LOCUS       NM_001042590           14670 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 8B (TMEM8B), transcript variant
            1, mRNA.
ACCESSION   NM_001042590
VERSION     NM_001042590.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14670)
  AUTHORS   Liu,L., Wang,R., Zhang,Z. and Wang,X.
  TITLE     Nasopharyngeal carcinoma-associated gene 6 inhibits cell viability,
            migration, invasion and induces apoptosis in osteosarcoma cells by
            inactivating the Wnt/beta-catenin signaling pathway
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300077
  REMARK    GeneRIF: Nasopharyngeal carcinomaassociated gene 6 inhibits cell
            viability, migration, invasion and induces apoptosis in
            osteosarcoma cells by inactivating the Wnt/betacatenin signaling
            pathway.
REFERENCE   2  (bases 1 to 14670)
  AUTHORS   Wang,Y.T., Sun,X.Y., Wang,H., Huang,T.T., Wang,Y. and Yang,M.X.
  TITLE     Effects of NGX6 expression on proliferation and invasion of
            nasopharyngeal carcinoma cells and survival of patients
  JOURNAL   Eur Rev Med Pharmacol Sci 21 (23), 5378-5385 (2017)
   PUBMED   29243779
  REMARK    GeneRIF: NGX6 is lowly expressed in nasopharyngeal carcinoma, and
            it can inhibit the proliferation and invasion of nasopharyngeal
            carcinoma cells.
REFERENCE   3  (bases 1 to 14670)
  AUTHORS   He,S., Zhong,Y., Shuai,C., Gao,D., Wei,P., Li,G. and Peng,S.
  TITLE     Tumor suppressor NGX6 inhibits the growth and metastasis of
            multiple cancers
  JOURNAL   Tumour Biol 37 (5), 5751-5760 (2016)
   PUBMED   26880583
  REMARK    GeneRIF: NGX6 possesses various biological functions, such as
            regulating protein expression of related genes, involving cell
            signal transduction pathways, negatively controlling cell cycle
            progression, inhibiting angiogenesis, and increasing the
            sensitivity of patients to anti-cancer drugs. Review.
            Review article
REFERENCE   4  (bases 1 to 14670)
  AUTHORS   Mezzavilla,M., Ulivi,S., Bianca,M.L., Carlino,D., Gasparini,P. and
            Robino,A.
  TITLE     Analysis of functional variants reveals new candidate genes
            associated with alexithymia
  JOURNAL   Psychiatry Res 227 (2-3), 363-365 (2015)
   PUBMED   25882097
  REMARK    GeneRIF: From our analysis, variants in the genes ABCB4, TP53AIP1,
            ARHGAP32 and TMEM88B were identified linked to the alexithymia
            phenotype.
REFERENCE   5  (bases 1 to 14670)
  AUTHORS   Xiao,J., Zhou,Y. and Zhu,W.
  TITLE     Association of ultrasonographic features with NGX6 expression and
            prognosis in invasive ductal breast carcinoma
  JOURNAL   Int J Clin Exp Pathol 8 (6), 6458-6465 (2015)
   PUBMED   26261522
  REMARK    GeneRIF: Ultrasonographic features are associated with NGX6
            expression in invasive ductal breast carcinoma. NGX6 is involved in
            the invasion and metastasis activity of IDBC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 14670)
  AUTHORS   Ma,J., Zhou,J., Fan,S., Wang,L., Li,X., Yan,Q., Zhou,M., Liu,H.,
            Zhang,Q., Zhou,H., Gan,K., Li,Z., Peng,C., Xiong,W., Tan,C.,
            Shen,S., Yang,J., Li,J. and Li,G.
  TITLE     Role of a novel EGF-like domain-containing gene NGX6 in cell
            adhesion modulation in nasopharyngeal carcinoma cells
  JOURNAL   Carcinogenesis 26 (2), 281-291 (2005)
   PUBMED   15498789
  REMARK    GeneRIF: NGX6 plays a role in cell adhesion modulation in NPC
            cells.
REFERENCE   7  (bases 1 to 14670)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   8  (bases 1 to 14670)
  AUTHORS   Zhang,X.M., Wang,X.Y., Sheng,S.R., Wang,J.R. and Li,J.
  TITLE     Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and
            colorectal cancer
  JOURNAL   World J Gastroenterol 9 (8), 1729-1733 (2003)
   PUBMED   12918109
  REMARK    GeneRIF: down-regulation may be closely associated with
            tumorigenesis and metastasis of colorectal carcinoma; may not
            contribute to development and progression of gastric carcinoma.
REFERENCE   9  (bases 1 to 14670)
  AUTHORS   Ma,J., Li,J., Zhou,J., Li,X.L., Tang,K., Zhou,M., Yang,J.B.,
            Yan,Q., Shen,S.R., Hu,G.X. and Li,G.Y.
  TITLE     Profiling genes differentially expressed in NGX6 overexpressed
            nasopharyngeal carcinoma cells by cDNA array
  JOURNAL   J Cancer Res Clin Oncol 128 (12), 683-690 (2002)
   PUBMED   12474055
REFERENCE   10 (bases 1 to 14670)
  AUTHORS   Li,J., Tan,C., Xiang,Q., Zhang,X., Ma,J., Wang,J.R., Yang,J.,
            Li,W., Shen,S.R., Liang,S. and Li,G.
  TITLE     Proteomic detection of changes in protein synthesis induced by NGX6
            transfected in human nasopharyngeal carcinoma cells
  JOURNAL   J Protein Chem 20 (3), 265-271 (2001)
   PUBMED   11565907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133410.32.
            
            On May 17, 2019 this sequence version replaced NM_001042590.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082765.1, SRR1660803.204650.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643932.2/ ENSP00000493496.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-728               AL133410.32        149109-149836
            729-918             AL133410.32        154342-154531
            919-1126            AL133410.32        154892-155099
            1127-1260           AL133410.32        161015-161148
            1261-1529           AL133410.32        161407-161675
            1530-1855           AL133410.32        162273-162598
            1856-1949           AL133410.32        165856-165949
            1950-2073           AL133410.32        166139-166262
            2074-2216           AL133410.32        166350-166492
            2217-2395           AL133410.32        166698-166876
            2396-2542           AL133410.32        172708-172854
            2543-2659           AL133410.32        173022-173138
            2660-14670          AL133410.32        173386-185396
FEATURES             Location/Qualifiers
     source          1..14670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..14670
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /note="transmembrane protein 8B"
                     /db_xref="GeneID:51754"
                     /db_xref="HGNC:HGNC:21427"
                     /db_xref="MIM:616888"
     exon            1..728
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2995
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /note="isoform c is encoded by transcript variant 1;
                     nasopharyngeal carcinoma related protein; nasopharyngeal
                     carcinoma expressed 6; nasopharyngeal carcinoma-associated
                     gene 6 protein"
                     /codon_start=1
                     /product="transmembrane protein 8B isoform c"
                     /protein_id="NP_001036055.2"
                     /db_xref="CCDS:CCDS94406.1"
                     /db_xref="GeneID:51754"
                     /db_xref="HGNC:HGNC:21427"
                     /db_xref="MIM:616888"
                     /translation="MAQPLSRPLVLSQSPPWPPAPPSPRFPHRPQPLPGSPSRTPFQS
                     LPLAWPPSRPRPSFHPLSQIPAQALSQPHSQCLLKALAQPRPLLQSPSQPFLPSHSLP
                     LFKPQCPAQPNPLSQPLPSSLCLPKSLPLVPPISHTLPLSQPRLKSGFQLPPALLLLL
                     LFSVLGPGAGGLFLTDYSTCSPRKLSPFRSFASTELFHFHVPEDTFLAVWNLIIFKEQ
                     GGTFGDHCPDQSVTVYFRSGAPPVINPLHTHFPGDTAVPGVFSLTLSWTLPNRTSGIF
                     NVSSPLPGDWFLAAHLPQAHGHISVKGLQDECQYLLQPQLIVRRLLDVAVLVPGRPSE
                     QTLSPHNRSALYKVFVPSFTYRVSAQLVCVGGRGVSACPLSLRLRPKAPPLHNSSSVA
                     CGGASGCQLELALPPWGHWVYVRVETSSRGPGRTIRFQLCVRLQECPQPGLLRALVPG
                     AAMNMPQSLGNQPLPPEPPSLGTPAEGPGTTSPPEHCWPVRPTLRNELDTFSVHFYIF
                     FGPSVALPPERPAVFAMRLLPVLDSGGVLSLELQLNASSVRQENVTVFGCLTHEVPLS
                     LGDAAVTCSKESLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRN
                     ATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYG
                     FQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCI
                     MDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNL
                     LGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVLLYAFVETRD
                     NYFYIHSIWHMLIAGSVGFLLPPRAKTDHGVPSGARARGCGYQLCINEQEELGLVGPG
                     GATVSSICAS"
     exon            729..918
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1126
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1260
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1529
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1855
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1949
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2073
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2216
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2395
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2542
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2659
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..14670
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3584
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /note="major polyA site"
     regulatory      5372..5377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /note="hexamer: AGTAAA"
     polyA_site      5395
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
     regulatory      14583..14588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /note="hexamer: AATAAA"
     polyA_site      14606
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
     regulatory      14632..14637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
                     /note="hexamer: AATAAA"
     polyA_site      14670
                     /gene="TMEM8B"
                     /gene_synonym="C9orf127; FP588; LINC00950; NAG-5; NAG5;
                     NGX6; NGX6a"
ORIGIN      
        1 acgccgacgt caagtcgagg ccgccgccgc ggggcctggt tatcgccggt tcagcgcagc
       61 ccggagtcgc ccaggcctga actcctaccc aggtccccgg cccccgcccc gggcccgcga
      121 ggacaccgga ggccaccccc cgggggtggg gagcggagcc gcgggccagc tctgcgagcg
      181 ccccgcgctg gcctgtccgg ccccgccccc gccccgggcc atggcccagc ccttgtcccg
      241 gcccctcgtc ctatcccaat ccccgccttg gcccccagcc ccgccctcgc cccgcttccc
      301 acatcggccc cagcccctgc ctgggtcccc atccaggacc cccttccagt ctctgcccct
      361 ggcctggccc ccatcccggc ctcggccctc gttccacccc ctgtcacaaa tcccagccca
      421 ggccctgtcc cagccccatt cccagtgttt gcttaaggcc ctggctcaac cccgtccctt
      481 gctgcagtcc ccatcacagc ccttccttcc atcccactcc ctgcccttgt tcaagcccca
      541 gtgtccagcc cagcccaacc cattatctca gcctttgccc tcatctctgt gtttacccaa
      601 gtctctccct ctagtccccc ctatctctca tactctgccc ctctcccagc ctagactcaa
      661 gtctgggttt cagctgccgc cagccctatt gctgctgttg ctgttctctg tccttggccc
      721 aggggctgga ggccttttcc tgactgatta ctccacctgc tcaccccgca agctgagtcc
      781 tttccgctcc tttgccagca ccgagctctt ccacttccat gttcctgagg acacattcct
      841 ggctgtttgg aacctcatca tcttcaagga gcaaggggga acttttgggg accactgccc
      901 agaccaaagt gtgactgtgt atttccggtc cggggcaccc cctgtcatca atcccctgca
      961 tacacacttc ccaggggaca cagctgtgcc tggggttttc tcactgaccc tcagctggac
     1021 actgcccaac cgcacctcag gcatctttaa cgtcagcagc cccttacctg gggactggtt
     1081 cttggctgcc caccttcccc aggcccacgg ccacatctct gtcaagggtc tccaggatga
     1141 gtgtcagtac ctccttcagc cgcagctgat tgtccggcgt ttgctggacg tcgctgtgct
     1201 ggttcctggc cggccctcag agcaaaccct ctccccacac aatcgctcag ccctgtacaa
     1261 ggtctttgtg cccagcttca cttacagggt ttcagcacag ctggtgtgtg tggggggccg
     1321 tggggtatct gcctgccccc tgtcactgcg tctgcgtccc aaagccccac ccctgcacaa
     1381 ctcaagctct gtggcctgtg gaggtgcctc aggatgccag ctggagctgg cactgccccc
     1441 ctgggggcac tgggtctacg tgcgtgtgga aacatcatcc cggggccctg gtaggaccat
     1501 ccgcttccag ctgtgtgtgc ggttgcaaga gtgcccacag cccggcctgc tccgagccct
     1561 ggtccctgga gctgccatga acatgcccca gtccctgggc aaccagccac tgcccccaga
     1621 accgccatcc cttggaaccc ctgcggaggg gcctgggacc acgtccccac ccgagcactg
     1681 ctggccagtg cgcccgactc tgcgcaacga gctggacacc ttctctgtcc acttctacat
     1741 cttctttggc ccaagtgtgg cccttccccc tgagcgccca gccgtgttcg ccatgaggct
     1801 gttgccagtg ctggacagtg gaggcgtcct cagcctggag ctccagctca atgcgagctc
     1861 cgtgcgccag gaaaacgtga cggtgtttgg atgcttgact cacgaggtgc ccttgagcct
     1921 gggggatgca gcagtgacct gttccaaaga gtccctggcc ggcttcctcc tctctgtcag
     1981 tgccaccacc agggttgcca ggctgcgaat cccattcccg cagacgggga cctggttcct
     2041 ggccctccgc tccctgtgcg gggtggggcc tcggttcgtg cggtgccgca acgcgacggc
     2101 cgaggtgcgg atgcgcacct tcctgtcccc atgcgtggac gactgcgggc cctacggcca
     2161 gtgcaagctg ctgcgcacac acaattatct gtacgcagcc tgcgagtgca aggccgggtg
     2221 gagaggctgg ggctgcaccg acagtgcaga tgcgctcacc tatggattcc agctgctgtc
     2281 cacactcctg ctctgcctga gcaacctcat gtttctgcca cctgtggtcc tggccattcg
     2341 gagtcgatat gtgctggaag ctgcagtcta caccttcacc atgttcttct ccacgttcta
     2401 tcatgcctgt gaccagccag gcatcgtggt tttctgcatc atggactacg atgtgctgca
     2461 gttctgtgat ttcctgggct ccttaatgtc cgtgtgggtc actgtcattg ccatggctcg
     2521 tttacagccc gtggtcaagc aggtgctgta tttgctggga gctatgctgc tgtccatggc
     2581 tctgcagctt gaccgacatg gactctggaa cctgcttgga cccagtctct tcgccctggg
     2641 gatcttggcc acagcctgga cagtacgcag cgtccgccgc cggcactgct acccacccac
     2701 gtggcgccgc tggcttttct acttgtgccc tggcagcctt attgcaggca gtgccgtcct
     2761 gctttatgct tttgtggaga cccgggacaa ctacttctac attcacagca tttggcatat
     2821 gctcattgcg ggcagtgtgg gcttcctgct gccccctcgt gccaagactg accacggggt
     2881 cccatctgga gcccgggccc ggggctgtgg ttaccagcta tgcatcaacg agcaggagga
     2941 gctgggcctc gtgggcccag gaggggccac tgtcagcagc atctgtgcca gctgagaggg
     3001 gctttgggcc tggccctgag gggatatgaa tgcttcctag agttctttct gggggtgtgg
     3061 agccctctta gaaggagaca ggctgtattt cttgaggaca tggagtcttt ctcaaggaca
     3121 caaaactctt ccagggacct ggagcccttc ccaggacatg gagaacttcc tgagggcctg
     3181 gagtccccct gcatcatgga gtccttctta aggactggag cctatgcagg cacagagtcc
     3241 ctcaggacca aggagtccct cctgcaggtg tggagccttt cctgggatgc agagccttcc
     3301 caagacatgg attccttccc agggagacaa agccctgtca ggagcacagc atctttccag
     3361 aggaggtgga gtctatcttg gggaaaccaa atttccagat tttcccagag gctcagcaac
     3421 tctggcctca ggcttccttc ccagaggcag cgtctgggct gtgctgtgct gtggaggagg
     3481 gattgcagga tggatggagc tgggactggg gctgtctggg tggctggtat cctcgtttga
     3541 tacaggtgga gtctgtgtgt ctccagtgat tgattggttc agaatggttc tgtgatgcct
     3601 tttttccccc tggggtcagg ggtgtgggga agtggggaaa gagggcccct cagggaatca
     3661 gcagggctga tgggagctac tgccggaggc ttttgtcaca ccctgtacac agtctgatcc
     3721 cgctcatctg ggccctgcat tcatttctaa acagtttcta atgcctattc cccaattcct
     3781 attgagcccg atttgcagta tctgaggggt gtgtgtgtgt gtgtgtgtgt ttatgtatgt
     3841 atacgtatgc tgagatgatt taaatcagtg agacagactt tccttatgat gcccacaccc
     3901 aacacagaag gaagccgagg tcccaggaaa ttggaatagc aggtacacgt ctcaggtgtg
     3961 caagaaatat cacaagaatg taacttctgt tttgagcccc catttttcct gagtgccaga
     4021 aaagatcatt tgtccatttg ggattccttc tctttccatg agggtcatag ctgagttctg
     4081 agggtcttac ataatgccaa gaagttggga gagcattctc actgatcacc agtgtccata
     4141 cttcatccat ccccgggatt tccatcattc catctggtcc ccagtcagag gtccagacag
     4201 ttcatctggg atgcagagag atttcttgtt cccatttgca ttactctctc agtcctaagg
     4261 ttctctctgc cacttctggg ccatatgtgg agacccgtaa agttgtctaa ggccttggct
     4321 atgcagacac accttgaagc tgtttctgct ctgggttttg acagacaagg catgagttgc
     4381 tgcatctgtt aaaactgcaa atctatcttg gcctggggtg tggagctcag ggactcttcc
     4441 ttttgggacc ctctgtgtca gtattctcac tacatcctct cctcctctct cttctttccc
     4501 cctttcgtta atattggagg tgaggaagcc ttacttaatg ttttctcctg aatctttttt
     4561 tttttgagac ggagttttgc tcttgttgcc caggctggaa tgcaatggtg cgatctcagc
     4621 tcactgcaac ctctgcctcc cgggttcaag tgattctcct gtctcagcct cccgagtagc
     4681 tgggattaga ggtgtgcacc accaagccca gctaattttt gtatttttag tagagatggg
     4741 gtttctccat gttggtcagg ctgctctcaa actcccggcc tcaggtgatc cacccgcctc
     4801 ggcctcccaa agtgctggga ttacagttgt gagccaccgc gcctggcctc tcctgaatct
     4861 tttatctatg ccttaagcct tttctgttcc cttcaggacc taggcttttg aaacccaaaa
     4921 gccaggaaaa catgcctttg ttatctgctt tctgcaatca cgtctcttcc atggggcact
     4981 gagcagagaa tggtgtggcc aagtgagtag tgagaagcag tgaggaggtg tgagctaggt
     5041 gtctgttccc attttagaaa atactgttcc tacatcagaa ataccacatt aagacgtata
     5101 gagccaggtc actgggatgc ttgaacccaa atagctggga ttctggacag agtcagcaga
     5161 gtacagaagg ctctgaagtg ggagacggag ctggggtgca tccctcccag tgaggagggg
     5221 tcatgagggg cgtctgggaa gagggacatt tgaactagga ttagctgagt tgccatgatg
     5281 ctaagataat gggagagtgt tctttgtggt caccagtgtc cacatggcat cccttccctg
     5341 agattttcat cactccctgt ggtcttcagt cagtaaagct cttagaacac ttgtatagtg
     5401 cctagtctgg tatgtgatgt ggtccaatat atgttagctt aaggtcacca cgtgtttgga
     5461 catggagagg gaacagcaag ggggaatgca gaggcaggaa agactgatat ttactccggg
     5521 cactgaatag ttcagtgtgc ctgggccagt gcatgtgcgc atgcttttgt gtgtggagtg
     5581 gggtggtgga ggtaagcagc caatgatatg attagataga taagtggagg ttgggtcttt
     5641 attctatggg aaatgaggag ccattggaga gattaagcag gagaggaaca tcagattggg
     5701 gttttgatgg ctggggcaga ggatggactt tgggagacct tggaggacaa agtgcagtga
     5761 ccacagctat tggaacattt gaaagagaaa tggtgaagcc ttcttaaagc aatatcggtg
     5821 gaaaggaggg gaccaattta agagctgtta ggagtgaact ctttaggact tggtgactga
     5881 ttgggtgtgt ggggtggtga ggtatgagag agcctaggat gatggtgata ttctgatttg
     5941 gggatggtgg tgccattccc tgagatggtg acaccacttt gggtgggggg aagatgagct
     6001 ccactttgga cagtttgagg tgcatgtggg attcccggag ggaagggggc cagcaatatg
     6061 acagtgctgg acgtagccgc tgaaccaggc ctgtctccag gctcccaaaa tgggaatcct
     6121 tggttgtctc ctgacttgtc tcagtggggg agatcccaag attcaaacag cccttccttg
     6181 ccttgaatac agggctgtgg ctggcagata ttgctgtacc cttgcatgta tctgtacata
     6241 cgactggact gagacccctg agcacttgca gctgcctggg gcatgttcag cagcacaggg
     6301 ctcaatcccc acagggtgat gttctgaaag cttctgagtg acaattcagt cccgcaaacc
     6361 ttccataggg aacatgctgt gggagctaca gagatgagcc agacccgact gaatcctgcc
     6421 ctgaaggagc tcacacggtg gtgaagtgtc atgaatgcaa gttagatggg acaagtgtga
     6481 agtggaagat cctgacaaag tgctgtagga tgtaaagaga gcgatctcaa agtgcaatgg
     6541 gaaaggatgc atgagagaga tggtgtctaa cctagctttg aaaactagtc ccagctatta
     6601 tcagagaaca gcacaataca tacaagggtg cgaagacatg ggggtgcggc agtacagata
     6661 atgtagcgag gggacagcca tgtgaagggc atagtggaaa atcaggctga agaagcaggt
     6721 gggggcagat tctggagggc cttgaggatt caactgaaga atttggactt aatggtaatg
     6781 ggagctgtca aaagtccttg atcagaagag tgatgaatca atccaggttt gaccaaagta
     6841 acagaaccac tatgagtgat aaaaagatta gacctttaca gtcatgggag cagttggaga
     6901 aatctgtgca aaactgttac ttctgcattt ggtgttgggc ctgaagctgt tacagctcag
     6961 ctgggccagc agttaggaaa gaaggctgag tgtgaagtga ggggcagtaa gggcacacta
     7021 gaatccagaa ggacaaactg gaacctgtgc ctggctctta tgccttcaat ctcagtgact
     7081 ggtgacctgc aggagaagct gtcacctttg ccatggagct tgcacttggc ccagcactca
     7141 gcacagtgga aggaggtgac ctggtgggga ctggacaggc tgtgctaatg gggagccagc
     7201 agatgagcaa catgggggtg ccctcactgt gtctggtgct gttccatttt ttttctttct
     7261 ttcttttttt tttttttgag acggagtctc actctgttgc ccaggctgga gtgcagtggc
     7321 gccatctcag ctcactgcag cctccacctc ccaagttcaa gcgatcctcc ctagtagctg
     7381 ggattacagg tgcaccacca cacctggcta attttttgtg tttttagtag aggcagggtt
     7441 tcatcacatt tcccgggctg gtctcgaact cctggcctca ggtgatcctc ccacctcggt
     7501 ctcccaaagt gctgggatta caggtatgag ccaccacacc tggcccactt ttgccttcca
     7561 aatcacatgc aaacttctct gtggccaacc ctaacccaca ccctctaacc tagtttggtt
     7621 gactcagtat aaagctacca cacgtgagct aaccagagct ttcttgggac gattaacttg
     7681 gcagcagccc gtgaaggata gatggtcagg ataaagaaag ccaaacctcc catagctctt
     7741 gggttgacac tgtcagctgg tgtggtagtc attaggccat tcacaaatct ctctgtccct
     7801 ctcgtttgcc atccagacac acgatagtgt gcttttcccc cttaacaata ggtgtggtcc
     7861 tgtgccttcc tgttgccatt gtgttggcca ctgaaatgta ggtggaggca acacagccac
     7921 ttctgagtag aagctttaag agtcagtgta ggctttgtta ctttcccttt tctttttgtc
     7981 atggtgacca gcagtgttcc caatggtagc tgttttgtca tcctgagtcc cagaggggtg
     8041 aagaccatga tgcggagcag aagccccacc agcctctggt ggacctgcat caggagcaag
     8101 aaacaaacct taatggcttt aagcctctca aggtttgagg tcatgaccac agcacaacct
     8161 agcctatgcc agctgacagg ggcagagggc agcagtagca gtgggatgct ttcctggaga
     8221 gcaaacctcc tctcagcaga gttaggacgg cagctttcac ctctgcattc ctcaggctgt
     8281 aaatgatggg gttcagcgag ggcgtcacaa ccccgtagaa caatgcgaca gtcttatcca
     8341 cgttgggatc cttggccttg ggtttgaagt acatgaagga gattgtccca taaaaaacca
     8401 ccaccactgt gcggtgggct gagcaggtgg agaaggcttt gcaccggcct gcagcagagg
     8461 gtaccctaag gatggcagac aggatgaaaa ggtaagacag gcagatgagc aagagggggg
     8521 ccagtgtcag gacggctgtg gccaccatta atgccagcgc attgagggag atgtccccac
     8581 aggccagttt tagcactgcc aagatctcat agaagtagtt gatgacgtgg ccacagaagg
     8641 ggaggtgcca gacaaggatg gactgtagca gtgagttggc aaagcctgtc ccccagctca
     8701 gcgctgccat ctgcatgcag gtctgcccac tcatgagctc tgggtaccta agcggctggc
     8761 agatagccac ataacggtca tatgccatca cagccagcag caggcactcc gttgatccca
     8821 gcgccagggt caggtacatc tgcagggcac agccagggaa ggaaatggtc ctctgggttt
     8881 ccaggaaatt gtctagcatg agaggcacaa aggaggaggt gccgcagatg tccatgaggg
     8941 agaggttgct gagaagtaca tggggttgtg caggcgaggg tgcagcacgt tcagccctat
     9001 gaggagggcg ttccccaaca cattcacgga gtagatgccc aggcagaaca caaacaggac
     9061 cacctccagg ttacagtgct cgtgtagccc catcaggacg tattccgtca cagctgtctg
     9121 gtttgcccac ttcatctcat tctctctcct tttccatctg gaccacccag ctttttggaa
     9181 aaagctccaa ctggcctggg agcccagtga cctgatgtct gagctgcagc aggtcagcct
     9241 ccctctctgg aatttagttt caccatctgt ataatgaggg agttggactt cagatctgca
     9301 atctggcctt ctcagcgctg cagttctgtg gacgtcactg aggggaggat ggggcacatt
     9361 ctagtcccct aggctcctct ctgctctccc caggatgggg tcagaggaga cagcagagaa
     9421 agattcatgt ttaaaatgat cgtttggaat ccaaagtgtt tttggtcatt aacaggaagc
     9481 atcttttcta cattacggtt tcatgtgacc aaattatggc catagtattt cagatttatt
     9541 catccactaa gtatttatta agtacctatt ctgtgctagg tatcaggtgc tggggctata
     9601 gcagtaagga aagtaagtgg acaaaaggat tccacacctg tcacaggcgc tgccccactc
     9661 cctgagtcag gtgagatgag ctccggaagg caggtgggta atggatgatg ctcacctagt
     9721 gttccttggg ccatgaagat caaatatttc agccccatag gatgtgtaag cttgatttct
     9781 ggtcatctct ccttaaggaa tcatggacca ttcattattt tgtttaaaag gacacataag
     9841 aacgtacatg tctcaataga gttactggtc acaggactga actgtggtca tgaaagccaa
     9901 gcaacttact ttctggcctc catattgctt tgtaggagaa atgatactga caatgatgtc
     9961 acacgaggag ggaagccagg cacgaatctg gtggaggtgc ggtcagttgt gaccagcttt
    10021 gcaaagggag cggtgggcga ggctgtggtc tctcccaggt gacctccatc gccatgcaga
    10081 gctgctctca cttctcctcg ggaaaggcca gcgtcaggta ttcctaggag gaagcccagg
    10141 tgtgtccaga gaacagtagt cttgttagaa ctggaaaaat gtcttatggc caggtggccc
    10201 ctggtctgaa ggaaaaatag gagctgagtg tgaactttta tcactcagaa gatataatcc
    10261 acctctcccc tcctgccctt cgctcctggg ttggttgtga ggacagtgct ttgtgacagc
    10321 agtggagccc tgtctgtcct tccgggctag atttcttctt tctcttattc ctcctgtttc
    10381 gttgtatcca cgatttgtcg agttgcaggg ctcacccttt cctgaagaaa ccatctcttt
    10441 tcccagctcc gcacctttgt ccgagatgga ggcgtgtcct cccgcccatc cccagtgggg
    10501 ggtgttctgc ccattctcca gagcccagca ctgctccatc tcttttcctc cctctccttc
    10561 cccttgctgt tacctgctgc cttcttgtgc tcccactgcc cttggccatc cctctgtgtc
    10621 attgtgcgct gtggtgcacc tgtcttctct actacacctt aagagcagga ctctgcctcc
    10681 ttcctaccag cacctcatgc agcaagtgct gccaatagca ggcacccagc agatagcgaa
    10741 tgcacgactc caaaacccag ctttgcctcc tggctgtagt tcagactagc tgtgtgacac
    10801 tgaccaagac acttgacctc tctcagactc agcttcctcc ttgaagactg ggatgctatg
    10861 tagctcagag gaaacataca cctgaaggtg ctgccccggg gggtgcaatg acctgttact
    10921 gaggctggat ggaggatggc atccatcatc agctacaggt gcctcctcta tctacaggtt
    10981 cctgctccat ctatactagc cacctcctgg acaagggctc cagtgtcctc catgacacca
    11041 gctttctcca gagcctgtgc aggatttcct tcctctaccc tgaatcaggg tgattcttaa
    11101 aggacagttt caggaacata taggggcact tgggtaatct tggtcagtaa ctgaccttta
    11161 actatcatcc atgtgaacat ctacagttag ggattttctt ggtgatgttt ggcaaaaagt
    11221 aaagaattcc ccaagtgtga agcctcattc attcacttat tcaacaaata gttattgagc
    11281 acctactatg tgttaggccc tgggccaggt gctgggaata cagcagagac agacctggct
    11341 cctgccctca tggagtttgc agtcattcat tcactcactc ggtgactttg gacacctccc
    11401 cctcctctct ccaggcttta gatctctgag attctctctg agtctgggat gtaaagacaa
    11461 agtaaaacct gaaatctgga aagcagaact ataagagctt tgtttctgat gggggtgttg
    11521 ctgcagacag aactatgtcc atctcaaatt ctgacactgg acacaggcgt gggggtttca
    11581 agcaggccaa gggtgggaaa ccacctgact gcatttttct ttatcactca cacctctaac
    11641 agtaagacca agtgggcctg gcggaggcat ttgagggctt ttgtgtgtgc aggctctggc
    11701 ccgtcctcct gccttgcctc caccgcatcc ctcatgcaca cctgctgcag cctcatcaga
    11761 ccactccctg tcttttggac aaagcctgtg tgctccagtc ccatccctct tcttgggcag
    11821 tttcttcagg ctggagtgcc tttcttttct actcatcctt caaggctcag ttcacacacc
    11881 actgtctcgt gcagccttct ctcagatggc ttcataaaac tgaccacccg gacaacaaga
    11941 tggtcacaca gctattagtg gaggttaagt tcattctgcc ttcattatag ttcatttttc
    12001 ttgtatatct ctctctgact agactatgag ctattgcagt gaaagggctg tgtccttcat
    12061 cactgtcacc ctccagtgac ccgcagccag gaggtgtcag tgattgccat ttgagttgaa
    12121 ctatttattg acatccagtg ttgttctgcc aaaaatcctg atcctaggca tggtggtttg
    12181 cacctgtggt cacagctact cagaaggctg aggtgggagg agtacttgag cccaggagtt
    12241 cgaggttaca gtgaactatg attgtgccac tgcactccag cctgggcaac agagtgaggc
    12301 cctttctcta aaaaagcaaa cgaagaacgc tgaacccaag gtcttgcctc aaaatcaatt
    12361 cccccttccc cctccaacac atacaccgca acagaatgat acagctattg tgattgctag
    12421 gagaagggct ttgggcagtg ccagtctcct gtttgcagta acacctgctc tttctgaaga
    12481 gctacatcag taacatggtg ggttttcctc acaacttaaa agtctgatcg taacacattc
    12541 atggaaacta gaaccagcac acgaaaccat tggcttgtgg ccctaaagaa ataactctgt
    12601 gtccagaaaa tgccatgtta ccaggttgcc tacagctttg cctgtaacat gggcacaggc
    12661 tgggacatca gatagaagct ggttcccatg gtggctgggt tgggatgggc taagttatgt
    12721 tgcagtaacg tacaacctca tcattttagt ggctagcatg acgaagtttt atttctcatg
    12781 ctacatgtct actgtggctt tcccggtggc tcagggttct cagagcccct ggcagatgga
    12841 ggctccaccc tgtgggacgt caccagttgt tatggctggg gaaggacaca ctggaggctc
    12901 ttgctgctct gagccacagg agacatttgt catatctgca cacagcccac tggccctgcg
    12961 gcatcctacc acctgcccag aaggaggaga accagaatta ctgctgagca gctcctctgc
    13021 atgtgggtgc aatggcgtct tatgactctc agaaagctac tctagtggcc atctaccagt
    13081 gtcacgcagt gtcacgctcg gtcatggcct ggaagatcag agtcacagag ggataggacc
    13141 tggagtgtct ctgaaaatag ctgcctggtt tcactccccg gttttacgcc tcttgagaag
    13201 cagagtgatg cctagaatga gccctggact gggagggcac gtcccaggtt tgaatcgggg
    13261 cctttgttcc ttttctgctg tatgactttg gtcagatttc tccttctgag aagtggagcc
    13321 aattaagcga tctccgatat gctgtaatct ctgaaacatt tcctcatatg tttctagcaa
    13381 cttccaacct gaggtctgat agacccaggg ttactttgca agctaactga catatcagtc
    13441 tcattgtctg gtaaatctaa ttttaaccac ttaatactta ttttaggctt cacaaattat
    13501 tttaaaagaa aagatagggg cataacaaga agaaagcttc ggttacaatt tccccgaaat
    13561 gcctggatct gggattcctg cttcctggct gtgtggcaga gaagatgagg atggccctgg
    13621 agtcagacgg gactagggtc caagccccag ctcttccact tgttaacaat gttctcagcc
    13681 tcagcttcct tacctatacc atggagacgg cagtatttcc ttgtgggctt gttttaagga
    13741 tccagtgaca ggaagcatgc gaagctctta gaacagagcc tggcactggt aaatagtcag
    13801 tgagcagtag atgatattat taccatcctg tccctatccc tgtcccccag caaatatttt
    13861 ggcttttaaa tgttttaaat gatttcttga gaataagcaa tgggtcagat gaaatctcct
    13921 tacctctcac ctactggcca tggcctaaat gtctgtaggg agctggagcc aggtgagggg
    13981 agctgtggtt tgggaagtgc cgagttcatt atgagcaagt gcacggtgct gggatgggct
    14041 aggttccccg cacctcgccc tgccactgcc tcccaggacc tgcctcttgc tcccctgcca
    14101 catagacagt ctgcttgccc cctgctttca gggacctcat ggtccctgcc caatttaaag
    14161 ttcaaactct gcaactgcac aaagttgcag gcttggcagc tgtgggacct gggcttcaga
    14221 gactccaggt tcctcggcct gccccaggag ggccctgctg aggtgaagtg ggcataggag
    14281 agagagtgga cagagaatct gaatactggg tcacgttgca gttctgcgcc ttggatgcca
    14341 taggctccag gcccataagc ccggcttcac taggcctggg tgtctgggtt gtgaaatggg
    14401 gtgtctcctt ccaggattgc cgtaaggacc tggattcatc aaagcttaaa gtaaattgct
    14461 ttgtaaggtg ggagacaccg agtacaggcg agggacttta ttaggtcagg gatttaatca
    14521 ggcatctgtt tttacagatt tctttattcc tgttccctcc cctccccttc ctgtcctttc
    14581 acaataaaga ataacaactt gacacagctt agagactaaa aatcatcctt caataaagca
    14641 gcagaagttg caaagtttcc tatgatgcta
//
