LOCUS       NM_203411                874 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 88 (TMEM88), transcript variant
            1, mRNA.
ACCESSION   NM_203411 XM_043273
VERSION     NM_203411.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 874)
  AUTHORS   Sun,Z., Ning,Q., Li,H., Hu,T., Tang,L., Wen,Q. and Shen,L.
  TITLE     Transmembrane protein 88 inhibits transforming growth
            factor-beta1-induced-extracellular matrix accumulation and
            epithelial-mesenchymal transition program in human pleural
            mesothelial cells through modulating TGF-beta1/Smad pathway
  JOURNAL   J Recept Signal Transduct Res 42 (1), 60-66 (2022)
   PUBMED   33167758
  REMARK    GeneRIF: Transmembrane protein 88 inhibits transforming growth
            factor-beta1-induced-extracellular matrix accumulation and
            epithelial-mesenchymal transition program in human pleural
            mesothelial cells through modulating TGF-beta1/Smad pathway.
REFERENCE   2  (bases 1 to 874)
  AUTHORS   Zhao,X., Li,G., Chong,T., Xue,L., Luo,Q., Tang,X., Zhai,X., Chen,J.
            and Zhang,X.
  TITLE     TMEM88 exhibits an antiproliferative and anti-invasive effect in
            bladder cancer by downregulating Wnt/beta-catenin signaling
  JOURNAL   J Biochem Mol Toxicol 35 (8), e22835 (2021)
   PUBMED   34057764
  REMARK    GeneRIF: TMEM88 exhibits an antiproliferative and anti-invasive
            effect in bladder cancer by downregulating Wnt/beta-catenin
            signaling.
REFERENCE   3  (bases 1 to 874)
  AUTHORS   Geng,Q., Chen,X. and Chen,N.
  TITLE     Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid
            cancer through restriction of Wnt/beta-catenin signaling
  JOURNAL   Exp Cell Res 395 (2), 112193 (2020)
   PUBMED   32710906
  REMARK    GeneRIF: Transmembrane protein 88 exerts a tumor-inhibitory role in
            thyroid cancer through restriction of Wnt/beta-catenin signaling.
REFERENCE   4  (bases 1 to 874)
  AUTHORS   Xu,T., Pan,L., Li,L., Hu,S., Zhou,H., Yang,C., Yang,J., Li,H.,
            Liu,Y., Meng,X. and Li,J.
  TITLE     MicroRNA-708 modulates Hepatic Stellate Cells activation and
            enhances extracellular matrix accumulation via direct targeting
            TMEM88
  JOURNAL   J Cell Mol Med 24 (13), 7127-7140 (2020)
   PUBMED   32463570
  REMARK    GeneRIF: MicroRNA-708 modulates Hepatic Stellate Cells activation
            and enhances extracellular matrix accumulation via direct targeting
            TMEM88.
REFERENCE   5  (bases 1 to 874)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 874)
  AUTHORS   Yu,X., Zhang,X., Zhang,Y., Jiang,G., Mao,X. and Jin,F.
  TITLE     Cytosolic TMEM88 promotes triple-negative breast cancer by
            interacting with Dvl
  JOURNAL   Oncotarget 6 (28), 25034-25045 (2015)
   PUBMED   26325443
  REMARK    GeneRIF: TMEM88 stimulated triple negative breast cancer cell
            invasion by interacting with DVL1.
REFERENCE   7  (bases 1 to 874)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   8  (bases 1 to 874)
  AUTHORS   Palpant,N.J., Pabon,L., Rabinowitz,J.S., Hadland,B.K.,
            Stoick-Cooper,C.L., Paige,S.L., Bernstein,I.D., Moon,R.T. and
            Murry,C.E.
  TITLE     Transmembrane protein 88: a Wnt regulatory protein that specifies
            cardiomyocyte development
  JOURNAL   Development 140 (18), 3799-3808 (2013)
   PUBMED   23924634
  REMARK    GeneRIF: TMEM88 is crucial for heart development and acts
            downstream of GATA factors in the pre-cardiac mesoderm to specify
            lineage commitment of cardiomyocyte.
REFERENCE   9  (bases 1 to 874)
  AUTHORS   Jang,J.S., Jeon,H.S., Sun,Z., Aubry,M.C., Tang,H., Park,C.H.,
            Rakhshan,F., Schultz,D.A., Kolbert,C.P., Lupu,R., Park,J.Y.,
            Harris,C.C., Yang,P. and Jen,J.
  TITLE     Increased miR-708 expression in NSCLC and its association with poor
            survival in lung adenocarcinoma from never smokers
  JOURNAL   Clin Cancer Res 18 (13), 3658-3667 (2012)
   PUBMED   22573352
  REMARK    GeneRIF: miRNA-708 acts as an oncogene contributing to tumor growth
            and disease progression by directly downregulating TMEM88
REFERENCE   10 (bases 1 to 874)
  AUTHORS   Lee,H.J., Finkelstein,D., Li,X., Wu,D., Shi,D.L. and Zheng,J.J.
  TITLE     Identification of transmembrane protein 88 (TMEM88) as a
            dishevelled-binding protein
  JOURNAL   J Biol Chem 285 (53), 41549-41556 (2010)
   PUBMED   21044957
  REMARK    GeneRIF: TMEM88 associates with Dvl proteins and regulates Wnt
            signaling in a context-dependent manner
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057812.1.
            
            On May 17, 2019 this sequence version replaced NM_203411.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057812.1, SRR5189655.212732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301599.7/ ENSP00000301599.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               BC057812.1         1-874
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..874
                     /gene="TMEM88"
                     /note="transmembrane protein 88"
                     /db_xref="GeneID:92162"
                     /db_xref="HGNC:HGNC:32371"
                     /db_xref="MIM:617813"
     exon            1..219
                     /gene="TMEM88"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..489
                     /gene="TMEM88"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 88 isoform 1"
                     /protein_id="NP_981956.1"
                     /db_xref="CCDS:CCDS11121.1"
                     /db_xref="GeneID:92162"
                     /db_xref="HGNC:HGNC:32371"
                     /db_xref="MIM:617813"
                     /translation="MADVPGAQRAVPGDGPEPRDPLDCWACAVLVTAQNLLVAAFNLL
                     LLVLVLGTILLPAVTMLGFGFLCHSQFLRSQAPPCTAHLRDPGFTALLVTGFLLLVPL
                     LVLALASYRRLCLRLRLADCLVPYSRALYRRRRAPQPRQIRASPGSQAVPTSGKVWV"
     exon            220..874
                     /gene="TMEM88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM88"
                     /note="hexamer: AATAAA"
     polyA_site      874
                     /gene="TMEM88"
                     /note="major polyA site"
ORIGIN      
        1 aggcgggcca tggcggatgt ccccggggca cagcgagcgg ttcctggtga cggcccagag
       61 ccccgggacc ccctggactg ttgggcctgc gctgttcttg taacagccca gaatctgctg
      121 gtggctgcct tcaatcttct cctgctggtg ctggtgctag ggaccatctt gctacccgct
      181 gtcaccatgc tgggcttcgg cttcctctgc cactctcagt tcctgcgctc ccaggcaccc
      241 ccttgcaccg cgcacctgcg ggaccccggt ttcacggccc tactggtcac cggattcctg
      301 ctcctcgtgc cgctgctcgt gcttgctctg gccagctacc gccgcctctg cctgcgcctc
      361 cgcctagccg attgcctcgt gccctacagc cgagcccttt atcggcgtcg gcgcgccccg
      421 cagccgcggc aaatccgggc ctcaccaggg tcccaggccg ttcccacatc aggaaaggtc
      481 tgggtctaat gaccctcgag tcaagaacaa ccctgacggc tgccctccct cttattcggc
      541 ccaaggactt gaagcccggc atcttccgac ctgccctgcc cccacccctg cctgagcgga
      601 gtcctagcat ccccttggga gcagcagcgt cagtggaccc agtgctgaga aaagccccca
      661 catcccggaa aacccacttt cctttcacga cccacatctc aatcctgaac atctaggctg
      721 gaacctgcac acctccccct cagctccgtc gtgaatggga caacaatctc gtgccctcgt
      781 tttatggtgc agcttctcta gtatttctgg ggctgggggg cggggctgga ggggaaggag
      841 tgtccacgca tcaataaaga tttaacgaac tgaa
//
