LOCUS       NM_016486               1465 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 69 (TMEM69), mRNA.
ACCESSION   NM_016486 XM_005270919
VERSION     NM_016486.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1465)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1465)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA451438.1 and BC013608.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016486.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.198381.1,
                                           SRR5189661.133351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372025.5/ ENSP00000361095.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA451438.1         7-18
            13-1465             BC013608.1         1-1453
FEATURES             Location/Qualifiers
     source          1..1465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1465
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /note="transmembrane protein 69"
                     /db_xref="GeneID:51249"
                     /db_xref="HGNC:HGNC:28035"
     exon            1..95
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /inference="alignment:Splign:2.1.0"
     exon            96..232
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..934
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /codon_start=1
                     /product="transmembrane protein 69"
                     /protein_id="NP_057570.2"
                     /db_xref="CCDS:CCDS41325.1"
                     /db_xref="GeneID:51249"
                     /db_xref="HGNC:HGNC:28035"
                     /translation="MLRFIQKFSQASSKILKYSFPVGLRTSRTDILSLKMSLQQNFSP
                     CPRPWLSSSFPAYMSKTQCYHTSPCSFKKQQKQALLARPSSTITYLTDSPKPALCVTL
                     AGLIPFVAPPLVMLMTKTYIPILAFTQMAYGASFLSFLGGIRWGFALPEGSPAKPDYL
                     NLASSAAPLFFSWFAFLISERLSEAIVTVIMGMGVAFHLELFLLPHYPNWFKALRIVV
                     TLLATFSFIITLVVKSSFPEKGHKRPGQV"
     exon            233..1465
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1446..1451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /note="hexamer: ATTAAA"
     polyA_site      1465
                     /gene="TMEM69"
                     /gene_synonym="C1orf154"
                     /note="major polyA site"
ORIGIN      
        1 acttgccgga agtgcctttc cagtggacct gggctgttgt tgcggttgtt ttccttctct
       61 ccgtgcaacg ctggcaagtc tcaaagtcgc cacagaaaca tgcccctgat tcagtgcctc
      121 tgcttagctg taacatgtta atcagaacta cctggcatct tcctgaacaa gactttcaat
      181 aggggccagt atgcttcgct tcatccagaa gttttctcaa gcatcttcaa agatactgaa
      241 gtactctttc ccagtgggac taagaaccag cagaacagat atactttctc tcaagatgtc
      301 tctccagcaa aacttttccc catgtccaag gccttggctt tcctcatcat ttccagcgta
      361 tatgagcaag acacagtgct atcatacatc cccctgcagc tttaaaaagc agcagaagca
      421 agcacttcta gccagaccct caagcaccat cacttaccta actgacagcc caaagccagc
      481 attatgtgta actctggcag gactaatccc cttcgttgct ccaccactgg tcatgctgat
      541 gacaaaaact tatattccca tattagcttt tactcagatg gcttatggag ccagtttcct
      601 atctttcttg ggtgggatca gatggggttt tgctctacca gaaggtagtc cagccaaacc
      661 agactacctt aatttagcta gcagtgcagc tcctcttttc ttttcatggt ttgccttcct
      721 tatttctgaa agacttagtg aagccatagt cacagtaata atgggtatgg gagtagcatt
      781 ccaccttgaa ctttttctct taccacatta tcccaactgg tttaaagccc tgaggatagt
      841 agtcacttta ttggccactt tttcatttat aatcacttta gtagttaaaa gtagttttcc
      901 agaaaaagga cataagagac ctggtcaagt ataaaaaata taaaagtctg ggaagtgagg
      961 agcacctctg cccagctgct gccccgtctg ggaagtgagg agcgcctctg cctggccgcc
     1021 tgaccatctg ggaagtgtga caagcgcctc tgcccggccg ctgtgcaacc ttccacgtgt
     1081 gaagtgacag ccttgtgtgt gatcttttct gtcttcccca agtttgcatt ttcgacatta
     1141 aagtttactt tttagttaaa agttttaaaa atatatatat ataaatacac tgtagataac
     1201 atttgtatgc cagctacacc tttttctact tctgtttggc tttttttccc cacaccaatg
     1261 gtaatttatc ttcacagatt gttcttcatt tctagaaatt gttacttcat ggtaattact
     1321 tgagcaaaag cttgaaaatc cctgacaagt acttttcatc tcatagtata ttagttttca
     1381 ctcagtcatt ttatgaataa tatagttatc cacttaaaca tttcaatatt ttaaccatct
     1441 tgaaaattaa agattaaaaa tcccc
//
