LOCUS       NM_001008495            4992 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 64 (TMEM64), transcript variant
            1, mRNA.
ACCESSION   NM_001008495 XM_095568
VERSION     NM_001008495.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4992)
  AUTHORS   Cao,D., Cai,J., Li,Y., Dong,R., Wang,Z. and Zuo,X.
  TITLE     [TMEM64 is highly expressed in hepatocellular carcinoma and
            promotes tumor cell proliferation and invasion]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (8), 1345-1355 (2023)
   PUBMED   37712271
  REMARK    GeneRIF: [TMEM64 is highly expressed in hepatocellular carcinoma
            and promotes tumor cell proliferation and invasion].
REFERENCE   2  (bases 1 to 4992)
  AUTHORS   Dera,A.A., Ranganath,L., Barraclough,R., Vinjamuri,S., Hamill,S.,
            Mandourah,A.Y. and Barraclough,D.L.
  TITLE     Altered Levels of mRNAs for Calcium-Binding/Associated Proteins,
            Annexin A1, S100A4, and TMEM64, in Peripheral Blood Mononuclear
            Cells Are Associated with Osteoporosis
  JOURNAL   Dis Markers 2019, 3189520 (2019)
   PUBMED   31814858
  REMARK    GeneRIF: Low TMEM64 expression is associated with Osteoporosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4992)
  AUTHORS   Kim,H., Kim,T., Jeong,B.C., Cho,I.T., Han,D., Takegahara,N.,
            Negishi-Koga,T., Takayanagi,H., Lee,J.H., Sul,J.Y., Prasad,V.,
            Lee,S.H. and Choi,Y.
  TITLE     Tmem64 modulates calcium signaling during RANKL-mediated osteoclast
            differentiation
  JOURNAL   Cell Metab 17 (2), 249-260 (2013)
   PUBMED   23395171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106038.3 and AB015752.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001008495.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.15848.1,
                                           SRR1660803.195076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2467146,
                                           SAMN03267756 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458549.7/ ENSP00000414786.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-973               AC106038.3         62695-63667
            974-1129            AC106038.3         77071-77226
            1130-4992           AB015752.1         111017-114879       c
FEATURES             Location/Qualifiers
     source          1..4992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..4992
                     /gene="TMEM64"
                     /note="transmembrane protein 64"
                     /db_xref="GeneID:169200"
                     /db_xref="HGNC:HGNC:25441"
                     /db_xref="MIM:620429"
     exon            1..973
                     /gene="TMEM64"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1321
                     /gene="TMEM64"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 64 isoform 1"
                     /protein_id="NP_001008495.2"
                     /db_xref="CCDS:CCDS34920.2"
                     /db_xref="GeneID:169200"
                     /db_xref="HGNC:HGNC:25441"
                     /db_xref="MIM:620429"
                     /translation="MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPAD
                     RLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAGGPGSGGGGVVVG
                     VAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGV
                     LLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLT
                     AWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLM
                     ASSVGLLPTQLLNSYLGTTLRTMEDVIAEQSVSGYFVFCLQIIISIGLMFYVVHRAQV
                     ELNAAIVACEMELKSSLVKGNQPNTSGSSFYNKRTLTFSGGGINVV"
     exon            974..1129
                     /gene="TMEM64"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..4992
                     /gene="TMEM64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM64"
                     /note="hexamer: AATAAA"
     polyA_site      3450
                     /gene="TMEM64"
                     /note="major polyA site"
     regulatory      4974..4979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM64"
                     /note="hexamer: AATAAA"
     polyA_site      4992
                     /gene="TMEM64"
ORIGIN      
        1 actccccgcc tggccgtcgc tcctccgctg actccgcgcc cttctacggg ccgtctccca
       61 ccctctgagc ggacgcaggg agtcgatgcc gggcgaaccg ggcgccatga agggcagctg
      121 cctaacgggc gccgcggcgg aggggctggc cggctgaggg cccgcgctgg gccgaggcat
      181 gcggagcccg ggcgggatcc tgctccaggc gctgccccgg ctgctgcagc acgccgccct
      241 cccgggcctc gccgagctgc cggcccgctg ggccctgccg cggggtgcgg gcggggacgg
      301 cccggcggac cgccttcccc gcgggggcgg ggcgagcgcg gcggcggcag cagcggcggc
      361 ctcgggcgcc ctgctcggcg cctatctgga gcgccacggt ccgcccgagg cttcggagct
      421 gccggagccg ggcggggcct tggcgggcgg ccccgggagt ggcggcggcg gcgtggtggt
      481 cggcgtggct gaggtgagaa actggcgctg ctgctgcctc ggcagcacct gttggtgccg
      541 gagcctcgtg ctggtctgcg tgttggccgc cctgtgcttc gcttccctgg ccctggtccg
      601 ccgctacctt caccacctcc tgctgtgggt ggagagcctt gactcgctgc tgggggtcct
      661 gctcttcgtc gtgggcttca tcgtggtctc tttcccctgc ggctggggct acatcgtgct
      721 caacgtggcc gctggctacc tgtacggctt cgtgctgggc atgggtctga tgatggtggg
      781 cgtcctcatc ggcaccttca tcgcccatgt ggtctgcaag cggctcctca ccgcctgggt
      841 ggccgccagg atccagagca gcgagaagct gagcgcggtt attcgcgtag tggagggagg
      901 aagcggcctg aaagtggtgg cgctggccag actgacaccc ataccttttg ggcttcagaa
      961 tgcagtgttt tcgattactg atctctcatt acccaactat ctgatggcat cttcggttgg
     1021 actgcttcct acccagcttc tgaattctta cttgggtacc accctgcgga caatggaaga
     1081 tgtcattgca gaacagagtg ttagtggata ttttgttttt tgtttacaga ttattataag
     1141 tataggcctc atgttttatg tagttcatcg agctcaagtg gaattgaatg cagctattgt
     1201 agcttgtgaa atggaactga aatcttctct ggttaaaggc aatcaaccaa ataccagtgg
     1261 ctcttcattc tacaacaaga ggaccctaac attttctgga ggtggaatca atgttgtatg
     1321 attctaatga gatacgtgat tgtcaagagc ctagtgtgct atctaaggtc tagcagtcac
     1381 ttcactagtg ggcagagaca agttctaatt gtattacagc acaaacaaaa ctgactagtt
     1441 tttaaattgc acaatttttt ttttttaaag caagaatcat tttctgggta tgtaagtgta
     1501 aatgtagatg caaatttggc tgcacctctt tatcatgcct gtattggcct ataggtctgc
     1561 actttagtgt tttttaattg ttttatttct gtgtatttac gaacagagaa ataacccaaa
     1621 tattatttct gcttagtgtc tttatttata aagcccatga gtagtttgta tgcatctttc
     1681 ctacttgtaa agatgagtaa aagtatgcag ttttaaattt ataatattat tggatgttct
     1741 ttgctttggt agtctttcca gaaaggataa acagtggttt ttgttttgtt ttgttttatt
     1801 gtttaagtgg gaccacttag cttcccgttt ccttactagt taaagaacag acattaattt
     1861 tcagttgaat gtatttttgc aggcatcata ttgttacagg gccatttaca cctattcaca
     1921 aagcttaaat cctaccttgt gggactgaag tgctcttaat ataactgttt attttcactg
     1981 tgtaatatgc aaagcaaaag ggaaattatt tggtggatgg tagctcaaaa ttggaactct
     2041 tgttctaatt cagttacatt ggctttaccc tccttagatt tttcatcaaa gggctgtccc
     2101 attgcaatct tactaaaaca ttttgttaaa ataaactctt ttccttttta tattaataat
     2161 taggctttta aataaagatg ttattccttt aaaatggtgg gcttaccatc attgaagatg
     2221 tcactcaggt ggccttgttt gatcaaaacg ccttttttaa aaaccaagct ttaaaaacat
     2281 gtttataatt tcatgaagta catatatatt gttcccatag tcttcagctt taaaactata
     2341 aatatgccca aattttgtta tttgccctac tttaagtagg tttattgtgt ttgttttttc
     2401 agtacttgtt tttctctgat aagactcagg aattctgaaa tgtgaaattg tctcaattct
     2461 ttctcttgta gcatgaatca aatgtattta ttaatagcac ttatgactat agaatataat
     2521 ttggcatatg attcatatta catatgtatt cgttttattt ttaaaatagt ttataaactt
     2581 aatgattttt ttttacaaat gaggttatag atattaatgc aaattttctg gtaggtatct
     2641 ctttttttgc tatgatgatt ccaacttatc agagacctcc catttgcctt ttcattacgg
     2701 tgaaagcttt gccctcatct actaaagtac aaaggaattc tttggaagca gattattcta
     2761 gtcttatgct agagatgaat ttgatcattt taatgtgtga tctttttgct ctatcaggta
     2821 taattgtttt cctttccttt ataatgggta agttttctca cctttgagta acagtaaagt
     2881 tcatttatat gtccatacct agaagaccag tgcaaatact ttgagagcac ctgggtctac
     2941 aggacataat tggcatctaa atcctcattt cttgctatta gtaggaaaac agatatagta
     3001 ttgtaatacc cttattcttt ttgaatccta attactcatt tcggtttttt ttctctcttt
     3061 tgaatctagt tgctggtttt cgtttaatga ttttagttta acaatcccaa ccaacaatac
     3121 atttgattta tttttttctg tctaacctga caaccttttt cttgtgcttc ttgtttgttg
     3181 gttagttttt gtgaaaggaa tcattgttta agatcactgt tttcatactt gttttacact
     3241 tcacgtattt tgaagtacat ttatttacta agcatttgtg acttgaataa tttcaccaaa
     3301 tgaatacatt ttggtagttt gtaatgagtt cttctaattg ttacactttg cttggtactt
     3361 aacaataaat atgtaaaggt aaaagaaata attttctgta ttctgccaat cttaatttta
     3421 tataataaat catccatttt tttcttaaaa tagtatggat tgactgtttc taaaatacca
     3481 atctgtggct gtggtttttc ttttcttcag catttccagc atccaagtaa acaatagtcc
     3541 cttatagtcc tgctacttga tgggtaaatt tggttgctgg gtttttaagt tgcactcaca
     3601 ataaatcgtg caaagcattg tcatgcctta tttactccat ttttaatcct gcatcccaga
     3661 tttatggcag caacacatat ctacaggata cttttatgtt gtccaaatat tgctgtcagt
     3721 catatgtact tataaaatgt ctccactcat gtatatttat agaaatgaaa tgtcaaattt
     3781 ctcagactgt taaagtgcag tataaagttg cttaatgcac acttaaaaat gatatataat
     3841 ttctgaatcc tatgaaatat gtgttctttt ttaattcttt gggagttttc ttaagtttta
     3901 catgtttttt ggtttattgt taatgatttt gtttactctt tgccaaattt tgtcatgtag
     3961 gttattttac aatagcacct ttaaaaaaaa tgtatatgct aatttactaa gcatattcat
     4021 gtccattttt atttgatcat ctgatttgtg aaataacttg aaatttgtac tgtttggttt
     4081 gtgaaaataa tattaccaaa tctctgtcat tagaatgtgt actttatgtt cagaagtgac
     4141 tgtgggttta ttcagagcca gccattctct cccttgatgc actttgtaac cagctacaca
     4201 tgcttttagg tggcttttcc ctgatagggt caagtatatg actataaaac atttttcttg
     4261 tgaagctatt aagttcatta gttactctta tttccccttg ttgtaactaa gtggtgcagg
     4321 tataagcata tccccagcat tcctgtgtgt gtgaatgtgc actgctgatt tggactgttc
     4381 ttgagaaagg tgctgtgaca tatgtcaata tttgttagct ctggggatat ctttagaatg
     4441 cttgagaaag ttgctaggtg tgtgccacat tggtgcaggt aaatccatgc tgttcacagc
     4501 caagcagcat ttgcagagaa aaggagagtt ttacatagac cccaggaaaa acagtactaa
     4561 cctggttgat ggccttggtg gtggaatttt gtttcagcca gaggctactc attatatcag
     4621 aatgatgttc agtataacac tatctgattt ttagattggt cgatttctgt tgtaatcaag
     4681 tatttaggat gtaatctttt taaagtcatt gctttaatct gaaaagccat tagaagggag
     4741 aggaatcact gttccacagg atatttaaaa ctcaggagtt caaataacct cacatattga
     4801 acataaactg ttaacttatt ccacaactaa attctaacct gatacttatg aattgcaaag
     4861 tgattgctgc aaactttttc taaggtggct gaagatttaa aatagatcat tctaaaggga
     4921 aatcagtaaa atgtcttgat aattggtatc caaatcactt gtgtgcctga gaaaataaaa
     4981 ggtaatattt ta
//
