LOCUS       NM_194291               9038 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 65 (TMEM65), mRNA.
ACCESSION   NM_194291 XM_001129168
VERSION     NM_194291.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9038)
  AUTHORS   Shi,L., Wang,X., Guo,S., Gou,H., Shang,H., Jiang,X., Wei,C.,
            Wang,J., Li,C., Wang,L., Zhao,Z., Yu,W. and Yu,J.
  TITLE     TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to
            activate PI3K-Akt-mTOR pathway and is a therapeutic target
  JOURNAL   Oncogene 43 (13), 931-943 (2024)
   PUBMED   38341472
  REMARK    GeneRIF: TMEM65 promotes gastric tumorigenesis by targeting YWHAZ
            to activate PI3K-Akt-mTOR pathway and is a therapeutic target.
REFERENCE   2  (bases 1 to 9038)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 9038)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9038)
  AUTHORS   Nazli,A., Safdar,A., Saleem,A., Akhtar,M., Brady,L.I.,
            Schwartzentruber,J. and Tarnopolsky,M.A.
  TITLE     A mutation in the TMEM65 gene results in mitochondrial myopathy
            with severe neurological manifestations
  JOURNAL   Eur J Hum Genet 25 (6), 744-751 (2017)
   PUBMED   28295037
  REMARK    GeneRIF: A novel homozygous splice variant (c.472+1G>A) in the
            TMEM65 gene identified in a patient with mitochondrial
            encephalomyopathy.  TMEM65 mutation severely affected mitochondrial
            content and respiration rate in dermal fibroblasts.
REFERENCE   5  (bases 1 to 9038)
  AUTHORS   Sharma,P., Abbasi,C., Lazic,S., Teng,A.C.T., Wang,D., Dubois,N.,
            Ignatchenko,V., Wong,V., Liu,J., Araki,T., Tiburcy,M., Ackerley,C.,
            Zimmermann,W.H., Hamilton,R., Sun,Y., Liu,P.P., Keller,G.,
            Stagljar,I., Scott,I.C., Kislinger,T. and Gramolini,A.O.
  TITLE     Evolutionarily conserved intercalated disc protein Tmem65 regulates
            cardiac conduction and connexin 43 function
  JOURNAL   Nat Commun 6, 8391 (2015)
   PUBMED   26403541
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9038)
  AUTHORS   Nishimura,N., Gotoh,T., Oike,Y. and Yano,M.
  TITLE     TMEM65 is a mitochondrial inner-membrane protein
  JOURNAL   PeerJ 2, e349 (2014)
   PUBMED   24765583
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090192.19, DB479586.1, BC032396.1, BM679703.1, BQ433192.1 and
            AW300050.1.
            
            On Aug 11, 2020 this sequence version replaced NM_194291.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041379.1, SRR14372079.3430535.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297632.8/ ENSP00000297632.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC090192.19        106188-106189       c
            3-39                DB479586.1         1-37
            40-367              DB479586.1         41-368
            368-701             AC090192.19        105489-105822       c
            702-2676            BC032396.1         1-1975
            2677-3227           BM679703.1         21-571              c
            3228-3862           BQ433192.1         1-635
            3863-4309           AW300050.1         12-458              c
            4310-9038           AC090192.19        39677-44405         c
FEATURES             Location/Qualifiers
     source          1..9038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..9038
                     /gene="TMEM65"
                     /note="transmembrane protein 65"
                     /db_xref="GeneID:157378"
                     /db_xref="HGNC:HGNC:25203"
                     /db_xref="MIM:616609"
     exon            1..848
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..1267
                     /gene="TMEM65"
                     /codon_start=1
                     /product="transmembrane protein 65"
                     /protein_id="NP_919267.2"
                     /db_xref="CCDS:CCDS6348.1"
                     /db_xref="GeneID:157378"
                     /db_xref="HGNC:HGNC:25203"
                     /db_xref="MIM:616609"
                     /translation="MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPP
                     GGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQE
                     KLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAA
                     LGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCI
                     LGMFPLIFFGGGEEDEKLETKS"
     exon            849..893
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     exon            894..961
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1016
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1059
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1165
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..9038
                     /gene="TMEM65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM65"
                     /note="hexamer: ATTAAA"
     polyA_site      3237
                     /gene="TMEM65"
                     /note="major polyA site"
     regulatory      3813..3818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM65"
                     /note="hexamer: AACAAA"
     polyA_site      3837
                     /gene="TMEM65"
                     /note="major polyA site"
     regulatory      9014..9019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM65"
                     /note="hexamer: AATAAA"
     polyA_site      9038
                     /gene="TMEM65"
                     /note="major polyA site"
ORIGIN      
        1 acttctgctg ccgctagggg tagcggcggc ggcggcggct gcggctcggg agcgcggctg
       61 ctttgagggc tcgggaacct tacagagtgg ggacgtgggg aggctagagg gtgagaaagc
      121 tggcgggaga gtagggcggc gctggaggag ggcggtgcgt ggctgactca tcctctggaa
      181 gatcagactg acagagacac acactagccc gccccgcccg cccgcgccgc tcctcctcag
      241 ccgggaggcg cccgcccgca ccgaccgccc gccctctccg ggcgctgtcc gggcccggcc
      301 gtctcagaga aagtttttcc catcggaggg gcgggagccg ccgcgggcct tttggaaagg
      361 aagtggggac ggaacaggag gcgagagccg cgcgggcccg cggagtgcat ggtgcccggc
      421 gcctcggctg cctggcagga ggacctcggg gcggggtcga gctgagccca gctccttctc
      481 gcctcagccg cgccagaaac cgccttgccg gacggccgcg ggggtcccag ctcctcagct
      541 cgccatgtcc cggctgctgc cgctgctgag gagccggacc gcgcgcagcc tgaggccggg
      601 cccggccgcc gccgccgcgc cccgcccgcc gtcctggtgc tgctgcgggc gggggctgct
      661 ggcgctcgcg ccccccggcg gcttgccggg cggccccagg cggctgggca cgcaccccaa
      721 gaaggagccc atggaggcgc tgaacacggc gcagggcgcg cgcgacttca tctacagcct
      781 gcactccacg gagaggagct gcctgctcaa agagctgcac cgcttcgagt ctattgccat
      841 tgcccaagaa aaattggaag ctccaccacc caccccagga cagctgagat atgtattcat
      901 ccacaatgcg atacctttca tagggtttgg ctttttggat aatgcaatta tgattgttgc
      961 tggaacccat attgaaatgt ctattggaat tattttggga atttcaacta tggcagctgc
     1021 tgctttggga aatcttgtgt cagatctagc tggacttgga cttgcaggct acgttgaagc
     1081 attggcttcc aggttaggcc tgtcaattcc tgatctcaca ccaaagcaag ttgacatgtg
     1141 gcaaacacgt cttagtacac atttgggcaa agctgttggg gtgactattg gctgcattct
     1201 aggaatgttt cctttaattt tctttggagg aggtgaagaa gatgaaaaac tggaaacgaa
     1261 aagttaatcc tcttagaata cctataaaaa gatgtaaact aatgtacctc agtaattaaa
     1321 tatgctgtca caacatttag gaattaagac agtaacagta tagatatggg atcaaataat
     1381 ttagcatgta ttatggaaaa cactaactta ttgtggcttg atcttcttag gacatctttt
     1441 ttaaaaagct gtttagtatc attttgtgta tattgttgaa atgctttttc atcaatagca
     1501 gtcaacattt tatcctttct ttttatattc ataatgttat ttaagtgtca ttgatgtact
     1561 gtattgactt ggggtttgct tatttgttac ttaacatgtg tacatgcatg aaagcatttt
     1621 tcgttgttcc ctgatagtta catttcaacc ttgggatttt tccaaattac ttaagatgtt
     1681 taatgtcagt taaagatttt tttaccctct ttttgggaac atcaattttg tactgttatg
     1741 cagtaaacat ttataataat ataatttcag tcatttctta actgtcacat ctattgaaaa
     1801 tggatataga tacaggtttt aagtatttta agtatatatt acttatttta attttctgac
     1861 tttactattt taagggccag agggttaatc acaaagagca attatgtggt ctccctgcta
     1921 catgaaaccg tgtatactaa caagcgtaca atttttagtt gatttttttt aaccttttag
     1981 tttcccagtt ttgaataatt acatggtgga ttctgacttt tgaggggaag caaatgatta
     2041 ttttagagtc tttgaaatgg ggattgtgga attagattga actaagggat ttaacatgat
     2101 gcttggaaat taagagacta aagctttttt taaaaaaagg tggaaaatag gaactgtcaa
     2161 gaaggtttat ggtataaatg atgaagttga agtgatgttt gaaagattaa tgagatacaa
     2221 tttatattat ttggtaaggt tttttttttt ccctccaaag atgtcatctt ctcatctgaa
     2281 tggaataagt ctgaataccc catattcata ctcctaatct cattatatct tatttagtga
     2341 attttattta tgaataattt ctgttgaagt gaaaactaga tatttaatat tttgcttttt
     2401 tgctacatag tctactcaaa aattacatga ggagaaatcc tttttccctt tgtttttctt
     2461 ttttcttctt ttgtggtatt taaagcatat tttaggttga agttacttat ttctagtctt
     2521 gtacttctgg cttaagtata accatgtaag aattataaat tttagttttc tgaaccctta
     2581 aactttttta gcatgtggtc tgttacacat gctaaaaaat tagtcttact tgtaacagcg
     2641 taattaaaca catcatggag gagagaaact taaaattaaa atagtatttt ggcttttgaa
     2701 gttatttgtg ttgctaaata gatgcagagg ttttacagca gtttatttta aggttttatt
     2761 tatacataat tactttgaac tcttcagagt agatattttt tcacaaggca gtttgtcata
     2821 aattctctca tgcgcttcag aatgcataag tgccatcctt taatcataga ctttgaggag
     2881 agaaagcata aaaatatagc atataatcta aaaataaata tataacatgc acaaataatg
     2941 tgacattctt actgaatcaa atcatgattc tagaacttga gatcttaaat agaatttcgg
     3001 tttgtatctt ccatataata accacacaca gataaccaca caaaaaatcc tttgtaaaat
     3061 ttctgattga taggattaga gtgcttaaat ttttgggggg ggaagggtgg ggtaaagtgt
     3121 aagtgctttc ttttgtccct aacttgtgta ttgatggcag tccactctgt tttctaaaaa
     3181 tgtattttac tgtggtgctt aacttcttat taattaaatc ccgtatcaga aaccttgcct
     3241 gtgactttag aaagggcttt tgattattgt tttttcttct tgctcttgaa agtaatctgg
     3301 tcccagggaa ttactggttt aactgaacat ctccagaatt atttaaggtg tcaaaatata
     3361 taaccttcac attgaaagat aattttaatt tatgggcata ataaaaattt gaatcattca
     3421 ggtaattttc aaaaaatgga gaccatttgt ctttaactga aggtatatgt ttaagatcat
     3481 agtctaccct agtatggtgc tttgccacaa agtgatttct gaagaatggt tctttttaag
     3541 ataatgactt catatgatca ttgtttcatg ttacttgcca caaataactt taatttaggt
     3601 tgaaactgga actgtttgtt tctcatatta gctacttctc tattaggagc acaagaacca
     3661 tagttaaatg caacatgagc tactttagtc ctgtttgttt aaatttgtgt tgtccatgta
     3721 ttatgattta ttaacttgtt gatgcatgta aattgggtgc attttgttgc catgtatgtt
     3781 aaatggtgac caatgttttt acaaaggaat tgaacaaaaa aagtatcttt taagaaattt
     3841 ggaatgtggt tttgattttg aaatttgatt tcttactaat ctcagagggc cttggtatat
     3901 tctgttacta aagcaaacag gattaatgaa tacggatttg ttacaaggtg gcagcaatgt
     3961 cactgagata gtgaatggaa caatttacca cctccctgga atctgcacct gagatacaac
     4021 atcagcgtat gagtgaagag tgagcccata gaaaagcttt agatagactc acataagtca
     4081 cactgatggg tatttacagc agatatatcc aagctgttta tgtaatagtc tcatttactt
     4141 tattcttttt ctctagaaca taaattttga aggtaatgga agtttatctt ttataccaaa
     4201 agtttgtatg agccattttg aagtaaatct ttctaatttt agaattatat tttctcgcca
     4261 tcttaagaca gtatattaaa tataatataa cctttttctt agtggctaag cattatcttt
     4321 atgtatatta ttattgtgtg gtaatgcagt accttgagaa tctagttttt atagttttca
     4381 tttttttttc tgatcttgct tctggcaact tttatctctc taatctgctt tttttctcag
     4441 ttgtctggac ttagaaactg gttagcctat cttaccataa attatttggg aaatactaaa
     4501 aaattggctt tggatcctga ctgagatgat gatgatgata gtagtagtag taataataat
     4561 agttcccttt tattaaacac ttatttggtc ctttatgcac tagtaattta cacacattat
     4621 tgcatttaat caccttaatg acaacattaa gttggggcta ttatcattat catctctatt
     4681 ttctcatagc taaattgagg catgaagagg ttagtttgcc actacgaata agtggactgg
     4741 aatcctattt tgtccaagta tgaagcctgt cttcttaact gctaggcagt agggacatca
     4801 gttgcatggg ctttgcaatg tctgctctct gcctaggttc ctttttacct ccagattcat
     4861 ggagtcattt tcttatctat aatttaagaa tattgtgctt acaatccaag attcatttaa
     4921 gaaatcttgt gttctttatt acatactatg tgctaggatg ttcaaggcac tgagtgaaca
     4981 accagaacat ctgtaccctc atgaagctta ttcttttggg gtgggtagta ataggggaag
     5041 agaacacaga aaagcaaata tacttttttt tgagatggag tcttgatgtc acccaggctg
     5101 gagtgcagtg gcgtgatctt ggcttattgc aacctctgct tcctgggttc aagtgattct
     5161 cctgcctcag cctcctgagt agctgggatt acagtcacgt gccaccgagc ctaatttttt
     5221 tgtattttta gtagaaacgg ggtttcacca tgttggccag gctggcctca gactcctgac
     5281 ctcctgagta gctgggatta caggcacgtg ccaccgagcc taattttttt gtatttttag
     5341 tagaaacggg gtttcaccat gttggccagg ctggcctcag actcctgacc tcaggtggtc
     5401 cacctgtctc ggcctcccaa agtgctggga ttacaggcgt gagcccctgc gcccacctgc
     5461 aaatatacac ttaaatattg tttatgtcag atggtggtaa gttctataga gataaatgaa
     5521 acaagataaa gaggatagaa agtaccagtg gtcataagtg aagatggtca gtgaagacct
     5581 gaaggaagcg aaggtacaaa cagtacagat attctgtgaa gagaaagtat catgctaggt
     5641 actagaaagt tggtgttaag aaaatctcag atatgtgaaa tatgtttcac tttggaattc
     5701 attgtaaaat gttttctttt tgtttcatat tactaataac tgcattaagc ctaaagagta
     5761 acagttaaat attaagatta atacttactt cttgcatgtt tactgacagc agtaggtgaa
     5821 aatggcacag aagtgtgggg aagcaaccct agaattcaaa aaagtctgta gatattccca
     5881 tcagcaaatc atttacagtt gactcttgaa caatggaggg attagggaca ccaaccccct
     5941 gtgctgctga aaatctgaat acaacttttt actctctcca aactttactt atagcctcct
     6001 attggctgga agcctttctg ataaataagc agtagattaa cacgtatttt gtatgttata
     6061 tgtatcatat attgtattaa aataaaggta gaagaaagaa aatgttatta aaatcatcag
     6121 gaagagaaaa tacatttact attcattaag tggatcatga taaaagtctt catcctcctt
     6181 gtcttcatgt tgagtaggct gaggtggagg aggaagagga aggattggtc ttgctcttag
     6241 tggtagcaga ggtgcaaggg gaagcaggaa aggcaggcac actacgtgta attatgaaaa
     6301 tgcattgtaa cttctgtctg atgttttgct ttttttcatt tctcaaaata tttctatata
     6361 tggtattaat ccttcttcca ccatttgctt tagttttagt gcctgtgtga tagaagggtt
     6421 catgttgtaa aatcagtctt gaataatcag aacacttcta ccagattgtc taatgttgat
     6481 ttgttttctg gcactgcttc taaatgtctt cctcctcatt ctgtggcact gattcagagg
     6541 cactcatctc caaaagctaa gcttttgaat tgcttagctt ttgattcact ccaggattca
     6601 gatcttgaaa ctttctaccc tccaccattt atttatttat ttaatttgac atatctacaa
     6661 cctctttcat gattttcttg attggctctg ttgtaaattc tgcgaagtca cacacaacat
     6721 ctggttgttt tcctcagcag gaatttattg ttttgggctt gatggctttc atgtcttctg
     6781 tagcaacaat ggcatcatca gtggtggaat ccttccagac tttgatgatg ttctctttgt
     6841 tagagttctc ttgcatggca ctgatggttc tttgcataga gtactgtgtg taatgagcct
     6901 ataggtcctt atgactccct gatctagaaa ctaaattaga gacattgtgt ttgggggcaa
     6961 atagatcact tcgatgcctt tagtattgaa ctcatggagt tctgggtggg tggccagggg
     7021 cattgtccag tatcaaaaca actttaaaag gcagtccttt actggcaagg tacttcctga
     7081 cttcaaagac aaaacagcaa tggagccaat ccagaaaaag ggttcttgtc gtccaggcct
     7141 tcttgttata ctgccagaag actggcagct ggtgtttatc ttttcccttc aagacttggg
     7201 agttaacagc tttatagata agtgcagtct tgatcataaa cccaacagca tttgcaaaaa
     7261 cccatagcat tagcctgtcc ctttctgcct taaaccctgg tgctcacttc tcttctttac
     7321 taataaatgt tctttgtggc atattattat ttttccataa tagggcactt ctgtctgcct
     7381 taagaacctg ttttggtaga tatgctttct cctcaatgat tttcttaatg gcatctggga
     7441 actcatttgc tgcctcttgg tcatcaggag ctgcctcttc tgttatctta acatttttaa
     7501 agccaaactt ctttctaata ttatcaagcc atcctttgct ggcattaaat tctctagatt
     7561 tagatccttc accttccttt tgctttaaat tgtcatataa tgaccgcctt ttctccaatc
     7621 atattagagc ctataggtac gtctttcttg tagcaatact gcacccacat aaaagttgca
     7681 tttttaatac gagataaaaa ggtatatcac aaaaagtgta aggtttgctg gtatagatgc
     7741 agtaatggct tcataaattt tcttaatttt ttttaacagt ggtccttatg ctggattcat
     7801 ttatcttgaa ggatgggcaa ctacagctgc agaccagtac acatcaagca atttaacttt
     7861 ttcttgtaat gtcatgactt tgctccttgg gagcacttcc agcgtcacta gcgggacttc
     7921 atatgggtcc cttggtatta ttgcaaggtt tatggttgta ctaaacatga tgaaaaataa
     7981 ctgagaacca tgagagatca ctttttacta cgatacacaa tttactggag agatgaactg
     8041 cccatgtgga gatgataaac atcacatggc attttaagtg aatacagcac ttgagctcac
     8101 agcaacagca acaggaggta gctctgaaat tatggtagta gtgcagtatg tactatagtt
     8161 aatcttatcc agttgtaatt tagtactgca tctttatgtt tgtctcaact gcaaatggct
     8221 ccaatgtata gtctgtgtat gcgttaagtt ttgataaatt ttaacttttt ttttttttga
     8281 gatggagtct tgctctgttg tccaggctgg agtgcagtgg caccatgccg gctcactgca
     8341 acctctgtct tctgggttca agtgattctc ctgcctcagc ctcccaagta gttgggatta
     8401 caggcatgca tccccatgcc cagctaattt ttgtattttt aggagaaaca gggtttcacc
     8461 atgttggcca ggctgctctt gaactcctga cctcaggtga tccgcctgcc tcggcctcct
     8521 gaagtgttgg gattacaggc gtgagccact gcgcccggcc aattttaact tttcataata
     8581 gatttgtata tatttatggt agtaaatgat aaaatagact agtgtctaca tatattatat
     8641 gaattcatga cacacctttt tcttagtttt tcagtatttc taagctacat ggtgcatctg
     8701 caagtttttt aaattgttgc aaatttccaa aaaaattttc aatatattta tcaaaatatg
     8761 catataagcg gtcctatgca gttcaaaccc gtgtttgaga atcaacttta tgacttccag
     8821 tgtcattctc caccatttct gcagtttatc acattttgct tcaggcagat ttggtaaatc
     8881 ttcaatgata gttctctagg ccattgtttt gtaacatgat caaatgctta atgggaaata
     8941 gaatatgtat atgtattctt tgtctaccaa ctaccaaaga aacaaatact cctcagtttg
     9001 acttgactta gtaaataaac ttgtgttggg ttaatgga
//
