LOCUS       NM_153229               2693 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 92 (TMEM92), transcript variant
            1, mRNA.
ACCESSION   NM_153229
VERSION     NM_153229.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2693)
  AUTHORS   Lin,M.Z., Teng,L.L., Sun,X.L., Zhang,L.P., Chen,F. and Yu,L.J.
  TITLE     Transmembrane protein 92 performs a tumor-promoting function in
            breast carcinoma by contributing to the cell growth, invasion,
            migration and epithelial-mesenchymal transition
  JOURNAL   Tissue Cell 67, 101415 (2020)
   PUBMED   32835947
  REMARK    GeneRIF: Transmembrane protein 92 performs a tumor-promoting
            function in breast carcinoma by contributing to the cell growth,
            invasion, migration and epithelial-mesenchymal transition.
REFERENCE   2  (bases 1 to 2693)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2693)
  AUTHORS   Li,J., Wang,J., Chen,Y., Yang,L. and Chen,S.
  TITLE     A prognostic 4-gene expression signature for squamous cell lung
            carcinoma
  JOURNAL   J Cell Physiol 232 (12), 3702-3713 (2017)
   PUBMED   28160492
REFERENCE   4  (bases 1 to 2693)
  AUTHORS   Alazami,A.M., Patel,N., Shamseldin,H.E., Anazi,S., Al-Dosari,M.S.,
            Alzahrani,F., Hijazi,H., Alshammari,M., Aldahmesh,M.A., Salih,M.A.,
            Faqeih,E., Alhashem,A., Bashiri,F.A., Al-Owain,M., Kentab,A.Y.,
            Sogaty,S., Al Tala,S., Temsah,M.H., Tulbah,M., Aljelaify,R.F.,
            Alshahwan,S.A., Seidahmed,M.Z., Alhadid,A.A., Aldhalaan,H.,
            AlQallaf,F., Kurdi,W., Alfadhel,M., Babay,Z., Alsogheer,M.,
            Kaya,N., Al-Hassnan,Z.N., Abdel-Salam,G.M., Al-Sannaa,N., Al
            Mutairi,F., El Khashab,H.Y., Bohlega,S., Jia,X., Nguyen,H.C.,
            Hammami,R., Adly,N., Mohamed,J.Y., Abdulwahab,F., Ibrahim,N.,
            Naim,E.A., Al-Younes,B., Meyer,B.F., Hashem,M., Shaheen,R.,
            Xiong,Y., Abouelhoda,M., Aldeeri,A.A., Monies,D.M. and
            Alkuraya,F.S.
  TITLE     Accelerating novel candidate gene discovery in neurogenetic
            disorders via whole-exome sequencing of prescreened multiplex
            consanguineous families
  JOURNAL   Cell Rep 10 (2), 148-161 (2015)
   PUBMED   25558065
REFERENCE   5  (bases 1 to 2693)
  AUTHORS   Listing,H., Mardin,W.A., Wohlfromm,S., Mees,S.T. and Haier,J.
  TITLE     MiR-23a/-24-induced gene silencing results in mesothelial cell
            integration of pancreatic cancer
  JOURNAL   Br J Cancer 112 (1), 131-139 (2015)
   PUBMED   25422915
REFERENCE   6  (bases 1 to 2693)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     Unexpected diversity in Shisa-like proteins suggests the importance
            of their roles as transmembrane adaptors
  JOURNAL   Cell Signal 24 (3), 758-769 (2012)
   PUBMED   22120523
REFERENCE   7  (bases 1 to 2693)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2693)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB072318.1, AK090637.1, AC015909.14 and AW293202.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_153229.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: Sequence Note: This RefSeq record was created from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. The genomic
            coordinates used for the transcript record were based on transcript
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090637.1, SRR5189664.13718.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000507382.2/ ENSP00000425144.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DB072318.1         40-45
            7-304               AK090637.1         1-298
            305-305             AC015909.14        90666-90666         c
            306-842             AK090637.1         300-836
            843-2266            AC015909.14        88507-89930         c
            2267-2691           AK090637.1         2261-2685
            2692-2693           AW293202.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..2693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..2693
                     /gene="TMEM92"
                     /note="transmembrane protein 92"
                     /db_xref="GeneID:162461"
                     /db_xref="HGNC:HGNC:26579"
                     /db_xref="MIM:619604"
     exon            1..105
                     /gene="TMEM92"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..516
                     /gene="TMEM92"
                     /codon_start=1
                     /product="transmembrane protein 92 precursor"
                     /protein_id="NP_694961.2"
                     /db_xref="CCDS:CCDS11562.1"
                     /db_xref="GeneID:162461"
                     /db_xref="HGNC:HGNC:26579"
                     /db_xref="MIM:619604"
                     /translation="MSQAWVPGLAPTLLFSLLAGPQKIAAKCGLILACPKGFKCCGDS
                     CCQENELFPGPVRIFVIIFLVILSVFCICGLAKCFCRNCREPEPDSPVDCRGPLELPS
                     IIPPERVRVSLSAPPPPYSEVILKPSLGPTPTEPPPPYSFRPEEYTGDQRGIDNPAF"
     exon            106..131
                     /gene="TMEM92"
                     /inference="alignment:Splign:2.1.0"
     exon            132..206
                     /gene="TMEM92"
                     /inference="alignment:Splign:2.1.0"
     exon            207..402
                     /gene="TMEM92"
                     /inference="alignment:Splign:2.1.0"
     exon            403..2693
                     /gene="TMEM92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM92"
                     /note="hexamer: GATAAA"
     polyA_site      1001
                     /gene="TMEM92"
                     /note="major polyA site"
     polyA_site      1246
                     /gene="TMEM92"
     regulatory      2670..2675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM92"
                     /note="hexamer: AATAAA"
     polyA_site      2693
                     /gene="TMEM92"
ORIGIN      
        1 ctctacacag gaaagctcag tggcccccaa gccaggatgt cccaagcttg ggtccccggc
       61 ctcgcgccca ccttgctgtt cagcctgctg gctggccccc aaaagattgc agccaaatgt
      121 ggtctcatcc ttgcctgccc caaaggattc aaatgctgtg gtgacagctg ctgccaggag
      181 aacgagctct tccctggccc cgtgaggatc ttcgtcatca tcttcctggt catcctgtcc
      241 gtcttttgca tctgtggcct ggctaagtgc ttctgtcgca actgcagaga gccggagcca
      301 gacagcccag tggattgccg ggggcccctg gaactgccct ccatcatccc cccagagagg
      361 gtcagagtat ccctttctgc gcccccaccc ccctacagtg aggtgattct gaagcccagc
      421 ctgggcccaa ctcccacaga gccaccccct ccctacagct tcaggcctga agaatatacc
      481 ggggatcaga ggggcattga caacccggcc ttctgagtca cctcctgcct ggaatcttgc
      541 catcagcaac ctcctcccca gtgcctcctg gatcaagcta gagactgctg gcaccccagg
      601 aatgtccctg cccatcctgc cgtgtctctg ttcattcttg gatttaactt attacttttt
      661 ctgcttctgt ttccacccca gctgcctctc ttgtcctgag ggttaggctg gagtgacagt
      721 ttccgcccac cccccagccc aagaaagagg ctgccggaaa gaaaatgctg accattggag
      781 gtgcccaaca gtagaatggg ctactgtgag gggtagtaag agccccattt ctggaggtat
      841 gcaaatcttg actggacagc cagctctgag attttatcag ggcacttcta tacctgtggg
      901 acattggact ggatgagccc tgagccagct tccactccta cctgaataga gaactcactg
      961 cacccaccca caacacatga taaacacatg tcctcactga atgttactga ttgcggctga
     1021 gggcctgcct ctggctgtgt ggggaggtgg gtggagaggt gagcccaggc actgctgagg
     1081 ggtgcggtga tggggtcgct gcgccgcaat cccaccactg atgagccacc tgggaggtct
     1141 gggaggacag tccatccatg ggccgccctc ggagagaggc ttgttctaga tgtattggct
     1201 gtctgttttt tgatgtctct gtgtgccaaa cagcctggaa atggggtacg cgtgtccctt
     1261 gtgtgggttt cccaatccct tccgcccaag gctttcctgg gacacatgga gcccagctct
     1321 ctggctgtct taccatgaga agttggtaag ttggctgtga gggggttgga tccaggaagc
     1381 agccctggga cagcccattc tgctgttgat agcaggaaac cacctgctgg gagacaatgg
     1441 gggtggggaa aagcccagga gagcagtggg tggggctggg catccgtgga gtggggcttt
     1501 aggagacctt gaacggcccc accctggaat ctcctacagg aaggtgagga ggtggcaggt
     1561 tccacccttc tctaccagcc ccgctcgctc gtgggagtta accccctagg ggagaagagt
     1621 cttcactggg gttcgaccca tgggggcctg gcatagtcat gcagaatggg gcgggacaat
     1681 gccaatgcct tgggactcag acagggctga gtgcctccac cctgattttt gcctctgcac
     1741 tgcgccccca cagcccactc aatgccagcc tccttctcca ggcagagagc cccatgtcaa
     1801 tgctggccaa agctctcagg aggattggag gtagaactgg ccctggtatg ccaacagggg
     1861 tgcctctttt agtgctctcc caataatgct catcctgggg gcatcaggac gcaggcaggt
     1921 ggcagagctg ggggcagctt gatggcacag gcagccccaa agatgccagg aacagggact
     1981 gtccgggtgt gggttcccag tgagataggg ccctggaagg agtgcagcag ttactgacaa
     2041 tatagtgcca gggttggcca taggagaatg agcccaagcg taagtggaag tttcccttta
     2101 ctttcaggga ttggtcaggg gtggcagaaa acatgtgggt tctttgtgta gatgtggcta
     2161 gttccaatta gagaagtcct gcagctgatg ttgccctcac cgtgatagca ggaggatgtt
     2221 gagaaatggg cttgggagac ctggaggaga agttaccctc ggcccagacg ttgccttcct
     2281 ttcatcacag ggcctttaac tcctcctagg gagtagcaga gtggccctag ggaaagtggc
     2341 catcctgaaa cctagtgttg ctgtgacctg gtgacagaaa tggaaacctc tgtggctctt
     2401 ctggtcatcc ttggtgggag tgggaatggt gtcacctttc tagagggcca tctggcacca
     2461 tgtaatcacg ccacagatct ttacgaagct cctgctatgt aggaaacact atgcctggca
     2521 ctgggtatcc attaaaatgt aaaatgcacg tgacctggca attccacttc tagaaatgag
     2581 ccttcagaag tgctcataca aaagagctca ataagtatca tgcactaatt cattgtgcca
     2641 ccagagctcc ctatgcagcc ttttaaaaga ataaatagga tctgtagcac caa
//
