LOCUS       NM_015497               2964 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens transmembrane protein 87A (TMEM87A), transcript
            variant 1, mRNA.
ACCESSION   NM_015497
VERSION     NM_015497.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Kang,H., Han,A.R., Zhang,A., Jeong,H., Koh,W., Lee,J.M., Lee,H.,
            Jo,H.Y., Maria-Solano,M.A., Bhalla,M., Kwon,J., Roh,W.S., Yang,J.,
            An,H.J., Choi,S., Kim,H.M. and Lee,C.J.
  TITLE     GolpHCat (TMEM87A), a unique voltage-dependent cation channel in
            Golgi apparatus, contributes to Golgi-pH maintenance and
            hippocampus-dependent memory
  JOURNAL   Nat Commun 15 (1), 5830 (2024)
   PUBMED   38992057
  REMARK    GeneRIF: GolpHCat (TMEM87A), a unique voltage-dependent cation
            channel in Golgi apparatus, contributes to Golgi-pH maintenance and
            hippocampus-dependent memory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Chakrabarti,S., Klich,J.D., Khallaf,M.A., Hulme,A.J.,
            Sanchez-Carranza,O., Baran,Z.M., Rossi,A., Huang,A.T., Pohl,T.,
            Fleischer,R., Furst,C., Hammes,A., Begay,V., Hornberg,H.,
            Finol-Urdaneta,R.K., Poole,K., Dottori,M. and Lewin,G.R.
  TITLE     Touch sensation requires the mechanically gated ion channel ELKIN1
  JOURNAL   Science 383 (6686), 992-998 (2024)
   PUBMED   38422143
  REMARK    GeneRIF: Touch sensation requires the mechanically gated ion
            channel ELKIN1.
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Patkunarajah,A., Stear,J.H., Moroni,M., Schroeter,L.,
            Blaszkiewicz,J., Tearle,J.L., Cox,C.D., Furst,C.,
            Sanchez-Carranza,O., Ocana Fernandez,M.D.A., Fleischer,R.,
            Eravci,M., Weise,C., Martinac,B., Biro,M., Lewin,G.R. and Poole,K.
  TITLE     TMEM87a/Elkin1, a component of a novel mechanoelectrical
            transduction pathway, modulates melanoma adhesion and migration
  JOURNAL   Elife 9, e53308 (2020)
   PUBMED   32228863
  REMARK    GeneRIF: TMEM87a/Elkin1, a component of a novel mechanoelectrical
            transduction pathway, modulates melanoma adhesion and migration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Hirata,T., Fujita,M., Nakamura,S., Gotoh,K., Motooka,D.,
            Murakami,Y., Maeda,Y. and Kinoshita,T.
  TITLE     Post-Golgi anterograde transport requires GARP-dependent
            endosome-to-TGN retrograde transport
  JOURNAL   Mol Biol Cell 26 (17), 3071-3084 (2015)
   PUBMED   26157166
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Dgany,O., Avidan,N., Delaunay,J., Krasnov,T., Shalmon,L.,
            Shalev,H., Eidelitz-Markus,T., Kapelushnik,J., Cattan,D.,
            Pariente,A., Tulliez,M., Cretien,A., Schischmanoff,P.O.,
            Iolascon,A., Fibach,E., Koren,A., Rossler,J., Le Merrer,M.,
            Yaniv,I., Zaizov,R., Ben-Asher,E., Olender,T., Lancet,D.,
            Beckmann,J.S. and Tamary,H.
  TITLE     Congenital dyserythropoietic anemia type I is caused by mutations
            in codanin-1
  JOURNAL   Am J Hum Genet 71 (6), 1467-1474 (2002)
   PUBMED   12434312
REFERENCE   7  (bases 1 to 2964)
  AUTHORS   Christian,S.L., Fantes,J.A., Mewborn,S.K., Huang,B. and
            Ledbetter,D.H.
  TITLE     Large genomic duplicons map to sites of instability in the
            Prader-Willi/Angelman syndrome chromosome region (15q11-q13)
  JOURNAL   Hum Mol Genet 8 (6), 1025-1037 (1999)
   PUBMED   10332034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074870.1, AF129927.1, AI434902.1 and AC036103.8.
            
            On May 17, 2019 this sequence version replaced NM_015497.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.148493.1, AK074870.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389834.9/ ENSP00000374484.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2272              AK074870.1         1-2272
            2273-2588           AF129927.1         761-1076
            2589-2959           AI434902.1         2-372               c
            2960-2964           AC036103.8         133944-133948       c
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..2964
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="transmembrane protein 87A"
                     /db_xref="GeneID:25963"
                     /db_xref="HGNC:HGNC:24522"
     exon            1..179
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1703
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="transmembrane protein 87A isoform 1 precursor"
                     /protein_id="NP_056312.2"
                     /db_xref="CCDS:CCDS32205.1"
                     /db_xref="GeneID:25963"
                     /db_xref="HGNC:HGNC:24522"
                     /translation="MAAAAWLQVLPVILLLLGAHPSPLSFFSAGPATVAAADRSKWHI
                     PIPSGKNYFSFGKILFRNTTIFLKFDGEPCDLSLNITWYLKSADCYNEIYNFKAEEVE
                     LYLEKLKEKRGLSGKYQTSSKLFQNCSELFKTQTFSGDFMHRLPLLGEKQEAKENGTN
                     LTFIGDKTAMHEPLQTWQDAPYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEY
                     LTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGMLEKAVF
                     YAEFQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVV
                     VAGALYLLFSGMEGVLRVTGAQTDLASLAFIPLAFLDTALCWWIFISLTQTMKLLKLR
                     RNIVKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRELWVDDAIWRLLFS
                     MILFVIMVLWRPSANNQRFAFSPLSEEEEEDEQKEPMLKESFEGMKMRSTKQEPNGNS
                     KVNKAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME"
     exon            180..240
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..326
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..440
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..494
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..539
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..657
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..719
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..903
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1003
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1097
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1166
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1275
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1334
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1438
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1512
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1574
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1630
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1661
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2964
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="hexamer: TATAAA"
     polyA_site      2879
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="major polyA site"
     polyA_site      2938
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
ORIGIN      
        1 gaaatgcttt cggtaggcac tccacggctg tgaagatggc ggcggctgcg tggcttcagg
       61 tgttgcctgt cattcttctg cttctgggag ctcacccgtc accactgtcg tttttcagtg
      121 cgggaccggc aaccgtagct gctgccgacc ggtccaaatg gcacattccg ataccgtcgg
      181 ggaaaaatta ttttagtttt ggaaagatcc tcttcagaaa taccactatc ttcctgaagt
      241 ttgatggaga accttgtgac ctgtctttga atataacctg gtatctgaaa agcgctgatt
      301 gttacaatga aatctataac ttcaaggcag aagaagtaga gttgtatttg gaaaaactta
      361 aggaaaaaag aggcttgtct gggaaatatc aaacatcatc aaaattgttc cagaactgca
      421 gtgaactctt taaaacacag accttttctg gagattttat gcatcgactg cctcttttag
      481 gagaaaaaca ggaggctaag gagaatggaa caaaccttac ctttattgga gacaaaaccg
      541 caatgcatga accattgcaa acttggcaag atgcaccata catttttatt gtacatattg
      601 gcatttcatc ctcaaaggaa tcatcaaaag aaaattcact gagtaatctt tttaccatga
      661 ctgttgaagt gaagggtccc tatgaatacc tcacacttga agactatccc ttgatgattt
      721 ttttcatggt gatgtgtatt gtatatgtcc tgtttggtgt tctgtggctg gcatggtctg
      781 cctgctactg gagagatctc ctgagaattc agttttggat tggtgctgtc atcttcctgg
      841 gaatgcttga gaaagctgtc ttctatgcgg aatttcagaa tatccgatac aaaggagaat
      901 ctgtccaggg tgctttgatc cttgcagagc tgctttcagc agtgaaacgc tcactggctc
      961 gaaccctggt catcatagtc agtctgggat atggcatcgt caagccacgc cttggagtca
     1021 ctcttcataa ggttgtagta gcaggagccc tctatctttt gttctctggc atggaagggg
     1081 tcctcagagt tactggggcc cagactgatc ttgcttcctt ggcctttatc cccttggctt
     1141 tcctagacac tgccttgtgc tggtggatat ttattagcct gactcaaaca atgaagctat
     1201 taaaacttcg gaggaacatt gtaaaactct ctttgtatcg gcatttcacc aacacgctta
     1261 ttttggcagt ggcagcatcc attgtgttta tcatctggac aaccatgaag ttcagaatag
     1321 tgacatgtca gtcggactgg cgggagctgt gggtagacga tgccatctgg cgcttgctgt
     1381 tctccatgat cctctttgtc atcatggttc tctggcgacc atctgcaaac aaccagaggt
     1441 ttgccttttc accattgtct gaggaagagg aggaggatga acaaaaggag cctatgctga
     1501 aagaaagctt tgaaggaatg aaaatgagaa gtaccaaaca agaacccaat ggaaatagta
     1561 aagttaacaa agcacaggaa gatgatttga agtgggtaga agagaatgtt ccttcttctg
     1621 tgacagatgt agcacttcca gcccttctgg attcagatga ggaacgaatg atcacacact
     1681 ttgaaaggtc caaaatggag taaggaatgg gaagatttgc agttaaagat ggctaccatc
     1741 agggaagaga tcagcatctg tgtcagtctt ctgtacggct ccatgggatt aaaggaagca
     1801 atgacatcct gatctgttcc ttgatctttg ggcattggag ttggcgagag gtgtcagaac
     1861 aaagagaaca tcttactgaa aacaagttca taagatgaga aaaatctacg agcttcttat
     1921 ttacaacact gctgccccct ttcctcccag actctgacat ggatgttcat gcaacttaag
     1981 tgtgttgttc ctgaactttc tgtaatgttt cattttttaa atctgacaaa ctaaaaagtt
     2041 taacgtcttc taaaagattg tcatcaacac cataatatgt aatctccagg agcaactgcc
     2101 tgtaattttt atttatttag ggagttacat aggtgatggg ggaaattgtt aactaccttt
     2161 cattttcctg ggaagtcaag gttacatctt gcagaggttg ttttgagaaa aaagggccct
     2221 tctgagttaa ggagccatag ttctatcaat gatcaaaaga aaaaaaaaaa aagagaaact
     2281 gttacagtat gattcagatc atttaaaaaa gcaaaatcaa gtgcaatttt gtttacaaat
     2341 ggtgtatatt aaagattttt ctatttcaga tgtactttaa agagaaatat tagcttaact
     2401 cttttgacat ctgctattgt gacacatccc attgctggca atgtggtgca cactccgaaa
     2461 cttttaacta ctgttttgta agcctccaag ggtggcattg cagggtcctt aggcaatgtt
     2521 ttgtttgcct ttatgcagag aggtgctcca agtgctgtga ttgagcaccg tgctagagga
     2581 actgtaatgc ttcagaagtt gtagcttata caaaggaaac aggtcctgct ggcttaattt
     2641 aaacagttat tgcatgaagt agcgtggagg ccctggactg ctgctcgttc tttaggatgg
     2701 actgttctgg tatctggtat tggtttagag actgttaata agggacatca caaggtgatg
     2761 ggattcattt gaagcactct atttctgttt taatggtttt atccaatttt gccttcccaa
     2821 gatttttgtt ctacataaaa agttcatgcc actttttaat ataaaaaaat ttaacaaaat
     2881 taatgtattt ttctcatttt tttcaaactt tttctaaaga ctctttctgt caaactcatg
     2941 aaaaatttct ttctatggct ttta
//
