LOCUS       NM_001288565            1994 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 3,
            mRNA.
ACCESSION   NM_001288565
VERSION     NM_001288565.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Baek,S., Chang,J.W., Yoo,S.M., Choo,J., Jung,S., Nah,J. and
            Jung,Y.K.
  TITLE     TMEM9 activates Rab9-dependent alternative autophagy through
            interaction with Beclin1
  JOURNAL   Cell Mol Life Sci 81 (1), 322 (2024)
   PUBMED   39078420
  REMARK    GeneRIF: TMEM9 activates Rab9-dependent alternative autophagy
            through interaction with Beclin1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Wang,Z., Zhao,P., Tian,K., Qiao,Z., Dong,H., Li,J., Guan,Z., Su,H.,
            Song,Y. and Ma,X.
  TITLE     TMEM9 promotes lung adenocarcinoma progression via activating the
            MEK/ERK/STAT3 pathway to induce VEGF expression
  JOURNAL   Cell Death Dis 15 (4), 295 (2024)
   PUBMED   38664392
  REMARK    GeneRIF: TMEM9 promotes lung adenocarcinoma progression via
            activating the MEK/ERK/STAT3 pathway to induce VEGF expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Zhang,S., Lee,S.H., Nie,L., Huang,Y., Zou,G., Jung,Y.S., Jun,S.,
            Zhang,J., Lien,E.M., Chen,J. and Park,J.I.
  TITLE     Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is
            required for mammary tumorigenesis
  JOURNAL   Cancer Commun (Lond) 43 (1), 159-163 (2023)
   PUBMED   36336962
  REMARK    GeneRIF: Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling
            integrity is required for mammary tumorigenesis.
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   He,J., Bu,Y., Li,X., Zhang,X. and Ma,L.
  TITLE     Tumor-Promoting Properties of TMEM9A in Breast Cancer Progression
            via Activating the Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Biol Pharm Bull 46 (1), 74-85 (2023)
   PUBMED   36596527
  REMARK    GeneRIF: Tumor-Promoting Properties of TMEM9A in Breast Cancer
            Progression via Activating the Wnt/beta-Catenin Signaling Pathway.
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Wei,W., Jiang,F., Liu,X.C. and Su,Q.
  TITLE     TMEM9 mediates IL-6 and IL-1beta secretion and is modulated by the
            Wnt pathway
  JOURNAL   Int Immunopharmacol 63, 253-260 (2018)
   PUBMED   30119033
  REMARK    GeneRIF: TMEM9 plays a significant role in TNF-alpha-enhanced
            cytokines (IL-6 and IL-1beta) secretion in LX-2 cells and that the
            canonical Wnt/beta-catenin signaling pathway is involved in the
            induction of these cytokine expressions.
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and
            Ye,Q.F.
  TITLE     Effects of TMEM9 gene on cell progression in hepatocellular
            carcinoma by RNA interference
  JOURNAL   Oncol Rep 36 (1), 299-305 (2016)
   PUBMED   27220462
  REMARK    GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest.
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B.
  TITLE     The lysosomal transmembrane protein 9B regulates the activity of
            inflammatory signaling pathways
  JOURNAL   J Biol Chem 283 (31), 21487-21494 (2008)
   PUBMED   18541524
  REMARK    GeneRIF: TMEM9B is a key component of inflammatory signaling
            pathways and suggest that endosomal or lysosomal compartments
            regulate these pathways
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Kveine,M., Tenstad,E., Dosen,G., Funderud,S. and Rian,E.
  TITLE     Characterization of the novel human transmembrane protein 9 (TMEM9)
            that localizes to lysosomes and late endosomes
  JOURNAL   Biochem Biophys Res Commun 297 (4), 912-917 (2002)
   PUBMED   12359240
  REMARK    GeneRIF: phylogenetically conserved, widely expressed transmembrane
            protein with a potential, but unknown function in intracellular
            transport that localizes to lysosomes and late endosomes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA364005.1, DA160051.1, CX751563.1, AK091726.1, AK054883.1 and
            AI201238.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001288565.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-7 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1055858.1, AK091726.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367330.6/ ENSP00000356299.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DA364005.1         82-111
            31-37               DA160051.1         5-11
            38-462              CX751563.1         1-425
            463-916             AK091726.1         429-882
            917-1944            AK054883.1         468-1495
            1945-1994           AI201238.1         27-76               c
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1994
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /note="transmembrane protein 9"
                     /db_xref="GeneID:252839"
                     /db_xref="HGNC:HGNC:18823"
                     /db_xref="MIM:616877"
     exon            1..617
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..1103
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; dermal papilla-derived protein 4; v-ATPase
                     assembly regulator TMEM9; proton-transporting V-type
                     ATPase complex assembly regulator TMEM9"
                     /codon_start=1
                     /product="proton-transporting V-type ATPase complex
                     assembly regulator TMEM9 isoform a precursor"
                     /protein_id="NP_001275494.1"
                     /db_xref="CCDS:CCDS1408.1"
                     /db_xref="GeneID:252839"
                     /db_xref="HGNC:HGNC:18823"
                     /db_xref="MIM:616877"
                     /translation="MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIY
                     NQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGAL
                     LLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGA
                     QQRWKLQVQEQRKTVFDRHKMLS"
     exon            618..709
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /inference="alignment:Splign:2.1.0"
     exon            710..818
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /inference="alignment:Splign:2.1.0"
     exon            819..950
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1994
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /note="hexamer: ATTAAA"
     polyA_site      1994
                     /gene="TMEM9"
                     /gene_synonym="DERM4; TMEM9A"
                     /note="major polyA site"
ORIGIN      
        1 gggtcttttg cggctgcagc gggcttgtag gttcgtggac gcggcattgg gggaggggac
       61 gggggtcgcg gggctattgg gggtcccagt ccggcttaag acctctgggc gtggtgggca
      121 ccggccttcg ccgtcggagc aggggtccca gactcgcacc caaaagttcc cgtcgggccc
      181 gagcggggag gagctgcggg gcgggcagag gcggagatgg cggagggcgg tgggacgtga
      241 tgcgcgggtc agagccgggc cttgagaagg aactggaggc ccctggcagc ggtgtcccct
      301 cgaggacccc tctgccgggc tcaccaggtg gctggcggag agccggagag ttgggcggga
      361 gggaagcagg gtttggcgac caggtttagc aggccttgga atcctggagc ccagccccca
      421 accccattcc cacttggccg gatggttaag ggcctagcgt gctggctgcg gtgtggccac
      481 cttccccttc tccgactccg tatctctttt tccaggtgtc cggctttgct ggcccagcaa
      541 gcctgataag catgaagctc ttatctttgg tggctgtggt cgggtgtttg ctggtgcccc
      601 cagctgaagc caacaagagt tctgaagata tccggtgcaa atgcatctgt ccaccttata
      661 gaaacatcag tgggcacatt tacaaccaga atgtatccca gaaggactgc aactgcctgc
      721 acgtggtgga gcccatgcca gtgcctggcc atgacgtgga ggcctactgc ctgctgtgcg
      781 agtgcaggta cgaggagcgc agcaccacca ccatcaaggt catcattgtc atctacctgt
      841 ccgtggtggg tgccctgttg ctctacatgg ccttcctgat gctggtggac cctctgatcc
      901 gaaagccgga tgcatatact gagcaactgc acaatgagga ggagaatgag gatgctcgct
      961 ctatggcagc agctgctgca tccctcgggg gaccccgagc aaacacagtc ctggagcgtg
     1021 tggaaggtgc ccagcagcgg tggaagctgc aggtgcagga gcagcggaag acagtcttcg
     1081 atcggcacaa gatgctcagc tagatgggct ggtgtggttg ggtcaaggcc ccaacaccat
     1141 ggctgccagc ttccaggctg gacaaagcag ggggctactt ctcccttccc tcggttccag
     1201 tcttcccttt aaaagcctgt ggcatttttc ctccttctcc ctaactttag aaatgttgta
     1261 cttggctatt ttgattaggg aagagggatg tggtctctga tctctgttgt cttcttgggt
     1321 ctttggggtt gaagggaggg ggaaggcagg ccagaaggga atggagacat tcgaggcggc
     1381 ctcaggagtg gatgcgatct gtctctcctg gctccactct tgccgccttc cagctctgag
     1441 tcttgggaat gttgttaccc ttggaagata aagctgggtc ttcaggaact cagtgtctgg
     1501 gaggaaagca tggcccagca ttcagcatgt gttcctttct gcagtggttc ttatcaccac
     1561 ctccctccca gccccagcgc ctcagcccca gccccagctc cagccctgag gacagctctg
     1621 atgggagagc tgggccccct gagcccactg ggtcttcagg gtgcactgga agctggtgtt
     1681 cgctgtcccc tgtgcacttc tcgcactggg gcatggagtg cccatgcata ctctgctgcc
     1741 ggtcccctca cctgcacttg aggggtctgg gcagtccctc ctctccccag tgtccacagt
     1801 cactgagcca gacggtcggt tggaacatga gactcgaggc tgagcgtgga tctgaacacc
     1861 acagcccctg tacttgggtt gcctcttgtc cctgaacttc gttgtaccag tgcatggaga
     1921 gaaaattttg tcctcttgtc ttagagttgt gtgtaaatca aggaagccat cattaaattg
     1981 ttttatttct ctca
//
