LOCUS       NM_001033504            4142 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 98 (TMEM98), transcript variant
            2, mRNA.
ACCESSION   NM_001033504
VERSION     NM_001033504.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4142)
  AUTHORS   Hassall,M.M., Javadiyan,S., Klebe,S., Awadalla,M.S., Sharma,S.,
            Qassim,A., White,M., Thomas,P.Q., Craig,J.E. and Siggs,O.M.
  TITLE     Phenotypic consequences of a nanophthalmos-associated TMEM98
            variant in human and mouse
  JOURNAL   Sci Rep 13 (1), 11017 (2023)
   PUBMED   37419942
  REMARK    GeneRIF: Phenotypic consequences of a nanophthalmos-associated
            TMEM98 variant in human and mouse.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4142)
  AUTHORS   Wu,S.G., Xu,J.Y., Lei,J., Hu,M. and Zhou,J.
  TITLE     Tumor-Suppressor Gene Transmembrane Protein 98 Promotes
            Proliferation and Inhibits Apoptosis in Ovarian Cancer
  JOURNAL   Front Biosci (Landmark Ed) 27 (7), 210 (2022)
   PUBMED   35866395
  REMARK    GeneRIF: Tumor-Suppressor Gene Transmembrane Protein 98 Promotes
            Proliferation and Inhibits Apoptosis in Ovarian Cancer.
REFERENCE   3  (bases 1 to 4142)
  AUTHORS   Koenighofer,M., Parzefall,T., Frohne,A., Frei,E., Waldstein,S.M.,
            Mitulovic,G., Schoefer,C., Frei,K. and Lucas,T.
  TITLE     A novel proline substitution (Arg201Pro) in alpha helix 8 of TMEM98
            causes autosomal dominant nanophthalmos-4, closed angle glaucoma
            and attenuated visual acuity
  JOURNAL   Exp Eye Res 205, 108497 (2021)
   PUBMED   33596443
  REMARK    GeneRIF: A novel proline substitution (Arg201Pro) in alpha helix 8
            of TMEM98 causes autosomal dominant nanophthalmos-4, closed angle
            glaucoma and attenuated visual acuity.
REFERENCE   4  (bases 1 to 4142)
  AUTHORS   Prasov,L., Guan,B., Ullah,E., Archer,S.M., Ayres,B.M.,
            Besirli,C.G., Wiinikka-Buesser,L., Comer,G.M., Del Monte,M.A.,
            Elner,S.G., Garnai,S.J., Huryn,L.A., Johnson,K., Kamat,S.S.,
            Lieu,P., Mian,S.I., Rygiel,C.A., Serpen,J.Y., Pawar,H.S.,
            Brooks,B.P., Moroi,S.E., Richards,J.E. and Hufnagel,R.B.
  TITLE     Novel TMEM98, MFRP, PRSS56 variants in a large United States high
            hyperopia and nanophthalmos cohort
  JOURNAL   Sci Rep 10 (1), 19986 (2020)
   PUBMED   33203948
  REMARK    GeneRIF: Novel TMEM98, MFRP, PRSS56 variants in a large United
            States high hyperopia and nanophthalmos cohort.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4142)
  AUTHORS   Ao,X., Li,X., Chen,Y., Zang,Z., Guo,W. and Liang,J.
  TITLE     TMEM98 mRNA promotes proliferation and invasion of gastric cells by
            directly interacting with NF90 protein
  JOURNAL   Cell Biol Int 44 (9), 1820-1830 (2020)
   PUBMED   32379372
  REMARK    GeneRIF: TMEM98 mRNA promotes proliferation and invasion of gastric
            cells by directly interacting with NF90 protein.
REFERENCE   6  (bases 1 to 4142)
  AUTHORS   Fu,W., Cheng,Y., Zhang,Y., Mo,X., Li,T., Liu,Y., Wang,P., Pan,W.,
            Chen,Y., Xue,Y., Ma,D., Zhang,Y. and Han,W.
  TITLE     The Secreted Form of Transmembrane Protein 98 Promotes the
            Differentiation of T Helper 1 Cells
  JOURNAL   J Interferon Cytokine Res 35 (9), 720-733 (2015)
   PUBMED   25946230
REFERENCE   7  (bases 1 to 4142)
  AUTHORS   Awadalla,M.S., Burdon,K.P., Souzeau,E., Landers,J., Hewitt,A.W.,
            Sharma,S. and Craig,J.E.
  TITLE     Mutation in TMEM98 in a large white kindred with autosomal dominant
            nanophthalmos linked to 17p12-q12
  JOURNAL   JAMA Ophthalmol 132 (8), 970-977 (2014)
   PUBMED   24852644
  REMARK    GeneRIF: A novel gene associated with nanophthalmos, TMEM98 most
            likely represents the cause of the disease.
REFERENCE   8  (bases 1 to 4142)
  AUTHORS   Ng,K.T., Lo,C.M., Guo,D.Y., Qi,X., Li,C.X., Geng,W., Liu,X.B.,
            Ling,C.C., Ma,Y.Y., Yeung,W.H., Shao,Y., Poon,R.T., Fan,S.T. and
            Man,K.
  TITLE     Identification of transmembrane protein 98 as a novel
            chemoresistance-conferring gene in hepatocellular carcinoma
  JOURNAL   Mol Cancer Ther 13 (5), 1285-1297 (2014)
   PUBMED   24608572
  REMARK    GeneRIF: we identified a panel of novel common
            chemoresistance-associated genes and demonstrated that TMEM98 is a
            chemoresistance-conferring gene in hepatocellular carcinoma.
REFERENCE   9  (bases 1 to 4142)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 4142)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084809.17 and AY358573.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001033504.1.
            
            Summary: This gene encodes a transmembrane protein. A missense
            mutation in this gene result in Nanophthalmos 4 (NNO4).
            Alternatively spliced transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2990598.1,
                                           SRR14038193.2212822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC084809.17        84344-84428
            86-270              AC084809.17        87666-87850
            271-402             AC084809.17        89365-89496
            403-436             AC084809.17        90482-90515
            437-552             AC084809.17        92523-92638
            553-612             AC084809.17        95668-95727
            613-1440            AC084809.17        96977-97804
            1441-1476           AY358573.1         1484-1519
            1477-4142           AC084809.17        97841-100506
FEATURES             Location/Qualifiers
     source          1..4142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4142
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="transmembrane protein 98"
                     /db_xref="GeneID:26022"
                     /db_xref="HGNC:HGNC:24529"
                     /db_xref="MIM:615949"
     exon            1..85
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..270
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..820
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /codon_start=1
                     /product="transmembrane protein 98"
                     /protein_id="NP_001028676.1"
                     /db_xref="CCDS:CCDS11274.1"
                     /db_xref="GeneID:26022"
                     /db_xref="HGNC:HGNC:24529"
                     /db_xref="MIM:615949"
                     /translation="METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSK
                     PIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICH
                     TLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTT
                     ALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEG
                     FLQEQSAI"
     exon            271..402
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..436
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..552
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..612
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..4142
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="hexamer: AGTAAA"
     polyA_site      1476
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="major polyA site"
     regulatory      4125..4130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
                     /note="hexamer: AATAAA"
     polyA_site      4142
                     /gene="TMEM98"
                     /gene_synonym="TADA1"
ORIGIN      
        1 atgctccgct gcaggcccgc gcccgcgccc ggactttgcc atcggcgggg cagtcgcggg
       61 atgcgcccgg gagccacagc ctgagcttta gcccatgagg aggatgtgac cgggactgag
      121 tcaggagccc tctggaagca tggagactgt ggtgattgtt gccataggtg tgctggccac
      181 catctttctg gcttcgtttg cagccttggt gctggtttgc aggcagcgct actgccggcc
      241 gcgagacctg ctgcagcgct atgattctaa gcccattgtg gacctcattg gtgccatgga
      301 gacccagtct gagccctctg agttagaact ggacgatgtc gttatcacca acccccacat
      361 tgaggccatt ctggagaatg aagactggat cgaagatgcc tcgggtctca tgtcccactg
      421 cattgccatc ttgaagattt gtcacactct gacagagaag cttgttgcca tgacaatggg
      481 ctctggggcc aagatgaaga cttcagccag tgtcagcgac atcattgtgg tggccaagcg
      541 gatcagcccc agggtggatg atgttgtgaa gtcgatgtac cctccgttgg accccaaact
      601 cctggacgca cggacgactg ccctgctcct gtctgtcagt cacctggtgc tggtgacaag
      661 gaatgcctgc catctgacgg gaggcctgga ctggattgac cagtctctgt cggctgctga
      721 ggagcatttg gaagtccttc gagaagcagc cctagcttct gagccagata aaggcctccc
      781 aggccctgaa ggcttcctgc aggagcagtc tgcaatttag tgcctacagg ccagcagcta
      841 gccatgaagg cccctgccgc catccctgga tggctcagct tagccttcta ctttttccta
      901 tagagttagt tgttctccac ggctggagag ttcagctgtg tgtgcatagt aaagcaggag
      961 atccccgtca gtttatgcct cttttgcagt tgcaaactgt ggctggtgag tggcagtcta
     1021 atactacagt taggggagat gccattcact ctctgcaaga ggagtattga aaactggtgg
     1081 actgtcagct ttatttagct cacctagtgt tttcaagaaa attgagccac cgtctaagaa
     1141 atcaagaggt ttcacattaa aattagaatt tctggcctct ctcgatcggt cagaatgtgt
     1201 ggcaattctg atctgcattt tcagaagagg acaatcaatt gaaactaagt aggggtttct
     1261 tcttttggca agacttgtac tctctcacct ggcctgtttc atttatttgt attatctgcc
     1321 tggtccctga ggcgtctggg tctctcctct cccttgcagg tttgggtttg aagctgagga
     1381 actacaaagt tgatgatttc ttttttatct ttatgcctgc aattttacct agctaccact
     1441 aggtggatag taaatttata cttatgtttc cctcaagtgt gtagttattg agtcaaattc
     1501 atatgcatgg tgtattgtgg gacatactta gatggaagga gagagcctaa gaatcctgag
     1561 gatgatttct gtgtatgcct caaaatgaga tatttaggct gggcgcggtg gctcacacct
     1621 gtaatcctcg cactttggga ggctaaggtg ggtggattgc ttgagcccag gagtttgaga
     1681 ccagcctggg caacatggtg aaacctcatc tctacacaaa ctacaaaaat tagctgggca
     1741 tggtgacacg tgcggctgct tggtaggctg aggtgggagg atcgcttgag cccaggaggt
     1801 gaaggttgca gtgagccctg attgtgccac tgcattccag cctgggcgac agagtgagac
     1861 catgtctcca aaacatacat atatataaaa tatatttaaa gacctcttgg agttcaggca
     1921 gaagtgaaga tagcactatg aagtagtttc cacattaaca atagcaatga cttgaacgat
     1981 gtgttccccc tttcttctga tattaatatc tgttcatttt gcaaacattg aaagattatg
     2041 aaagctatga cccagaatca caattatata atttggatac atacccaaat ggcataattt
     2101 ctgtcataag cctgtaggaa aagcttgaat tcttcacttc tcagattctc agagccagct
     2161 tgctcttggg agaggggcct ggtatagggg ctgcccaggt tcgtagccta tgctgtcaag
     2221 catgtttgga gttgcacatc tgttcccatg tcattttctc tgtctaactg aagtcagaaa
     2281 attcctcagc tggattctgg ggaaccagga acccatattc ccaaatccaa gattgggacc
     2341 tggtttgtct ttccatttgg gcacatttca ttctttccag gaaaacaggc cacttccaac
     2401 ctgcacaatg tacaccaaac cacagaacca cagctgggat atggagtcag gagagggaag
     2461 ctggagctca actctcatgg actaaaggat ggattctgga tgggctccag gggacacctt
     2521 attggattgg tggcttccat caactcttaa aaacgttaag tggtgaactt tcccgtcctg
     2581 tcaagctgtg aatggggaat gtatacaaag tcactttgac ttttctattt gaggcctcca
     2641 cagtaaacat ccagagtcat cctatttttg tctttttacc tccctttcag aacctgtttt
     2701 cgtaattaga ctggaaagca attcatgcta agtttgcaat ggctgccaca gttgtaagtg
     2761 tcccctgcat tttaacctgc actagagccc taagccacag agaagcagtt ctgaattggt
     2821 atctcaaata ccatccacct ggtgtgggtc tgcagggtgg agagctttcc cagcacccct
     2881 gaagcaatgc ccaatgtcga ttaccttctc tgagtcctgg caagtcctgg cacattggct
     2941 ttctggatcc cttagatgct gccctttctg ttgtgaggag aggttgccga agatattgga
     3001 ggtgtctgct ggactgtagg atttctgatc ccactgctgt gtagtttttt tttctagtgc
     3061 tggacaagta agaagcctct ggataaattt ggtgttggtg gctgatggtt gaagtggaag
     3121 cagtctttgg ggtaggaggc aatgccactc ctctaggccc ttcgggagtt ggctgaagtt
     3181 acttcctccc ttggaagggg ctggttagtg agtgccaggg atctcaggac tgtctctgtg
     3241 ccaggtgtgg tttcccaggc aacagacaca ttcctaagtg cctagttctc tagcgtctgt
     3301 atacatggta gtagagcctt ccttccatgt ctctcttccc tctggcctgg aataggagca
     3361 ttagactcaa attctgatga aaaagaaatt acttggagat agagattcaa tgtgaagaga
     3421 acaagatatt tgaagtcaga attaggtttg aatttgggct cagtgactta cagtgtgagc
     3481 ttggtcaagt tcttaacatt ctggtcctta gcattctcat ctgtatggtc aaggctattg
     3541 tcattgggtt ggtatgtcaa caagcaaaac ggtatgtgtg agctgcccaa ttgtgggcct
     3601 ggttctgatt agccaatgtt aacacccttc tctccacagc ttcccattct ctgatgccgc
     3661 tgacccagat ggcgtcacct cagttaccat ggcttggtcc aagcagtgac ttctgttcat
     3721 gggctctgga attgagtggc caaaaatctg gaatccctac agtagggaga gtagccttgt
     3781 ccctgcccca ctacaagtct gttcatatga agacatacaa agccgtcgcc tctaatcagt
     3841 gttcaaaggg tcgattgtgc aactcacatt cctccagaga aattccccca gcttgtgaga
     3901 tctccaagag ggaacacgta ttcctggcat ccaacttccc ctggtgctcc ccctgacctg
     3961 cctcattcca ggagttccct ctccagagac cctgtgtgcc cacacgagca gacttttaga
     4021 aaatggccta cagttcaaag gccctgcatt gctttatggc cttggaaatg tggggaaagt
     4081 gtcagatgaa gaatttctat cctcctcacc tcctccctgt ctccaataaa tgcataccaa
     4141 ga
//
