LOCUS       NM_001276274            1027 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 80 (TMEM80), transcript variant
            5, mRNA.
ACCESSION   NM_001276274
VERSION     NM_001276274.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1027)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1027)
  AUTHORS   Li,C., Jensen,V.L., Park,K., Kennedy,J., Garcia-Gonzalo,F.R.,
            Romani,M., De Mori,R., Bruel,A.L., Gaillard,D., Doray,B., Lopez,E.,
            Riviere,J.B., Faivre,L., Thauvin-Robinet,C., Reiter,J.F.,
            Blacque,O.E., Valente,E.M. and Leroux,M.R.
  TITLE     MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary
            Transition Zone
  JOURNAL   PLoS Biol 14 (3), e1002416 (2016)
   PUBMED   26982032
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1027)
  AUTHORS   Venkatesh,B., Ravi,V., Lee,A.P., Warren,W.C. and Brenner,S.
  TITLE     Basal vertebrates clarify the evolutionary history of
            ciliopathy-associated genes Tmem138 and Tmem216
  JOURNAL   Mol Biol Evol 30 (1), 62-65 (2013)
   PUBMED   22936720
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131934.13.
            
            On Jun 18, 2020 this sequence version replaced NM_001276274.1.
            
            Transcript Variant: This variant (5) represents the longest
            transcript and encodes the longest isoform (5).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC131934.13        54879-54909         c
            32-51               AC131934.13        51837-51856         c
            52-145              AC131934.13        50490-50583         c
            146-238             AC131934.13        50018-50110         c
            239-440             AC131934.13        47579-47780         c
            441-1027            AC131934.13        45697-46283         c
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1027
                     /gene="TMEM80"
                     /note="transmembrane protein 80"
                     /db_xref="GeneID:283232"
                     /db_xref="HGNC:HGNC:27453"
                     /db_xref="MIM:620248"
     exon            1..31
                     /gene="TMEM80"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..645
                     /gene="TMEM80"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="transmembrane protein 80 isoform 5"
                     /protein_id="NP_001263203.2"
                     /db_xref="CCDS:CCDS91399.1"
                     /db_xref="GeneID:283232"
                     /db_xref="HGNC:HGNC:27453"
                     /db_xref="MIM:620248"
                     /translation="MAAPRRGRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYK
                     SQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLAASLALTAGTALLS
                     AHFLLWQALVLWADWALSATLLALHGLEAVLQVVAIAAFTSGHGELQDSPEDPLHTPA
                     PERLGPPPSPAPALAEDQLGTPAIWRTQPTNHADQGRTPSLKLETCCLHG"
     exon            32..51
                     /gene="TMEM80"
                     /inference="alignment:Splign:2.1.0"
     exon            52..145
                     /gene="TMEM80"
                     /inference="alignment:Splign:2.1.0"
     exon            146..238
                     /gene="TMEM80"
                     /inference="alignment:Splign:2.1.0"
     exon            239..440
                     /gene="TMEM80"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1027
                     /gene="TMEM80"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgggta agatggcggc cccgcggcga gggagaggat cctccacagt gctctcttca
       61 gttccccttc aaatgctgtt ttatctcagc ggaacgtact acgccctgta tttcctcgcc
      121 acgctcctga tgatcacgta taaaagtcag gtgttcagct atcctcaccg ctacctggtc
      181 ctcgatcttg ctctgctgtt tctgatgggg attctagaag cagttcggtt atacctgggc
      241 accaggggca acctgacaga ggctgagagg ccgctggccg ccagcctggc cctcacggct
      301 ggcaccgccc tcctctctgc ccacttcctg ctttggcagg ccctagtgtt gtgggcggac
      361 tgggccctca gcgccacgct cctggccctt cacggcctgg aggccgtcct gcaggtggtt
      421 gccatcgcgg ccttcaccag tggccacggt gagctgcagg acagccctga ggacccactt
      481 cacacaccag cgcctgagcg cctcgggcca cctccctcac cagcgcctgc actcgcagaa
      541 gaccagctgg gcacacctgc catctggagg acccagccca caaaccatgc agaccaggga
      601 aggaccccct ccctgaagct ggagacctgt tgccttcatg gttaatggat cctgatacct
      661 ccagtctcag cgagcacaca aaggcagtgg tcacctgttc cacagggaac gccatggctc
      721 caggtgaccc ggagtggatg gggcccgaga ggccagcctg gactgtctcc tgagggcagg
      781 ctccgcactc aaaatcgtgt tgacaggcac ccgtttagga gtggagaggg accccacccc
      841 ccagctgtcc tctccagcgc ctgtttccca cttggccact cccagctctg cctccaggaa
      901 gggtgagggc acgggtgcac cgaggggttg gcgtgtgtga ccctgagctc tgggtcaggg
      961 caagctcatg catggagcag gatcacggca ggttcctgga gatcaaacgg caaaggctgt
     1021 aaaccag
//
