LOCUS       NM_001304748            1876 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 74B (TMEM74B), transcript
            variant 2, mRNA.
ACCESSION   NM_001304748 XM_005260747
VERSION     NM_001304748.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031665.19.
            
            On Sep 30, 2020 this sequence version replaced NM_001304748.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 5-9 all encode the same isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM545116.1, SRR14038191.788997.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2146411,
                                           SAMEA2153733 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429036.2/ ENSP00000400552.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-680               AL031665.19        71612-72291         c
            681-858             AL031665.19        71081-71258         c
            859-1876            AL031665.19        67880-68897         c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1876
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /note="transmembrane protein 74B"
                     /db_xref="GeneID:55321"
                     /db_xref="HGNC:HGNC:15893"
     exon            1..680
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            681..858
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /inference="alignment:Splign:2.1.0"
     CDS             828..1598
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /note="isoform 1 is encoded by transcript variant 2;
                     transmembrane protein C20orf46"
                     /codon_start=1
                     /product="transmembrane protein 74B isoform 1"
                     /protein_id="NP_001291677.1"
                     /db_xref="CCDS:CCDS13011.1"
                     /db_xref="GeneID:55321"
                     /db_xref="HGNC:HGNC:15893"
                     /translation="MPPAQGYEFAAAKGPRDELGPSFPMASPPGLELKTLSNGPQAPR
                     RSAPLGPVAPTREGVENACFSSEEHETHFQNPGNTRLGSSPSPPGGVSSLPRSQRDDL
                     SLHSEEGPALEPVSRPVDYGFVSALVFLVSGILLVVTAYAIPREARVNPDTVTAREME
                     RLEMYYARLGSHLDRCIIAGLGLLTVGGMLLSVLLMVSLCKGELYRRRTFVPGKGSRK
                     TYGSINLRMRQLNGDGGQALVENEVVQVSETSHTLQRS"
     exon            859..1876
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /note="hexamer: AATACA"
     polyA_site      1876
                     /gene="TMEM74B"
                     /gene_synonym="C20orf46"
                     /note="major polyA site"
ORIGIN      
        1 gccttccggg tcccgcgtct gtgggcaagg gcaggagcag ggggtgtgga ctgggccggc
       61 gggagcgggc gcggtgggca gccggcgtgc tggggctttc tgcgcgcaac tttgggtaca
      121 acagcgtgga cctgcgtgtg cgtatctgcg cgccccaagg ctttgtgtac aactcgtgcg
      181 tgtgtctatc gactgggttt tgtgaagctt cacccacagc cgctgtgcgt ccctctctcc
      241 gggtgtcagt gcgcgcggcg ggtggggtat tgggcccctg cgggtcttgg tggatctggc
      301 ttgggtctca ctcccagggg cactttgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
      361 acgcgcgtgt gcgtgtgacg gggtactcgc gtggcccgaa gatccgaggg tcacactacg
      421 tgacttctgg gtgtctgtgg gtactgctgt gggaacagct gctgggggag tgtgtgtgga
      481 actggagtgt tcctttcagg acctgtctga ctgcagatga aattagtaac tggtggggtc
      541 gtggggtgtg aatggtgggc gggagcagct atgtcagttg gtgtgtttct gcttatgtta
      601 gggtaattgg gcacggcctt tgtgtaactg gtgaatatct ctgaacctgg gcatgaaaca
      661 gagagatgtc ctaactctgg taaaagcagt ctgggcgcag gctggggacc cagatggaat
      721 tcaaacttat gcctgctctc aaggtgctca cggttgctga taaacagctg gataaaatga
      781 agagtctatg agtgagggat gcagagccag ggaaggctgg tggagtgatg ccaccagcac
      841 aggggtatga gtttgcagct gccaaggggc caagggatga gctggggccc tccttcccaa
      901 tggcatctcc ccctggtctg gaactgaaga cactgagcaa tggtccccaa gccccaagga
      961 gatcagctcc cctgggccca gtggccccaa ccagggaggg tgtggagaat gcctgcttct
     1021 cctcagagga gcatgagacc catttccaga accctgggaa cacgagactg ggcagctcac
     1081 ccagtccccc tgggggtgtc tcctcactgc cccgatccca gcgggatgat ctgtcccttc
     1141 attcagagga ggggccagcc ctggagcccg tgagccgccc ggtggattat ggctttgttt
     1201 ccgccctcgt tttcctggtg agtgggattc ttctggtggt gacagcatac gccatccccc
     1261 gtgaggctcg agtcaatccg gacacagtga cagcgcggga gatggaacga ctggagatgt
     1321 actacgcccg cctaggctcc cacctggaca ggtgcatcat cgcaggcctc gggctgctca
     1381 cggtgggcgg catgctcttg tcggtgctgc tcatggtctc cctgtgcaag ggcgagctgt
     1441 accgccggag gaccttcgtc cccggcaagg gctccaggaa gacctacggc tccattaacc
     1501 tgcgcatgag acagctcaat ggggatgggg gccaggccct ggtggagaat gaagttgtcc
     1561 aggtctcaga gactagccac accctccaga ggtcttaaga actagcccac cttatctggc
     1621 tgctttagct ccagtgctac aaggtccacc ccctgctccc gcccacctga cccctgccaa
     1681 ggccctgggg ttttaaactg agctcacata gggccttgtg gaagaagtac tgggtgctgg
     1741 agggagagct cggggcccag cccatgcccc acacgggcaa gcagcccact gatctgtttt
     1801 gtagctgagg ttttgcatac ggttttgttt ggaggatggc ttctgctgct aaaaatacaa
     1861 aagtttggaa accgct
//
