LOCUS       NM_001286487            3049 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens transmembrane protein 87A (TMEM87A), transcript
            variant 3, mRNA.
ACCESSION   NM_001286487 XM_005254288
VERSION     NM_001286487.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3049)
  AUTHORS   Kang,H., Han,A.R., Zhang,A., Jeong,H., Koh,W., Lee,J.M., Lee,H.,
            Jo,H.Y., Maria-Solano,M.A., Bhalla,M., Kwon,J., Roh,W.S., Yang,J.,
            An,H.J., Choi,S., Kim,H.M. and Lee,C.J.
  TITLE     GolpHCat (TMEM87A), a unique voltage-dependent cation channel in
            Golgi apparatus, contributes to Golgi-pH maintenance and
            hippocampus-dependent memory
  JOURNAL   Nat Commun 15 (1), 5830 (2024)
   PUBMED   38992057
  REMARK    GeneRIF: GolpHCat (TMEM87A), a unique voltage-dependent cation
            channel in Golgi apparatus, contributes to Golgi-pH maintenance and
            hippocampus-dependent memory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3049)
  AUTHORS   Chakrabarti,S., Klich,J.D., Khallaf,M.A., Hulme,A.J.,
            Sanchez-Carranza,O., Baran,Z.M., Rossi,A., Huang,A.T., Pohl,T.,
            Fleischer,R., Furst,C., Hammes,A., Begay,V., Hornberg,H.,
            Finol-Urdaneta,R.K., Poole,K., Dottori,M. and Lewin,G.R.
  TITLE     Touch sensation requires the mechanically gated ion channel ELKIN1
  JOURNAL   Science 383 (6686), 992-998 (2024)
   PUBMED   38422143
  REMARK    GeneRIF: Touch sensation requires the mechanically gated ion
            channel ELKIN1.
REFERENCE   3  (bases 1 to 3049)
  AUTHORS   Hoel,C.M., Zhang,L. and Brohawn,S.G.
  TITLE     Structure of the GOLD-domain seven-transmembrane helix protein
            family member TMEM87A
  JOURNAL   Elife 11, e81704 (2022)
   PUBMED   36373655
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3049)
  AUTHORS   Patkunarajah,A., Stear,J.H., Moroni,M., Schroeter,L.,
            Blaszkiewicz,J., Tearle,J.L., Cox,C.D., Furst,C.,
            Sanchez-Carranza,O., Ocana Fernandez,M.D.A., Fleischer,R.,
            Eravci,M., Weise,C., Martinac,B., Biro,M., Lewin,G.R. and Poole,K.
  TITLE     TMEM87a/Elkin1, a component of a novel mechanoelectrical
            transduction pathway, modulates melanoma adhesion and migration
  JOURNAL   Elife 9, e53308 (2020)
   PUBMED   32228863
  REMARK    GeneRIF: TMEM87a/Elkin1, a component of a novel mechanoelectrical
            transduction pathway, modulates melanoma adhesion and migration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3049)
  AUTHORS   Hirata,T., Fujita,M., Nakamura,S., Gotoh,K., Motooka,D.,
            Murakami,Y., Maeda,Y. and Kinoshita,T.
  TITLE     Post-Golgi anterograde transport requires GARP-dependent
            endosome-to-TGN retrograde transport
  JOURNAL   Mol Biol Cell 26 (17), 3071-3084 (2015)
   PUBMED   26157166
REFERENCE   6  (bases 1 to 3049)
  AUTHORS   Dgany,O., Avidan,N., Delaunay,J., Krasnov,T., Shalmon,L.,
            Shalev,H., Eidelitz-Markus,T., Kapelushnik,J., Cattan,D.,
            Pariente,A., Tulliez,M., Cretien,A., Schischmanoff,P.O.,
            Iolascon,A., Fibach,E., Koren,A., Rossler,J., Le Merrer,M.,
            Yaniv,I., Zaizov,R., Ben-Asher,E., Olender,T., Lancet,D.,
            Beckmann,J.S. and Tamary,H.
  TITLE     Congenital dyserythropoietic anemia type I is caused by mutations
            in codanin-1
  JOURNAL   Am J Hum Genet 71 (6), 1467-1474 (2002)
   PUBMED   12434312
REFERENCE   7  (bases 1 to 3049)
  AUTHORS   Christian,S.L., Fantes,J.A., Mewborn,S.K., Huang,B. and
            Ledbetter,D.H.
  TITLE     Large genomic duplicons map to sites of instability in the
            Prader-Willi/Angelman syndrome chromosome region (15q11-q13)
  JOURNAL   Hum Mol Genet 8 (6), 1025-1037 (1999)
   PUBMED   10332034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY036655.1, BC069240.1, AF129927.1 and AI434902.1.
            
            On Nov 6, 2013 this sequence version replaced XM_005254288.1.
            
            Transcript Variant: This variant (3) lacks an exon in the 5' coding
            region and initiates translation at an alternate downstream start
            codon, compared to variant 1. The encoded isoform (3) has a
            distinct N-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.266402.1, BC069240.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               HY036655.1         1-157
            158-2348            BC069240.1         1-2191
            2349-2362           AF129927.1         746-759
            2363-2678           AF129927.1         761-1076
            2679-3049           AI434902.1         2-372               c
FEATURES             Location/Qualifiers
     source          1..3049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3049
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="transmembrane protein 87A"
                     /db_xref="GeneID:25963"
                     /db_xref="HGNC:HGNC:24522"
     exon            1..330
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1793
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transmembrane protein 87A isoform 3"
                     /protein_id="NP_001273416.1"
                     /db_xref="GeneID:25963"
                     /db_xref="HGNC:HGNC:24522"
                     /translation="MAHSDTVVDGEPCDLSLNITWYLKSADCYNEIYNFKAEEVELYL
                     EKLKEKRGLSGKYQTSSKLFQNCSELFKTQTFSGDFMHRLPLLGEKQEAKENGTNLTF
                     IGDKTAMHEPLQTWQDAPYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEYLTL
                     EDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGMLEKAVFYAE
                     FQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVVVAG
                     ALYLLFSGMEGVLRVTGAQTDLASLAFIPLAFLDTALCWWIFISLTQTMKLLKLRRNI
                     VKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRELWVDDAIWRLLFSMIL
                     FVIMVLWRPSANNQRFAFSPLSEEEEEDEQKEPMLKESFEGMKMRSTKQEPNGNSKVN
                     KAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME"
     exon            331..416
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..530
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..584
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..629
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..747
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..809
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..993
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1093
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1187
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1256
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1365
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1424
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1528
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1602
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1664
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1720
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1751
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..3049
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2950..2955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="hexamer: TATAAA"
     polyA_site      2969
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /note="major polyA site"
     polyA_site      3028
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
ORIGIN      
        1 agtaggtcca aagtctcacg gcgcacagac gactgtctga gagaggggcc gctacgccgc
       61 acagcaaaca agctccgcga cgtttccagg acccggataa tcccgccctt agagcagagc
      121 cggaagaagg cgggacgaac cggaagaggg tgaaatgctt tcggtaggca ctccacggct
      181 gtgaagatgg cggcggctgc gtggcttcag gtgttgcctg tcattcttct gcttctggga
      241 gctcacccgt caccactgtc gtttttcagt gcgggaccgg caaccgtagc tgctgccgac
      301 cggtccaaat ggcacattcc gataccgtcg ttgatggaga accttgtgac ctgtctttga
      361 atataacctg gtatctgaaa agcgctgatt gttacaatga aatctataac ttcaaggcag
      421 aagaagtaga gttgtatttg gaaaaactta aggaaaaaag aggcttgtct gggaaatatc
      481 aaacatcatc aaaattgttc cagaactgca gtgaactctt taaaacacag accttttctg
      541 gagattttat gcatcgactg cctcttttag gagaaaaaca ggaggctaag gagaatggaa
      601 caaaccttac ctttattgga gacaaaaccg caatgcatga accattgcaa acttggcaag
      661 atgcaccata catttttatt gtacatattg gcatttcatc ctcaaaggaa tcatcaaaag
      721 aaaattcact gagtaatctt tttaccatga ctgttgaagt gaagggtccc tatgaatacc
      781 tcacacttga agactatccc ttgatgattt ttttcatggt gatgtgtatt gtatatgtcc
      841 tgtttggtgt tctgtggctg gcatggtctg cctgctactg gagagatctc ctgagaattc
      901 agttttggat tggtgctgtc atcttcctgg gaatgcttga gaaagctgtc ttctatgcgg
      961 aatttcagaa tatccgatac aaaggagaat ctgtccaggg tgctttgatc cttgcagagc
     1021 tgctttcagc agtgaaacgc tcactggctc gaaccctggt catcatagtc agtctgggat
     1081 atggcatcgt caagccacgc cttggagtca ctcttcataa ggttgtagta gcaggagccc
     1141 tctatctttt gttctctggc atggaagggg tcctcagagt tactggggcc cagactgatc
     1201 ttgcttcctt ggcctttatc cccttggctt tcctagacac tgccttgtgc tggtggatat
     1261 ttattagcct gactcaaaca atgaagctat taaaacttcg gaggaacatt gtaaaactct
     1321 ctttgtatcg gcatttcacc aacacgctta ttttggcagt ggcagcatcc attgtgttta
     1381 tcatctggac aaccatgaag ttcagaatag tgacatgtca gtcggactgg cgggagctgt
     1441 gggtagacga tgccatctgg cgcttgctgt tctccatgat cctctttgtc atcatggttc
     1501 tctggcgacc atctgcaaac aaccagaggt ttgccttttc accattgtct gaggaagagg
     1561 aggaggatga acaaaaggag cctatgctga aagaaagctt tgaaggaatg aaaatgagaa
     1621 gtaccaaaca agaacccaat ggaaatagta aagttaacaa agcacaggaa gatgatttga
     1681 agtgggtaga agagaatgtt ccttcttctg tgacagatgt agcacttcca gcccttctgg
     1741 attcagatga ggaacgaatg atcacacact ttgaaaggtc caaaatggag taaggaatgg
     1801 gaagatttgc agttaaagat ggctaccatc agggaagaga tcagcatctg tgtcagtctt
     1861 ctgtacggct ccatgggatt aaaggaagca atgacatcct gatctgttcc ttgatctttg
     1921 ggcattggag ttggcgagag gtgtcagaac aaagagaaca tcttactgaa aacaagttca
     1981 taagatgaga aaaatctacg agcttcttat ttacaacact gctgccccct ttcctcccag
     2041 actctgacat ggatgttcat gcaacttaag tgtgttgttc ctgaactttc tgtaatgttt
     2101 cattttttaa atctgacaaa ctaaaaagtt taacgtcttc taaaagattg tcatcaacac
     2161 cataatatgt aatctccagg agcaactgcc tgtaattttt atttatttag ggagttacat
     2221 aggtgatggg ggaaattgtt aactaccttt cattttcctg ggaagtcaag gttacatctt
     2281 gcagaggttg ttttgagaaa aaagggccct tctgagttaa ggagccatag ttctatcaat
     2341 gatcaaaaga aaaaaaaaaa aagagaaact gttacagtat gattcagatc atttaaaaaa
     2401 gcaaaatcaa gtgcaatttt gtttacaaat ggtgtatatt aaagattttt ctatttcaga
     2461 tgtactttaa agagaaatat tagcttaact cttttgacat ctgctattgt gacacatccc
     2521 attgctggca atgtggtgca cactccgaaa cttttaacta ctgttttgta agcctccaag
     2581 ggtggcattg cagggtcctt aggcaatgtt ttgtttgcct ttatgcagag aggtgctcca
     2641 agtgctgtga ttgagcaccg tgctagagga actgtaatgc ttcagaagtt gtagcttata
     2701 caaaggaaac aggtcctgct ggcttaattt aaacagttat tgcatgaagt agcgtggagg
     2761 ccctggactg ctgctcgttc tttaggatgg actgttctgg tatctggtat tggtttagag
     2821 actgttaata agggacatca caaggtgatg ggattcattt gaagcactct atttctgttt
     2881 taatggtttt atccaatttt gccttcccaa gatttttgtt ctacataaaa agttcatgcc
     2941 actttttaat ataaaaaaat ttaacaaaat taatgtattt ttctcatttt tttcaaactt
     3001 tttctaaaga ctctttctgt caaactcatg aaaaatttct ttctatggc
//
