LOCUS       XM_047422410            3707 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens transmembrane protein 67 (TMEM67),
            transcript variant X11, mRNA.
ACCESSION   XM_047422410
VERSION     XM_047422410.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..3707
                     /gene="TMEM67"
                     /gene_synonym="JBTS6; MECKELIN; MKS3; NPHP11; TNEM67"
                     /note="transmembrane protein 67; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 14 ESTs, 130 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:91147"
                     /db_xref="HGNC:HGNC:28396"
                     /db_xref="MIM:609884"
     CDS             236..2038
                     /gene="TMEM67"
                     /gene_synonym="JBTS6; MECKELIN; MKS3; NPHP11; TNEM67"
                     /codon_start=1
                     /product="meckelin isoform X4"
                     /protein_id="XP_047278366.1"
                     /db_xref="GeneID:91147"
                     /db_xref="HGNC:HGNC:28396"
                     /db_xref="MIM:609884"
                     /translation="MPEKGVTEDGWNCISCPSDLTAEGKCHCPIGHILDSNSGKWLLT
                     RRIFLVDAVSGRENDLGTQPRVIRVATQISLSVHLVPNTINGNIYPPLITIAYSDIDI
                     KDANSQSVKVSFSVTYEMDHGEAHVQTDIALGVLGGLAVLASLLKTAGWKRRIGSPMI
                     DLQTVVKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPIQEERFVTYV
                     GCAFALKALQFLHKLISQITIDVFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTY
                     FVANEWNEIQTVRKINSLFQVLTVLFFLEVVGFKNLALMDSSSSLSRNPPSYIAPYSC
                     ILRYAVSAALWLAIGIIQVVFFAVFYERFIEDKIRQFVDLCSMSNISVFLLSHKCFGY
                     YIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFEIAISNQMRQHYDR
                     IHETLIRKNGPARLLSSSASTFEQSIKAYHMMNKFLGSFIDHVHKEMDYFIKDKLLLE
                     RILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIFDLLFFCVVDLACQNFILAS
                     FLTYLQQEIFRYIRNTVGQKNLASKTLVDQRFLI"
ORIGIN      
        1 gaggcttcca gcgtcggtac catggcgacg cgcggtgggg ctggggtggc aatggcggtt
       61 tggtccctct tatccgcccg ggccgtgacc gcgttccttc tgttgttcct ccctcgcttc
      121 ttacaggccc agaccttctc tttccctttc cagcagccgg agaagtgcga caacaaccag
      181 tactttgata tctccgccct ctcgtgtgtt ccttgtggag ctaaccagag gcaagatgcc
      241 cgagaaaggt gttacagaag atggctggaa ctgcatttct tgccctagtg acttaactgc
      301 cgaaggaaaa tgtcactgtc ccattggcca tattttagac agcaactctg gaaagtggct
      361 tctaactcgg cgcattttct tagtggatgc agtaagtgga cgagaaaatg acttaggaac
      421 tcagccaaga gtaattcgag ttgctactca aatatcactg agtgtccacc ttgtacccaa
      481 cacaataaat ggaaacatct accctccctt aatcaccatt gcctacagtg acattgatat
      541 caaagatgcc aacagccagt ctgtgaaggt ttctttctca gtcacatatg aaatggatca
      601 tggagaagca catgtccaga cagatattgc tttgggtgta ttgggtgggc tagctgtttt
      661 agcatctctt ttgaagacag caggatggaa gaggcgcatt gggagtccca tgattgattt
      721 acagacagtt gtgaaattct tggtgtacta tgctggtgat ctggccaatg ttttctttat
      781 catcacagtg ggaacaggtc tttactggct tattttcttc aaagcacaga agtctgtgtc
      841 tgttttgctg ccaatgccaa ttcaggaaga acgttttgtc acttatgttg gatgtgcctt
      901 tgctctgaag gcactacaat ttttgcataa gctcatatcc cagattacaa tagatgtatt
      961 ctttattgat tgggagcgac ctaaaggaaa ggttcttaaa gctgttgaag gtgagggtgg
     1021 tgtacgaagt gccactgttc ctgtaagcat atggagaaca tattttgtag caaatgaatg
     1081 gaatgaaatt cagactgtga gaaaaattaa ttcactcttt caagtactta ctgtcctctt
     1141 ctttttggag gttgtgggat tcaagaactt agcattaatg gactcatctt ctagtctttc
     1201 tagaaaccca cctagctaca tagctcctta tagctgcatt ttgagatatg cagtgtctgc
     1261 tgctctttgg ctagccattg gaattataca ggtcgtgttc tttgctgtct tttatgagag
     1321 atttatagaa gataaaattc gacagttcgt tgatttatgc tctatgagta atatatcagt
     1381 gtttctgtta tcccacaaat gttttggata ttacattcat ggtagatcag tacatgggca
     1441 tgcagatact aatatggaag aaatgaatat gaaccttaaa agagaagcgg aaaatttgtg
     1501 tagccagaga ggtttggtac ccaacacaga tggtcagact tttgagattg caatttctaa
     1561 ccagatgaga caacattatg acagaattca tgagacacta ataaggaaaa atggtcctgc
     1621 tagactactg agttcatcag caagtacttt tgagcagagt ataaaagcat atcatatgat
     1681 gaataaattt cttggctcct tcattgacca tgttcataag gaaatggatt actttataaa
     1741 agataagttg cttcttgaaa gaattcttgg aatggaattc atggaaccaa tggaaaaaag
     1801 catcttttac aatgatgaag gttattcttt cagcagtgtc ctgtattatg gaaatgaagc
     1861 tactcttctt atttttgatc tgctgttctt ctgtgttgtg gatttggctt gccaaaattt
     1921 tattttagca tccttcctta catatctaca acaagagatt tttagatata tccgtaatac
     1981 agtaggacaa aagaatttgg catccaaaac attggtggat caaagatttt tgatttaact
     2041 tcctgaataa ataacttaaa gactcagtat aatcatggcc aaaaaaaagt catgatatca
     2101 ggttagtttg ccatattttt taaaacttat aatgcagact attctgtttt tgttttttat
     2161 ttgcagaaag atttattttt ataacttggg aatatataac ctgatataat agaaaatact
     2221 gttttcccat tgtgtgtagt atttaatgca gtaaataata aattaatact gacagtgagg
     2281 ccaaaaaaaa tctaaatgtt gctttcagca taatactttt taatgctaat taaaacagtc
     2341 cccatcattt gtctctgtag attattttat aaactgagag ctgcctgaat cttctcacat
     2401 tgacaaagta atttgattcc aagtttaaga ctagttttca gtttgatatt ttcatgtttt
     2461 gtgtgcttat ggttaaataa atgttgaaag atattttcaa gtttacttag aaattttaaa
     2521 ttgtattatt gctgattcaa tttgcatcat tctaattgct catcctcttt ggcagtggat
     2581 taattcactg ttgggttaat atgcatctca tgaaatgata tcttttcatt cctttgtata
     2641 cctgtattag gtcagtatac gctttccatg aaatatattt gcatttctaa tatagtttac
     2701 atttattaag ttataacgta tgacattttt cccaatatca ttttttatac attttaatta
     2761 cttaatgttt taagagttct cttccagagt tttgcttttc aattacgttt aaagactgta
     2821 aataacaaac agtaaggctg ggcgctgtgg cttacgcctg taatcccagc actttggaag
     2881 gccaaggcac gtggatcact ttaggtcagg agttcaagaa cagcctggcc aacatggaaa
     2941 accccatctc tacaaaaaat acaaaaatta gttggatgtg gtggcctgta atcccagcta
     3001 tttgggaggc tgaggcatga gaatagcttg aaaccaggag gtggaggctg tagtgagcca
     3061 gatagcacca ctgcactcca gccaggatga cagagcaaga ccctgtctca gaaaaaacaa
     3121 aaacaaaaca ctgtaaatgt atcatgtttc tcactgcttt ctatgttaat gctgtgtaaa
     3181 tacttaaaat ggaatactgt ataaatatta tttatatttt ctcagatgaa aatatatact
     3241 aaaacatttg gtatttctgt tttctgtttc attaatgtat atctgatgga gtaccattta
     3301 ggaatataac attattgggg cagaggtccc agccattgcc aaagttgaat cttttacatt
     3361 tccctgaatc ttgaggatga ctgaaaagga agtctttgaa actgcagttt ctgaaggatc
     3421 acagtacagg aatgccttta taaaagctgc agagataaat acatgtactt atatggcatg
     3481 gatatttaaa accactcact cagaagcata tgaaagaaat tcaaccatca ttcaacatag
     3541 aagaagttaa ttttagtgca aaagttttta agtattaaat ttcacaataa aggatcaatt
     3601 ggcttacttg ctgataaatt aaaacagaaa acatttaaaa tcattctaaa ttttgtatga
     3661 tatttttatt ttggctaggt gcataaaaat gtgttcagat tttcata
//
