LOCUS       NM_001123376            2880 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 72 (TMEM72), transcript variant
            1, mRNA.
ACCESSION   NM_001123376 XM_001717287 XM_926597 XM_937160
VERSION     NM_001123376.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2880)
  AUTHORS   Ding,J., Matsumiya,T., Miki,Y., Hayakari,R., Shiba,Y.,
            Kawaguchi,S., Seya,K. and Imaizumi,T.
  TITLE     ER export signals mediate plasma membrane localization of
            transmembrane protein TMEM72
  JOURNAL   FEBS J 290 (10), 2636-2657 (2023)
   PUBMED   36478074
  REMARK    GeneRIF: ER export signals mediate plasma membrane localization of
            transmembrane protein TMEM72.
REFERENCE   2  (bases 1 to 2880)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2880)
  AUTHORS   Wrzesinski,T., Szelag,M., Cieslikowski,W.A., Ida,A., Giles,R.,
            Zodro,E., Szumska,J., Pozniak,J., Kwias,Z., Bluyssen,H.A. and
            Wesoly,J.
  TITLE     Expression of pre-selected TMEMs with predicted ER localization as
            potential classifiers of ccRCC tumors
  JOURNAL   BMC Cancer 15, 518 (2015)
   PUBMED   26169495
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC127790.1 and AL353801.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001123376.2.
            
            Summary: This gene encodes a transmembrane protein which may be
            expressed specifically in the kidney. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB235418.1, SRR1803613.172084.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389583.5/ ENSP00000374234.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-883               BC127790.1         22-904
            884-2880            AL353801.13        110381-112377
FEATURES             Location/Qualifiers
     source          1..2880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..2880
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /note="transmembrane protein 72"
                     /db_xref="GeneID:643236"
                     /db_xref="HGNC:HGNC:31658"
     exon            1..246
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1004
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kidney-specific secretory protein of 37 kDa"
                     /codon_start=1
                     /product="transmembrane protein 72 isoform 1"
                     /protein_id="NP_001116848.1"
                     /db_xref="CCDS:CCDS41504.1"
                     /db_xref="GeneID:643236"
                     /db_xref="HGNC:HGNC:31658"
                     /translation="MQLQVFWTGLEYTCRLLGITTAAVLIGVGTETFLQGQFKSLAFY
                     LLFTGAAVSICEGAYFVAQLLAICFQCQPGSLADRVREKAHWLGCFQKFLAYLLLSVA
                     CFLHPVLVWHVTIPGSMLIITGLAYFLLSKRKKRKAAPEVLASPEQYTDPSSSAVSTT
                     GSGDTEQTYTFHGALKEGPSSLFIHMKSILKGTKKPSALQPPNTLMELSLEPADSLAK
                     KKQVHFEDNLVRIVPSLAEGLDDGDSEPEETTSDTTPIIPPPQAPLFLSSLTATGLF"
     exon            247..313
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /inference="alignment:Splign:2.1.0"
     exon            314..385
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /inference="alignment:Splign:2.1.0"
     exon            386..525
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /inference="alignment:Splign:2.1.0"
     exon            526..2880
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /note="hexamer: AATAAA"
     polyA_site      2880
                     /gene="TMEM72"
                     /gene_synonym="C10orf127; KSP37"
                     /note="major polyA site"
ORIGIN      
        1 gagccctatt cacacctcgg ccaggctgcg gtggccagga ctggtttggg aaggcagggc
       61 cccggtgtgc agccacagcc agcagcctcc tacctacaca agggtgttcg ggagcatctc
      121 agggccgaag actttgctgc ctgccctgcc aggactttgt cctcacccct ggcaccatgc
      181 agctccaggt gttctggact gggctggaat acacctgccg gctcctgggc atcaccactg
      241 ctgcagtgtt gatcggcgtg ggcactgaga ccttcctcca gggccagttc aaaagcctgg
      301 ctttctatct gctgtttaca ggagccgctg tctccatatg tgaaggggcc tactttgtgg
      361 ctcagctgct ggccatctgc ttccagtgtc aaccagggtc cctggcagac agagtaaggg
      421 agaaagccca ctggctgggc tgcttccaga agttcctggc ctacctgctg ctgtcggtgg
      481 cctgcttcct ccacccggtc ctggtctggc acgtgaccat cccaggctcc atgctcatca
      541 tcaccggcct ggcctacttc cttctgagca agcggaagaa gaggaaagct gcccccgagg
      601 tgctggcctc cccagagcag tacacagacc cctctagcag cgctgtgagc accaccggct
      661 ctggggacac agagcaaacc tacactttcc atggggccct caaggagggg cccagctccc
      721 ttttcatcca catgaagagt atcctgaagg ggactaagaa gcccagtgcc ctccagcccc
      781 ccaacaccct gatggagctg agcctggagc cagccgactc cctggccaag aagaagcagg
      841 tgcactttga agacaacttg gtccgcatag tcccctccct cgccgaaggt ctggatgatg
      901 gggacagtga gccagaggag accacctctg acacgacacc catcattccc cctccccagg
      961 ccccactctt cctgtcatct cttacagcca ccggcctgtt ctgagcgctt gctccagcct
     1021 ggaggacgct cagtgagggg tctacctagc tcaatggccc tccctggagt ttcagggtct
     1081 tctctggtca gcttttcaag gggtaaccag acacccccac actggctggg cccctgaggc
     1141 catcaggagg tgtgactggc cagcatttct ggagaggcct cgagggaggc acaaacaagg
     1201 ctcacgccac ctcaagccag cacaagctcc ttcctcctgg ccacaggtgg ggaaaccctt
     1261 atgcttcccc aacaagacca tcactgccac tgcgcacgag gctgcaggtg ccattgactc
     1321 agcccagaag ggacagagga tgtctgccca gcaaaagcct ctgggctttt cttactccca
     1381 acccagggca caacactcag tgaggaacct atggtccacc catctctgca ggcccaggga
     1441 agtgtcagta acttaagcat ctctaaggca gagaaggtgg ctgtgggtct tgaccaacca
     1501 agactgctca gggtcgggag gggaggctgc aggcctctgg tgggagcagc cgggccgtgg
     1561 gccacattct ctgcatgctc tagggctggg gctgagctgc tcaggaaaac aatgccgctc
     1621 tgtgctcact gtgggaaagc caggccagat gagcaaagct cattccagaa acatggctgg
     1681 ggacttccag cctccttacc acatggcctt tccaagattc caggttgatg atgcaaactg
     1741 aacgcagtga atgccagggc ccagaaggca atgtctgctg tgggcaggac cacagaggct
     1801 gcccaggggt ggcacagcac agagaagtgt cagtgccgtg tttaggcact tggtagcaga
     1861 ataggtgata aatataaatg tcttcaaaat gaaaggaagt gaggggggaa gaagaggagg
     1921 gaaaatggga ggataggagg aagtgggcag gcaggcaagt tctctgccat ggggccacgg
     1981 aagtgacagt taacccagaa ggaacaaaga catctgaatc agatattcct ttgtaaatct
     2041 gtaaaggatt tgcaatatag gctttacttc taaaaattgt tgtcgggtcc atgaggctgt
     2101 tgccaggaag agcacacaca ccattcttca tggcaactgc agtgagggag cagtcaggag
     2161 gaagagtcct gtggcttctc agtccctgtg gaggctaacg caaagctctg tagaacaagc
     2221 cttagagtgc atgctctatg gtctaatgag aaacttgtgt ttgtgcttgc acacgtttca
     2281 atgttcccta caggatattt tacaaaggta tgaaaataat ggccaaccag aagctagtat
     2341 cagtttgggg cctaaatgca gcaggtgttc ctgataagca gataagcaga gctcttcctg
     2401 cagtagccca ggtctcacca aatgacaaat ggctaatcaa gacactcctg caagcccttg
     2461 atggtgagag ctgcagagct gtttcttcag ctgccatcaa ggcaggacct caggacctga
     2521 ctgtctacag tcagggaata gtgaacaata tgggatatgg gtataggtag gtggtagaca
     2581 aggatcgtgc cccatggctg atgggccggg tgtctcaggc aggccccctg tgcacagaaa
     2641 gagcctaagt gcagagaagc caggcatctt tcccctgtca actgtggaag gggaatgtga
     2701 tggccacaga caccctcatg gcacagacat ggccagcctc tgacgttcct ctgcatcaga
     2761 gtagttctgt cctcgaagcc ccagtcagca gagctggatg accagatcgc aagaagcaaa
     2821 ccagaaagtg tgatggcaga gatgtcagat cccgtttaat aaacacttca gtaaacccaa
//
