LOCUS       NM_020644               1844 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TMEM9 domain family member B (TMEM9B), transcript
            variant 1, mRNA.
ACCESSION   NM_020644
VERSION     NM_020644.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Thurner,L., Muller,A., Cerutti,M., Martin,T., Pasquali,J.L.,
            Gross,W.L., Preuss,K.D., Pfreundschuh,M. and Voswinkel,J.
  TITLE     Wegener's granuloma harbors B lymphocytes with specificities
            against a proinflammatory transmembrane protein and a tetraspanin
  JOURNAL   J Autoimmun 36 (1), 87-90 (2011)
   PUBMED   20951001
  REMARK    GeneRIF: transmembrane protein 9B was identified as a putative
            antigenic target in Wegener's granulomatosis
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B.
  TITLE     The lysosomal transmembrane protein 9B regulates the activity of
            inflammatory signaling pathways
  JOURNAL   J Biol Chem 283 (31), 21487-21494 (2008)
   PUBMED   18541524
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA563443.1, AY359069.1, AA433929.1 and AI346520.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020644.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.197884.1,
                                           SRR1660803.149233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534025.6/ ENSP00000433361.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA563443.1         299-340
            43-1621             AY359069.1         17-1595
            1622-1714           AA433929.1         46-138              c
            1715-1844           AI346520.1         10-139              c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1844
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="TMEM9 domain family member B"
                     /db_xref="GeneID:56674"
                     /db_xref="HGNC:HGNC:1168"
                     /db_xref="MIM:620293"
     exon            1..234
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..726
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; transmembrane protein 9B"
                     /codon_start=1
                     /product="transmembrane protein 9B isoform a precursor"
                     /protein_id="NP_065695.1"
                     /db_xref="CCDS:CCDS7796.1"
                     /db_xref="GeneID:56674"
                     /db_xref="HGNC:HGNC:1168"
                     /db_xref="MIM:620293"
                     /translation="MATLWGGLLRLGSLLSLSCLALSVLLLAQLSDAAKNFEDVRCKC
                     ICPPYKENSGHIYNKNISQKDCDCLHVVEPMPVRGPDVEAYCLRCECKYEERSSVTIK
                     VTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFANAHDVLA
                     RSRSRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVLS"
     exon            235..326
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            327..435
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            436..570
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1844
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="hexamer: AAGAAA"
     polyA_site      1539
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="major polyA site"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="hexamer: AATAAA"
     polyA_site      1752
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="major polyA site"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
                     /note="hexamer: TATAAA"
     polyA_site      1844
                     /gene="TMEM9B"
                     /gene_synonym="C11orf15"
ORIGIN      
        1 agacggaagt gcgggcggag gatccccagc cgggtcccaa gcctgtgcct gagcctgagc
       61 ctgagcctga gcccgagccg ggagccggtc gcgggggctc cgggctgtgg gaccgctggg
      121 cccccagcga tggcgaccct gtggggaggc cttcttcggc ttggctcctt gctcagcctg
      181 tcgtgcctgg cgctttccgt gctgctgctg gcgcagctgt cagacgccgc caagaatttc
      241 gaggatgtca gatgtaaatg tatctgccct ccctataaag aaaattctgg gcatatttat
      301 aataagaaca tatctcagaa agattgtgat tgccttcatg ttgtggagcc catgcctgtg
      361 cgggggcctg atgtagaagc atactgtcta cgctgtgaat gcaaatatga agaaagaagc
      421 tctgtcacaa tcaaggttac cattataatt tatctctcca ttttgggcct tctacttctg
      481 tacatggtat atcttactct ggttgagccc atactgaaga ggcgcctctt tggacatgca
      541 cagttgatac agagtgatga tgatattggg gatcaccagc cttttgcaaa tgcacacgat
      601 gtgctagccc gctcccgcag tcgagccaac gtgctgaaca aggtagaata tgcacagcag
      661 cgctggaagc ttcaagtcca agagcagcga aagtctgtct ttgaccggca tgttgtcctc
      721 agctaattgg gaattgaatt caaggtgact agaaagaaac aggcagacaa ctggaaagaa
      781 ctgactgggt tttgctgggt ttcattttaa taccttgttg atttcaccaa ctgttgctgg
      841 aagattcaaa actggaagca aaaacttgct tgattttttt ttcttgttaa cgtaataata
      901 gagacatttt taaaagcaca cagctcaaag tcagccaata agtcttttcc tatttgtgac
      961 ttttactaat aaaaataaat ctgcctgtaa attatcttga agtcctttac ctggaacaag
     1021 cactctcttt ttcaccacat agttttaact tgactttcaa gataattttc agggtttttg
     1081 ttgttgttgt tttttgtttg tttgttttgg tgggagaggg gagggatgcc tgggaagtgg
     1141 ttaacaactt ttttcaagtc actttactaa acaaactttt gtaaatagac cttaccttct
     1201 attttcgagt ttcatttata ttttgcagtg tagccagcct catcaaagag ctgacttact
     1261 catttgactt ttgcactgac tgtattatct gggtatctgc tgtgtctgca cttcatggta
     1321 aacgggatct aaaatgcctg gtggcttttc acaaaaagca gattttcttc atgtactgtg
     1381 atgtctgatg caatgcatcc tagaacaaac tggccatttg ctagtttact ctaaagacta
     1441 aacatagtct tggtgtgtgt ggtcttactc atcttctagt acctttaagg acaaatccta
     1501 aggacttgga cacttgcaat aaagaaattt tattttaaac ccaagcctcc ctggattgat
     1561 aatatataca catttgtcag catttccggt cgtggtgaga ggcagctgtt tgagctccaa
     1621 tgtgtgcagc tttgaactag ggctggggtt gtgggtgcct cttctgaaag gtctaaccat
     1681 tattggataa ctggcttttt tcttcctatg tcctctttgg aatgtaacaa taaaaataat
     1741 ttttgaaaca tccatcagtg tatctatcta tgtctcctag ttttttcctc ctccctcttt
     1801 tgctgtataa tgagattgaa gatataaaga cattttgtac cctg
//
