LOCUS       NM_032323               2155 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 79 (TMEM79), transcript variant
            1, mRNA.
ACCESSION   NM_032323
VERSION     NM_032323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Zhang,W., Fan,C., Yi,Z., Du,T., Wang,N., Tian,W., Pan,Q., Ma,X. and
            Wang,Z.
  TITLE     TMEM79 Ameliorates Cerebral Ischemia/Reperfusion Injury Through
            Regulating Inflammation and Oxidative Stress via the Nrf2/NLRP3
            Pathway
  JOURNAL   Immunol Invest 53 (6), 872-890 (2024)
   PUBMED   38809063
  REMARK    GeneRIF: TMEM79 Ameliorates Cerebral Ischemia/Reperfusion Injury
            Through Regulating Inflammation and Oxidative Stress via the
            Nrf2/NLRP3 Pathway.
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Wang,Y., Jin,Q., Zhang,S. and Wang,Y.
  TITLE     Overexpression of TMEM79 combined with SMG5 is related to
            prognosis, tumor immune infiltration and drug sensitivity in
            hepatocellular carcinoma
  JOURNAL   Eur J Med Res 28 (1), 490 (2023)
   PUBMED   37936239
  REMARK    GeneRIF: Overexpression of TMEM79 combined with SMG5 is related to
            prognosis, tumor immune infiltration and drug sensitivity in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Elias,P.M. and Wakefield,J.S.
  TITLE     Mechanisms of abnormal lamellar body secretion and the
            dysfunctional skin barrier in patients with atopic dermatitis
  JOURNAL   J Allergy Clin Immunol 134 (4), 781-791 (2014)
   PUBMED   25131691
  REMARK    Review article
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Chen,P., Takeuchi,F., Lee,J.Y., Li,H., Wu,J.Y., Liang,J., Long,J.,
            Tabara,Y., Goodarzi,M.O., Pereira,M.A., Kim,Y.J., Go,M.J.,
            Stram,D.O., Vithana,E., Khor,C.C., Liu,J., Liao,J., Ye,X., Wang,Y.,
            Lu,L., Young,T.L., Lee,J., Thai,A.C., Cheng,C.Y., van Dam,R.M.,
            Friedlander,Y., Heng,C.K., Koh,W.P., Chen,C.H., Chang,L.C.,
            Pan,W.H., Qi,Q., Isono,M., Zheng,W., Cai,Q., Gao,Y., Yamamoto,K.,
            Ohnaka,K., Takayanagi,R., Kita,Y., Ueshima,H., Hsiung,C.A., Cui,J.,
            Sheu,W.H., Rotter,J.I., Chen,Y.D., Hsu,C., Okada,Y., Kubo,M.,
            Takahashi,A., Tanaka,T., van Rooij,F.J., Ganesh,S.K., Huang,J.,
            Huang,T., Yuan,J., Hwang,J.Y., Gross,M.D., Assimes,T.L., Miki,T.,
            Shu,X.O., Qi,L., Chen,Y.T., Lin,X., Aung,T., Wong,T.Y., Teo,Y.Y.,
            Kim,B.J., Kato,N. and Tai,E.S.
  CONSRTM   CHARGE Hematology Working Group
  TITLE     Multiple nonglycemic genomic loci are newly associated with blood
            level of glycated hemoglobin in East Asians
  JOURNAL   Diabetes 63 (7), 2551-2562 (2014)
   PUBMED   24647736
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Saunders,S.P., Goh,C.S., Brown,S.J., Palmer,C.N., Porter,R.M.,
            Cole,C., Campbell,L.E., Gierlinski,M., Barton,G.J., Schneider,G.,
            Balmain,A., Prescott,A.R., Weidinger,S., Baurecht,H., Kabesch,M.,
            Gieger,C., Lee,Y.A., Tavendale,R., Mukhopadhyay,S., Turner,S.W.,
            Madhok,V.B., Sullivan,F.M., Relton,C., Burn,J., Meggitt,S.,
            Smith,C.H., Allen,M.A., Barker,J.N., Reynolds,N.J., Cordell,H.J.,
            Irvine,A.D., McLean,W.H., Sandilands,A. and Fallon,P.G.
  TITLE     Tmem79/Matt is the matted mouse gene and is a predisposing gene for
            atopic dermatitis in human subjects
  JOURNAL   J Allergy Clin Immunol 132 (5), 1121-1129 (2013)
   PUBMED   24084074
  REMARK    GeneRIF: Tmem79/Matt is the matted mouse gene and is a predisposing
            gene for atopic dermatitis in human subjects.
            Erratum:[J Allergy Clin Immunol. 2015 Dec;136(6):1710. doi:
            10.1016/j.jaci.2015.10.002.. PMID: 28843836]
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315767.1, BC005094.1 and BF448444.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032323.2.
            
            Transcript Variant: This variant (1) encodes a 394aa protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279842.990.1, AK315767.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405535.3/ ENSP00000384748.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1310              AK315767.1         15-1324
            1311-2120           BC005094.1         1347-2156
            2121-2155           BF448444.1         15-49               c
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2155
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /note="transmembrane protein 79"
                     /db_xref="GeneID:84283"
                     /db_xref="HGNC:HGNC:28196"
                     /db_xref="MIM:615531"
     exon            1..82
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /inference="alignment:Splign:2.1.0"
     exon            83..882
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1310
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /note="mattrin"
                     /codon_start=1
                     /product="transmembrane protein 79"
                     /protein_id="NP_115699.1"
                     /db_xref="CCDS:CCDS1138.1"
                     /db_xref="GeneID:84283"
                     /db_xref="HGNC:HGNC:28196"
                     /db_xref="MIM:615531"
                     /translation="MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGA
                     ESLRVGSSAGSPTAIEGAEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRDIEPEPP
                     ESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQPQEDLIVRCEAGEGECRTFM
                     PPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALILFPCLLYGA
                     YAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRRE
                     VEIHRRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVG
                     RSFRGFGYGLTFLPLLSMLMWNLYYMFVVEPERMLTATESRLDYPDHARSASDYRPRP
                     WG"
     exon            883..1096
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..2155
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2138..2143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /note="hexamer: AATAAA"
     polyA_site      2155
                     /gene="TMEM79"
                     /gene_synonym="MATT"
                     /note="major polyA site"
ORIGIN      
        1 gcagagccag caggtagctg ggcagctcct tcccggacgg acggatggac agacgctggg
       61 gaccctccac tccatatgga aagatgacat gaccttgtgg tagatcccag aactgaggcc
      121 ccaggatgac agaacaggag accctggccc tactggaagt gaagaggtct gattccccag
      181 agaagagctc accccaggcc ttggttccca atggccggca gccagaaggg gaaggtgggg
      241 ccgaatcccc gggagctgag tccctcagag tggggtcttc agctggatct cccacagcca
      301 tagagggggc tgaggatggt ctagacagca cagtaagtga ggctgccacc ttgccctggg
      361 ggactggccc tcagcccagt gctccgttcc cggatccccc tggctggcgg gacattgaac
      421 cagagccccc tgagtcagaa ccacttacca agctagagga gctgcccgaa gacgatgcca
      481 acctgctgcc tgagaaagcg gcccgtgcct tcgtgcctat tgacctacag tgcattgagc
      541 ggcagcccca agaagacctt atcgtgcgct gtgaggcagg cgagggcgag tgccgaacct
      601 tcatgccccc ccgggtcacc caccccgacc ccactgagcg caagtgggct gaggcagtgg
      661 tgaggccgcc tggctgttcc tgtgggggct gcgggagctg tggagaccgt gagtggctaa
      721 gggctgtggc ctccgtggga gccgcactca ttctcttccc ttgcctacta tacggggcat
      781 atgccttcct gccgtttgat gtcccacggc tgcccaccat gagttcccgc ctgatctaca
      841 cactgcgctg cggggtcttt gccaccttcc ccattgtgct ggggatcctg gtgtacgggc
      901 tgagcctgtt atgcttttct gcccttcggc cctttgggga gccacggcgg gaggtggaga
      961 tccaccggcg atatgtggcc cagtcggtcc agctctttat tctctacttc ttcaacctgg
     1021 ccgtgctttc cacttacctg ccccaggata ccctcaaact gctccctctg ctcactggtc
     1081 tctttgccgt ctcccggctg atctactggc tgacctttgc cgtgggccgc tccttccgag
     1141 gcttcggcta cggcctgacg tttctgccac tgctgtcgat gctgatgtgg aacctctact
     1201 acatgttcgt ggtggagccg gagcgcatgc tcactgccac cgagagccgc ctggactacc
     1261 cggaccacgc ccgctcggcc tccgactaca ggccccgccc ctggggctga gcctctccgc
     1321 cctcgccctc ggagtagggg gtagcggctt gggtctgaca catctttgaa ccttgtggcc
     1381 aggcctggac ttcgccccca ggcctaggac cgcggtgggt ggaaccctgc tactgcccca
     1441 acagggactc caatcaatcg gagttctccc cttgccggag ctgcccttca cctttggggc
     1501 ccgagacagt cataagggat ggacttagtt ttcttgcagg gaaaaaggtg gacagccgtg
     1561 tttcttaagg atgctgaggg catggggcca ggaccagggg agaggcacag ctccttcctg
     1621 agcagcctct caccactgcc acaaggctcc ctaatgctgg tctctgctcc actccccggc
     1681 ttcccgtgag gcaggaggca gagccacagc caaggccctg accacttctg tgccagttgt
     1741 ctaagcagag cgcctcaggg acgctggaaa tgccttaagg atagaggctg ggcatcacat
     1801 caaatgggac tgtggtgttt ggtgaaaacc ttcctgagga tctggattca ggaccctcca
     1861 tgactggcct atttactgtt tacagctggc cagtgcagag ctgctgctct tttacctttt
     1921 taggcccctg taacttccca cctttaaact gcccagaagg catgcctctc ccacaggaag
     1981 aggggagcag acagggaaat ctgcctacca agaggggtgt gtgtgtcttt gtgcccacac
     2041 gtggtggctg gggagtgcct ggatggtgcg gtggttgatg ttaacctagt gtgtgtgtgt
     2101 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtaacaat aaattactac cagtc
//
