LOCUS       XM_006716686            4589 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens transmembrane protein 67 (TMEM67),
            transcript variant X8, mRNA.
ACCESSION   XM_006716686
VERSION     XM_006716686.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006716686.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..4589
                     /gene="TMEM67"
                     /gene_synonym="JBTS6; MECKELIN; MKS3; NPHP11; TNEM67"
                     /note="transmembrane protein 67; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 24
                     ESTs, 198 long SRA reads, 1 Protein, and 97% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 45 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:91147"
                     /db_xref="HGNC:HGNC:28396"
                     /db_xref="MIM:609884"
     CDS             236..2920
                     /gene="TMEM67"
                     /gene_synonym="JBTS6; MECKELIN; MKS3; NPHP11; TNEM67"
                     /codon_start=1
                     /product="meckelin isoform X1"
                     /protein_id="XP_006716749.1"
                     /db_xref="GeneID:91147"
                     /db_xref="HGNC:HGNC:28396"
                     /db_xref="MIM:609884"
                     /translation="MPEKGVTEDGWNCISCPSDLTAEGKCHCPIGHILVERDINGTLL
                     SQATCELCDGNENSFMVVNALGDRCVRCEPTFVNTSRSCACSEPNILTGGLCFSSTGN
                     FPLRRISAARYGEVGMSLTSEWFAKYLQSSAAACWVYANLTSCQALGNMCVMNMNSYD
                     FATFDACGLFQFIFENTAGLSTVHSISFWRQNLPWLFYGDQLGLAPQVLSSTSLPTNF
                     SFKGENQNTKLKFVAASYDIRGNFLKWQTLEGGVLQLCPDTETRLNAAYSFGTTYQQN
                     CEIPISKILIDFPTPIFYDVYLEYTDENQHQYILAVPVLNLNLQHNKIFVNQDSNSGK
                     WLLTRRIFLVDAVSGRENDLGTQPRVIRVATQISLSVHLVPNTINGNIYPPLITIAYS
                     DIDIKDANSQSVKVSFSVTYEMDHGEAHVQTDIALGVLGGLAVLASLLKTAGWKRRIG
                     SPMIDLQTVVKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPIQEERF
                     VTYVGCAFALKALQFLHKLISQITIDVFFIDWERPKGKVLKAVEGEGGVRSATVPVSI
                     WRTYFVANEWNEIQTVRKINSLFQVLTVLFFLEVVGFKNLALMDSSSSLSRNPPSYIA
                     PYSCILRYAVSAALWLAIGIIQVVFFAVFYERFIEDKIRQFVDLCSMSNISVFLLSHK
                     CFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFEIAISNQMRQ
                     HYDRIHETLIRKNGPARLLSSSASTFEQSIKAYHMMNKFLGSFIDHVHKEMDYFIKDK
                     LLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIFDLLFFCVVDLACQNF
                     ILASFLTYLQQEIFRYIRNTVGQKNLASKTLVDQRFLI"
ORIGIN      
        1 gaggcttcca gcgtcggtac catggcgacg cgcggtgggg ctggggtggc aatggcggtt
       61 tggtccctct tatccgcccg ggccgtgacc gcgttccttc tgttgttcct ccctcgcttc
      121 ttacaggccc agaccttctc tttccctttc cagcagccgg agaagtgcga caacaaccag
      181 tactttgata tctccgccct ctcgtgtgtt ccttgtggag ctaaccagag gcaagatgcc
      241 cgagaaaggt gttacagaag atggctggaa ctgcatttct tgccctagtg acttaactgc
      301 cgaaggaaaa tgtcactgtc ccattggcca tattttagtg gaaagagaca ttaatggaac
      361 attgttgtct caagcaactt gtgagctctg tgatggaaat gaaaactctt ttatggtagt
      421 aaatgcttta ggagacaggt gcgtccgatg tgagccaaca tttgttaata ccagcaggtc
      481 ctgtgcatgt tcagaaccta acattttaac agggggatta tgtttcagca gcacagggaa
      541 ttttcctcta cgtagaattt cagctgcacg ttatggagaa gttggcatgt ctttaacttc
      601 agaatggttt gcaaagtatt tgcaatcatc agcagctgca tgttgggtat atgccaatct
      661 aacatcttgt caagctcttg gaaatatgtg tgtgatgaac atgaattctt acgactttgc
      721 cacatttgat gcatgtggac tatttcagtt tatctttgaa aatactgctg gactgagcac
      781 tgttcattct atttcatttt ggagacagaa tcttccttgg ctgttttatg gagaccagtt
      841 aggattagca cctcaagtgc tcagttctac ctctcttcct acaaatttca gttttaaagg
      901 agaaaaccag aatacaaaac tgaagtttgt tgctgcttcc tatgatataa gaggaaattt
      961 tctcaagtgg caaactttag aaggaggtgt tttacagctt tgtccagaca cagagacaag
     1021 gctaaatgct gcttattcat ttggaacaac ctaccaacaa aattgtgaga ttcctatctc
     1081 taagatctta attgactttc ccactcctat attttatgat gtgtaccttg aatatactga
     1141 tgaaaatcaa catcaatata ttttggctgt gcctgtgtta aacctaaatc ttcaacataa
     1201 taagatattt gtgaaccaag acagcaactc tggaaagtgg cttctaactc ggcgcatttt
     1261 cttagtggat gcagtaagtg gacgagaaaa tgacttagga actcagccaa gagtaattcg
     1321 agttgctact caaatatcac tgagtgtcca ccttgtaccc aacacaataa atggaaacat
     1381 ctaccctccc ttaatcacca ttgcctacag tgacattgat atcaaagatg ccaacagcca
     1441 gtctgtgaag gtttctttct cagtcacata tgaaatggat catggagaag cacatgtcca
     1501 gacagatatt gctttgggtg tattgggtgg gctagctgtt ttagcatctc ttttgaagac
     1561 agcaggatgg aagaggcgca ttgggagtcc catgattgat ttacagacag ttgtgaaatt
     1621 cttggtgtac tatgctggtg atctggccaa tgttttcttt atcatcacag tgggaacagg
     1681 tctttactgg cttattttct tcaaagcaca gaagtctgtg tctgttttgc tgccaatgcc
     1741 aattcaggaa gaacgttttg tcacttatgt tggatgtgcc tttgctctga aggcactaca
     1801 atttttgcat aagctcatat cccagattac aatagatgta ttctttattg attgggagcg
     1861 acctaaagga aaggttctta aagctgttga aggtgagggt ggtgtacgaa gtgccactgt
     1921 tcctgtaagc atatggagaa catattttgt agcaaatgaa tggaatgaaa ttcagactgt
     1981 gagaaaaatt aattcactct ttcaagtact tactgtcctc ttctttttgg aggttgtggg
     2041 attcaagaac ttagcattaa tggactcatc ttctagtctt tctagaaacc cacctagcta
     2101 catagctcct tatagctgca ttttgagata tgcagtgtct gctgctcttt ggctagccat
     2161 tggaattata caggtcgtgt tctttgctgt cttttatgag agatttatag aagataaaat
     2221 tcgacagttc gttgatttat gctctatgag taatatatca gtgtttctgt tatcccacaa
     2281 atgttttgga tattacattc atggtagatc agtacatggg catgcagata ctaatatgga
     2341 agaaatgaat atgaacctta aaagagaagc ggaaaatttg tgtagccaga gaggtttggt
     2401 acccaacaca gatggtcaga cttttgagat tgcaatttct aaccagatga gacaacatta
     2461 tgacagaatt catgagacac taataaggaa aaatggtcct gctagactac tgagttcatc
     2521 agcaagtact tttgagcaga gtataaaagc atatcatatg atgaataaat ttcttggctc
     2581 cttcattgac catgttcata aggaaatgga ttactttata aaagataagt tgcttcttga
     2641 aagaattctt ggaatggaat tcatggaacc aatggaaaaa agcatctttt acaatgatga
     2701 aggttattct ttcagcagtg tcctgtatta tggaaatgaa gctactcttc ttatttttga
     2761 tctgctgttc ttctgtgttg tggatttggc ttgccaaaat tttattttag catccttcct
     2821 tacatatcta caacaagaga tttttagata tatccgtaat acagtaggac aaaagaattt
     2881 ggcatccaaa acattggtgg atcaaagatt tttgatttaa cttcctgaat aaataactta
     2941 aagactcagt ataatcatgg ccaaaaaaaa gtcatgatat caggttagtt tgccatattt
     3001 tttaaaactt ataatgcaga ctattctgtt tttgtttttt atttgcagaa agatttattt
     3061 ttataacttg ggaatatata acctgatata atagaaaata ctgttttccc attgtgtgta
     3121 gtatttaatg cagtaaataa taaattaata ctgacagtga ggccaaaaaa aatctaaatg
     3181 ttgctttcag cataatactt tttaatgcta attaaaacag tccccatcat ttgtctctgt
     3241 agattatttt ataaactgag agctgcctga atcttctcac attgacaaag taatttgatt
     3301 ccaagtttaa gactagtttt cagtttgata ttttcatgtt ttgtgtgctt atggttaaat
     3361 aaatgttgaa agatattttc aagtttactt agaaatttta aattgtatta ttgctgattc
     3421 aatttgcatc attctaattg ctcatcctct ttggcagtgg attaattcac tgttgggtta
     3481 atatgcatct catgaaatga tatcttttca ttcctttgta tacctgtatt aggtcagtat
     3541 acgctttcca tgaaatatat ttgcatttct aatatagttt acatttatta agttataacg
     3601 tatgacattt ttcccaatat cattttttat acattttaat tacttaatgt tttaagagtt
     3661 ctcttccaga gttttgcttt tcaattacgt ttaaagactg taaataacaa acagtaaggc
     3721 tgggcgctgt ggcttacgcc tgtaatccca gcactttgga aggccaaggc acgtggatca
     3781 ctttaggtca ggagttcaag aacagcctgg ccaacatgga aaaccccatc tctacaaaaa
     3841 atacaaaaat tagttggatg tggtggcctg taatcccagc tatttgggag gctgaggcat
     3901 gagaatagct tgaaaccagg aggtggaggc tgtagtgagc cagatagcac cactgcactc
     3961 cagccaggat gacagagcaa gaccctgtct cagaaaaaac aaaaacaaaa cactgtaaat
     4021 gtatcatgtt tctcactgct ttctatgtta atgctgtgta aatacttaaa atggaatact
     4081 gtataaatat tatttatatt ttctcagatg aaaatatata ctaaaacatt tggtatttct
     4141 gttttctgtt tcattaatgt atatctgatg gagtaccatt taggaatata acattattgg
     4201 ggcagaggtc ccagccattg ccaaagttga atcttttaca tttccctgaa tcttgaggat
     4261 gactgaaaag gaagtctttg aaactgcagt ttctgaagga tcacagtaca ggaatgcctt
     4321 tataaaagct gcagagataa atacatgtac ttatatggca tggatattta aaaccactca
     4381 ctcagaagca tatgaaagaa attcaaccat cattcaacat agaagaagtt aattttagtg
     4441 caaaagtttt taagtattaa atttcacaat aaaggatcaa ttggcttact tgctgataaa
     4501 ttaaaacaga aaacatttaa aatcattcta aattttgtat gatattttta ttttggctag
     4561 gtgcataaaa atgtgttcag attttcata
//
