LOCUS       NM_206832               1226 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens transmembrane and immunoglobulin domain containing 1
            (TMIGD1), transcript variant 1, mRNA.
ACCESSION   NM_206832 XM_371037
VERSION     NM_206832.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Zhou,L., Zhu,L., Wu,X., Hu,S., Zhang,S., Ning,M., Yu,J. and Chen,M.
  TITLE     Decreased TMIGD1 aggravates colitis and intestinal barrier
            dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease
  JOURNAL   BMC Med 21 (1), 287 (2023)
   PUBMED   37542259
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Mu,L., Wang,Y., Hu,Y., Shi,C., Alman,B.A., Zhang,C. and She,J.
  TITLE     The Role of TMIGD1 as a Tumor Suppressor in Colorectal Cancer
  JOURNAL   Genet Test Mol Biomarkers 26 (4), 174-183 (2022)
   PUBMED   35481970
  REMARK    GeneRIF: The Role of TMIGD1 as a Tumor Suppressor in Colorectal
            Cancer.
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   De La Cena,K.O.C., Ho,R.X., Amraei,R., Woolf,N., Tashjian,J.Y.,
            Zhao,Q., Richards,S., Walker,J., Huang,J., Chitalia,V.C. and
            Rahimi,N.
  TITLE     Transmembrane and Immunoglobulin Domain Containing 1, a Putative
            Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in
            Colon Cancer Cells
  JOURNAL   Am J Pathol 191 (1), 157-167 (2021)
   PUBMED   33129760
  REMARK    GeneRIF: Transmembrane and Immunoglobulin Domain Containing 1, a
            Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint
            Arrest in Colon Cancer Cells.
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Zabana,Y., Loren,V., Domenech,E., Aterido,A.,
            Garcia-Jaraquemada,A., Julia,A., Vicario,M., Pedrosa,E.,
            Ferreiro,M., Troya,J., Lozano,J.J., Sarrias,M.R., Cabre,E.,
            Manosa,M. and Manye,J.
  TITLE     Transcriptomic identification of TMIGD1 and its relationship with
            the ileal epithelial cell differentiation in Crohn's disease
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 319 (2), G109-G120 (2020)
   PUBMED   32508154
  REMARK    GeneRIF: Transcriptomic identification of TMIGD1 and its
            relationship with the ileal epithelial cell differentiation in
            Crohn's disease.
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   Hartmann,C., Schwietzer,Y.A., Kummer,D., Kirschnick,N., Hoppe,E.,
            Thuring,E.M., Glaesner-Ebnet,M., Brinkmann,F., Gerke,V., Reuter,S.,
            Nakayama,M. and Ebnet,K.
  TITLE     The mitochondrial outer membrane protein SYNJ2BP interacts with the
            cell adhesion molecule TMIGD1 and can recruit it to mitochondria
  JOURNAL   BMC Mol Cell Biol 21 (1), 30 (2020)
   PUBMED   32303178
  REMARK    GeneRIF: The mitochondrial outer membrane protein SYNJ2BP interacts
            with the cell adhesion molecule TMIGD1 and can recruit it to
            mitochondria.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Arafa,E., Bondzie,P.A., Rezazadeh,K., Meyer,R.D., Hartsough,E.,
            Henderson,J.M., Schwartz,J.H., Chitalia,V. and Rahimi,N.
  TITLE     TMIGD1 is a novel adhesion molecule that protects epithelial cells
            from oxidative cell injury
  JOURNAL   Am J Pathol 185 (10), 2757-2767 (2015)
   PUBMED   26342724
  REMARK    GeneRIF: identified TMIGD1 as a novel cell adhesion molecule
            expressed in kidney epithelial cells that protects kidney
            epithelial cells from oxidative cell injury to promote cell
            survival
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087644.8.
            
            On May 17, 2019 this sequence version replaced NM_206832.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358153.1, AK290266.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328886.5/ ENSP00000332404.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC087644.8         94128-94185         c
            59-165              AC087644.8         92180-92286         c
            166-444             AC087644.8         89379-89657         c
            445-723             AC087644.8         84944-85222         c
            724-827             AC087644.8         78938-79041         c
            828-868             AC087644.8         77321-77361         c
            869-1226            AC087644.8         76461-76818         c
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1226
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /note="transmembrane and immunoglobulin domain containing
                     1"
                     /db_xref="GeneID:388364"
                     /db_xref="HGNC:HGNC:32431"
     exon            1..58
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
     exon            59..165
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..872
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane and immunoglobulin
                     domain-containing protein 1; AWKS9372"
                     /codon_start=1
                     /product="transmembrane and immunoglobulin
                     domain-containing protein 1 isoform 1 precursor"
                     /protein_id="NP_996663.1"
                     /db_xref="CCDS:CCDS32605.1"
                     /db_xref="GeneID:388364"
                     /db_xref="HGNC:HGNC:32431"
                     /translation="MAWKSSVIMQMGRFLLLVILFLPREMTSSVLTVNGKTENYILDT
                     TPGSQASLICAVQNHTREEELLWYREEGRVDLKSGNKINSSSVCVSSISENDNGISFT
                     CRLGRDQSVSVSVVLNVTFPPLLSGNDFQTVEEGSNVKLVCNVKANPQAQMMWYKNSS
                     LLDLEKSRHQIQQTSESFQLSITKVEKPDNGTYSCIAKSSLKTESLDFHLIVKDKTVG
                     VPIEPIIAACVVIFLTLCFGLIARRKKIMKLCMKDKDPHSETAL"
     exon            166..444
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
     exon            445..723
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
     exon            724..827
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
     exon            828..868
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1226
                     /gene="TMIGD1"
                     /gene_synonym="TMIGD; UNQ9372"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggttttca ggcagaggaa cagttggcca aggaagtcag cttctcagag ctcaagagta
       61 gatctgagtt taactcatta aagatggcat ggaagagcag tgtcataatg caaatgggaa
      121 gatttcttct cttagtaatt ttatttctgc cacgtgagat gacaagttct gttttaactg
      181 tgaatggtaa aactgagaac tatatcctgg atactacacc tggctcccaa gcatctctga
      241 tatgtgctgt tcaaaaccac accagagagg aagaactgct ctggtaccga gaggagggga
      301 gagtggattt gaaatctgga aacaaaatca attccagctc tgtctgtgtc tcttccatca
      361 gtgaaaatga caacggaatc agctttacct gcaggctggg gagggatcag tccgtgtccg
      421 tttcggtggt gctgaatgtt acttttcctc ctctcctaag tggaaacgac ttccaaacag
      481 ttgaggaagg cagtaatgtg aagttggttt gcaatgtgaa agccaacccc caggctcaaa
      541 tgatgtggta caaaaacagt agtctcctcg atttagagaa aagccgtcac caaatccaac
      601 agacaagtga gtcttttcag ctgtcaatca ccaaagtcga gaagcctgac aacggaacct
      661 acagttgtat tgcaaagtca tctctgaaaa cggagagctt ggactttcac ctgattgtta
      721 aagataaaac tgtgggtgta ccaatagagc ccattattgc tgcatgtgtt gtgatctttc
      781 tgacattgtg ctttggactg attgctagaa gaaagaaaat aatgaagctc tgcatgaagg
      841 ataaagaccc tcacagtgaa acagctctat gagaaagctg agatgccatc gaatacagag
      901 agagttttgc atcaggacct ccacaattta tgtagtccca tctgtattta ttgctattat
      961 taaattcact cctgtcactc ctgtttcatt aatcacttaa cagtagttgt taggactaat
     1021 ttgatacact tgtggaacat ttttatggaa agagctatta agaatgaaaa gtaagatttt
     1081 gttaagtctt ctccttgaag tatatgttaa ttaattgaga tttgttccaa ataggttggt
     1141 aatcatttac tgtttagtgt gttttttttc taggtaggag atacttgggt ctcacaaatt
     1201 ggtgcaaagc caaaaaaaaa aaaaaa
//
