LOCUS       NM_001169126            1213 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens transmembrane and immunoglobulin domain containing 2
            (TMIGD2), transcript variant 2, mRNA.
ACCESSION   NM_001169126
VERSION     NM_001169126.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1213)
  AUTHORS   Boulhen,C., Ait Ssi,S., Benthami,H., Razzouki,I., Lakhdar,A.,
            Karkouri,M. and Badou,A.
  TITLE     TMIGD2 as a potential therapeutic target in glioma patients
  JOURNAL   Front Immunol 14, 1173518 (2023)
   PUBMED   37261362
  REMARK    GeneRIF: TMIGD2 as a potential therapeutic target in glioma
            patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1213)
  AUTHORS   Li,Y., Lv,C., Yu,Y., Wu,B., Zhang,Y., Lang,Q., Liang,Z., Zhong,C.,
            Shi,Y., Han,S., Xu,F. and Tian,Y.
  TITLE     KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in
            immune responses and its potential therapeutic approach for cancer
            immunotherapy
  JOURNAL   J Adv Res 47, 137-150 (2023)
   PUBMED   35933091
  REMARK    GeneRIF: KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of
            HHLA2 in immune responses and its potential therapeutic approach
            for cancer immunotherapy.
            Review article
REFERENCE   3  (bases 1 to 1213)
  AUTHORS   Guo,H., Zhang,C., Tang,X., Zhang,T., Liu,Y., Yu,H., Li,Y. and
            Wang,R.
  TITLE     HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2
            in Hepatocellular Carcinoma Cells
  JOURNAL   Inflammation 45 (4), 1585-1599 (2022)
   PUBMED   35175496
  REMARK    GeneRIF: HHLA2 Activates the JAK/STAT Signaling Pathway by Binding
            to TMIGD2 in Hepatocellular Carcinoma Cells.
REFERENCE   4  (bases 1 to 1213)
  AUTHORS   Sun,L., Amraei,R. and Rahimi,N.
  TITLE     NEDD4 regulates ubiquitination and stability of the cell adhesion
            molecule IGPR-1 via lysosomal pathway
  JOURNAL   J Biomed Sci 28 (1), 35 (2021)
   PUBMED   33962630
  REMARK    GeneRIF: NEDD4 regulates ubiquitination and stability of the cell
            adhesion molecule IGPR-1 via lysosomal pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1213)
  AUTHORS   Amraei,R., Alwani,T., Ho,R.X., Aryan,Z., Wang,S. and Rahimi,N.
  TITLE     Cell adhesion molecule IGPR-1 activates AMPK connecting cell
            adhesion to autophagy
  JOURNAL   J Biol Chem 295 (49), 16691-16699 (2020)
   PUBMED   32978258
  REMARK    GeneRIF: Cell adhesion molecule IGPR-1 activates AMPK connecting
            cell adhesion to autophagy.
REFERENCE   6  (bases 1 to 1213)
  AUTHORS   Xiao,Y., Li,H., Yang,L.L., Mao,L., Wu,C.C., Zhang,W.F. and Sun,Z.J.
  TITLE     The Expression Patterns and Associated Clinical Parameters of Human
            Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2
            and Transmembrane and Immunoglobulin Domain Containing 2 in Oral
            Squamous Cell Carcinoma
  JOURNAL   Dis Markers 2019, 5421985 (2019)
   PUBMED   31089395
  REMARK    GeneRIF: High TMIGD2 expression levels in oral squamous cell
            carcinoma cells indicate poor prognosis.  TMIGD2 expression
            inversely correlated with the TIM3, LAG3, and B7H3 levels.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1213)
  AUTHORS   Chen,Q., Wang,J., Chen,W., Zhang,Q., Wei,T., Zhou,Y., Xu,X., Bai,X.
            and Liang,T.
  TITLE     B7-H5/CD28H is a co-stimulatory pathway and correlates with
            improved prognosis in pancreatic ductal adenocarcinoma
  JOURNAL   Cancer Sci 110 (2), 530-539 (2019)
   PUBMED   30548441
  REMARK    GeneRIF: B7-H5/CD28H is a co-stimulatory signal pathway, and
            expression of B7-H5 is associated with improved disease prognosis
            in patients with pancreatic cancer.
REFERENCE   8  (bases 1 to 1213)
  AUTHORS   Wang,Y.H.W., Meyer,R.D., Bondzie,P.A., Jiang,Y., Rahimi,I.,
            Rezazadeh,K., Mehta,M., Laver,N.M.V., Costello,C.E. and Rahimi,N.
  TITLE     IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier
            Function
  JOURNAL   J Mol Biol 428 (24 Pt B), 5019-5033 (2016)
   PUBMED   27838321
  REMARK    GeneRIF: The authors demonstrate that IGPR-1 is localized to
            endothelial adherens junctions and, through trans-homophilic
            dimerization, regulates endothelial cell-cell adhesion and barrier
            function.
REFERENCE   9  (bases 1 to 1213)
  AUTHORS   Zhu,Y., Yao,S., Iliopoulou,B.P., Han,X., Augustine,M.M., Xu,H.,
            Phennicie,R.T., Flies,S.J., Broadwater,M., Ruff,W., Taube,J.M.,
            Zheng,L., Luo,L., Zhu,G., Chen,J. and Chen,L.
  TITLE     B7-H5 costimulates human T cells via CD28H
  JOURNAL   Nat Commun 4, 2043 (2013)
   PUBMED   23784006
  REMARK    GeneRIF: B7 homologue 5 (B7-H5), was identified as a specific
            ligand for CD28H.
REFERENCE   10 (bases 1 to 1213)
  AUTHORS   Rahimi,N., Rezazadeh,K., Mahoney,J.E., Hartsough,E. and Meyer,R.D.
  TITLE     Identification of IGPR-1 as a novel adhesion molecule involved in
            angiogenesis
  JOURNAL   Mol Biol Cell 23 (9), 1646-1656 (2012)
   PUBMED   22419821
  REMARK    GeneRIF: Authors identified IGPR-1, also called TMIGD2, gene as a
            novel cell adhesion receptor that is expressed in various human
            organs and tissues, mainly in cells with epithelium and endothelium
            origins.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358964.1 and BU629751.1.
            
            On Jul 16, 2021 this sequence version replaced NM_001169126.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358964.1, DRR138522.853168.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595645.6/ ENSP00000470561.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1088              AY358964.1         5-1092
            1089-1208           AY358964.1         1095-1214
            1209-1213           BU629751.1         16-20               c
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1213
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /note="transmembrane and immunoglobulin domain containing
                     2"
                     /db_xref="GeneID:126259"
                     /db_xref="HGNC:HGNC:28324"
                     /db_xref="MIM:614715"
     exon            1..50
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..841
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; immunoglobulin-containing and proline-rich
                     receptor 1; immunoglobulin and proline-rich receptor 1;
                     CD28 homolog; CD28 homologue"
                     /codon_start=1
                     /product="transmembrane and immunoglobulin
                     domain-containing protein 2 isoform 2 precursor"
                     /protein_id="NP_001162597.1"
                     /db_xref="CCDS:CCDS59334.1"
                     /db_xref="GeneID:126259"
                     /db_xref="HGNC:HGNC:28324"
                     /db_xref="MIM:614715"
                     /translation="MGSPGMVLGLLVQIWALQEASSLSVQQGPNLLQVRQGSQATLVC
                     QVDQATAWERLRVKWTKDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPV
                     SLNHSGAYVCWAAVEIPELEEAEGNITRLFVDPDDPTQNRNRIASFPGFLFVLLGVGS
                     MGVAAIVWGAWFWGRRSCQQRDSGNAFYSNVLYRPRGAPKKSEDCSGEGKDQRGQSIY
                     STSFPQPAPRQPHLASRPCPSPRPCPSPRPGHPVSMVRVSPRPSPTQQPRPKGFPKVG
                     EE"
     exon            51..410
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..452
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..554
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1213
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /note="hexamer: AATAAA"
     polyA_site      1213
                     /gene="TMIGD2"
                     /gene_synonym="CD28H; IGPR-1; IGPR1"
                     /note="major polyA site"
ORIGIN      
        1 aggaatgggg tccccgggca tggtgctggg cctcctggtg cagatctggg ccctgcaaga
       61 agcctcaagc ctgagcgtgc agcaggggcc caacttgctg caggtgaggc agggcagtca
      121 ggcgaccctg gtctgccagg tggaccaggc cacagcctgg gaacggctcc gtgttaagtg
      181 gacaaaggat ggggccatcc tgtgtcaacc gtacatcacc aacggcagcc tcagcctggg
      241 ggtctgcggg ccccagggac ggctctcctg gcaggcaccc agccatctca ccctgcagct
      301 ggaccctgtg agcctcaacc acagcggggc gtacgtgtgc tgggcggccg tagagattcc
      361 tgagttggag gaggctgagg gcaacataac aaggctcttt gtggacccag atgaccccac
      421 acagaacaga aaccggatcg caagcttccc aggattcctc ttcgtgctgc tgggggtggg
      481 aagcatgggt gtggctgcga tcgtgtgggg tgcctggttc tggggccgcc gcagctgcca
      541 gcaaagggac tcaggaaatg cattctacag caacgtccta taccggcccc ggggggcccc
      601 aaagaagagt gaggactgct ctggagaggg gaaggaccag aggggccaga gcatttattc
      661 aacctccttc ccgcaaccgg ccccccgcca gccgcacctg gcgtcaagac cctgccccag
      721 cccgagaccc tgccccagcc ccaggcccgg ccaccccgtc tctatggtca gggtctctcc
      781 tagaccaagc cccacccagc agccgaggcc aaaagggttc cccaaagtgg gagaggagtg
      841 agagatccca ggagacctca acaggacccc acccataggt acacacaaaa aaggggggat
      901 cgaggccaga cacggtggct cacgcctgta atcccagcag tttgggaagc cgaggcgggt
      961 ggaacacttg aggtcagggg tttgagacca gcctggcttg aacctgggag gcggaggttg
     1021 cagtgagccg agattgcgcc actgcactcc agcctgggcg acagagtgag actccgtctc
     1081 aaaaaaaaca aaaagcagga ggattgggag cctgtcagcc ccatcctgag accccgtcct
     1141 catttctgta atgatggatc tcgctcccac tttcccccaa gaacctaata aaggcttgtg
     1201 aagaaaaagc aaa
//
