LOCUS       NM_015544               4218 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 98 (TMEM98), transcript variant
            1, mRNA.
ACCESSION   NM_015544 XM_005257958
VERSION     NM_015544.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4218)
  AUTHORS   Hassall,M.M., Javadiyan,S., Klebe,S., Awadalla,M.S., Sharma,S.,
            Qassim,A., White,M., Thomas,P.Q., Craig,J.E. and Siggs,O.M.
  TITLE     Phenotypic consequences of a nanophthalmos-associated TMEM98
            variant in human and mouse
  JOURNAL   Sci Rep 13 (1), 11017 (2023)
   PUBMED   37419942
  REMARK    GeneRIF: Phenotypic consequences of a nanophthalmos-associated
            TMEM98 variant in human and mouse.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4218)
  AUTHORS   Wu,S.G., Xu,J.Y., Lei,J., Hu,M. and Zhou,J.
  TITLE     Tumor-Suppressor Gene Transmembrane Protein 98 Promotes
            Proliferation and Inhibits Apoptosis in Ovarian Cancer
  JOURNAL   Front Biosci (Landmark Ed) 27 (7), 210 (2022)
   PUBMED   35866395
  REMARK    GeneRIF: Tumor-Suppressor Gene Transmembrane Protein 98 Promotes
            Proliferation and Inhibits Apoptosis in Ovarian Cancer.
REFERENCE   3  (bases 1 to 4218)
  AUTHORS   Koenighofer,M., Parzefall,T., Frohne,A., Frei,E., Waldstein,S.M.,
            Mitulovic,G., Schoefer,C., Frei,K. and Lucas,T.
  TITLE     A novel proline substitution (Arg201Pro) in alpha helix 8 of TMEM98
            causes autosomal dominant nanophthalmos-4, closed angle glaucoma
            and attenuated visual acuity
  JOURNAL   Exp Eye Res 205, 108497 (2021)
   PUBMED   33596443
  REMARK    GeneRIF: A novel proline substitution (Arg201Pro) in alpha helix 8
            of TMEM98 causes autosomal dominant nanophthalmos-4, closed angle
            glaucoma and attenuated visual acuity.
REFERENCE   4  (bases 1 to 4218)
  AUTHORS   Prasov,L., Guan,B., Ullah,E., Archer,S.M., Ayres,B.M.,
            Besirli,C.G., Wiinikka-Buesser,L., Comer,G.M., Del Monte,M.A.,
            Elner,S.G., Garnai,S.J., Huryn,L.A., Johnson,K., Kamat,S.S.,
            Lieu,P., Mian,S.I., Rygiel,C.A., Serpen,J.Y., Pawar,H.S.,
            Brooks,B.P., Moroi,S.E., Richards,J.E. and Hufnagel,R.B.
  TITLE     Novel TMEM98, MFRP, PRSS56 variants in a large United States high
            hyperopia and nanophthalmos cohort
  JOURNAL   Sci Rep 10 (1), 19986 (2020)
   PUBMED   33203948
  REMARK    GeneRIF: Novel TMEM98, MFRP, PRSS56 variants in a large United
            States high hyperopia and nanophthalmos cohort.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4218)
  AUTHORS   Ao,X., Li,X., Chen,Y., Zang,Z., Guo,W. and Liang,J.
  TITLE     TMEM98 mRNA promotes proliferation and invasion of gastric cells by
            directly interacting with NF90 protein
  JOURNAL   Cell Biol Int 44 (9), 1820-1830 (2020)
   PUBMED   32379372
  REMARK    GeneRIF: TMEM98 mRNA promotes proliferation and invasion of gastric
            cells by directly interacting with NF90 protein.
REFERENCE   6  (bases 1 to 4218)
  AUTHORS   Fu,W., Cheng,Y., Zhang,Y., Mo,X., Li,T., Liu,Y., Wang,P., Pan,W.,
            Chen,Y., Xue,Y., Ma,D., Zhang,Y. and Han,W.
  TITLE     The Secreted Form of Transmembrane Protein 98 Promotes the
            Differentiation of T Helper 1 Cells
  JOURNAL   J Interferon Cytokine Res 35 (9), 720-733 (2015)
   PUBMED   25946230
REFERENCE   7  (bases 1 to 4218)
  AUTHORS   Awadalla,M.S., Burdon,K.P., Souzeau,E., Landers,J., Hewitt,A.W.,
            Sharma,S. and Craig,J.E.
  TITLE     Mutation in TMEM98 in a large white kindred with autosomal dominant
            nanophthalmos linked to 17p12-q12
  JOURNAL   JAMA Ophthalmol 132 (8), 970-977 (2014)
   PUBMED   24852644
  REMARK    GeneRIF: A novel gene associated with nanophthalmos, TMEM98 most
            likely represents the cause of the disease.
REFERENCE   8  (bases 1 to 4218)
  AUTHORS   Ng,K.T., Lo,C.M., Guo,D.Y., Qi,X., Li,C.X., Geng,W., Liu,X.B.,
            Ling,C.C., Ma,Y.Y., Yeung,W.H., Shao,Y., Poon,R.T., Fan,S.T. and
            Man,K.
  TITLE     Identification of transmembrane protein 98 as a novel
            chemoresistance-conferring gene in hepatocellular carcinoma
  JOURNAL   Mol Cancer Ther 13 (5), 1285-1297 (2014)
   PUBMED   24608572
  REMARK    GeneRIF: we identified a panel of novel common
            chemoresistance-associated genes and demonstrated that TMEM98 is a
            chemoresistance-conferring gene in hepatocellular carcinoma.
REFERENCE   9  (bases 1 to 4218)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 4218)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084809.17 and AY358573.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015544.2.
            
            Summary: This gene encodes a transmembrane protein. A missense
            mutation in this gene result in Nanophthalmos 4 (NNO4).
            Alternatively spliced transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents a predominant
            transcript. This variant and variants 2 and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.149046.1,
                                           SRR1803616.21277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579849.6/ ENSP00000463245.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC084809.17        84344-84428
            86-161              AC084809.17        87518-87593
            162-346             AC084809.17        87666-87850
            347-478             AC084809.17        89365-89496
            479-512             AC084809.17        90482-90515
            513-628             AC084809.17        92523-92638
            629-688             AC084809.17        95668-95727
            689-1518            AC084809.17        96977-97806
            1519-1552           AY358573.1         1486-1519
            1553-4218           AC084809.17        97841-100506
FEATURES             Location/Qualifiers
     source          1..4218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4218
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="transmembrane protein 98"
                     /db_xref="GeneID:26022"
                     /db_xref="HGNC:HGNC:24529"
                     /db_xref="MIM:615949"
     exon            1..85
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..161
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..346
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..896
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /codon_start=1
                     /product="transmembrane protein 98"
                     /protein_id="NP_056359.2"
                     /db_xref="CCDS:CCDS11274.1"
                     /db_xref="GeneID:26022"
                     /db_xref="HGNC:HGNC:24529"
                     /db_xref="MIM:615949"
                     /translation="METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSK
                     PIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICH
                     TLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTT
                     ALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEG
                     FLQEQSAI"
     exon            347..478
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..512
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..628
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..688
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..4218
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1525..1530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="hexamer: AGTAAA"
     polyA_site      1552
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="major polyA site"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="hexamer: AATAAA"
     polyA_site      4218
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
ORIGIN      
        1 atgctccgct gcaggcccgc gcccgcgccc ggactttgcc atcggcgggg cagtcgcggg
       61 atgcgcccgg gagccacagc ctgaggccct caggtctctg caggtgtcgt ggaggaacct
      121 agcacctgcc atcctcttcc ccaatttgcc acttccagca gctttagccc atgaggagga
      181 tgtgaccggg actgagtcag gagccctctg gaagcatgga gactgtggtg attgttgcca
      241 taggtgtgct ggccaccatc tttctggctt cgtttgcagc cttggtgctg gtttgcaggc
      301 agcgctactg ccggccgcga gacctgctgc agcgctatga ttctaagccc attgtggacc
      361 tcattggtgc catggagacc cagtctgagc cctctgagtt agaactggac gatgtcgtta
      421 tcaccaaccc ccacattgag gccattctgg agaatgaaga ctggatcgaa gatgcctcgg
      481 gtctcatgtc ccactgcatt gccatcttga agatttgtca cactctgaca gagaagcttg
      541 ttgccatgac aatgggctct ggggccaaga tgaagacttc agccagtgtc agcgacatca
      601 ttgtggtggc caagcggatc agccccaggg tggatgatgt tgtgaagtcg atgtaccctc
      661 cgttggaccc caaactcctg gacgcacgga cgactgccct gctcctgtct gtcagtcacc
      721 tggtgctggt gacaaggaat gcctgccatc tgacgggagg cctggactgg attgaccagt
      781 ctctgtcggc tgctgaggag catttggaag tccttcgaga agcagcccta gcttctgagc
      841 cagataaagg cctcccaggc cctgaaggct tcctgcagga gcagtctgca atttagtgcc
      901 tacaggccag cagctagcca tgaaggcccc tgccgccatc cctggatggc tcagcttagc
      961 cttctacttt ttcctataga gttagttgtt ctccacggct ggagagttca gctgtgtgtg
     1021 catagtaaag caggagatcc ccgtcagttt atgcctcttt tgcagttgca aactgtggct
     1081 ggtgagtggc agtctaatac tacagttagg ggagatgcca ttcactctct gcaagaggag
     1141 tattgaaaac tggtggactg tcagctttat ttagctcacc tagtgttttc aagaaaattg
     1201 agccaccgtc taagaaatca agaggtttca cattaaaatt agaatttctg gcctctctcg
     1261 atcggtcaga atgtgtggca attctgatct gcattttcag aagaggacaa tcaattgaaa
     1321 ctaagtaggg gtttcttctt ttggcaagac ttgtactctc tcacctggcc tgtttcattt
     1381 atttgtatta tctgcctggt ccctgaggcg tctgggtctc tcctctccct tgcaggtttg
     1441 ggtttgaagc tgaggaacta caaagttgat gatttctttt ttatctttat gcctgcaatt
     1501 ttacctagct accactaggt ggatagtaaa tttatactta tgtttccctc aagtgtgtag
     1561 ttattgagtc aaattcatat gcatggtgta ttgtgggaca tacttagatg gaaggagaga
     1621 gcctaagaat cctgaggatg atttctgtgt atgcctcaaa atgagatatt taggctgggc
     1681 gcggtggctc acacctgtaa tcctcgcact ttgggaggct aaggtgggtg gattgcttga
     1741 gcccaggagt ttgagaccag cctgggcaac atggtgaaac ctcatctcta cacaaactac
     1801 aaaaattagc tgggcatggt gacacgtgcg gctgcttggt aggctgaggt gggaggatcg
     1861 cttgagccca ggaggtgaag gttgcagtga gccctgattg tgccactgca ttccagcctg
     1921 ggcgacagag tgagaccatg tctccaaaac atacatatat ataaaatata tttaaagacc
     1981 tcttggagtt caggcagaag tgaagatagc actatgaagt agtttccaca ttaacaatag
     2041 caatgacttg aacgatgtgt tccccctttc ttctgatatt aatatctgtt cattttgcaa
     2101 acattgaaag attatgaaag ctatgaccca gaatcacaat tatataattt ggatacatac
     2161 ccaaatggca taatttctgt cataagcctg taggaaaagc ttgaattctt cacttctcag
     2221 attctcagag ccagcttgct cttgggagag gggcctggta taggggctgc ccaggttcgt
     2281 agcctatgct gtcaagcatg tttggagttg cacatctgtt cccatgtcat tttctctgtc
     2341 taactgaagt cagaaaattc ctcagctgga ttctggggaa ccaggaaccc atattcccaa
     2401 atccaagatt gggacctggt ttgtctttcc atttgggcac atttcattct ttccaggaaa
     2461 acaggccact tccaacctgc acaatgtaca ccaaaccaca gaaccacagc tgggatatgg
     2521 agtcaggaga gggaagctgg agctcaactc tcatggacta aaggatggat tctggatggg
     2581 ctccagggga caccttattg gattggtggc ttccatcaac tcttaaaaac gttaagtggt
     2641 gaactttccc gtcctgtcaa gctgtgaatg gggaatgtat acaaagtcac tttgactttt
     2701 ctatttgagg cctccacagt aaacatccag agtcatccta tttttgtctt tttacctccc
     2761 tttcagaacc tgttttcgta attagactgg aaagcaattc atgctaagtt tgcaatggct
     2821 gccacagttg taagtgtccc ctgcatttta acctgcacta gagccctaag ccacagagaa
     2881 gcagttctga attggtatct caaataccat ccacctggtg tgggtctgca gggtggagag
     2941 ctttcccagc acccctgaag caatgcccaa tgtcgattac cttctctgag tcctggcaag
     3001 tcctggcaca ttggctttct ggatccctta gatgctgccc tttctgttgt gaggagaggt
     3061 tgccgaagat attggaggtg tctgctggac tgtaggattt ctgatcccac tgctgtgtag
     3121 tttttttttc tagtgctgga caagtaagaa gcctctggat aaatttggtg ttggtggctg
     3181 atggttgaag tggaagcagt ctttggggta ggaggcaatg ccactcctct aggcccttcg
     3241 ggagttggct gaagttactt cctcccttgg aaggggctgg ttagtgagtg ccagggatct
     3301 caggactgtc tctgtgccag gtgtggtttc ccaggcaaca gacacattcc taagtgccta
     3361 gttctctagc gtctgtatac atggtagtag agccttcctt ccatgtctct cttccctctg
     3421 gcctggaata ggagcattag actcaaattc tgatgaaaaa gaaattactt ggagatagag
     3481 attcaatgtg aagagaacaa gatatttgaa gtcagaatta ggtttgaatt tgggctcagt
     3541 gacttacagt gtgagcttgg tcaagttctt aacattctgg tccttagcat tctcatctgt
     3601 atggtcaagg ctattgtcat tgggttggta tgtcaacaag caaaacggta tgtgtgagct
     3661 gcccaattgt gggcctggtt ctgattagcc aatgttaaca cccttctctc cacagcttcc
     3721 cattctctga tgccgctgac ccagatggcg tcacctcagt taccatggct tggtccaagc
     3781 agtgacttct gttcatgggc tctggaattg agtggccaaa aatctggaat ccctacagta
     3841 gggagagtag ccttgtccct gccccactac aagtctgttc atatgaagac atacaaagcc
     3901 gtcgcctcta atcagtgttc aaagggtcga ttgtgcaact cacattcctc cagagaaatt
     3961 cccccagctt gtgagatctc caagagggaa cacgtattcc tggcatccaa cttcccctgg
     4021 tgctccccct gacctgcctc attccaggag ttccctctcc agagaccctg tgtgcccaca
     4081 cgagcagact tttagaaaat ggcctacagt tcaaaggccc tgcattgctt tatggccttg
     4141 gaaatgtggg gaaagtgtca gatgaagaat ttctatcctc ctcacctcct ccctgtctcc
     4201 aataaatgca taccaaga
//
