LOCUS       NM_203376               1332 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 81 (TMEM81), mRNA.
ACCESSION   NM_203376 XM_371337
VERSION     NM_203376.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Deneke,V.E., Blaha,A., Lu,Y., Suwita,J.P., Draper,J.M., Phan,C.S.,
            Panser,K., Schleiffer,A., Jacob,L., Humer,T., Stejskal,K.,
            Krssakova,G., Roitinger,E., Handler,D., Kamoshita,M., Vance,T.D.R.,
            Wang,X., Surm,J.M., Moran,Y., Lee,J.E., Ikawa,M. and Pauli,A.
  TITLE     A conserved fertilization complex bridges sperm and egg in
            vertebrates
  JOURNAL   Cell 187 (25), 7066-7078 (2024)
   PUBMED   39423812
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY359081.1 and BC061592.1.
            
            On May 17, 2019 this sequence version replaced NM_203376.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY359081.1, BC061592.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367167.4/ ENSP00000356135.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AY359081.1         1-57
            58-1332             BC061592.1         1-1275
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1332
                     /gene="TMEM81"
                     /gene_synonym="HC3107; KVLA2788; UNQ2788"
                     /note="transmembrane protein 81"
                     /db_xref="GeneID:388730"
                     /db_xref="HGNC:HGNC:32349"
     exon            1..1332
                     /gene="TMEM81"
                     /gene_synonym="HC3107; KVLA2788; UNQ2788"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..908
                     /gene="TMEM81"
                     /gene_synonym="HC3107; KVLA2788; UNQ2788"
                     /codon_start=1
                     /product="transmembrane protein 81 precursor"
                     /protein_id="NP_976310.1"
                     /db_xref="CCDS:CCDS1450.1"
                     /db_xref="GeneID:388730"
                     /db_xref="HGNC:HGNC:32349"
                     /translation="MKVLATSFVLGSLGLAFYLPLVVTTPKTLAIPEKLQEAVGKVII
                     NATTCTVTCGLGYKEETVCEVGPDGVRRKCQTRRLECLTNWICGMLHFTILIGKEFEL
                     SCLSSDILEFGQEAFRFTWRLARGVISTDDEVFKPFQANSHFVKFKYAQEYDSGTYRC
                     DVQLVKNLRLVKRLYFGLRVLPPNLVNLNFHQSLTEDQKLIDEGLEVNLDSYSKPHHP
                     KWKKKVASALGIGIAIGVVGGVLVRIVLCALRGGLQQ"
     regulatory      1313..1318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM81"
                     /gene_synonym="HC3107; KVLA2788; UNQ2788"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="TMEM81"
                     /gene_synonym="HC3107; KVLA2788; UNQ2788"
                     /note="major polyA site"
ORIGIN      
        1 gttttattga caatacatgc atcatatctt ttgactttga aggatatctc atgtcaaagg
       61 aatcaagtta tgatttatag aggattcagc tggaatacct tgtgggtgct ggctgagggt
      121 ggcaaaacgc ctaccgagac atgaaggttt tagccactag ttttgtcctt gggagcctgg
      181 ggttggcctt ctacctgcct ttggtggtga ctacacctaa aacactggcc atccctgaga
      241 agctgcaaga agctgtgggg aaagttatca tcaatgccac aacctgtact gtcacctgtg
      301 gccttggcta taaggaggag accgtctgtg aggtgggccc tgatggagtg agaaggaaat
      361 gtcagactcg gcgcttagaa tgtctgacca actggatctg tgggatgctc catttcacca
      421 ttctcattgg caaggaattt gagcttagct gtctgagttc agacatcttg gagtttggac
      481 aggaagcttt ccggttcacc tggagacttg ctcgaggtgt catctccact gacgatgagg
      541 tcttcaaacc ctttcaagcc aactcccact ttgtgaagtt taaatatgct caggagtatg
      601 actctgggac atatcgctgt gatgtgcagc tggtaaaaaa cttgagactc gtcaagaggc
      661 tctattttgg gttgagggtc cttcctccta acttggtgaa tctgaatttc catcagtcac
      721 ttactgagga tcagaagtta atagatgagg gattggaagt taatctggac agctactcca
      781 agcctcacca cccaaagtgg aaaaagaagg tggcgtcagc cttgggaata ggaattgcca
      841 ttggagtggt tggtggcgtg ttggtgagga ttgtcctctg tgcgctaagg gggggcctgc
      901 agcagtgaca gcttcaagaa cttaacagcc ttgctcctga agaactggct gcccaggaag
      961 ccaagctagc tttttagggg agtgttccag ctgctggtag tggatcagct tagagggaac
     1021 actcccacag ccaaaagaat gagtgggaga aatggagggg acaatctcct gggagctatg
     1081 cgcagtaacc taacttcctt atgtcccatg gatctcttcc tgatcttccc tgcccattgg
     1141 gtacccagga aactgcaagc attgcctgtg ttcctgggaa gagttctaag aagcttgcat
     1201 tcattttcta ccctttatga cttggatgcc tccccacctc catttcccct cttctgagct
     1261 gtgtattcat gtagagggat gtattcagcc tttttagtga acattttttt tcaataaaag
     1321 taattcacag ta
//
