LOCUS       NM_001098821            1080 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 91 (TMEM91), transcript variant
            1, mRNA.
ACCESSION   NM_001098821
VERSION     NM_001098821.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Sallman Almen,M., Bringeland,N., Fredriksson,R. and Schioth,H.B.
  TITLE     The dispanins: a novel gene family of ancient origin that contains
            14 human members
  JOURNAL   PLoS One 7 (2), e31961 (2012)
   PUBMED   22363774
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA673235.1, AK130820.1 and AI214374.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098821.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279865.2531.1, AK130820.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392002.7/ ENSP00000375859.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               DA673235.1         1-341
            342-866             AK130820.1         651-1175
            867-1080            AI214374.1         12-225              c
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1080
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /note="transmembrane protein 91"
                     /db_xref="GeneID:641649"
                     /db_xref="HGNC:HGNC:32393"
                     /db_xref="MIM:618294"
     exon            1..322
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..561
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..870
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /note="isoform a is encoded by transcript variant 1;
                     interferon induced transmembrane protein domain containing
                     6; dispanin subfamily C member 3"
                     /codon_start=1
                     /product="transmembrane protein 91 isoform a"
                     /protein_id="NP_001092291.1"
                     /db_xref="CCDS:CCDS42571.1"
                     /db_xref="GeneID:641649"
                     /db_xref="HGNC:HGNC:32393"
                     /db_xref="MIM:618294"
                     /translation="MDSPSLRELQQPLLEGTECETPAQKPGRHELGSPLREIAFAESL
                     RGLQFLSPPLPSVSAGLGEPRPPDVEDMSSSDSDSDWDGGSRLSPFLPHDHLGLAVFS
                     MLCCFWPVGIAAFCLAQKTNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALV
                     TLAAYLASRDPP"
     exon            562..711
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..1080
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /note="hexamer: ATTAAA"
     polyA_site      1080
                     /gene="TMEM91"
                     /gene_synonym="DSPC3; IFITMD6; SynDIG3"
                     /note="major polyA site"
ORIGIN      
        1 agagcttggg cctgggctca cgaggaaggg gctgcagttc tccaaggatt cccgcctgct
       61 cccagacccc cgggagtcgt aggaacccgt tcctggacgc tgacgtcggc tttcagggat
      121 ccctcgccgg acgccgcgga gggacagagc ctgggaagcc gtcgccccgc cccgtccccg
      181 cccccgcgcg cagcgggccc ggggcgctga gacccgcgta gagcaaagcg caaggtccca
      241 gcgccccttg gatcctcggt ggcagggtcc gggcaagtgt cattgcgagg gttcaggaag
      301 ccccggcctg tgatcgtgag cggaaacccc tcctggagtt tccccaaagc catggacagc
      361 cctagtcttc gtgagcttca acagcctctg ctggagggca cagaatgtga gacccctgcc
      421 cagaagcctg gcaggcatga gctggggtcc cccttaagag agatagcctt tgccgagtcc
      481 ctgaggggtt tgcagttcct gtcaccgcct cttccctccg tgagcgctgg cctgggggaa
      541 ccaaggcccc ctgatgttga ggacatgtca tccagtgaca gtgactcgga ctgggatgga
      601 ggcagccgtc tttcaccatt tctaccccac gaccacctcg gcttggctgt cttctccatg
      661 ctgtgttgtt tctggcccgt tggcatcgct gccttctgtc tagcccagaa gaccaacaag
      721 gcttgggcca agggggacat ccagggggca ggggccgcct cccgccgtgc cttcctgctg
      781 ggggtcctcg ccgtcgggct gggcgtgtgc acgtatgcgg ctgccctggt gaccctggct
      841 gcctaccttg cctcccgaga cccgccctag ttgcccctac agccctcact gtgaaccctg
      901 aggccggcag cccagcaaat ctgtgggcag agagtggaga atcttggtgg atgaggctgc
      961 ggcggcggca ggagcatcta gaaacgggag cgagctggac tggaaccctt ccccttcctg
     1021 gccaccgctc ttcgggcggc agcaacctga gattaaacac cagacaccct tgcagccaaa
//
