LOCUS       NM_001382403            2057 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 71 (TMEM71), transcript variant
            9, mRNA.
ACCESSION   NM_001382403
VERSION     NM_001382403.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2057)
  AUTHORS   Wang,K.Y., Huang,R.Y., Tong,X.Z., Zhang,K.N., Liu,Y.W., Zeng,F.,
            Hu,H.M. and Jiang,T.
  TITLE     Molecular and clinical characterization of TMEM71 expression at the
            transcriptional level in glioma
  JOURNAL   CNS Neurosci Ther 25 (9), 965-975 (2019)
   PUBMED   31180187
  REMARK    GeneRIF: Molecular and clinical characterization of TMEM71
            expression at the transcriptional level in glioma.
REFERENCE   3  (bases 1 to 2057)
  AUTHORS   Ythier,D., Larrieu,D., Binet,R., Binda,O., Brambilla,C., Gazzeri,S.
            and Pedeux,R.
  TITLE     Sumoylation of ING2 regulates the transcription mediated by Sin3A
  JOURNAL   Oncogene 29 (44), 5946-5956 (2010)
   PUBMED   20676127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF228727.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4368604.1,
                                           SRR14038192.3774770.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000677595.1/ ENSP00000504388.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AF228727.4         57733-57839         c
            108-183             AF228727.4         56097-56172         c
            184-244             AF228727.4         54491-54551         c
            245-457             AF228727.4         49042-49254         c
            458-630             AF228727.4         44199-44371         c
            631-819             AF228727.4         25055-25243         c
            820-895             AF228727.4         19297-19372         c
            896-957             AF228727.4         11411-11472         c
            958-1015            AF228727.4         11252-11309         c
            1016-2057           AF228727.4         7198-8239           c
FEATURES             Location/Qualifiers
     source          1..2057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..2057
                     /gene="TMEM71"
                     /note="transmembrane protein 71"
                     /db_xref="GeneID:137835"
                     /db_xref="HGNC:HGNC:26572"
                     /db_xref="MIM:620287"
     exon            1..107
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            108..183
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1031
                     /gene="TMEM71"
                     /note="isoform 9 is encoded by transcript variant 9"
                     /codon_start=1
                     /product="transmembrane protein 71 isoform 9"
                     /protein_id="NP_001369332.1"
                     /db_xref="CCDS:CCDS94343.1"
                     /db_xref="GeneID:137835"
                     /db_xref="HGNC:HGNC:26572"
                     /db_xref="MIM:620287"
                     /translation="MYRISQLMSTPVASSSRLEREYAGELSPTCIFPSFTCDSLDGYH
                     SFECGSIDPLTGSHYTCRRSPRLLTNGYYIWTEDSFLCDKDGNITLNPSQTSVMYKEN
                     LVRIFRKKKRICHSFSSLFNLSTSKSWLHGSIFGDINSSPSEDNWLKGTRRLDTDHCN
                     GNADDLDCSSLTDDWESGKMNAESVITSSSSHIISQPPGGNSHSLSLQSQLTASERFQ
                     ENSSDHSETRLLQEVFFQAILLAVCLIISACARWFMGEILASVFTCSLMITVAYVKSL
                     FLSLASYFKTTACARFVKI"
     exon            184..244
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            245..457
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            458..630
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            631..819
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            820..895
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            896..957
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1015
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..2057
                     /gene="TMEM71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM71"
                     /note="hexamer: AATAAA"
     polyA_site      1522
                     /gene="TMEM71"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM71"
                     /note="hexamer: AATAAG"
     polyA_site      2057
                     /gene="TMEM71"
                     /note="major polyA site"
ORIGIN      
        1 actcatttat accaggaaac agacaagaga acaagaggct gccgaagaca aaacttctct
       61 gcaagcacct gtgcacagca atgtgcgtgg gcatctgtga gaagaagaga atctgtgaag
      121 tttgagcaag cggccttccc aagatgtacc gaatatctca actgatgtca acaccagtag
      181 caagttcttc caggttggaa agagaatatg ctggagagct gtctcccacg tgcattttcc
      241 caagtttcac ctgtgattcc ctggatggtt accattcttt tgaatgcggc tccatagatc
      301 ccctgacagg ctcccactat acctgtcgcc gaagtcccag actcctcacc aatggctact
      361 atatttggac tgaagacagc ttcctgtgcg acaaagatgg caacataact ctgaacccat
      421 cccagaccag cgttatgtat aaggagaact tagttaggat atttagaaag aaaaagagaa
      481 tctgccattc cttttcttct ctcttcaacc tcagtacctc caaatcttgg ctgcatggaa
      541 gtatctttgg tgacatcaac tcttctccaa gtgaagacaa ctggttgaag gggaccagga
      601 ggttggacac agaccattgc aatggaaatg cagatgattt agactgttct tctctgactg
      661 atgactggga gtcagggaag atgaatgcag agtctgtgat cacctcctct tccagccaca
      721 tcatatctca gcctcctgga ggaaactccc atagcttgtc tcttcagtcc cagttgacag
      781 cttctgaacg tttccaagag aatagttcgg atcattcaga aaccaggttg ttgcaagagg
      841 tcttctttca ggcaatcctg cttgctgtgt gcttaatcat ttctgcatgt gcaagatggt
      901 ttatgggaga aatattagcc agtgtcttca catgctcatt gatgataact gtagcttatg
      961 tgaaatcatt gtttctcagc cttgccagct atttcaaaac cactgcctgt gctcggtttg
     1021 tcaaaatttg acaaccattt aggaatgcct tcgatgaatg tcctccatct gaatatctgg
     1081 aaattgtcca acttgcagtc tacttggaat caagtgtttt attggaaggg agtaagcgag
     1141 taatggagaa aaagccattt tagtttgact atgtgatttt aaaatgatct cagtttttcc
     1201 atcaaaatta taatatgctc atgaaaataa tattaatttg ccttcccttt gcaaacaccg
     1261 gcagttgaaa ggaaaaggac ggggaatgtg atggaaaaga gaccgcctgg aataaatgtc
     1321 cccctatgat tctttaaggc agtggttctc gagcttgaat tttcattagg aaattctgtg
     1381 aggagcttgt aaccagattt ctgggtctgc cacatgcacc tatctcttgc tgaattgctt
     1441 taatagaata atgagagcaa gtttgtctaa ctaataccaa cctgacaact tgaataacaa
     1501 taaatgcaat ttgtacataa aatataatgc tgcaaaagtt tgtcattcac ctcagtggag
     1561 tgacttgata ttaggtggta accgtagatg atggttaata tgaaaatgga caggaaagaa
     1621 gcattttctg aaagttatat tcttttgaac cacgttctaa accaagtttt taatcttctt
     1681 ggggctcgta attacctttc actttaatgt cacttaaaga tataacacag aaaaatgcct
     1741 tgagggcaaa atataggcaa aacaccaatg cgctttcaaa tgcatgaaaa tggtgcagtt
     1801 gtacccttga gccttgactc aagggctgta gatgttccct ttccaccccc cacacttggt
     1861 gcgtgttcac aaagcaaata tggcctgtaa ttcaaatttg ttctatgtga tactctctga
     1921 gtaaaaactc atacatgcag aaaattgtct ttgctcgaaa tgataatgcc aaaatataac
     1981 tttatatata atttgcattt agtacatttt tggttaaaaa ataaactaat aaataagtga
     2041 agtcatcagc aaattta
//
