LOCUS       NM_001363177            2179 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens transmembrane protein 68 (TMEM68), transcript variant
            6, mRNA.
ACCESSION   NM_001363177 XM_017013040
VERSION     NM_001363177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2179)
  AUTHORS   McLelland,G.L., Lopez-Osias,M., Verzijl,C.R.C., Ellenbroek,B.D.,
            Oliveira,R.A., Boon,N.J., Dekker,M., van den Hengel,L.G., Ali,R.,
            Janssen,H., Song,J.Y., Krimpenfort,P., van Zutphen,T., Jonker,J.W.
            and Brummelkamp,T.R.
  TITLE     Identification of an alternative triglyceride biosynthesis pathway
  JOURNAL   Nature 621 (7977), 171-178 (2023)
   PUBMED   37648867
  REMARK    GeneRIF: Identification of an alternative triglyceride biosynthesis
            pathway.
REFERENCE   2  (bases 1 to 2179)
  AUTHORS   Wang,Y., Zeng,F., Zhao,Z., He,L., He,X., Pang,H., Huang,F. and
            Chang,P.
  TITLE     Transmembrane Protein 68 Functions as an MGAT and DGAT Enzyme for
            Triacylglycerol Biosynthesis
  JOURNAL   Int J Mol Sci 24 (3), 2012 (2023)
   PUBMED   36768334
  REMARK    GeneRIF: Transmembrane Protein 68 Functions as an MGAT and DGAT
            Enzyme for Triacylglycerol Biosynthesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2179)
  AUTHORS   Chang,P., Heier,C., Qin,W., Han,L., Huang,F. and Sun,Q.
  TITLE     Molecular identification of transmembrane protein 68 as an
            endoplasmic reticulum-anchored and brain-specific protein
  JOURNAL   PLoS One 12 (5), e0176980 (2017)
   PUBMED   28472192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2179)
  AUTHORS   Zhan,M., Chen,G., Pan,C.M., Gu,Z.H., Zhao,S.X., Liu,W., Wang,H.N.,
            Ye,X.P., Xie,H.J., Yu,S.S., Liang,J., Gao,G.Q., Yuan,G.Y.,
            Zhang,X.M., Zuo,C.L., Su,B., Huang,W., Ning,G., Chen,S.J.,
            Chen,J.L. and Song,H.D.
  CONSRTM   China Consortium for Genetics of Autoimmune Thyroid Disease
  TITLE     Genome-wide association study identifies a novel susceptibility
            gene for serum TSH levels in Chinese populations
  JOURNAL   Hum Mol Genet 23 (20), 5505-5517 (2014)
   PUBMED   24852370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA121422.1, AK056932.1, AL832935.1, AC100817.5 and DB370750.1.
            
            On May 10, 2018 this sequence version replaced XM_017013040.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.215928.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               DA121422.1         1-110
            111-155             AK056932.1         59-103
            156-1445            AL832935.1         49-1338
            1446-2176           AC100817.5         115617-116347       c
            2177-2179           DB370750.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..2179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..2179
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /note="transmembrane protein 68"
                     /db_xref="GeneID:137695"
                     /db_xref="HGNC:HGNC:26510"
     exon            1..110
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            111..155
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            156..323
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..805
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.22"
                     /note="isoform 5 is encoded by transcript variant 6;
                     2-acylglycerol/1,2-diacylglycerol O-acyltransferase;
                     monoacylglycerol/Diacylglycerol O-acyltransferase;
                     DGAT1/2-independent enzyme synthesizing storage lipids"
                     /codon_start=1
                     /product="DGAT1/2-independent enzyme synthesizing storage
                     lipids isoform 5"
                     /protein_id="NP_001350106.1"
                     /db_xref="GeneID:137695"
                     /db_xref="HGNC:HGNC:26510"
                     /translation="MEKIPEDGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADH
                     FVFKIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALISDETYNIVWGH
                     RRGFAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFRWLYEKFRYPFAPMYGGFPVKL
                     RTYLGDPIPYDPQITAEELAEKTKNAVQALIDKHQRIPGNIMSALLERFH"
     exon            324..517
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            518..578
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            579..718
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            719..2179
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /note="hexamer: ATTAAA"
     polyA_site      2179
                     /gene="TMEM68"
                     /gene_synonym="DIESL; MGAT/DGAT"
                     /note="major polyA site"
ORIGIN      
        1 agccgccgct tggcttcttt cacacgggtt gcttcggagg aatccgccgt gcaaatctgt
       61 ccgccccctt ggccactgat cccccgaaga gcttctgtcg ccgctctagg aatagagaca
      121 ttgaagtttg ggacaagata tttatctaac ttctggttat gaagttcatg gaatggaaaa
      181 aataccagaa gatggaccag cacttataat tttttatcat ggagctattc ctatagattt
      241 ttactatttc atggctaaaa tatttataca caaaggcaga acttgccgag tagtagctga
      301 tcactttgtc tttaaaattc cagggtttag tttattactg gatgtgtttt gtgctctaca
      361 tggaccaaga gaaaaatgtg ttgaaattct gaggagtggc cacttgttag ctatctcacc
      421 aggtggagtt cgagaagccc taattagtga tgaaacttat aacatcgtat ggggtcatcg
      481 cagaggcttt gctcaggttg caattgatgc aaaagtgccc attattccta tgtttacaca
      541 aaatattcga gaaggattta gatcacttgg aggaacaagg ttatttaggt ggctttatga
      601 aaaattccgc tatccatttg ctccaatgta tggaggtttt ccagtgaagt tacggaccta
      661 tttaggcgac cccattccgt atgacccaca gataacagcg gaagaattag ctgaaaagac
      721 gaagaatgct gttcaagctt tgattgataa gcaccaaaga ataccaggaa acattatgag
      781 tgctttgtta gaacgttttc attgataaca aagggtcaac tagaagatga tttagtacat
      841 ttatattaaa tgtttgtatc taaggtactg tcttctgaat tttgtaggtc ctataattag
      901 tattttttaa aaaaatcatg ttaataagca tctttcacag aattcgtttc tttaaaatag
      961 tcaattttgt ttttgcaatt gtgtcaaata ctaacaaatt acacacctag taattcagaa
     1021 aaagatgtct tatttgtaaa ttcctaacaa tttatgctaa acatatagat tcttaagttt
     1081 attaataaca gcagtttagg ttaaacaaac attcctggat aatgcgttaa atttctgtat
     1141 ctgtcgccct gagctgattt tgaaagatgg tataagctag gggttagtat agttgtttaa
     1201 gttagaaaaa acatgctgtt gtctgcccct cattcccttc atgaccttgg gcaagtcacg
     1261 taatgttttt gtgcctcaac aattcacttt ttaaaaacat gatcgtatga tgaatgatat
     1321 tattttgtta tttatattta ctgtgattga taactgttga accaaaataa taaaataatt
     1381 aatttaaaca atgtcaaaat cctttagcag ttatgtatat attttctcca ttgtgtgttt
     1441 aaattatgtc atgtccagtt gccaagcaca atgaaaaaga tgtattattt tttaaattga
     1501 ataaaaaatt aggaaaaata aaatttctaa ttattatttt tagtatgata tttttaacaa
     1561 gagtctatag gcaaacaata tagggtgtgc tgtgcattgt cagccctata ctgtggtctt
     1621 aataatgcca gcttaaaaat cactgttgtg ctctgcattt cgtgtgttag aagctgattc
     1681 taggctgagg aaagcaagag ttctctactt ttgctcaata ttgaggctta cccagtttga
     1741 ctctacagcc agtgaagtgg tttattgctt caataaaaat atacttgaat gatgaattta
     1801 tttatgtttt gttttgtttt tatttagaga tggggttttg ccatgttggc caggctggtc
     1861 ttgaactcct gacctcaggt gatccacctg cctcagcctc ccaacttgct gggattacag
     1921 gtgtgagcca ccatgcccag cctgaatgat gaatttatgt gaacacaaag ccctctgaaa
     1981 aattaatgat tttcaatttg ttgtcttctt gaaaactgaa tttaagtatt atttaaacag
     2041 aaaagtgtca gaaatcaaat gcagtatctc cctctccctt ttttaaatgt tgaattagta
     2101 gggtttttgt atagcttttt gtattgtgtg tatttatgat atgtgaaatg tacataaaat
     2161 taaacaatgt gaaaataaa
//
