to 3311)
  AUTHORS   Sung,L.A., Fan,Y. and Lin,C.C.
  TITLE     Gene assignment, expression, and homology of human tropomodulin
  JOURNAL   Genomics 34 (1), 92-96 (1996)
   PUBMED   8661028
REFERENCE   7  (bases 1 to 3311)
  AUTHORS   Sung,L.A. and Lin,J.J.
  TITLE     Erythrocyte tropomodulin binds to the N-terminus of hTM5, a
            tropomyosin isoform encoded by the gamma-tropomyosin gene
  JOURNAL   Biochem Biophys Res Commun 201 (2), 627-634 (1994)
   PUBMED   8002995
REFERENCE   8  (bases 1 to 3311)
  AUTHORS   Ursitti,J.A. and Fowler,V.M.
  TITLE     Immunolocalization of tropomodulin, tropomyosin and actin in spread
            human erythrocyte skeletons
  JOURNAL   J Cell Sci 107 (Pt 6), 1633-1639 (1994)
   PUBMED   7962203
REFERENCE   9  (bases 1 to 3311)
  AUTHORS   Sussman,M.A., Bilak,M., Kedes,L., Engel,W.K. and Askanas,V.
  TITLE     Tropomodulin is highly concentrated at the postsynaptic domain of
            human and rat neuromuscular junctions
  JOURNAL   Exp Cell Res 209 (2), 388-391 (1993)
   PUBMED   8262158
REFERENCE   10 (bases 1 to 3311)
  AUTHORS   Sung,L.A., Fowler,V.M., Lambert,K., Sussman,M.A., Karr,D. and
            Chien,S.
  TITLE     Molecular cloning and characterization of human fetal liver
            tropomodulin. A tropomyosin-binding protein
  JOURNAL   J Biol Chem 267 (4), 2616-2621 (1992)
   PUBMED   1370827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002660.2, DA015088.1,
            AF131836.1 and BU783086.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003275.3.
            
            Summary: This gene encodes a member of the tropomodulin family. The
            encoded protein is an actin-capping protein that regulates
            tropomyosin by binding to its N-terminus, inhibiting
            depolymerization and elongation of the pointed end of actin
            filaments and thereby influencing the structure of the erythrocyte
            membrane skeleton. Multiple transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Oct
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.104002.1,
                                           SRR1803611.258297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259365.9/ ENSP00000259365.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               BC002660.2         28-261
            235-583             DA015088.1         235-583
            584-1725            BC002660.2         611-1752
            1726-3128           AF131836.1         162-1564            c
            3129-3311           BU783086.1         15-197              c
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..3311
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /note="tropomodulin 1"
                     /db_xref="GeneID:7111"
                     /db_xref="HGNC:HGNC:11871"
                     /db_xref="MIM:190930"
     exon            1..138
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            139..306
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1266
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /note="e-tropomodulin; erythrocyte tropomodulin; E-Tmod"
                     /codon_start=1
                     /product="tropomodulin-1"
                     /protein_id="NP_003266.1"
                     /db_xref="CCDS:CCDS6726.1"
                     /db_xref="GeneID:7111"
                     /db_xref="HGNC:HGNC:11871"
                     /db_xref="MIM:190930"
                     /translation="MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALL
                     PAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKP
                     LDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEG
                     LNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAE
                     ALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEAL
                     PYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMN
                     NNDLVRKRRLADLTGPIIPKCRSGV"
     exon            307..463
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            464..583
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            584..673
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            674..804
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            805..912
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1056
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1201
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..3311
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1756..1761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /note="hexamer: ATTAAA"
     polyA_site      1774
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /note="hexamer: ATTAAA"
     polyA_site      2822
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /note="major polyA site"
     regulatory      3286..3291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
                     /note="hexamer: AATAAA"
     polyA_site      3311
                     /gene="TMOD1"
                     /gene_synonym="D9S57E; ETMOD; TMOD"
ORIGIN      
        1 gagctcgtcc agccccgcgc tgcgctcgcc cgcccgctgc ccgccggagc accgcggcct
       61 ccgcccgcgt ccatctgccc gccgcccgcg cctgttccgc agcccgcgtc cgcgccggcc
      121 ccacagctct gcgtccgggt attactcagc acagaaattc aggagacaca gacaagttct
      181 tccacgatgt cgtacagacg agaactagag aaataccgtg acctggatga agatgaaatc
      241 cttggagccc taacagagga agagctgagg accctggaaa atgagctgga tgagctggac
      301 cctgataatg cactgctgcc tgcaggcctg aggcagaagg atcagaccac caaggcgccc
      361 acgggcccct ttaaaagaga ggagctcttg gatcacttgg aaaagcaagc aaaggagttt
      421 aaggaccgag aagatctggt cccctacaca ggggaaaaac gaggaaaggt ctgggttcct
      481 aagcagaagc cactggatcc tgtgctggaa agtgtgacgc tggaaccgga gctggaggaa
      541 gccttggcaa atgcttcaga tgcagaactc tgtgacattg cagcgatcct gggcatgcac
      601 acgctcatga gtaaccagca gtactaccag gccctgagca gcagctccat catgaacaag
      661 gaggggctca acagcgtgat taaacccaca caatacaagc ctgtgcccga cgaagaacca
      721 aattcaacag acgtagagga aacgctggaa cggataaaga acaacgaccc aaaacttgaa
      781 gaagttaacc tcaataatat ccggaatatc cccatcccca ccctcaaggc atatgcagaa
      841 gccctgaaag aaaactcata tgtgaagaag ttcagcatcg tggggacacg gagtaatgac
      901 cccgtggcgt atgcccttgc tgagatgctc aaggagaaca aggtgttgaa gacactgaat
      961 gtggaatcca acttcatttc tggagctggg attctgcgcc tggtagaagc cctcccatac
     1021 aacacttctc tggtggaaat gaaaattgac aaccagagcc agcccctggg caacaaagtg
     1081 gaaatggaga ttgtgagcat gttggaaaaa aacgcaacac ttctcaaatt cggctaccac
     1141 tttacccagc aaggaccccg gcttcgggca tccaacgcaa tgatgaacaa caatgacctt
     1201 gtgaggaaga ggaggcttgc ggacctgact gggcccatca ttcccaagtg ccggagtggt
     1261 gtctagtgtg tggcggtgga gtccatgcct ttgaactgga tgtgttctat tgatgacctg
     1321 tgctctgcag gggaaaccag aaggcaaaat gctggcagca tgaaaccctt ttgtggttca
     1381 gttctttatg cactaaggtt ttaggttgac tagtggttgt agttgaaaat tttataaaat
     1441 accgttaatg tgaagttttt ctttagtcac agaagttgaa tctggttatt atttaaaaac
     1501 tagaagcccc caaaccagca gatcttactg aagatgatgt tccagcagca gcgacttagc
     1561 cccaggagcc cagtttcaat ggccttgctg tgtggtgttt caagtgcatt taaaatgtgt
     1621 gacacagaaa cggcacactc ttccacatgc ttttgaagta ttataaaaca ctttattaca
     1681 aatttgtctt agctattagc aaataaaact gattatcatt ctttattaac cctccttgga
     1741 attttgaaaa cctcgattaa agttgccaaa ttgattactg gatccagaac acaattttcc
     1801 cctcagaaca gatagacaga ctgaagccac tgaactctgc caggagtcaa catgagattc
     1861 cttttgctgg atatgcagaa atgataggaa aaaaaccaat ggtgaaattt caagtttcaa
     1921 aaaccaacct ttcattacca atcccaggca acaaacatgt ccctgagtgt tctttaagaa
     1981 catttgggat ttatgtacaa tttaatactg gagttagaac tttttcctta ttgaatgcca
     2041 accttatgat ggatgtgaaa atctacggcc aaatactttt gaaaacacct ttctatattg
     2101 cacagtgggc aaatggctta tgtgaggtaa gacactagag ggataaattt ccagatcaac
     2161 atggctatgg tatttagtaa tggcccagct tagagacttc agctactgat ctcatcactt
     2221 attagacaaa ttgctgctga ccttacgcct gtatattaag cctccgcagg atgccggaca
     2281 atggtgaaga aactccagat atcaaggaat tgggaaatcc tggccaaacc accccaagat
     2341 gattacactg aaatgtagta ttagtactgc tgccagatct ctttttaaca tcatgtgcgt
     2401 ctcttgggat ccagcaaaag tgttaagcca caatgccctt gtgcctttta atataccaca
     2461 gtgccagtta aactaatatt tttgtttgtt gcttttggga gttattttca ttagtgattt
     2521 cagcaaatct catgataaag gacaaggtca agaactccag agcactgagc agagaggctg
     2581 gtgatgaaaa ggtgaaggcc tgcgcactga actgtaaggc agtgggcagt acagggtaac
     2641 tggaggcggg gccagggcct cagcgctatg gaagagtgtc cactgaggct gcacatggcc
     2701 caggagtggc accatgttgc agggacaacc atccccattt ggcttctcct taaaacacaa
     2761 ttgcagctgc attctgcatc gctgaaaact gcaatataat attaaatctg ttggtctatg
     2821 catggctgcg tatgtgtttc ttggaacctg tgtgacaggg acatgtgcct ggcacactgg
     2881 ccagaagact gggcagccac catggcagtg ctggatgacc tcagtaagaa tgtgtcatgt
     2941 attccaggtg ctgatctaaa aactgtggct caaatgtcac cgagcttata tgaagctccc
     3001 agagagaaca tttaaaagct cagagagtaa gtgctgggga aagcagagct atcagaggaa
     3061 atctctcata gaaacgaaac caaaccaaca gaaaatgaag aaggccacat ctttaaggcc
     3121 acctctgcct ctatcagatg agctgctggt ctagatcagg ggctggcaaa cttttctgta
     3181 aaaggccaga cagtaaaaat ttccgatttt gcaggccaca tagtgtctgt tgcaactatt
     3241 caactctgcc atagatcatg tgtaaaggaa tgggtgtggc tgttcaataa actatacagt
     3301 tgacccttga a
//
