LOCUS       NM_153015               6283 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 74 (TMEM74), transcript variant
            1, mRNA.
ACCESSION   NM_153015
VERSION     NM_153015.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6283)
  AUTHORS   Gennarelli,M., Monteleone,P., Minelli,A., Monteleone,A.M.,
            Rossi,A., Rocca,P., Bertolino,A., Aguglia,E., Amore,M., Bellino,S.,
            Bellomo,A., Biondi,M., Bucci,P., Carpiniello,B., Cascino,G.,
            Cuomo,A., Dell'Osso,L., di Giannantonio,M., Giordano,G.M.,
            Marchesi,C., Oldani,L., Pompili,M., Roncone,R., Rossi,R.,
            Siracusano,A., Tenconi,E., Vita,A., Zeppegno,P., Galderisi,S. and
            Maj,M.
  CONSRTM   Italian Network for Research on Psychoses
  TITLE     Genome-wide association study detected novel susceptibility genes
            for social cognition impairment in people with schizophrenia
  JOURNAL   World J Biol Psychiatry 23 (1), 46-54 (2022)
   PUBMED   34132174
  REMARK    GeneRIF: Genome-wide association study detected novel
            susceptibility genes for social cognition impairment in people with
            schizophrenia.
REFERENCE   2  (bases 1 to 6283)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6283)
  AUTHORS   Sun,Y., Deng,J., Xia,P., Chen,W. and Wang,L.
  TITLE     The Expression of TMEM74 in Liver Cancer and Lung Cancer
            Correlating With Survival Outcomes
  JOURNAL   Appl Immunohistochem Mol Morphol 27 (8), 618-625 (2019)
   PUBMED   29629952
  REMARK    GeneRIF: The results suggested that TMEM74 acts as an oncogene and
            a potential diagnostic marker and a therapeutic target for liver
            cancer and lung cancer.
REFERENCE   4  (bases 1 to 6283)
  AUTHORS   Sun,Y., Chen,Y., Zhang,J., Cao,L., He,M., Liu,X., Zhao,N., Yin,A.,
            Huang,H. and Wang,L.
  TITLE     TMEM74 promotes tumor cell survival by inducing autophagy via
            interactions with ATG16L1 and ATG9A
  JOURNAL   Cell Death Dis 8 (8), e3031 (2017)
   PUBMED   29048433
  REMARK    GeneRIF: TMEM74 promotes tumor cell survival by inducing autophagy
            via interactions with ATG16L1 and ATG9A.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6283)
  AUTHORS   Sun,Y., Li,Q., Zhang,J., Chen,Z., He,Q., Liu,X., Zhao,N., Yin,A.,
            Huang,H., He,M., Cao,L. and Wang,L.
  TITLE     Autophagy regulatory molecule, TMEM74, interacts with BIK and
            inhibits BIK-induced apoptosis
  JOURNAL   Cell Signal 36, 34-41 (2017)
   PUBMED   28412412
  REMARK    GeneRIF: the results revealed the autophagy modulator TMEM74
            interrelates with apoptosis inducer BIK and inhibits its function.
REFERENCE   6  (bases 1 to 6283)
  AUTHORS   Yu,C., Wang,L., Lv,B., Lu,Y., Zeng,L., Chen,Y., Ma,D., Shi,T. and
            Wang,L.
  TITLE     TMEM74, a lysosome and autophagosome protein, regulates autophagy
  JOURNAL   Biochem Biophys Res Commun 369 (2), 622-629 (2008)
   PUBMED   18294959
  REMARK    GeneRIF: These findings demonstrate that TMEM74 may be involved in
            promoting functional autophagy during cell starvation and other
            stress conditions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030710.2, AK055230.1, AC104247.5 and D60265.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153015.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.263401.1,
                                           SRR1660809.177279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297459.4/ ENSP00000297459.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BC030710.2         22-74
            54-2140             AK055230.1         1-2087
            2141-6253           AC104247.5         91871-95983
            6254-6281           D60265.1           1-28                c
            6282-6283           AC104247.5         96012-96013
FEATURES             Location/Qualifiers
     source          1..6283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..6283
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /note="transmembrane protein 74"
                     /db_xref="GeneID:157753"
                     /db_xref="HGNC:HGNC:26409"
                     /db_xref="MIM:613935"
     exon            1..119
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /inference="alignment:Splign:2.1.0"
     exon            120..6283
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1076
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /codon_start=1
                     /product="transmembrane protein 74"
                     /protein_id="NP_694560.1"
                     /db_xref="CCDS:CCDS6310.1"
                     /db_xref="GeneID:157753"
                     /db_xref="HGNC:HGNC:26409"
                     /db_xref="MIM:613935"
                     /translation="MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQK
                     QCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNC
                     CSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEE
                     DDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLE
                     KESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYG
                     SFNFRMKTSTNENTLELSLVEEDALAVQS"
     regulatory      1700..1705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /note="major polyA site"
     regulatory      6265..6270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /note="hexamer: AATGAA"
     polyA_site      6283
                     /gene="TMEM74"
                     /gene_synonym="NET36"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgagc ggcgtgcaga ggctacaagt gccgtagctg gtgattgggg gactttctcc
       61 gggaaccgtg ccgggagagc gcgcggtgct ggagccgcac cgggtggccg aagcagaaga
      121 ctttccggaa gctgctgggg gatgtctgac tagctctcat ggagctccac taccttgcta
      181 agaagagcaa ccaggcagac ctctgtgatg ccagggactg gagttcaaga gggctgcctg
      241 gtgaccaggc agatacagca gccacaagag ctgctctctg ctgtcagaaa cagtgtgcat
      301 ccaccccaag agcaaccgag atggaagggt ctaaacttag ttcttctcca gcatccccct
      361 cctcctctct gcaaaacagt actcttcagc cagatgcctt tccaccagga cttctccact
      421 cagggaacaa ccaaataaca gcggaacgga aagtctgtaa ctgctgcagc caggaattag
      481 aaacttcttt tacctatgtg gacaaaaaca tcaacttgga gcagcggaac cggagctcgc
      541 catcagcaaa agggcataat caccctgggg agcttggctg ggaaaatcca aatgagtggt
      601 cccaagaggc tgccatatct ttgatatctg aagaggagga tgatacaagt tcagaagcca
      661 cgtcttcagg gaagtctata gactatggtt tcatcagcgc catcttgttc ttggtcactg
      721 ggatcctgct cgtgatcatc tcttacatcg tcccacggga agtgactgtg gaccccaaca
      781 ctgtggcagc ccgggagatg gagcgcctgg agaaggagag tgcgaggctg ggggctcacc
      841 tggaccgctg tgtgattgcg gggctctgcc tcctcacgct ggggggcgtc atcctgtcct
      901 gcttgttaat gatgtccatg tggaaggggg agctctatcg tcgaaacaga tttgcctctt
      961 ccaaagagtc tgcaaaactc tatggttctt tcaacttcag gatgaaaacc agcacgaatg
     1021 aaaacactct ggaactgtcc ttggtagagg aagatgcgct tgctgtacag agttaattct
     1081 ggttgtgaat atcttgagag tctgccttgg cattttataa tatgaaaaaa gttaatttat
     1141 aaaaattcac agtgcaattt atttgcctgg caagaaaagt ttatttcaca aaccaacagc
     1201 cagtaagtgt ttttgttctc tatgtgtctt ctatttagaa gaaaagccat gtaagatgta
     1261 taagaaacca caaccagcca cacctatcct tctgaagagc tgaaggctaa ttaatctgta
     1321 atggccaaga acttctactt cgatagaaaa atatttctaa tgacccagtc tacaaattat
     1381 ttcttttaca caaatatatg atgttattct ttggacacta ggtggtccta cacacagtag
     1441 gatcaattgc taatctactt tgtgaaaaag aactaagcac taatcaataa taaggcttac
     1501 atctaattct caaaggtgct tatccatttt cttgctaaat tatccttctt gtaatttggc
     1561 taaacactaa aacatggaat ttttagtttg aatattttga agtttgagga tgttgggctt
     1621 tccttattgt aaaaaatgtt atgtttgaaa ttattcctgt tttcaaaaat ggtaattaag
     1681 tcattaggat aaactttcta ataaaaaaaa attatgtaaa tcattgtaag accaatgtga
     1741 atttaaacca cagtgttggt gccagatatt agccagggtc acaggctctt ttttaaaatg
     1801 aagtcaaatt agttactgat ataagtttta tattttgtga ttttgccatc atactggtta
     1861 tctgtgctct tgaagtctgc tggttctcac accagcagca agaggcaagg catgagacat
     1921 tttaaatata tttccagaca tctaaacatc tagacaggcc tgagtcatga ttggctctgg
     1981 tgtgcttcca ggtaacatct tgttattgct gtttggggaa aaccaccaat agaattgcag
     2041 ctagactttt ggggactgtg cctcgcaggc tgtatcactt gctgtaggcc aagcaacgag
     2101 cacttccctc atggtagcaa cagtccttaa gcccaaagcc aaaaaaaaat aaaatggaaa
     2161 gagagattca atacactgat ttaatgggga ctgtagtcat cgtcagaact cacctcccac
     2221 tcacagtggt ctagatgtca ttcagcaact gtgaactctt gcctcatgca gcacaaactc
     2281 ttctctaaga gcagcatgat gagcaaggtg ctcactttgc aagacacaca ctgggtgttc
     2341 acagtgacag accgcctcat tatggtgacg gttcagaaaa gggatgggaa atgcagcctc
     2401 agaaatacct tacattttgc aactctgcct ggaggttttt ccaacctgtg ctctaagagt
     2461 tgttgtaact tccatgattg tgttaccagg atcagggggt cattcttaaa aagaggacag
     2521 gagctgggaa ttggtatgag acagcaggaa tgaggaagta agaaagtgat ttctttgcag
     2581 atttttaaag gctatttcaa atgtctgaag tttgtggtgt tgtggacaac tgtggaatac
     2641 atgggtgact ttggcaaaat gtgtgaatca ggatatttat gtggatgagc tctcatgggt
     2701 gtcagattga tttgatgagt gaggtatgct gcatatgact taagggttga actgaaatac
     2761 aaaaagggag gctcagaaga tagtaaaaag agaggatggg catatgaaag aattattaag
     2821 taaaaatgag aaattatatg gccatcagag gaagctagat gtagttaatt gccttatgtt
     2881 atagagcaat actgattact gaaaagaaag aattgagatg acataaacat gatttttgct
     2941 ttctgttgct gtatttttgt gctttttgaa caaactttgt tttactgtga ctctcatttc
     3001 atgatttttg ttgaggctgc cttaccagtg gtataagttt tatattctga aggtttctaa
     3061 gtccagctct agcctgctta aggatccact ttggatgatg ttgaaacaag aaggaaacga
     3121 tctgctgagt gagtaggtct gagctgtgtg ttaaaaaaag aaggcattaa aaaaaagaag
     3181 gcattaaaga aaaaactaat gtttattcat agaagctaaa tgagatcaac tgagttttta
     3241 tttattggtg aaacaggatt aattagccaa atggcagact aaactgaatt aatgtggaat
     3301 caattttcag tttatgaagg aagaggagtt tgggaatcaa gtgttaggag gtcttttcac
     3361 ttgataataa agcttttcat gtggaagcat ttaatgaatc ttgcagggct accaaataat
     3421 atagatttga tctagaggta acattttgaa aaatgccatt ttggaaaaaa aatattcaac
     3481 gggggagaaa aagacctaac acatcaaaat acatttcctt tcttttccct agaatgctat
     3541 aatttccttt aaaatttaaa atcgaaatgt ggtaagtaaa tgcacacttc aacattattt
     3601 aaatctgcta acatatagag cacctctctt ttaaggttct acttatctga gggcaaacca
     3661 ttacacatta catgattttg aaaatcatct gaatgacttc ttttgggctg tggtgacatt
     3721 attcagatac ttgccttaat cgacttttcc ctgggtattt ggtttatgta gcccttatcc
     3781 atcctgcctg aattcaatat gaagattact tgaatttaaa atgatggtaa cacaggcaaa
     3841 gaaaagccat gtgctttatt tcctgttttt cccaatctga caaagagtgt ttttggctct
     3901 agaggtactt tggcaagacc aggtgatgca ttctatagac attgggcata caatacctat
     3961 agttttggtc ttgcatcctt catggagatt tgtgaccttc cgtctgtctc ttcaatatgg
     4021 tgctggttgt tacctgtgaa agtttttatt gctagtccta gagaagaaaa acatatttca
     4081 gtggttctag gtctttagct tatttacatg gttttagaaa tctaaactca agagtcatct
     4141 tcctagtctc aatgagaaga cagctcgtct ttcagcagtg tggcccaatg gggtgagtta
     4201 cagaaagaaa gctgtctttc tcctttatta ctgggatcta cacgctgctg gtggatgatt
     4261 taaggctcct aatatcttta taagccagtt ctttttaggg caccttaaac tgttagtggt
     4321 agagtttgca aagagttttc tttgcagcgc tgtgtgtcct tcccacccat tgggagctct
     4381 taaagcagat cacataataa gatgtactgg cccctcatat aaagaacagc ttttcgtcat
     4441 gctccccact gtgtaggtga tttatagttt acaggaagac aagactgctt ggaaccatga
     4501 agttcttgga ggccatggtt gcttttaccc acatgactgc tataaccctt gattctgttc
     4561 tatcaagtta cttgccttga tatcatcaca tgctttgctg tctgcttaaa atatgagttc
     4621 atccccctca tacttatttg ttttagggac ccaattggac cagtgctggc acatgccctt
     4681 caaggtacaa tttctgaaaa gagactgcgc tgccaaactt atgtgtgcct ttacctcagt
     4741 ccccccagta taaggggtga cttaatcttg ataaatgagt gactgagcac catgctagtt
     4801 aaatattgag aattaaaagc ctgaacccaa tggctctatt tttttttacc accttctgac
     4861 aagcaaaaat tctaggcagg agcatgtgaa cattttggtc ttcatctttc acgtgtgcaa
     4921 tgataggtgt atgcaaaatt ttacttggat taattgtcaa gttaaaaaag tgttctatat
     4981 gtatatctct taggagaagg tttttcaacc tgaaggtcag atttcattgc agcaattaat
     5041 gccatcaaaa aaacgtggtc tgacaaaaaa gattcacaac ctttgccagt ggttcaccta
     5101 ttacagcaag atgtaatact atcaatactt actgttctct gtaatgggtt taacctttcc
     5161 cagaattgga cataaagaat gactacgatg agaagattat aatgaagtct tactggcttt
     5221 tcctagtcta aaaagagtac ttaagaaaga gaattaacat atcatttcct tttggctgat
     5281 ttttagctat atctgttttt ggttcataat attctatatt atcatctcac aaattttata
     5341 agtcttggga aataatttgc ctgcctagtg aattgacact gtaaaaagca agacgttatt
     5401 ttaaacacat aaaactaatt tcaagaatct gtggcttaca ctcaagagtg tactcgtggt
     5461 ttatgtttgt gtgcagattt atgtgcactc aagtctatgt gcatttggac tatattttat
     5521 agttatacag ctttaatatc caaagttatt gttagaataa ttttattata ggaatttggc
     5581 atgccttact attgacatta agaagaagag aagtctttca caagtcatga atgaagaatt
     5641 tggaatcagc ctcagaatga gatgccataa ttattataaa cctgttttgg ttgttcagcc
     5701 tcccacaaat atttattaat ttgtttttta acctctcaat ttcaggctca tgagagtgtg
     5761 agatatttgg aaattatttt accgtgaatt gttattttat ttcaggggac tatggggagt
     5821 atattccttt gtttcaaatt tgggtaactc tcctgtgttt caggaacagc tctccctatt
     5881 ttttcactgc catcttcagg cttcctagcc aggctccaaa caaatgtcat ataagaaaga
     5941 aagattaatt attacatatt gtgtattgag agtttgtacc ctgtggttct catcgtgctg
     6001 ttaattttac ttttcttgcc aaacaaaaat aatttgacat tgattatgtg ctttttgata
     6061 ttttcaaggg caattattaa ggttatgagc tctttcttag ggcacttgat gccttatatg
     6121 ttaatagcaa gtgtgtcata tcattttaaa ataaaactat tcaaaggctt tattgtgttt
     6181 attaagctta atttaaattg gaatctgtaa tgctgatttg gtcttttaaa attatatttg
     6241 aaattatttg tccaaaaaaa ttaaaatgaa tatttacccc taa
//
