LOCUS       NM_173804               1246 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 86B (TMEM86B), transcript
            variant 1, mRNA.
ACCESSION   NM_173804
VERSION     NM_173804.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1246)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1246)
  AUTHORS   Wu,L.C., Pfeiffer,D.R., Calhoon,E.A., Madiai,F., Marcucci,G.,
            Liu,S. and Jurkowitz,M.S.
  TITLE     Purification, identification, and cloning of lysoplasmalogenase,
            the enzyme that catalyzes hydrolysis of the vinyl ether bond of
            lysoplasmalogen
  JOURNAL   J Biol Chem 286 (28), 24916-24930 (2011)
   PUBMED   21515882
  REMARK    GeneRIF: Transient transfection of human embryonic kidney (HEK)
            293T cells showed that TMEM86b cDNA yielded lysoplasmalogenase
            activity, and Western blot analyses confirmed the synthesis of
            TMEM86b protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC023000.1, BX448118.2, CV029437.1, AC010327.8 and BC033193.1.
            
            On Jul 31, 2019 this sequence version replaced NM_173804.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023000.1, SRR14038192.2138415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327042.5/ ENSP00000321038.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               BC023000.1         502-690
            190-190             BX448118.2         420-420
            191-544             CV029437.1         169-522
            545-1105            AC010327.8         120225-120785       c
            1106-1246           BC033193.1         1369-1509
FEATURES             Location/Qualifiers
     source          1..1246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1246
                     /gene="TMEM86B"
                     /note="transmembrane protein 86B"
                     /db_xref="GeneID:255043"
                     /db_xref="HGNC:HGNC:28448"
                     /db_xref="MIM:617806"
     exon            1..73
                     /gene="TMEM86B"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..703
                     /gene="TMEM86B"
                     /EC_number="3.3.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysoplasmalogenase; alkenylglycerophosphocholine
                     hydrolase; alkenylglycerophosphoethanolamine hydrolase;
                     lysoplasmalogenase TMEM86B"
                     /codon_start=1
                     /product="lysoplasmalogenase TMEM86B isoform 1"
                     /protein_id="NP_776165.3"
                     /db_xref="CCDS:CCDS12920.1"
                     /db_xref="GeneID:255043"
                     /db_xref="HGNC:HGNC:28448"
                     /db_xref="MIM:617806"
                     /translation="MDAGKAGQTLKTHCSAQRPDVCRWLSPFILSCCVYFCLWIPEDQ
                     LSWFAALVKCLPVLCLAGFLWVMSPSGGYTQLLQGALVCSAVGDACLIWPAAFVPGMA
                     AFATAHLLYVWAFGFSPLQPGLLLLIILAPGPYLSLVLQHLEPDMVLPVAAYGLILMA
                     MLWRGLAQGGSAGWGALLFTLSDGVLAWDTFAQPLPHAHLVIMTTYYAAQLLITLSAL
                     RSPVPKTD"
     exon            74..320
                     /gene="TMEM86B"
                     /inference="alignment:Splign:2.1.0"
     exon            321..1246
                     /gene="TMEM86B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM86B"
                     /note="hexamer: GATAAA"
     polyA_site      1246
                     /gene="TMEM86B"
                     /note="major polyA site"
ORIGIN      
        1 gctctggggc tatcaggcca gcatggacgc tggcaaagcg gggcagaccc tgaagactca
       61 ctgctcagcc cagcgcccag atgtctgcag gtggctgagc cccttcatcc tctcctgctg
      121 cgtgtacttc tgcctctgga ttcccgagga ccagctgtcc tggttcgctg ccctggtcaa
      181 gtgcctgccc gtcctctgcc tggctgggtt cctgtgggtc atgtccccaa gcgggggcta
      241 cacccagctc ctccagggag cccttgtgtg ctcggctgtg ggggacgctt gcctcatctg
      301 gccggcagcc ttcgtccctg gcatggccgc ctttgccacc gcccacctcc tctacgtctg
      361 ggccttcggc ttctctcccc tgcagcccgg cctgctgctg ctcatcatcc tggcccctgg
      421 cccctacctc agccttgtgc tccagcacct cgagccggat atggtcctgc cggtggcagc
      481 ctatgggctg atcctgatgg ccatgctgtg gcgcggcctg gcccagggcg ggagtgccgg
      541 ctggggcgcg ctgctcttca cgctctctga tggcgtgctg gcctgggaca ccttcgccca
      601 gcccctgccc catgcccacc tggtgatcat gaccacctac tatgctgccc agctcctcat
      661 cacactgtca gccctcagga gcccggtgcc caagactgac tgactaggga gcttgaaggg
      721 ccggtgttca ggccctctcc tcctgcaagg acctgggcct cccagcccag cccagcctga
      781 gaaataccct cagcagcgaa gcttcctgac gcctgtctgc aggcgccgct gccgccgtcg
      841 cttctggctg aagacgtttg aggacgattt gcggaattcc aagtccacta ctgggttcca
      901 gctgccttcc cccggttctg actccagatc cctggctcct cagccaggcc cacatggagc
      961 cctcccagcc accagcctgc ctccatgttc actgtcggcc ccacagcctg cccgccccct
     1021 gctgctgctc tgaatccgtt ttccctgtgg gtgtggaacc gtagatgttg ctgttaccgt
     1081 aggagaggcc tcggggaggg tcatgattgt gataaaccat cgcggttaat gacagcagaa
     1141 ggttctttgt cgctccccat ggaccaggcc tggtgcccag tgggaccctc catggccctc
     1201 tggtgggggg attcgggggg ataaagtgag gattgtgcag aactga
//
